ライフサイエンスコーパス: pimozide

1 9 to 0.88; clozapine) to 6.14 (4.81 to 6.55; pimozide).

2 greater extrapyramidal symptoms relative to pimozide.

3 treatment with the 5-HT7 receptor antagonist pimozide (1 mg/kg, intraperitoneal) lowered cAMP in non-

4 - 4.28 ml h-1; P < 0.05, paired t test), and pimozide (1.5 x 10-4 M), another blocker of cyclic nucle

5 fects of both 5-HT and 5-MeOT are blocked by pimozide (10 microM) and SB-269970 [(R)-3-(2-(2-(4-methy

6 Pimozide (10 microM) caused inhibition of whole-cell cat

7 Furthermore, pimozide, a well-known antipsychotic drug, upregulates N

8 Related phenothiazines and pimozide also inhibited HCV infection and preferentially

9 Pimozide also selectively inhibits colony formation of C

10 administration of the dopamine antagonists, pimozide and alpha-flupenthixol, to rats reduced Pavlovi

11 inhibited by antagonists of T-type channels (pimozide and amiloride) as well as by antagonists whose

12 valuated the relative efficacy and safety of pimozide and haloperidol in the treatment of Gilles de l

13 The therapeutic doses of pimozide and haloperidol were equivalent (mean = 3.4 mg/

14 r inhibition with pharmacologic antagonists (pimozide and haloperidol) reduced proliferation of pancr

15 Simultaneously inhibiting STAT5 with pimozide and the kinase inhibitors imatinib or nilotinib

16 idazolam, St. John's Wort, carbamazepine and pimozide, are contraindicated with DAAs.

17 pproach, we identified the psychotropic drug pimozide as a STAT5 inhibitor.

18 rapy used included benzhexol, tetrabenazine, pimozide, baclofen, chlorpromazine, haloperidol, carbama

19 s research shows that a dopamine antagonist, pimozide, changes response rates through the direct acti

20 Pimozide decreases STAT5 tyrosine phosphorylation, altho

21 Furthermore, pimozide decreases the expression of STAT5 target genes

22 Using a reconstituted system, we show that pimozide directly inhibits the channel and we determine

23 Pimozide displaces the acyl chains within the fenestrati

24 M(p)(ro), and, importantly, three, that is, pimozide, ebastine, and bepridil, are basic molecules th

25 However, phenothiazines and pimozide exhibited improved genotype coverage including

26 o 0.95; clopenthixol) to 1.15 (0.36 to 1.47; pimozide), for sedation (30 770 participants) from 0.92

27 ed after 6 weeks of each treatment (placebo, pimozide, haloperidol), with a 2-week placebo baseline p

28 Sequential addition of Zn(2+) and pimozide, in either order, revealed no overlapping inhib

29 geted pharmacologic inhibition of STAT5 with pimozide induced apoptosis in primary T-PLL cells.

30 Pharmacologic inhibition of STAT5 with pimozide-induced differentiation and loss of LSCs, while

31 Importantly, pimozide induces similar effects in the presence of the

32 ntified that the typical antipsychotic agent pimozide is a SCOT inhibitor that can alleviate obesity-

33 At equivalent doses, pimozide is superior to haloperidol for controlling symp

34 CL5 neutralizing antibody or STAT5 inhibitor Pimozide led to reverse CD8+ T cell-enhanced BECs prolif

35 ggested that the FDA-approved small molecule pimozide might inhibit TWIK-2.

36 ug therapy with benzhexol, tetrabenazine and pimozide or haloperidol may be beneficial in some cases.

37 ying rise in [Ca(2+)](i) was also blocked by pimozide or penfluridol.

38 evation in [Ca(2+)](i) could be inhibited by pimozide or penfluridol.

39 All three DPBPs tested (pimozide, penfluridol, and fluspirilene) improved glycem

40 of high [K(+)](o) or the Ca channel blockers pimozide, penfluridol, or Ni(2+), but not nifedipine or

41 Trifluoperizine, trifluperidol and pimozide produced time-dependent blockade of hKv2.1 with

42 Pimozide proved significantly different from placebo in

43 hibitor tofacitinib, and the STAT5 inhibitor pimozide reversed steroid resistance of BAL ILC2s.

44 functional epithelial Na(+) channels (ENaC), pimozide-sensitive cation channels, K(+) channels, and t

45 ic fibrosis transmembrane regulator, but few pimozide-sensitive cation channels.

46 nd supported the notion that the Zn(2+)- and pimozide-sensitive currents are identical.

47 Although pimozide, sertindole, droperidol, and haloperidol have b

48 Furthermore, pimozide significantly reduced leukemia burden in vivo a

49 Addition of the neuroleptic drug pimozide to inhibit ID1 expression enhanced the cytotoxi

50 0 770 participants) from 0.92 (0.17 to 2.03; pimozide) to 10.20 (4.72 to 29.41; zuclopenthixol), for

51 The inhibitory effect of pimozide was concentration dependent with an IC(50) of a

52 ivalent dose formulations of haloperidol and pimozide was conducted with 22 subjects, aged 7-16 years

53 ment with ivosidenib and the STAT5 inhibitor pimozide was superior to each agent alone in inducing di

54 gs, such as chlorpromazine, fluphenazine and pimozide, were more toxic than the atypical drugs, inclu