ライフサイエンスコーパス: plakoglobin

1 he stratum corneum (e.g., corneodesmosin and plakoglobin).

2 en associated with mutations in JUP encoding plakoglobin.

3 tiple desmosomal proteins including Dsc3 and plakoglobin.

4 ered to express the Naxos-associated form of plakoglobin.

5 fewer desmosomes in cells expressing mutant plakoglobin.

6 residue at position 39 in the N-terminus of plakoglobin.

7 n due to post-translational stabilization of plakoglobin.

8 implications for understanding the roles of plakoglobin.

9 ox is also found in the N-terminal domain of plakoglobin.

10 how mediates the distribution or function of plakoglobin.

11 uding desmoglein 1 and 2, plakophilin 2, and plakoglobin.

12 ical actin are enhanced by overexpression of plakoglobin.

13 resulting in normal levels of the truncated plakoglobin.

14 wo Armadillo-like proteins, beta-catenin and plakoglobin.

15 5-fold more potently than wild type or S28A plakoglobin.

16 adherens junction proteins beta-catenin and plakoglobin.

17 the cell adhesion cofactors beta-catenin and plakoglobin.

18 ine phosphorylation of both beta-catenin and plakoglobin.

19 ollins, that bind to the cytoplasmic protein plakoglobin.

20 lication as were "free," unfettered forms of plakoglobin.

21 ns multiple desmosomal components, including plakoglobin.

22 ers by the chimera required co-expression of plakoglobin.

23 constructed two "membrane-anchored" forms of plakoglobin.

24 iate filaments and the catenin-family member plakoglobin.

25 LUG-high cancer cells elevated the levels of plakoglobin.

26 decreased the levels of mRNA and protein of plakoglobin.

27 earts, where they co-localized with PKP2 and plakoglobin.

28 uppressed canonical Wnt signaling by nuclear plakoglobin.

29 binds to desmoglein-1 more weakly than does plakoglobin.

30 have reduced migration due to restoration of plakoglobin.

31 loss leads to upregulation of gamma-catenin (plakoglobin), a partial functional homolog, whose neural

32 gamma-Catenin (Plakoglobin), a well-described structural protein functi

33 Plakoglobin, a member of the catenin family, is localize

34 In mouse models, knockdown of plakoglobin abrogates CTC cluster formation and suppress

35 st that insufficiency of the truncated Naxos plakoglobin accounts for disease manifestation.

36 ; after the midblastula transition exogenous plakoglobin accumulates in embryonic nuclei.

37 embrane-tethered beta-catenin or its paralog plakoglobin activates Wnt signaling, suggesting that nuc

38 of ARVC demonstrates for the first time how plakoglobin affects beta-catenin activity in the heart a

39 anize desmosomes; however, overexpression of plakoglobin, along with E-cadherin, did permit desmosome

40 d either to beta-catenin/alpha-catenin or to plakoglobin/alpha-catenin dimers.

41 expression of the truncated Naxos-associated plakoglobin also results in an AC-like phenotype; theref

42 HEK293 cells expressing mutant plakoglobin also showed higher rates of proliferation an

43 eduction in immunoreactive signal levels for plakoglobin (also known as gamma-catenin), a protein tha

44 ratinocytes resulted in (i) glycosylation of plakoglobin and (ii) increased levels of plakoglobin due

45 clear localization of the desmosomal protein plakoglobin and a 2-fold reduction in canonical Wnt/beta

46 sed peroxovanadate to tyrosine phosphorylate plakoglobin and beta-catenin and to dissociate adherens

47 Plakoglobin and beta-catenin are homologous armadillo re

48 Plakoglobin and beta-catenin bind strongly and with simi

49 Tyrosine phosphorylation of plakoglobin and beta-catenin resulted in their rapid tra

50 ucts were used to investigate the ability of plakoglobin and beta-catenin that had redistributed from

51 Binding of plakoglobin and beta-catenin to the intracellular region

52 The distribution of plakoglobin and beta-catenin was determined by immunoflu

53 rmadillo protein gene family, which includes plakoglobin and beta-catenin, have important functions i

54 ween the adhesion and signaling functions of plakoglobin and beta-catenin.

55 Plakoglobin and Cx43 signals were also reduced in most f

56 translocation was associated with increased plakoglobin and decreased beta-catenin binding to nuclea

57 It is shown that the complex formed between plakoglobin and desmoglein 1 has an overall molecular we

58 olecular organization of complexes formed by plakoglobin and desmoglein 1, 2, or 3 are further examin

59 te filament cytoskeleton, presumably through plakoglobin and desmoplakin.

60 Plakoglobin and DP-NTP co-immunoprecipitated when extrac

61 In addition, plakoglobin and DP-NTP were recruited to cell-cell inter

62 ctivation on the subcellular distribution of plakoglobin and its association with its junctional bind

63 regulate the post-translational stability of plakoglobin and keratinocyte cell-cell adhesion.

64 alpha-catenin binds to both beta-catenin and plakoglobin and may link the cadherin/catenin complex to

65 lular catenins (alpha-, beta-, gamma-catenin/plakoglobin and p120CAs).

66 t bind the common desmosomal plaque proteins plakoglobin and plakophilin 1, is integrated into functi

67 ts with all four DSCR ligands, strongly with plakoglobin and plakophilin and more weakly with desmopl

68 esmoplakin, and the armadillo family members plakoglobin and plakophilin-1 were examined.

69 Our recent proteomics experiments identified plakoglobin and plakophilin-2 (PKP2) as putative K(ATP)

70 Thus, cleavage of beta-catenin and plakoglobin and shedding of VE-cadherin may act in conce

71 To begin to identify links between plakoglobin and the cortical actin polymerization machin

72 The relatively weak signaling by plakoglobin and the failure of the S28A mutation to enha

73 eveal that the effects of LMP1 on junctional plakoglobin and the initiation of a cadherin switch like

74 oreactive signals for the desmosomal protein plakoglobin and the major cardiac gap junction protein C

75 There was no detectable association between plakoglobin and the MUC1 CT.

76 Both plakoglobin and the related protein beta-catenin are pos

77 plexes comprising relatives of beta-catenin (plakoglobin) and p120 catenin (plakophilins).

78 in, E-cadherin, alpha-catenin, beta-catenin, plakoglobin, and actin) and the proliferation marker Ki-

79 remains associated with its catenin partner, plakoglobin, and causes a reduction in the levels of end

80 ha inhibitor Go6976 revealed that cadherins, plakoglobin, and desmoplakin have significantly reduced

81 , some cell junction proteins (beta-catenin, plakoglobin, and E-cadherin) were more phosphorylated in

82 PM proteins, such as beta1-integrin, plakoglobin, and major histocompatibility complex class

83 Keratins K15, K19, and K20, plakoglobin, and MEOX1 were excluded as candidates by di

84 hile cadherin-binding proteins beta-catenin, plakoglobin, and p120(ctn) are members of the Armadillo

85 e show here that beta-catenin, gamma-catenin/plakoglobin, and p120-Cas are all significantly tyrosine

86 desmoglein 3, desmocolin A/B, desmoplakin I, plakoglobin, and plakophilin), indicating that desmosome

87 al molecules, VE-cadherin, beta-catenin, and plakoglobin, and reduced the ICAM-1-mediated phosphoryla

88 s of PKP2, the associated desmosomal protein plakoglobin, and the gap-junction protein connexin-43.

89 ined, including alpha-catenin, beta-catenin, plakoglobin, and zyxin, but none was identified at the h

90 s have suggested that both alpha-catenin and plakoglobin are important for the adhesive function of c

91 E-cadherin, beta-catenin, and gamma-catenin (plakoglobin) are all concentrated in caveolae membranes.

92 Catenins (alpha-, beta- and gamma- or plakoglobin) are cytoplasmic cadherin-associated protein

93 in sensitivity experiments indicate that the plakoglobin arm domain by itself is more flexible than t

94 The crystal structure of the plakoglobin armadillo domain bound to phosphorylated E-c

95 y thus implicates SLUG-induced repression of plakoglobin as a motility determinant in highly dissemin

96 ples, identifies the cell junction component plakoglobin as highly differentially expressed.

97 In addition, we show that beta-catenin and plakoglobin associate only with phosphorylated proN-cadh

98 Thus, a modest reduction of plakoglobin associated with E-cadherin is apparently not

99 y regulate desmosome assembly by controlling plakoglobin availability.

100 hesion molecule E-cadherin; beta-catenin and plakoglobin bind a carboxy-terminal region in a mutually

101 Separate domains of plakoglobin bind to cadherin and alpha-catenin, suggesti

102 beta-Catenin and plakoglobin bind with similar weak affinities to desmoco

103 Inhibition of Trim32 enhanced plakoglobin binding to PI3K-p85 and promoted PI3K-Akt-Fo

104 ein desmoplakin in a manner dependent on the plakoglobin-binding domain of the Dsg3 tail.

105 Absent the plakoglobin-binding site the chimeric molecule colocaliz

106 Deletion of the 87 amino acid long plakoglobin-binding site within the intracellular cadher

107 In normal muscle plakoglobin binds the insulin receptor and PI3K subunit

108 not affect Tcf/Lef activity or the amount of plakoglobin bound to Tcf4.

109 ized from the cell surface in a complex with plakoglobin but not desmoplakin.

110 ysis indicated that DP-NTP binds directly to plakoglobin but not Dsg1.

111 LMP1 decreased overall levels of junctional plakoglobin but the remaining junctional plakoglobin was

112 Plakoglobin, but normally not beta-catenin, is also a st

113 In one model, Naxos plakoglobin bypassed the nonsense-mediated mRNA decay pa

114 These data indicate that plakoglobin can act cytoplasmically to generate a WNT-li

115 Similar results are observed with ectopic plakoglobin, casting doubt on a normal role for plakoglo

116 Ablation of plakoglobin caused increase beta-catenin stabilization a

117 Despite gap junction remodeling, plakoglobin CKO hearts were refractory to induced arrhyt

118 ent with altered desmosome ultrastructure in plakoglobin CKO hearts.

119 Plakoglobin CKO mice exhibited progressive loss of cardi

120 ibute to the cardiac hypertrophy response in plakoglobin CKO mice.

121 wn cells; levels of E-cadherin, desmoplakin, plakoglobin, claudin-4, occludin, zonula occludens 1, an

122 atenin and the remainder of beta-catenin and plakoglobin co-elute in a high molecular weight complex

123 cant fraction of alpha- and beta-catenin and plakoglobin co-elute with cadherin in a high molecular w

124 plakin in organizing the desmosomal cadherin-plakoglobin complex and provide new insights into the hi

125 lpha-catenin compete directly for binding to plakoglobin, consistent with the absence of alpha-cateni

126 In mice, cardiomyocyte-specific plakoglobin deficiency recapitulates many aspects of hum

127 G) and an NH(2)-terminally truncated form of plakoglobin (DeltaN80PG) in mouse epidermis and hair fol

128 of primary tumor cells held together through plakoglobin-dependent intercellular adhesion, and though

129 show that cdc42 cannot rescue the effects of plakoglobin depletion, showing that plakoglobin is requi

130 ed behavior in embryos, is also abrogated by plakoglobin depletion.

131 esmosomal components, including desmoplakin, plakoglobin, desmoglein 1 and 2, and desmocollin 1a and

132 moglein 3; however, the stoichiometry of the plakoglobin/desmoglein 1 complex does not appear to exce

133 verall molecular weight greater than that of plakoglobin/desmoglein 2 or plakoglobin/desmoglein 3; ho

134 ter than that of plakoglobin/desmoglein 2 or plakoglobin/desmoglein 3; however, the stoichiometry of

135 nd showed markedly decreased localization of plakoglobin, desmoplakin, and connexin43 at intercalated

136 report that the mechanical junction proteins plakoglobin, desmoplakin, and N-cadherin are also upregu

137 binding partners to plakoglobin, the loss of plakoglobin did not affect its association with Tcf4.

138 The resultant decreased levels of nuclear plakoglobin did not affect Tcf/Lef activity or the amoun

139 have studied the roles of alpha-catenin and plakoglobin directly, by depleting the maternal mRNAs co

140 ve the cortical actin skeleton, showing that plakoglobin does not mediate its effect by its known lin

141 However, plakoglobin does rescue the effect of cdc42 depletion, s

142 in-deleted cadherin, which is uncoupled from plakoglobin, does not impair adhesion, indicating that t

143 se uptake, and induced fiber growth, whereas plakoglobin down-regulation reduced PI3K-Akt-FoxO signal

144 of plakoglobin and (ii) increased levels of plakoglobin due to post-translational stabilization of p

145 E-cadherin, alpha-catenin, beta-catenin, and plakoglobin during transendothelial migration under phys

146 However, the mechanisms underlying plakoglobin dysfunction involved in the pathogenesis of

147 The plakoglobin:E-cadherin ratio decreased in Dsg1-expressin

148 h is caused by a 2-base pair deletion in the plakoglobin-encoding gene JUP that results in a truncate

149 sed in L-cells, the desmosomal cadherins and plakoglobin exhibited a diffuse distribution.

150 Akt and NF-kappaB and shows that the loss of plakoglobin expression by LMP1 is a significant factor i

151 growth, tight and gap junction formation and plakoglobin expression.

152 blocked tyrosine phosphorylation of Dsg2 and plakoglobin following epidermal growth factor stimulatio

153 cytoplasmic distribution and, together with plakoglobin, form detergent-insoluble aggregates.

154 In addition, plakoglobin functions as a signaling protein via its abi

155 ression of at least a subset of these genes, plakoglobin, galectin 7, sciellin, and SPRR3, was also d

156 ulation of the closely related family member plakoglobin (gamma-catenin) that maintained both adheren

157 In common with beta-catenin and plakoglobin (gamma-catenin), p120(ctn) contains a centra

158 beta-catenin but decreased nuclear levels of plakoglobin (gamma-catenin).

159 th a robust phosphorylation of beta-catenin, plakoglobin/gamma-catenin, and p120(cas) on tyrosine res

160 r the association of catenins (beta-catenin, plakoglobin/gamma-catenin, or p120(cas)) with E-cadherin

161 e found that SLUG inhibits the expression of plakoglobin gene directly in these cells.

162 cible cardiorestricted knockout (CKO) of the plakoglobin gene in mice.

163 A homozygous 2 base pair deletion in the plakoglobin gene was identified only in the 19 affected

164 gh the knockdown of the transcription of the plakoglobin gene.

165 Moreover, expression of anchored plakoglobins had no apparent effect on the cytoplasmic o

166 gration of epithelial cells, and the loss of plakoglobin has been identified as a contributing factor

167 In fact, plakoglobin has been proposed to suppress tumorigenesis.

168 A recessive mutation in the gene encoding plakoglobin has been shown to cause Naxos disease, a car

169 st that increasing levels of truncated or WT plakoglobin has potential as a therapeutic approach to N

170 Additionally, because beta-catenin and plakoglobin have both structural and regulatory function

171 tations in desmosomal genes, desmoplakin and plakoglobin, have been implicated in the pathogenesis of

172 me, a dominant mutation in the gene encoding plakoglobin in a German family with ARVC but no cutaneou

173 The finding of a deletion in plakoglobin in ARVC suggests that the proteins involved

174 To investigate the role of plakoglobin in ARVC, we generated an inducible cardiores

175 koglobin, casting doubt on a normal role for plakoglobin in axis specification and indicating that ec

176 ransgenic mice expressing desmosomal protein plakoglobin in myocyte lineages.

177 raction between K(ATP) channels and PKP2 and plakoglobin in rat heart.

178 tyrosine phosphorylation of beta-catenin and plakoglobin in regulating adherens junction mediated cel

179 Forced expression of plakoglobin in SLUG-high cells had the reverse effects o

180 Immunofluorescence showed the lack of plakoglobin in the epidermis.

181 To investigate the role of plakoglobin in these functions we expressed a full-lengt

182 Knockdown of plakoglobin in these low motility non-invasive breast ca

183 t desmoglein 1 binds to its catenin partner, plakoglobin, in an approximately 6:1 stoichiometry.

184 ion of the epithelial markers E-cadherin and plakoglobin, increased expression of the mesenchymal mar

185 Overexpression of plakoglobin induces neural axis duplication in Xenopus a

186 To determine if the desmosomal cadherins and plakoglobin interact with the amino-terminal domain of d

187 In contrast to desmoplakin-plakoglobin interactions, the interaction between desmop

188 Plakoglobin is a component of both desmosomes and adhere

189 Plakoglobin is a junctional protein that can also serve

190 However, when plakoglobin is artificially engineered to restrict it to

191 rior to the midblastula transition exogenous plakoglobin is cytoplasmic and concentrated in the corti

192 ) to chromosome 17q21, in which the gene for plakoglobin is encoded.

193 that observed when expression of keratin or plakoglobin is inhibited.

194 xis duplication in Xenopus and the exogenous plakoglobin is localized to nuclei.

195 We report that plakoglobin is modified by the addition of O-GlcNAc at a

196 Plakoglobin is not expressed in this region during stage

197 Plakoglobin is one of two vertebrate proteins closely re

198 cantly accumulate, whereas soluble wild type plakoglobin is readily detected.

199 fects of plakoglobin depletion, showing that plakoglobin is required for cdc42-mediated cortical acti

200 to test whether the nuclear localization of plakoglobin is required for its inductive effects.

201 ns junction and desmosome-associated protein plakoglobin is unknown.

202 canonical Wnt signaling, imposed by nuclear plakoglobin, is the responsible mechanism for the pathog

203 , DSG2 (n = 5), DSC2 (n = 3), and junctional plakoglobin (JUP) (n = 2).

204 Mutations in the plakoglobin (JUP) gene have been identified in arrhythmo

205 homozygous loss-of-function mutation of the Plakoglobin (Jup) gene, which encodes a major component

206 de filaggrin (FLG), dystonin (DST), junction plakoglobin (JUP), and plakophilin-3 (PKP3), and are inv

207 g 4 encoding desmosomal proteins (Junctional plakoglobin (JUP), Desmoplakin (DSP), Plakophilin 2, and

208 dhesion proteins of the desmosome, including plakoglobin (JUP).

209 oth abundance of CTC clusters and high tumor plakoglobin levels denote adverse outcomes.

210 Moreover, we demonstrate that increasing plakoglobin levels rescues cadherin expression, desmosom

211 n the molecular and functional properties of plakoglobin, LMP1 was overexpressed in the NPC cell line

212 dherens junctions can form in the absence of plakoglobin, making use only of beta-catenin, such junct

213 However, plakoglobin may have other activities: it is expressed i

214 cells lacking Dsc but expressing myc-tagged plakoglobin (MPg).

215 binding of SLUG also increased the levels of plakoglobin mRNA, protein, and promoter activity in the

216 m loss or gain of function consequent to the plakoglobin mutation.

217 on to enhance its stability, may explain why plakoglobin mutations are infrequent in malignancies.

218 activity are found in many human tumors, but plakoglobin mutations are not commonly found.

219 es and cardiomyopathies seen with Trim32 and plakoglobin mutations.

220 DSP (desmoplakin) and JUP (junction protein plakoglobin) mutations are responsible for a subset of p

221 Mutant PKP2 iPSC-CMs demonstrate abnormal plakoglobin nuclear translocation and decreased beta-cat

222 To investigate the functional consequence of plakoglobin O-glycosylation, we cloned and overexpressed

223 Tethered plakoglobin or beta-catenin might signal on their own or

224 main interactions with the armadillo protein plakoglobin or coexpression of its companion suprabasal

225 ockdown of two desmosomal proteins, junction plakoglobin or desmocolin-1, switched the morphine spati

226 t in the early Xenopus embryo, activation of plakoglobin (or beta-catenin) inhibits the activity of X

227 that mediates the interaction of Dsc1a with plakoglobin, or the CSI region that is involved in the b

228 Surprisingly, plakoglobin overexpression alone enhanced PI3K-Akt-FoxO

229 Unlike beta-catenin and plakoglobin, p120 does not interact with alpha-catenin,

230 rease in the cytoskeleton-associated pool of plakoglobin (Pg) and a corresponding increase in the cyt

231 h desmosomal cadherins, which interface with plakoglobin (PG) and desmoplakin (DP) to associate with

232 sion of the intercalated disc plaque protein plakoglobin (Pg) and direct phosphorylation at S665 by p

233 We demonstrate that plakoglobin (Pg) in conjunction with lymphoid enhancer-b

234 ted signaling properties of junction protein plakoglobin (PG) in the pathogenesis of ARVC.

235 Plakoglobin (PG) is a major component of the intracellul

236 Plakoglobin (PG) is a member of the Armadillo family of

237 Plakoglobin (PG) is a member of the Armadillo family of

238 The armadillo family protein plakoglobin (Pg) is a well-characterized component of an

239 iously reported that cardiac tissue-specific plakoglobin (PG) knockout (PG CKO) mice have no apparent

240 Desmoplakin (DP), plakoglobin (PG), and plakophilin 1 (PP1) are desmosomal

241 The obligate desmosomal constituent, plakoglobin (PG), is involved in coupling transmembrane

242 Thus, by promoting plakoglobin-PI3K dissociation, Trim32 reduces PI3K-Akt-F

243 2, encoding desmosomal proteins desmoplakin, plakoglobin, plakophilin 2 (PKP2), desmoglein 2 (DSG2),

244 Thus, we speculate that plakoglobin plays a signaling role in desmosome organiza

245 l architecture in the early embryo, and that plakoglobin plays an essential role in the assembly, mai

246 We showed previously that depletion of plakoglobin protein during the egg to gastrula stages ca

247 to stably express either wild-type or mutant plakoglobin protein showed that the mutant protein was a

248 Plakoglobin provides a key linkage in protein chains tha

249 Plakoglobin regulates cell adhesion by providing a modul

250 junction in which adherens-junction-derived plakoglobin regulates nuclear transcription by antagoniz

251 a raise the possibility that beta-catenin or plakoglobin released from the adherens junctions by tyro

252 These proteins, along with plakoglobin, remain equally distributed between detergen

253 Depletion of plakoglobin results in a partial loss of adhesion, and a

254 ot bind to endogenous alpha-catenin, whereas plakoglobin retains its binding capacity.

255 tion sequence" does not change the timing of plakoglobin's nuclear localization, suggesting that it i

256 ion S37A; however, the analogous mutation in plakoglobin (S28A) does not alter its half-life.

257 ndent manner, leading us to hypothesize that plakoglobin sequestration by truncated Dsg1 destabilizes

258 We propose a model whereby plakoglobin serves as a linker between the cadherins and

259 The plakoglobin signal level was reduced diffusely in ARVC s

260 To determine whether a diminished plakoglobin signal level was specific for ARVC, we analy

261 In every sample, levels of N-cadherin and plakoglobin signals at junctions were indistinguishable

262 LMP1 did not affect plakoglobin stability but did decrease plakoglobin trans

263 patterns of alpha-catenin, beta-catenin, and plakoglobin suggest that these proteins are directly lin

264 esmoplakin and also interacted directly with plakoglobin, suggesting that p0071 may regulate desmosom

265 ions of cyclin D2, IGFBP-6, osteopontin, and plakoglobin, suggesting that these genes represent immed

266 ecipitated with E-cadherin, Desmoglein 1 and Plakoglobin, suggesting that they form a complex (es) th

267 horylated beta-catenin, and junction protein plakoglobin (the latter translocated from the junction).

268 n, a protein with common binding partners to plakoglobin, the loss of plakoglobin did not affect its

269 exhibits weak but specific interactions with plakoglobin, the plakin domain of desmoplakin, plakophil

270 or regulating the binding of beta-catenin or plakoglobin to (i) E-cadherin and (ii) alpha-catenin.

271 EF1 and TCF4 synergize with beta-catenin and plakoglobin to activate OT, both suppress the signaling

272 We conclude that binding of plakoglobin to desmoglein 3 is an important step in desm

273 of tyrosine phosphorylated beta-catenin and plakoglobin to E-cadherin and to alpha-catenin was subst

274 Moreover, restoration of Naxos plakoglobin to WT levels resulted in normal heart functi

275 ffect plakoglobin stability but did decrease plakoglobin transcription.

276 In Wnt signaling, beta-catenin and plakoglobin transduce signals to the nucleus through int

277 Transgene plakoglobin translocated to nucleus, detected by immunob

278 g that the S39_K40insS mutation may increase plakoglobin turnover via proteasomal degradation.

279 sufficient to cause nuclear translocation of plakoglobin, upregulation of adipogenic genes in vitro,

280 beta-Catenin and gamma-catenin (plakoglobin), vertebrate homologs of Drosophila armadill

281 Plakoglobin was also ubiquitous.

282 tyrosine phosphorylation of beta-catenin and plakoglobin was associated with decreased cell-cell adhe

283 nal plakoglobin but the remaining junctional plakoglobin was found associated with the induced N-cadh

284 After short term EGF treatment, plakoglobin was rapidly phosphorylated, and tyrosine-pho

285 assess differences between beta-catenin and plakoglobin, we compared several of their biochemical pr

286 negatively regulated by the catenin protein plakoglobin, we postulated that the transcriptional repr

287 Low levels of plakoglobin were also detected in human NPC tissues.

288 gulation of cyclin D2 and down-regulation of plakoglobin were demonstrated in GLI1-amplified compared

289 ptide (DP-NTP), the desmosomal cadherins and plakoglobin were observed in punctate clusters that also

290 e cortical actin skeleton after depletion of plakoglobin, whereas the microtubule and cytokeratin ske

291 Vac8p is related to beta-catenin and plakoglobin, which connect a specific region of the plas

292 beta-Catenin and plakoglobin, which form intracellular links between vasc

293 Plakoglobin, which functions in both cell-cell adhesion

294 lial cells) linked to either beta-catenin or plakoglobin, which is linked to alpha-catenin, which is

295 These data suggest that plakoglobin, which is the only known common component to

296 creased expression of the junctional protein plakoglobin, which was shown to be partially responsible

297 mes (plakophilin (PKP) 1 and 2, desmoplakin, plakoglobin--which is also present in adherens junctions

298 y removal of phosphate from beta-catenin and plakoglobin with added tyrosine phosphatase, and (ii) ty

299 ar of cells in the tissue and association of plakoglobin with cadherin is diminished.

300 egulates the association of beta-catenin and plakoglobin with E-cadherin and alpha-catenin.

301 This increased association of junctional plakoglobin with N-cadherin was a distinguishing feature