ライフサイエンスコーパス: plague

1 agent of bubonic, pneumonic, and septicemic plague.

2 in-dependent T cell-mediated defense against plague.

3 itive to lethality from secondary septicemic plague.

4 tibody responses that are protective against plague.

5 is causes bubonic, pneumonic, and septicemic plague.

6 uces the progression of secondary septicemic plague.

7 ion primary response 88 (MyD88) in pneumonic plague.

8 thus hastens the flea-borne transmission of plague.

9 s maximalist reconstructions of late antique plague.

10 iniosis, Far East scarlet-like fever and the plague.

11 However, they are susceptible to plague.

12 important role in determining the outcome of plague.

13 rium Yersinia pestis, the causative agent of plague.

14 significantly increased survival of bubonic plague.

15 Yersinia pestis results in primary pneumonic plague.

16 ravity whilst quarantined during the bubonic plague.

17 tibody therapy in the mouse model of bubonic plague.

18 and biological threats, such as anthrax and plague.

19 ing from food-borne illnesses to the bubonic plague.

20 the causative agent of bubonic and pneumonic plague.

21 antly attenuated in a mouse model of bubonic plague.

22 mmatory responses to cause primary pneumonic plague.

23 of all antimicrobials used for treatment of plague.

24 ost important steps to improving survival of plague.

25 ssociated with increased odds of survival of plague.

26 ntimicrobials considered to be effective for plague.

27 auses a rapid, lethal disease referred to as plague.

28 ls in the dermis in a mouse model of bubonic plague.

29 r virulence of Yersinia pestis, the agent of plague.

30 limate disruptions, famines, major wars, and plagues.

31 cases classified by primary clinical form of plague, 93.6% were bubonic, 5.9% pneumonic, and 0.5% sep

32 aracterize the evolution of a USA300 variant plaguing a patient population at increased risk of infec

33 Yersinia pestis causes bubonic plague, a fulminant disease where host immune responses

34 The COVID19 crisis has magnified the issues plaguing academic science, but it has also provided the

35 rations reflective of early-stage septicemic plague, Ail weakly recruits Vn and fails to recruit fact

36 torical images labelled as depictions of the plague, although artistic and textual evidence shows tha

37 ble for inclusion and described 160 cases of plague among pregnant women.

38 ticles in any language with terms related to plague and antimicrobials.

39 thers for publications with terms related to plague and antimicrobials.

40 d elsewhere that Mus spretus SEG mice resist plague and develop an immune response characterized by a

41 s genus are A. astaci, the cause of crayfish plague and its close relative, A. invadans, which causes

42 /pathogen interactions that define pneumonic plague and showcase the utility of human precision-cut l

43 host/pathogen interactions during pneumonic plague and solidify the role of Pla in promoting optimal

44 The fact that both the data of the Florence plague and those of the Covid-19 pandemic are successful

45 7 contributed to the lethality of septicemic plague and was associated with the suppression of neutro

46 ral vaccine candidate for protection against plague and yersiniosis for human and veterinary applicat

47 racyclines substantially improve survival of plague, and fluoroquinolones may be equally as effective

48 ia, including causative agents of dysentery, plague, and typhoid fever, rely on a type III secretion

49 e; possible triggers include climate change, plague, and wider sociopolitical developments.

50 nya, hantavirus, Rift Valley fever, cholera, plague, and Zika.

51 igor and is subject to the inaccuracies that plague anecdotal decision-making.

52 ue in 1896 suggest that, only a decade after plague arrived, a heritable, plague-resistant phenotype

53 ve immunity to prevent bubonic and pneumonic plague, as well as yersiniosis, in mice and would be a p

54 The plague bacillus Yersinia pestis is unique among the path

55 the selective destruction of immune cells by plague bacteria are unknown.

56 A common issue plaguing battery anodes is the large consumption of lith

57 Yersinia pestis, the causative agent of plague, binds host cells to deliver cytotoxic Yop protei

58 B resolves many of the issues that routinely plague biomedical researchers intending to work with dat

59 ponent for the integrated management of both plagues, but local eradication successes have been limit

60 malignancies, they have simultaneously been plagued by a cytokine release syndrome (CRS) that can ha

61 of all-solid-state rechargeable batteries is plagued by a large interfacial resistance between a soli

62 Unfortunately, tree ring analysis can be plagued by biases, resulting in spurious growth trends.

63 tient population which tends to be older and plagued by comorbidities such as diabetes mellitus and h

64 daveric biologic mesh has been expensive and plagued by complications such as seroma, infection, and

65 rinting of inorganic semiconductors has been plagued by concomitant generation of crystallography def

66 We report that the current evidence base is plagued by considerable methodologic heterogeneity in al

67 d desalination processes, in particular, are plagued by crystal growth (known as scaling), which rest

68 advanced and end-stage heart failure, remain plagued by device thrombogenicity.

69 amplification are highly relevant, yet still plagued by diverse drawbacks including erroneous target

70 he computational and statistical methods are plagued by fundamental identifiability issues, instabili

71 be undergoing a re-eutrophication and it is plagued by harmful algal blooms.

72 However, the field has been plagued by heterogeneity in the distributions of synthes

73 ever, the current Ag-NW thin films are often plagued by high NW-NW contact resistance and poor long-t

74 promise for this purpose; however, they are plagued by high organoid-to-organoid variability(2,3).

75 The target article is plagued by imprecision, making it largely impossible to

76 been considered the drugs of choice but are plagued by increasing resistance and adverse drug effect

77 ired cell types using this approach is often plagued by inefficiency, slow conversion, and an inabili

78 ols and therapeutics, but they are typically plagued by instability and short half-lives in vivo.

79 d structure formation even for small RNAs is plagued by intractably large state spaces.

80 owever, progress of Li(2) S cathode has been plagued by its intrinsic drawbacks, including high activ

81 nsity and long operation lifetimes, they are plagued by limited energy density.

82 fected or cancerous cells; however, they are plagued by low stability and uneven expression.

83 ensely popular methodology, which is however plagued by mathematical intractability.

84 y rechargeable batteries, but its cycling is plagued by morphological irreversibility and dendrite gr

85 bility, and sensitivity of those systems are plagued by network leakage.

86 minant of the Cervidae family, is habitually plagued by pathogens in its natural environment (e.g. Ha

87 However, their application is plagued by poor chemical and structural stability.

88 ic vehicle operations, but their adoption is plagued by poor cycle life due to the structural and che

89 ls are attractive for thermal insulation but plagued by poor mechanical stability and degradation und

90 p polymeric alternatives, however, have been plagued by poor retention and off-target toxicity due to

91 ardiac performance after such treatments are plagued by relatively low detection ability.

92 Doing so at the nanoscale has thus far been plagued by significant scalability problems, particularl

93 ct outcomes of mitral regurgitation (MR) are plagued by small size, inconsistent etiologies, and lack

94 Applications of zeolites in catalysis are plagued by strong diffusion resistance, which results fr

95 Such markets are plagued by strong incentives for fraudulent behavior of

96 iables, organ transplantation is still often plagued by substantial initial dysfunction, variably ref

97 ioherbicides in affluent countries are still plagued by technological hurdles and limited market pote

98 a combination of BRAF and MEK inhibitors is plagued by the development of drug resistance.

99 opment of a competitive magnesium battery is plagued by the existing notion of poor magnesium mobilit

100 charge transport properties remain elusive, plagued by the issues of excessive contact resistance an

101 trochemical performance of red phosphorus is plagued by the large volume variation upon sodiation.

102 Nutrition research is plagued by the reproducibility crisis.

103 Current treatment options are plagued by toxicity, lengthy treatment regimens, and gro

104 roteins in heterogeneous media are generally plagued by two distinct obstacles: lack of sensitivity d

105 ersion of one amide to another, is typically plagued by unfavourable kinetic and thermodynamic factor

106 Among 533 total reported plague cases during 1942-2018, 426 (80%) received high-e

107 etermined the geographic pattern of sporadic plague cases.

108 Plague, caused by the bacterium Yersinia pestis, has kil

109 Host survival during plague, caused by the Gram-negative bacterium Yersinia p

110 Pneumonic plague, caused by Yersinia pestis, is a rapidly progress

111 and protection against bubonic and pneumonic plague challenges, with 80% and 90% survival, respective

112 tality estimates assert that the Justinianic Plague (circa 541 to 750 CE) caused tens of millions of

113 Two fundamental challenges plague clinical translation of vaccine-adjuvants: reduci

114 izing on extensive archival data from Indian Plague Commission investigations.

115 Plague continued to afflict Europe for more than five ce

116 esponsible for pandemic outbreaks, pneumonic plague continues to be a challenge for medical treatment

117 ate side-effects and proarrhythmic potential plaguing CPVT pharmacological management today.

118 f the inaccurate functional annotations that plague databases, functional inferences from diverse sou

119 Plague develops as a consequence of bacterial neutraliza

120 biologically relevant i.d. model of bubonic plague differs significantly from the s.c. model in mult

121 mely high-prevalence outbreak (61%) of white-plague disease at 14 sites off southeastern Florida.

122 a annularis corals during a concurrent white plague disease outbreak and bleaching event.

123 White-plague disease was observed near Virginia Key, Florida,

124 is causes bubonic, pneumonic, and septicemic plague, diseases that are rapidly lethal to most mammals

125 One problem plaguing drug development efforts is the lack of a suita

126 highlighted a significant role for pneumonic plague during outbreaks of Y. pestis infections.

127 he safety of 9 antimicrobials considered for plague during pregnancy (amikacin, gentamicin, plazomici

128 les were included if they reported a case of plague during pregnancy and at least 1 maternal or fetal

129 owledge about the clinical manifestations of plague during pregnancy, specifically the maternal, feta

130 d provide postexposure prophylaxis (PEP) for plague during pregnancy.

131 ta as well as information about the risks of plague during pregnancy.

132 d plague experts to identify publications on plague during pregnancy.

133 ials should be used for treatment and PEP of plague during pregnancy; the choice of antimicrobials ma

134 atical model coupling environmentally forced plague dynamics with evolutionary selection of rats, cap

135 3 and 4 pathogens, such as anthrax, bubonic plague, Ebola and Marburg fever.

136 eveal the temporal patterns of a sequence of plague epidemics in London, United Kingdom, from the 14t

137 climate fluctuations that preceded regional plague epidemics, based on a dataset of 7,711 georeferen

138 g commensal rats of cities undergoing severe plague epidemics.

139 production rates and ubiquitous contaminants plague experimental practices.

140 ases, performed hand searches, and consulted plague experts to identify publications on plague during

141 en due to either the presence of now-extinct plague foci in Europe itself, or successive disease intr

142 e ports indicates the absence of a permanent plague focus in the inland areas of Europe.

143 e of a previously uncharacterized historical plague focus that persisted for at least three centuries

144 we describe the characteristics of pneumonic plague, focusing on its disease progression and pathogen

145 s from one of the last European outbreaks of plague, from 1722 in Marseille, France.

146 The economic crisis plaguing Greece was expected to impact consumption of ph

147 Yet, by the 17th century, the dynamics of plague had changed, leading to its slow decline in Weste

148 Importantly, recent epidemics of plague have highlighted a significant role for pneumonic

149 Most US patients with plague have received effective antimicrobials.

150 Recently developed in vivo models of plague have resulted in new ideas regarding bacterial sp

151 verity, and difficulty of treating pneumonic plague highlight how differences in the route of disease

152 obials are considered effective for treating plague; however, well-defined information on the relativ

153 tolerable burden of malaria has for too long plagued humanity and the prospect of eradicating malaria

154 Despite plaguing humanity for thousands of years, the host facto

155 ost successful parasites, many of which have plagued humans throughout our history.

156 many of the practical limitations that have plagued hydrogen-bond donor catalysis and enables use of

157 in colonial India after the introduction of plague in 1896 suggest that, only a decade after plague

158 rto Rico and a rapidly unfolding outbreak of plague in 2017 in Madagascar.

159 by Yersinia pestis began as the Justinianic Plague in 541 within the Roman Empire and continued as t

160 ly effective treatment options for pneumonic plague in AGMs.

161 provide complete protection against bubonic plague in animal models, the mechanisms responsible for

162 Plague in Colorado and New Mexico as well as cholera in

163 been responsible for the many resurgences of plague in Europe following the Black Death.

164 trade routes were to blame for the spread of plague in European history, yet this relationship has ne

165 Yersinia, including Y. pestis, the agent of plague in humans, and Y. pseudotuberculosis, the related

166 e routes played a dominant role in spreading plague in pre-industrial Europe.

167 evidence for the presence of the Justinianic Plague in the British Isles, previously only hypothesize

168 treatment information for all patients with plague in the United States (US) as collected under the

169 he LALIA event and outbreak of the Justinian Plague in the year 541.

170 of Yersinia pestis, the etiological agent of plague, in Neolithic farmers in Sweden, pre-dating and b

171 It has been used to support plague indications for fluoroquinolones and to test the

172 These data were submitted to FDA and plague indications were approved.

173 instabilities that are poorly understood and plague industrial processes.

174 Plague infection in mice is characterized by high mortal

175 of serum resistance may be essential during plague infection.

176 of Y. pestis during the septicemic stage of plague infections.

177 tence of an extra-European reservoir feeding plague into Western Europe in multiple waves.

178 Plague is a rapidly lethal human disease caused by the b

179 Plague is a rare and severe zoonotic illness with limite

180 Plague is initiated by Yersinia pestis, a highly virulen

181 The AGM model of pneumonic plague is reproducible, well-characterized, and mimics h

182 Pneumonic plague is the deadliest form of disease caused by Yersin

183 Pneumonic plague is the most severe manifestation of plague, with

184 recise role in the pathogenesis of pneumonic plague is yet to be defined.

185 Yersinia pestis, the etiologic agent of plague, is a bacterium associated with wild rodents and

186 Yersinia pestis, the bacterium that causes plague, is a highly pathogenic organism.

187 We focus on the Australian plague locust, for which excellent field and experimenta

188 tions to biosensors, where electrode fouling plagues long-term sensor performance.

189 Although high optical losses still plague many approaches, phonon polariton (PhP) materials

190 e the contexts of official wars continues to plague many parts of the world.

191 light on the practical limitations that have plagued many of the H-bond donor-catalyzed reactions dev

192 er resistance to deactivation by coking that plagues many industrial catalysts.

193 but also address resistance issues that are plaguing many chemotherapeutic regimens.

194 Indiscriminate antimicrobial use has plagued medicine since antibiotics were first introduced

195 to 100% survivability to mice in a pneumonic plague model at 20 to 50 LD50.

196 In the murine plague model, TLR7 was a significant contributor to the

197 The curse of dimensionality plagues models of reinforcement learning and decision ma

198 In the plague mouse model, a single immunization with the EV76

199 If low statistical power plagues neuroscience, then this reduces confidence in th

200 ter epidemics that culminated with the Great Plague of 1665, we estimate that the epidemic growth rat

201 it was responsible for three pandemics: the Plague of Justinian in the 6(th) century AD, which persi

202 periodic fever syndromes and septic shock-a plague on modern medicine.

203 tion of individuals with suspected smallpox, plague, or cholera.

204 lusions from RADseq data, a problem that has plagued other genetic marker types in the past.

205 Health disparities plague our healthcare system.

206 Major trade routes decided the major plague outbreak hotspots, while navigable rivers determi

207 ld be considered in pre-event planning for a plague outbreak or BT event.

208 y modern period and the 6,656 geo-referenced plague outbreak records in AD1347-1760.

209 a dataset of 7,711 georeferenced historical plague outbreaks and 15 annually resolved tree-ring reco

210 radigm: None has a clear independent link to plague outbreaks and none supports maximalist reconstruc

211 urthermore, the negative correlation between plague outbreaks and their distance from major trade por

212 These fungi have been plagued over the past century by different perspectives

213 Near the end of the second plague pandemic (1348 to ~1700 CE), lead pollution incre

214 entified in genomes connected with the first plague pandemic (541-750 AD), suggesting a comparable ev

215 entric approach for the discussion on Second Plague Pandemic dynamics in Europe.

216 ssia, 18th century) is now the latest Second Plague Pandemic genome and the first non-European sample

217 xt]-Weibull distributions with data from the plague pandemic of 1417 in Florence as well as data from

218 nsistent with the existence of a prehistoric plague pandemic that likely contributed to the decay of

219 The second plague pandemic, caused by Yersinia pestis, devastated E

220 This epidemic marked the start of the second plague pandemic, which lasted in Europe until the early

221 uals of Mediterranean decent during historic plague pandemics.

222 lower ends of the height spectrum that have plagued past IBW equations.

223 A case study in Germany indicates that plague penetrated further into Europe through the local

224 , the datasets suggest continuity across the plague period.

225 Plague presents an optimal system for interrogating such

226 Thus, FPR1 is a plague receptor on immune cells in both humans and mice,

227 ned, we found 762 published cases of treated plague reported from 1937 to 2019.

228 icrobials and illness outcome among cases of plague reported from 1942-2018.

229 published data on antimicrobial treatment of plague reported in aggregate.

230 A total of 2631 cases of human plague reported within these articles were included.

231 To locate these putative plague reservoirs, we studied the climate fluctuations t

232 Incorporating increased plague resistance among rats as a consequence of intense

233 lution based on experimental observations of plague resistance and reveal the buffering effect of suc

234 this study, we have further delineated this plague resistance locus to a region of less than 20 cM t

235 This programming plays a key role in the plague-resistance phenotype and may be similarly signifi

236 a decade after plague arrived, a heritable, plague-resistant phenotype had become prevalent among co

237 Bubonic plague results when Yersinia pestis is deposited in the

238 The reasons for plague's persistence and abrupt disappearance in Europe

239 Furthermore, plague selection of FPR1 alleles appears to have shaped

240 Together with plague, smallpox and typhus, epidemics of dysentery have

241 Yet, statistical artifacts commonly plague the analysis of relative abundance data.

242 ectrolyte solves four key problems that have plagued the development of large-scale Li-ion batteries

243 fundamental catalytic limitations that have plagued the electrochemical production of hydrogen for d

244 e with global biodiversity hotspots and have plagued the everyday reality of many countries throughou

245 ery promising approach to a problem that has plagued the field of ion-selective electrodes and field

246 This fundamental question has plagued the molecular electrocatalysis community during

247 lic byproducts, a severe limitation that has plagued the physiological application of previous design

248 One technical issue that has always plagued the post-processing of Illumina genotyping array

249 The main limitation plaguing the broader applicability of TDA is the lack of

250 A long-standing problem plaguing the field of transition metal catalyzed C-H fun

251 king, resolving the intrinsic "n(2) problem" plaguing the identification of this post-translational m

252 tions is representative of systemic problems plaguing the regulation of chemicals in food.

253 Additional treatment options for pneumonic plague, the most severe form of infection by Yersinia pe

254 ersinia pestis, the deadly agent that causes plague, the protein Ail and lipopolysaccharide (LPS)(6)

255 long-ranged electrostatic interactions have plagued theory and simulation alike.

256 DA-CuCN avoids polymerization that otherwise plagues these alkylations and generates a reactive metal

257 e limiting secondary complications that have plagued traditional hormone replacement interventions.

258 vide enough information to infer the mode of plague transmission in any given epidemic; nevertheless,

259 on our findings, we propose the mechanism of plague transmission in historical Europe, which is imper

260 produces the biofilm required for efficient plague transmission.

261 inolones, and sulfonamides are effective for plague treatment, although publication bias and low numb

262 s diseases of historical importance, such as plague, tuberculosis, and leprosy.

263 bacteria, including the causative agents of plague, typhoid fever, whooping cough, sexually transmit

264 am-negative bacteria, including purveyors of plague, typhoid fever, whooping cough, sexually transmit

265 While bias can plague uncontrolled research, this study has biological

266 hermal oxidation and corrosion problems that plague unprotected metal meshes, while also maintaining

267 finding solutions to the problems that have plagued us for centuries.

268 f-adjuvanting Y. pestis OMVs provide a novel plague vaccine candidate and that the rational design of

269 Several plague vaccine candidates are currently at various stage

270 ew correlate of protection for evaluation of plague vaccine candidates.

271 ar Typhi strain to create a bivalent mucosal plague vaccine that produces both the protective F1 caps

272 tested and developed into a live attenuated plague vaccine(s).

273 e now commonplace claim that the Justinianic Plague was a primary causal factor of them.

274 The AGM model of pneumonic plague was used to explore the effect of delaying treatm

275 allergy, i.e., asthma and allergic rhinitis, plaguing westernized countries, with up to 8% of young c

276 effective for the treatment of inhalational plague when administered within 2-6 hours of fever onset

277 t or prophylax pregnant women with suspected plague with highly effective antimicrobials as quickly a

278 versity remains methodically challenging and plagued with biases.

279 P) in hypertensive patients, though both are plagued with BP response variability.

280 traditional biochemical fractionation can be plagued with contaminants and loss of key components.

281 rge-scale cardiovascular clinical trials are plagued with escalating costs and low enrollment.

282 tempts to infer its deep phylogeny have been plagued with methodological artefacts.

283 ries proteomics experiments, which are often plagued with missing data points, we also integrate an i

284 fortunately, the higher energy densities are plagued with problems associated with the irreversibilit

285 he sampling of biomolecules, especially when plagued with rare events.

286 However, such biohybrid systems are often plagued with suboptimal electrodes, which limits the inc

287 try and single-cell RNA-seq (scRNA-seq), are plagued with systematic errors that may severely affect

288 hough many are prone to radiation damage and plagued with temperature instabilities.

289 s), but the current lead-free PSCs are still plagued with the critical issues of low efficiency and p

290 c (63%), pneumonic (21%), or septicemic (5%) plague, with associated case fatality rates of 17%, 27%,

291 c plague is the most severe manifestation of plague, with mortality rates approaching 100% in the abs

292 contained 1) a group of patients treated for plague, with outcomes reported by antimicrobial regimen,

293 ues to cause sporadic cases and outbreaks of plague worldwide and is considered a tier 1 bioterrorism

294 trol malaria, typhus, body lice, and bubonic plague worldwide, until countries began restricting its

295 llus anthracis (anthrax) or Yersinia pestis (plague) would prompt a public health emergency.

296 ble historical interest - pre-modern bubonic plague (Yersinia pestis), smallpox (Variola virus) and c

297 he catastrophic European Black Death/bubonic plague (Yersinia pestis).

298 tica (Ye), as well as the causative agent of plague, Yersinia pestis (Yp).

299 ed environment where the agent of flea-borne plague, Yersinia pestis, must replicate to produce a tra

300 The causative agent of plague, Yersinia pestis, uses a type III secretion syste