ライフサイエンスコーパス: pipecolic acid

1 analyzed for the presence of alpha-AASA and pipecolic acid.

2 the alpha-allylation of tert-butoxycarbonyl pipecolic acid.

3 f FK506 has focused on esters of proline and pipecolic acid.

4 thogonally protected cis and trans-3-hydroxy pipecolic acid.

5 access to all four isomers of the 3-hydroxy pipecolic acid.

6 ing metabolites pipecolic acid and N-hydroxy-pipecolic acid.

7 ctive amidation of the resulting unprotected pipecolic acid.

8 hesis of novel 2,6-cis-6-substituted-4-oxo-L-pipecolic acids.

9 mbled utilizing one-pot cyclodimerization of pipecolic acids.

10 rmationally restricted analogues of proline, pipecolic acid, 2-aminoadipic acid, or glutamic acid.

11 enic acid (1.8-fold), glucose (68-fold), and pipecolic acid (6.5-fold).

12 noid dehydroabietinal, the lysine catabolite pipecolic acid, a glycerol-3-phosphate-dependent factor

13 We show that systemic pipecolic acid accumulation is an early metabolic respon

14 multicomponent coupling between l-proline or pipecolic acid, aldehydes, and isonitriles is described.

15 This resulted in the first series of pipecolic acid amides, which had much lower molecular we

16 Levels of both pipecolic acid and certain metabolites shown to be eleva

17 synthesis of the two SSR priming metabolites pipecolic acid and N-hydroxy-pipecolic acid.

18 ein domain can be successfully loaded with l-pipecolic acid and, to a lesser extent, l-proline.

19 orted here had increased CSF alpha-AASA, CSF pipecolic acid, and known or likely pathogenic mutations

20 trans-3-Methyl-proline, pipecolic acid, and leucic acid were able to replace the

21 he urinary elevations in glycine betaine and pipecolic acid (as well as proline) indicated defective

22 The larger ring homolog aza-pipecolic acid (azPip), in which this internal hydrogen

23 The occurrence of pipecolic acid betaine (homostachydrine) and its biosynt

24 report for the first time the occurrence of pipecolic acid betaine (homostachydrine) and its precurs

25 Pipecolic acid betaine (PAB) concentrations were signifi

26 ha-aminoadipic semialdehyde (alpha-AASA) and pipecolic acid both in brain and liver tissues, similar

27 alidate its ability to convert L-lysine to L-pipecolic acid by a cyclodeamination reaction that invol

28 een applied to the synthesis of (R)- and (S)-pipecolic acid derivatives, (+)-beta-conhydrine, (S)-(+)

29 For example, a library of 20 pipecolic acid derivatives, a recurring motif in various

30 me approach also provides improved access to pipecolic acid derivatives.

31 esents fresh avenues for the biosynthesis of pipecolic acid derivatives.

32 plified here by the synthesis of enantiopure pipecolic acid derivatives.

33 ly identified priming activators azelaic and pipecolic acid, elaborates on the similarity to defense

34 biocatalytic synthesis of alkyl- substituted pipecolic acids from O-acetyl-L-homoserine and beta-keto

35 2R,2'S) enantiomers of 1 were derived from l-pipecolic acid in 96% optical purity.

36 yclic lactam scaffolds were synthesized from pipecolic acid in a sequence of reactions that was initi

37 by catalyzing the formation of 1-O-glucosyl-pipecolic acid in Arabidopsis thaliana.

38 -AASA), piperideine-6-carboxylate (P6C), and pipecolic acid in body fluids.

39 Notably, specific pipecolic acids in this library were obtained via hydrol

40 osoma cruzi MIPs in complex with fluorinated pipecolic acid inhibitors.

41 It has been assumed that pipecolic acid is generated from lysine by the cyclodeam

42 ketopiperazines (DKPs) using enantioenriched pipecolic acids is described.

43 f saccharopine oxidation, N-oxalylglycine, L-pipecolic acid, L-leucine, alpha-ketoglutarate, glyoxyli

44 tion for this finding is not clear, elevated pipecolic acid levels may serve as a diagnostic marker f

45 Pipecolic acid, linked to systemic acquired resistance i

46 as devised to convert annulation products to pipecolic acid monomers.

47 N-hydroxy-pipecolic acid (NHP) and a glycosylated derivative are p

48 Recently, N-hydroxy-pipecolic acid (NHP) was identified as another regulator

49 and instead rely on the metabolite N-hydroxy-pipecolic acid (NHP).

50 5-alkyl-, 5,5-dialkyl-, and 5,5,6-trialkyl-l-pipecolic acids of high diastereomeric ratio.

51 e-2-COOH; 4,4'-Bip=4,4'-biphenylalanine; Pip=pipecolic acid) of IC50=0.95 nM and EC50=0.99 nM at hMC5

52 e (a-AASA), piperideine-6-carboxylate (P6C), pipecolic acid (PA) and alpha-aminoadipic acid (alpha-AA

53 Clinically abnormal concentrations of pipecolic acid (PA) were present in CM plasma, and nearl

54 at CAMTA123 also repress the biosynthesis of pipecolic acid (Pip) in healthy plants.

55 Salicylic acid (SA) and pipecolic acid (Pip) levels were quantified and function

56 ic genes (ALD1 and FMO1) and reduced NHP and pipecolic acid (Pip) levels.

57 The nonprotein amino acid pipecolic acid (Pip) regulates plant systemic acquired r

58 identification of the non-protein amino acid pipecolic acid (Pip), a common Lys catabolite in plants

59 y plant metabolites, salicylic acid (SA) and pipecolic acid (Pip), in the establishment of plant syst

60 A single nonproteinogenic pipecolic acid residue is installed into the scaffold by

61 Interestingly, some uncommon derivatives of pipecolic acid, such as N-methylpipecolic acid, 4-hydrox

62 From d-pipecolic acid, the (2R,2'R) and (2S,2'R) enantiomers of

63 the resulting 2,6-cis-6-substituted 4-oxo-l-pipecolic acids to the corresponding 4-hydroxy-L-pipecol

64 h increased levels of the salicylic acid and pipecolic acid, two compounds that are involved in syste

65 id synthesis of both substituted proline and pipecolic acid type derivatives.

66 With the exception of the 3-hydroxy-l-pipecolic acid unit, little is known about the biosynthe

67 colic acids to the corresponding 4-hydroxy-L-pipecolic acids was also performed.

68 In contrast to pipecolic acid, which exhibits a high cis amide populati