ライフサイエンスコーパス: pioneer

1 mbryonic nucleus of the fan-shaped body ("FB pioneers").

2 r5-derived CENs migrate independently of the pioneer.

3 neurons fasciculate with the fan-shaped body pioneers.

4 resources that Nobel laureate Elinor Ostrom pioneered.

5 w supported by psychophysical experiments he pioneered.

6 nal analysis focused specifically around the Pioneer 100 gut microbiomes.

7 The Pioneer 100 Wellness Project involved quantitatively pro

8 Although high-income countries pioneered 1960s precautionary antibiotic regulations to

9 mes (albiglutide), REWIND (dulaglutide), and PIONEER 6 (oral semaglutide).

10 In this work, we pioneered a combination of ultralow flow (ULF) high-effi

11 Monterey Bay Aquarium Research Institute has pioneered a robotic Environmental Sample Processor (ESP)

12 Pioneering a combined approach of single-metal-particle

13 pt experimental result in a fibre resonator, pioneering a new technique that does not require specifi

14 network, Odd-paired (opa), is necessary for pioneering accessibility of late segmentation network CR

15 extra-cardiac malformations, caused ectopic pioneer activities, profoundly diminishing GATA4, FOXA1/

16 In contrast, the function of pioneer activity in self-renewing cell divisions and acr

17 The pioneer activity of transcription factors allows for ope

18 Our study sheds light on the constant pioneer activity required to maintain the dynamic plurip

19 ction allow nucleosome scanning that confers pioneer activity to transcription factors.

20 ction is intrinsic to the protein or whether pioneering activity is developmentally modulated, we stu

21 Our data reveal that the pioneering activity of Grh is temporally regulated and l

22 Of these, we show that the pioneering activity of the maternal pluripotency factors

23 localize EBF1's pioneering activity to a prion-like domain that mediates

24 critical for liver development through their pioneering activity, which initiates a highly complex re

25 The results present significant and pioneering advances in the synthesis of new classes of 2

26 rcutaneous coronary intervention enrolled in PIONEER AF-PCI (An Open-Label, Randomized, Controlled, M

27 Based on a unique set of methodologies, PIONEER aims to advance the field of prostate cancer car

28 Although pioneered almost two decades ago, it only recently prove

29 Selective ablation of the fan-shaped body pioneers altered the architecture of the larval fan-shap

30 Our studies pioneer an approach that allows a rapid iteration of the

31 covalent chemical bond based on Ruedenberg's pioneering analysis of H[Formula: see text] and H(2) and

32 to the spinal cord, indicating that distinct pioneer and secondary events occur at the DREZ.

33 pment of MOFs as colloids, taking ZIF-8 as a pioneering and successful case that clearly shows the be

34 d alongside a global perspective on research pioneers and commercially available products.

35 he CSB family was overlooked by valence-bond pioneers and then demonstrates that the unique status of

36 le NAMPT activators such as SBI-797812 are a pioneering approach to raise intracellular NAD(+) and re

37 Instead, actin-rich invadopodia in the pioneer axon are necessary and sufficient for DREZ entry

38 accumulate in the central growth cone as the pioneer axon breaches the spinal boundary at the dorsal

39 n-rich invasion structures dynamically drive pioneer axon entry into the spinal cord, indicating that

40 stabilizes stable base clusters and disrupts pioneer axon formation.

41 se results show a specific role for Ret51 in pioneer axon growth, and suggest a critical role for lon

42 ures dynamically remodel to produce a single pioneer axon in a 'top-down' scaffolding event.

43 r neurons and Ret51 isoform was required for pioneer axon outgrowth.

44 specific tetanus toxin expression results in pioneer axon pathfinding defects and altered spinal entr

45 nomous functioning of invasive structures in pioneer axon spinal entry.

46 We then identify that activation of Rac1 in pioneer axons destabilizes stable base clusters and disr

47 Here, we identify that DRG pioneer axons enter the DREZ before the arrival of neura

48 these hypotheses, we visualized the entry of pioneer axons into the dorsal root entry zone (DREZ) wit

49 etalloproteinase (MMP) mmp14a is required in pioneer axons to navigate across the boundary of the spi

50 esicles in navigation of dorsal root ganglia pioneer axons.

51 tical analyses revealed minor changes in the pioneer bacteria (class level) and archaea (order level)

52 The pioneer bacteria and archaea (without filtration) were i

53 Results indicate that, early after birth, pioneer bacteria colonize the infant gut and by one mont

54 -cell spread is heterogeneous, and that rare pioneer bacteria determine the frontier of infection foc

55 ion foci are irregular and dominated by rare pioneer bacteria that spread farther than the rest.

56 nly by temperate bacteriophages induced from pioneer bacteria, and later by viruses that replicate in

57 selective force for the dissimilarity of the pioneer bacterial and archaeal diversity was the shear r

58 Since the discovery of the pioneering bimetallic {MnII4[MIV(CN)8]2} and {MnII9[MV(C

59 nderstanding such gene regulation arose from pioneering biophysical studies in eubacteria.

60 TERM, created and pioneered by an interdisciplinary group of clinicians, b

61 thelium of the rhombencephalic roof plate is pioneered by distinct mesenchymal cells at the dorsal mi

62 liver, a structural model of the lobule was pioneered by Elias in 1949.

63 Pioneered by the Mayo Clinic, multimodal therapy with ne

64 Overall, our results suggest that the pioneering capabilities of TP53 are driven by nonspecifi

65 scription factors is well understood to have pioneer capacity.

66 th systems must respond to this situation by pioneering care and service delivery models that promote

67 -positive, extracellular matrix-remodeling, "pioneer" cell phenotype that is the first to invest with

68 t this effect arises from interactions among pioneering cells at the front of the expanding populatio

69 of cerebellar cortical function based on the pioneering circuit models described by John Eccles, Masa

70 ed more than seven decades ago in Vonnegut's pioneering cloud seeding experiments, it remains unclear

71 ooperative production of alarm signals among pioneer clustering neutrophils fuels the growth of dense

72 ty increased during the year starting from a pioneering community that is gradually succeeded by a mo

73 Through the identification of a pioneer complex for meiotic recombination, this study br

74 t activation in which HELLS and PRDM9 form a pioneer complex to create a unique epigenomic environmen

75 12) report the functional significance of a "pioneer complex" in mouse meiotic recombination.

76 The initial pioneers consisted of the cold-adapted photoautotrophic

77 scribe how such research efforts have led to pioneering developments and are driving the advancement

78 This research makes the pioneering discovery of D2R-induced AP threshold plastic

79 c materials and techniques, supported by the pioneering discovery of dental adhesion; the significant

80 on and trafficking is emerging, making these pioneering drug discovery efforts tractable.

81 We used the 1960s notebooks of pioneering East African naturalist C.J.P. Ionides to ext

82 Many pioneering efforts have been made to predict TF binding

83 In particular, this includes the pioneering efforts to study the nanoscale electrodynamic

84 a's Senate Bill 1070, enacted in 2010, was a pioneering example of these efforts.

85 Although HIV is a pioneering example, similar single-cell approaches have

86 ovide an informative journey, from the early pioneering examples in the field, most of them based on

87 Pioneering experimental work(4) offered a rare glimpse i

88 astrulation (sog) to better understand how a pioneer factor affects the kinetic parameters of transcr

89 SMARCA2 mutant NPCs, where it functions as a pioneer factor at de novo enhancers.

90 genes is linked to reduced expression of the pioneer factor Cebpa and is rescued by reintroducing NLS

91 ental Cell, Chew et al. (2019) show that the pioneer factor DUX4 is misexpressed in tumors, where it

92 ional machinery through interacting with the pioneer factor FOXA1 and facilitating AR recruitment to

93 roles for SMAD2 and SMAD3 with the forkhead pioneer factor FOXH1 as a partner in the regulation of d

94 ls with enzalutamide enhances recruitment of pioneer factor GATA2, AR, Mediator subunits MED1 and MED

95 We show that GATA6 is a pioneer factor in cardiac development, regulating SMYD1

96 9 cells but in contrast to its function as a pioneer factor in Th17 cells, BATF is neither sufficient

97 d throughout Drosophila development and is a pioneer factor in the larva.

98 Recently, Matsuda et al. (Pioneer factor NeuroD1 rearranges transcriptional and ep

99 other TFs and degeneracy at key bases in the pioneer factor target motif responsible for direct DNA b

100 in vivo system, we examined the function of pioneer factor TFAP2A at discrete stages of neural crest

101 Recent studies suggest TP53 functions as a pioneer factor that can target its TFBS within nucleosom

102 general timing factor and likely late-acting pioneer factor that drives a secondary wave of zygotic g

103 Forkhead box A1 (FOXA1) is a pioneer factor that facilitates chromatin binding and fu

104 SOX2 is a prominent pioneer factor that is essential for pluripotency and se

105 scription factor BLMP-1/Blimp1 operates as a pioneer factor to decompact chromatin near its target lo

106 n profiling suggests that Egr functions as a pioneer factor to directly regulate early wound-induced

107 We find that zelda encoding the pioneer factor Zelda is marked by 6mA.

108 ygotic genome activation, and binding of the pioneer factor Zelda.

109 ins in opening chromatin, in contrast to the pioneer factor, Glial cells missing, which facilitates H

110 ted in the embryo and is thought to act as a pioneer factor, increasing enhancer accessibility for tr

111 esistance by facilitating the binding of the pioneer factor, Pu.1 and cofactor, Irf8, to nucleate new

112 To determine whether pioneer-factor function is intrinsic to the protein or w

113 ese properties are similar to those of human pioneer factors (PFs), suggesting that the mechanism of

114 opening of chromatin by interactions between pioneer factors and core histones promotes genetic progr

115 Pioneer factors are transcriptional regulators with the

116 The on-target pioneer factors Ascl1 and Myod1 are sequence-related but

117 AR signaling is dependent upon these three pioneer factors both before and after the clinical trans

118 Pioneer factors can bind nucleosomal DNA to enable gene

119 ro and chromatin binding in vivo reveal that pioneer factors can directly perturb nucleosome structur

120 Thus, pioneer factors endow the competence for fate changes in

121 While all three pioneer factors exert effects that promote carcinogenesi

122 While previous studies of pioneer factors have revealed their functions in transcr

123 taining motif-enriched sequences targeted by pioneer factors in vivo.

124 ent understanding of the mechanisms by which pioneer factors initiate gene network changes and will u

125 s suggest that chromatin access of on-target pioneer factors is primarily driven by the protein-DNA i

126 cell type-specific forms of gene regulation, pioneer factors open tightly packed, inaccessible chroma

127 Our findings show how pioneer factors regulate distinct genomic targets in a s

128 In all, these pioneer factors represent some of the most promising pot

129 Pioneer factors subsequently enable other transcription

130 Pioneer factors such as Zelda (Zld) help initiate zygoti

131 eir functions in transcriptional regulation, pioneer factors that open chromatin for other physiologi

132 transcriptional activity has uncovered three pioneer factors that open up chromatin and facilitate AR

133 wide at cellularization, suggesting both are pioneer factors with common as well as distinct targets.

134 this study broadens the conceptual scope of pioneer factors, indicating their functional significanc

135 We demonstrate that other proteins, such as pioneer factors, Mediator and histone modifiers influenc

136 t alpha-helical region, conserved among FOXA pioneer factors, that interacts with core histones and c

137 rk independently of HOX-as well as potential pioneer factors.

138 unction to sustain muscle fate downstream of pioneer factors.

139 teristic for a special class of TFs known as pioneer factors.

140 ic chromosomes, a property shared with other pioneer factors.

141 lear whether the continued activity of these pioneering factors is required throughout zygotic genome

142 xtension that is distinct from the classical pioneer-follower model and highlight the role of mechani

143 s" were comparable to those achieved by the "pioneers" following 150 procedures in similar cases.

144 key characteristics approach similar to that pioneered for carcinogen hazard identification to female

145 sing spray-drying microencapsulation, and is pioneering for its use of DSC to determine the best prop

146 The pioneer forkhead box (FOX)A2 transcription factor is spe

147 cle serves as a ready reference guide to the pioneering formal studies in cardiovascular disease (CVD

148 Thus, FOXA1 mutations alter its pioneering function and perturb normal luminal epithelia

149 the embryo may require specific, continuous pioneering functions to activate the genome.

150 Pioneering gene therapy trials have shown that the genet

151 tems and structural data retrieving, and the pioneer generation of true hsTYR inhibitors.

152 cts, led to accumulation of activated Ret in pioneer growth cones, and reduced retrograde Ret51 trans

153 apacity, and relieve symptoms of oHCM in the PIONEER-HCM phase 2 study.

154 In PIONEER-HF (Comparison of Sacubitril/Valsartan Versus En

155 The PIONEER-HF (comParIson Of sacubitril/valsartaN versus En

156 etermined the proportion of patients meeting PIONEER-HF eligibility criteria (PIONEER-HF eligible) an

157 patients, 31.6% (95% CI, 30.3-32.9) for the PIONEER-HF eligible cohort, and 32.2% (95% CI, 31.4-33.0

158 patients, 32.6% (95% CI, 31.3-33.9) for the PIONEER-HF eligible cohort, and 33.1% (95% CI, 32.3-33.9

159 nts meeting PIONEER-HF eligibility criteria (PIONEER-HF eligible) and those meeting a set of limited

160 en compared between the all HFrEF with ADHF, PIONEER-HF eligible, and actionable cohorts using linked

161 PIONEER-HF inclusion criteria were met by 71 633 (71.8%)

162 clinical outcomes for patients eligible for PIONEER-HF only modestly differ when compared with those

163 m to determine the representativeness of the PIONEER-HF trial among patients hospitalized for ADHF us

164 The PIONEER-HF trial was a prospective, multicenter, double-

165 bilized From an Acute Heart Failure Episode [PIONEER-HF]; NCT02554890).

166 imates of Model Accuracy (EMA), which uses a pioneering hybrid quasi-single model approach.

167 3 hidradenitis suppurativa clinical trials (PIONEER I and II) to date.

168 ociety in North America, SER has long been a pioneer in promoting diversity and inclusion.

169 He was a pioneer in targeted cancer therapy and was instrumental

170 Alan Fersht, a pioneer in the field of structural biology, has studied

171 Keeler (1900-1994), a pioneer in the study of retinal genetics.

172 George Oster was a pioneer in using mechanical models to interrogate morpho

173 The "ten simple rules" format, pioneered in computational biology, was applied here to

174 ize in Physiology or Medicine was awarded to pioneers in the field of cancer immunotherapy, as the ut

175 al and social challenges that confronted the pioneers in this field of study, and the considerable pr

176 The IDA pioneers Inouye, Shinkai, and Anslyn inspired researcher

177 Our work resurrects Jennings' pioneering insights and adds to the list of exceptional

178 The PIONEER Intraoperative and Perioperative OCT Study is a

179 Our experiments verify that the pioneer is an r4-derived neuron and reaffirm its role in

180 s Programme (BD4BO), the overarching goal of PIONEER is to provide high-quality evidence on prostate

181 ent Through the Power of Big Data in Europe (PIONEER) is a European network of excellence for big dat

182 ruggability and will serve as a resource for pioneering kinase inhibitor development to address curre

183 are the best evidence for the ecology of the pioneering large land plants that transformed the Earth

184 we show that GAGA factor (GAF), a Drosophila pioneer-like factor, functions with both SWI/SNF and ISW

185 and how p53 binds to DNA and chromatin, its pioneer-like role, and how this affects gene regulation.

186 of hunchback by the activator Bicoid and the pioneer-like transcription factor Zelda in living Drosop

187 ed cells progressing through the cell cycle, pioneering microarray studies defined cell cycle genes b

188 or her contributions over seven decades as a pioneering microscopist, an inspiring researcher, mentor

189 Intermediate progenitors (IPs, Tbr2+) pioneered migrations, supporting and guiding later emigr

190 imidazolate framework-8 (ZIF-8) has become a pioneering MOF constituent of colloidal science.

191 nvestigate whether the previously described "pioneer" neuron that leads FBMN migration through the hi

192 Ret receptor was highly enriched in sensory pioneer neurons and Ret51 isoform was required for pione

193 experimental strategies to use organoids to pioneer new understanding of human brain pathology.

194 Historically, urology has pioneered new surgical techniques and technologies.

195 Pioneering new research has unraveled distinct roles and

196 scientific community with an opportunity to pioneer novel models that effectively engage virtual par

197 phases of palate development is necessary to pioneer novel prenatal interventions.

198 s across developmental time that is aided by pioneer nucleosome binding.

199 TFs can employ either direct DNA binding or "pioneer" nucleosome binding at different enhancer target

200 We sought to revisit these pioneering observations because mutations in NOD2, the g

201 George Oster stood out as a pioneer of this paradigm shift from descriptive to quant

202 rgent plant lineages and important ecosystem pioneers, often form nutritional mutualisms with arbuscu

203 ogy to viruses, and recently she published a pioneering paper showing how the meningeal lymphatic vas

204 Most eyes that underwent surgery in the pioneering phase of DMEK showed excellent and stable cli

205 These species are likely the pioneer plants for revegetation on sandy land.

206 Not only does this report pioneer programmed gene-editing in parasitic flatworms,

207 er these errors are due to the disruption of pioneer projections from prethalamus to thalamus and fou

208 echnologies and experimental approaches they pioneered, ranging from cell fractionation to immunoprec

209 nce, they should serve as an inspiration for pioneering research not just to develop such tools but a

210 Tissue clearing has gained attention as a pioneering research tool for imaging of large tissue sam

211 Circulating tumor cells are tumor-derived pioneers responsible for the metastatic spread of cancer

212 The pioneering ribosome can both physically associate and ki

213 Here we show that RNAPs outpace pioneering ribosomes in the Gram-positive model bacteriu

214 nts, validating their degradation during the pioneer round of translation.

215 licing and displaced by ribosomes during the pioneer round of translation.

216 rn medical treatments, emergence of multiple pioneer scientists and physicians with great contributio

217 At Massachusetts General Hospital, we pioneered simultaneous hematopoietic cell (HCT)/kidney t

218 areas, reflecting a shift in composition to pioneer species with acquisitive traits.

219 Pioneering studies focused on the role of these factors

220 However, and besides a few pioneering studies in the 20th century, it is only in th

221 xtrastriate cortex), and Vivien Casagrande's pioneering studies of this system using the tree shrew a

222 The rich literature of pioneering studies on tumor heterogeneity analysis spurr

223 Those pioneering studies proved the feasibility of retrosynthe

224 Pioneering studies showed that introduction of blood fro

225 This review moves through pioneering studies to exciting new findings.

226 has been established, a critical analysis of pioneering studies will be presented.

227 This is a pioneer study on the in vitro screening of neuroactive p

228 The development of dialysis by early pioneers such as Willem Kolff and Belding Scribner set i

229 es and short- and medium-term outcomes of 4 "pioneering" surgeons from stage 2 were compared with 4 "

230 Fan-shaped body pioneers survive into the adult stage, where they develo

231 Then, several pioneering techniques for facile observation of structur

232 Our experiment involves pioneering techniques to coherently swap qubits encoded

233 s demonstrate how a single sequence-specific pioneer TF can synergize with remodelers to activate set

234 ctural basis for nucleosome recognition by a pioneer TF that is essential for understanding how chrom

235 Pioneer TFs are thought to induce chromatin opening by r

236 Specialized pioneer TFs bind nucleosome-wrapped DNA to perform this

237 nt regulatory programs: the binding sites of pioneer TFs of FOX family are specifically enriched in s

238 on these results, we propose that HOX13 TFs pioneer the distal limb-specific chromatin accessibility

239 ndness prevention inexplicably led me to (re)pioneer the effects, treatment, and prevention of vitami

240 Here we pioneer the use of their spin-labeled variants as report

241 f influenza vaccines, our research group has pioneered the development of computationally optimized b

242 It has been 50 years since Francis Fontan pioneered the operation that today bears his name.

243 Yoshiki Sasai pioneered the organoid field with his idea of mimicking

244 One of the forerunners that pioneered the revolution of high-throughput genomic tech

245 n and malignancy in thyroid cancer, and have pioneered the use of ICAM-1 targeted CAR T cells as a no

246 Narasaka and Johnson pioneered the way in the use of nitrogen electrophiles,

247 This study pioneers the generation and application of an optochemog

248 Present study pioneers the technology of pulsed laser irradiation in l

249 demonstrate that activator protein 1 (AP-1) 'pioneers' the senescence enhancer landscape and defines

250 f fate-changing transcription factors act as pioneers; they scan and target nucleosomal DNA and initi

251 We found that the pioneer transcription factor Ascl1 alone is sufficient f

252 FOXA1 functions as a pioneer transcription factor by facilitating the access

253 lncRNA (LINC00675) that is regulated by the pioneer transcription factor FOXA1 and encodes a conserv

254 Mutations in the pioneer transcription factor FOXA1 are a hallmark of est

255 During cellular reprogramming, the pioneer transcription factor GATA3 binds chromatin, and

256 EBF1 is a pioneer transcription factor involved in B lymphocyte sp

257 metastatic prostate tumors, FOXA1 encodes a pioneer transcription factor involved in disease onset a

258 regions enriched with binding motifs of the pioneer transcription factor PU.1.

259 found that inserting an enhancer containing pioneer transcription factor sites coupled to Notch dime

260 Forkhead box A1 (FOXA1) is a pioneer transcription factor that is essential for the n

261 associated with hypermethylation of FOXA1, a pioneer transcription factor that promotes the luminal p

262 These include enrichment of the pioneer transcription factor Zelda, and lack of SIN3A an

263 T Distinct cell types often require the same pioneer transcription factor, raising the issue of how o

264 ation of the glucocorticoid receptor (GR), a pioneer transcription factor.

265 ansactivation of the bICP0 E promoter by two pioneer transcription factors (GR and KLF4) correlates w

266 Stress-induced pioneer transcription factors are proposed to activate k

267 Our results indicate that pioneer transcription factors can use binding energy to

268 Nonetheless, much of how pioneer transcription factors coordinate changes in chro

269 Pioneer transcription factors have the intrinsic biochem

270 Pioneer transcription factors have the unique property o

271 cell-type-specific sites is dependent on the pioneer transcription factors OCT4 (POU5F1) and SOX2, bu

272 GR and KLF4, both pioneer transcription factors, cooperated to stimulate b

273 Two pioneer transcription factors, GR and Kruppel-like trans

274 mplifies fibroblast transgenesis for the two pioneer transcription factors, Ngn2 and Ascl1, and marke

275 with RNA polymerase III initiation, bound by pioneer transcription factors, or located in broad domai

276 Pioneer transcription factors, which bind nucleosomes, c

277 By targeting P, TRIM69 inhibits pioneer transcription of the incoming virion-associated

278 in PU.1 is a myeloid lineage-determining and pioneering transcription factor due to its ability to bi

279 H2A.Z/H3.3 double-variant nucleosome and the pioneering transcription factor forkhead box A1 (FOXA1),

280 th unknown function in LUAD, adjacent to the pioneering transcription factor FOXA2.

281 'Pioneer' transcription factors are required for stem-cel

282 d from 2007 to the end of 2019, yet relevant pioneering transformations are eventually included.

283 s was a post hoc analysis of all eyes in the PIONEER undergoing surgical repair with primary macula-i

284 Since the pioneering use of (131)I in differentiated thyroid cance

285 These pioneers were succeeded by, amongst others, cyanobacteri

286 and major liver resections faster than the "pioneers" who were self-taught in LLS.

287 We recount pioneering work and seminal studies performed within the

288 The technique relies on pioneering work by Kaufman and colleagues, commercialize

289 motivated by the desire to fully generalize pioneering work from the Sharpless and Finn groups in wh

290 This pioneering work has made a new model of the human intest

291 awing on literature in other disciplines and pioneering work in ecology, we present a standardised fr

292 Pioneering work in Escherichia coli revealed that DNA to

293 recent computational models and some of the pioneering work in the 1970s and 80s.

294 s tribute to Delphine Parrott, who conducted pioneering work in the fields of T cell biology, lymphoi

295 The pioneering work of Powell established the first relation

296 neurons have intrigued scientists since the pioneering work of Santiago Ramon y Cajal.

297 Pioneering work on the dimensions of mind perception has

298 Although pioneering works in organic synthesis have largely contr

299 Pioneering works using organotin reagents or catalysts w

300 ons must outweigh the anticipated risks of a pioneering xenotransplant procedure.