ライフサイエンスコーパス: plasma protein

1 on of selenium-sulfur bond between p-XSC and plasma protein.

2 sulted in expression of a hybrid CFHR2-CFHR5 plasma protein.

3 3b/c/d, indicating subendothelial leakage of plasma proteins.

4 s in M-like protein-mediated binding of host plasma proteins.

5 condition of changing radioligand binding to plasma proteins.

6 ermitting routine quantification of multiple plasma proteins.

7 n and degradation along with accumulation of plasma proteins.

8 ts identified a large number of differential plasma proteins.

9 become sensitive to neutralization by mouse plasma proteins.

10 s, however, increased expression of genes of plasma proteins.

11 ort is the largest dataset of bovine seminal plasma proteins.

12 to cause enhanced glomerular permeability to plasma proteins.

13 to identification of a large number of novel plasma proteins.

14 active fragment production in the absence of plasma proteins.

15 d this might be involved in the retention of plasma proteins.

16 ype in response to subendothelial leakage of plasma proteins.

17 cosylated glycoforms of 9 glycopeptides in 7 plasma proteins.

18 luding progressive increases in immunity and plasma proteins.

19 of protein quantitative trait loci for 1,478 plasma proteins.

20 However, bumetanide is heavily bound to plasma proteins (~98%) and highly ionized at physiologic

21 ng protein-3 (IGFBP-3), pregnancy-associated plasma protein A (PAPP-A2), IGF-II and IGFBP-5 in 838 ch

22 Trophoblast-derived pregnancy-associated plasma protein A (PAPPA) is specifically elevated in pre

23 inhibitor of the enzyme pregnancy-associated plasma protein-A (PAPP-A), which modulates IGF-I activit

24 ncin metalloproteinase, pregnancy-associated plasma protein-A (PAPP-A), which modulates insulin-like

25 ting metalloproteinase, pregnancy-associated plasma protein-A (PAPP-A).

26 ertebrate-specific gene pregnancy-associated plasma protein-aa (pappaa).

27 ochondria and survival: Pregnancy-associated plasma protein-aa (Pappaa).

28 Plasma protein absorption assays and flow cytometry anal

29 Combinations of plasma proteins accurately identified children with a re

30 Although the total amount of plasma proteins adsorbed on nanoparticles does not deter

31 distribution, charge, coating molecules, and plasma protein adsorption) that can be effectively tuned

32 o investigate how a systemic absence of this plasma protein affects leukocyte recruitment in alveolit

33 h by mass spectrometry was identified as the plasma protein alpha1-microglobulin, an established mega

34 ly, we quantified urinary excretion of blood plasma proteins alpha1-microglobulin, albumin, and IgG.

35 s increased affinity for lipid particles and plasma proteins also facilitates the transport of ASO fr

36 thromboelastometry [ROTEM]) and fibrinolysis plasma protein analysis including the fibrinolytic media

37 SeP is a liver-derived plasma protein and a major supplier of selenium, which i

38 Plasma protein and brain tissue binding are very importa

39 ins are representatives of the main types of plasma protein and have different shapes and sizes.

40 an overlap in genetic control between total plasma protein and IgG glycosylation.

41 t of individual inflammatory perturbation of plasma protein and lipid mediators associated with TB in

42 Among 92 plasma proteins and 135 lipid subspecies quantified with

43 We quantified the levels of 4077 plasma proteins and 2619 proteins in duodenal biopsy sam

44 Plasma proteins and autoantibodies were measured across

45 FeCl3 induces aggregation of all plasma proteins and blood cells, independent of endothel

46 ASO interactions with several abundant human plasma proteins and determined the effect of salt and pH

47 ng to oedema, excitotoxicity, and ingress of plasma proteins and inflammatory cells.

48 The liver is essential for the synthesis of plasma proteins and integration of lipid metabolism.

49 permeability leads to excessive exudation of plasma proteins and leukocytes in the interstitium, whic

50 l tool for the unbiased in-depth analysis of plasma proteins and may advance biomarker discovery, as

51 We identified expression patterns of plasma proteins and miRNAs that associated with increase

52 Increased microvascular permeability to plasma proteins and neutrophil emigration are hallmarks

53 stitial space limits the space available for plasma proteins and other macromolecules.

54 altered fucosylation of N-linked glycans on plasma proteins and that glycan biomarkers could improve

55 platelets with cellular adhesion molecules, plasma proteins, and lipids.

56 We used an aptamer-based assay of 1129 plasma proteins, and patient clinical details were conce

57 rt non-cell autonomously through circulating plasma proteins, and that plasma protein dynamics can si

58 Since certain plasma proteins are regulated through extracellular phos

59 Our aim was to discover plasma proteins associated with early AD pathology by in

60 tibody prevents mural cell loss and modifies plasma proteins associated with Notch3 activity, includi

61 lysis of the IMMACULATE cohort identified 36 plasma proteins associated with post-MI HF (data set 2),

62 Understanding plasma proteins associated with post-MI HF and their gen

63 ty-capture plasma proteomics to measure 1305 plasma proteins at 1 month post-MI in a New Zealand coho

64 We analyzed 263 plasma proteins at baseline and 6 months into the interv

65 trated that the most adsorbed quantity among plasma proteins belongs to fibrinogen (alpha, beta and g

66 oth values were significantly lower than the plasma protein binding (71% +/- 5%) and red cell uptake

67 of (99m)Tc-PSMA-I&S was observed due to high plasma protein binding (94%) of the tracer.

68 u-PSMA-I&F was only slightly delayed by high plasma protein binding (94%-95%), and very low accumulat

69 The plasma protein binding (PPB%) was calculated and found t

70 This peptide showed relative high plasma protein binding abilities and a human plasma half

71 n log D, solubility, in vitro clearance, and plasma protein binding also hold in transformation space

72 ng oligonucleotides (MTOs) provide increased plasma protein binding and biodistribution to liver, and

73 ctive starting point, (b) the probability of plasma protein binding and cytotoxicity are often increa

74 ble in vivo performance may result from high plasma protein binding and extensive biliary excretion.

75 cholesterol to PS ASOs and their effects on plasma protein binding and on enhancing ASO potency in t

76 The plasma protein binding and red cell uptake of (99m)Tc(CO

77 vations are presented to illustrate that low plasma protein binding does not necessarily lead to high

78 o metabolic stability, plasma stability, and plasma protein binding for a representative set of compo

79 Plasma protein binding of (18)F-FDS was low (<0.1%), and

80 nges for drug development have been the high plasma protein binding of lead structures, interspecies

81 4, aqueous kinetic solubility, and estimated plasma protein binding values in ranges predictive of go

82 tly lower affinity for FAP in vitro, whereas plasma protein binding was higher for [(18)F]FGlc-FAPI.

83 and hepatocyte stability, MDCK permeability, plasma protein binding).

84 omparatively high log D(7.4) values and high plasma protein binding, adding to their stability.

85 ed high kidney extraction and excretion, low plasma protein binding, and high metabolic stability as

86 al effects, in vivo antinociceptive effects, plasma protein binding, and metabolic stability.

87 Plasma protein binding, red cell uptake, and percentage

88 ic binding to hCD80-positive tissue and high plasma protein binding.

89 satisfactory liver microsomes stability and plasma protein binding.

90 monkeys, after correcting for differences in plasma protein binding.

91 ompound 17 demonstrate low clearance and low plasma protein binding.

92 Analysis of the plasma-protein binding profiles of the ASO-conjugates by

93 alian cell lines was reduced, solubility and plasma-protein binding were improved while retaining pot

94 , low intrinsic microsome clearance, and low plasma-protein binding.

95 rafiltration assay was used to determine the plasma protein-binding properties of (177)Lu-cm09.

96 Serum and plasma proteins bound to the nanoworms are mostly interc

97 les of molecular bonds; each bond involves a plasma protein bridging the gap between specific recepto

98 OT binds strongly to plasma proteins, but a reduction/alkylation (R/A) proced

99 nity for lipid particles, albumin, and other plasma proteins by lipid-conjugation facilitates ASO tra

100 ntify and quantify AGE modification sites in plasma proteins by reversed phase HPLC mass spectrometry

101 peripheral nervous system are shielded from plasma proteins by the blood-brain barrier and blood-ner

102 was used for further candidate enrichment of plasma proteins by using Fisher meta-analysis, resamplin

103 The plasma protein C3 is a central element in the activation

104 our data suggest that modulating binding to plasma proteins can influence ASO activity and distribut

105 Circulating plasma proteins can reflect the physiological response t

106 Finally, plasma proteins capable of binding PS ASOs in human plas

107 e, it engages a tightly regulated network of plasma proteins, cell surface receptors, and regulators.

108 ted with early AD pathology by investigating plasma protein changes at the asymptomatic and symptomat

109 Microvascular-epithelial exudation of bulk plasma proteins characteristically occurs in asthmatic p

110 collected for immunophenotyping, analysis of plasma proteins, coagulation studies, and gene analysis

111 uppress irreversible interactions with blood-plasma protein cocktails.

112 he major negative regulator of the AP is the plasma protein complement factor H (FH).

113 This study demonstrated that C3b:plasma protein complexes form in the fluid-phase during

114 ood pressure, lactate level, base excess and plasma protein concentration compared to the Control gro

115 We found that total plasma protein concentration increased during hibernatio

116 ontaneous breathing trial-induced changes in plasma protein concentration, 0.96 (0.90-1.01) for chang

117 Plasma protein concentration, hemoglobin concentration,

118 s has been shown to be more dependent on the plasma protein concentrations and the type of zeolites t

119 tor, assessed with the median cutoff method, plasma protein concentrations were also not associated w

120 Measurement of plasma protein concentrations with ELISA revealed a redu

121 ar lung water indexed for ideal body weight, plasma protein concentrations, hemoglobin concentration,

122 e natriuretic peptide level, hemoglobin, and plasma protein concentrations.

123 Histidine-rich glycoprotein (HRG) is a plasma protein consisting of 6 distinct functional domai

124 How the kidney prevents urinary excretion of plasma proteins continues to be debated.

125 P2 pathway of ultrafiltrated, disulfide-rich plasma proteins could be a source of cystine in proximal

126 7 standard clinical laboratory tests and 263 plasma proteins could not accurately predict gut alpha-d

127 ies showed that the complexes consisted of a plasma protein covalently bound to C3b in a 1:1 molar ra

128 ur mouse brain vasculome with representative plasma protein databases demonstrated significant overla

129 vascular excretion of the genetically tagged plasma protein DBP-EGFP, we show that the developmental

130 though the concentrations of most individual plasma proteins decreased, as did the white blood cell t

131 Among the 190 differential plasma proteins detected by iTRAQ, carbamoyl-phosphate s

132 wledge, this marks the lowest LOD for a real plasma protein detection based on label-free LSPR shift

133 tivity and ruggedness, compared to the whole plasma protein digestion approach alone.

134 Several different plasma proteins displayed a discrete high molecular SDS-

135 )-Glycoprotein I (beta(2)GPI) is an abundant plasma protein displaying phospholipid-binding propertie

136 omes with an artificial corona made of human plasma proteins drastically reduces capture by circulati

137 complex concentrates (PCC) are fractionated plasma protein drugs that reverse warfarin anticoagulati

138 hrough circulating plasma proteins, and that plasma protein dynamics can simulate some the beneficial

139 Kallistatin, an endogenous plasma protein, exhibits pleiotropic properties in inhib

140 M detection of seven out of eight endogenous plasma proteins expressed at ng/mL or subng/mL levels in

141 Here, we show that plasma protein expression patterns strongly encode for m

142 me or anticipate clinical trajectories using plasma protein expression would allow personalization of

143 pt vascular responses to CSD and the ensuing plasma protein extravasation (PPE).

144 ascade is triggered by the activation of the plasma protein factor XII (FXII) and leads to kallikrein

145 The plasma proteins Factor H (FH) and its alternate splice v

146 The plasma proteins factor XII (FXII) and prekallikrein (PK)

147 ficial surfaces and biologic substances, the plasma proteins factor XII (FXII) and prekallikrein unde

148 s thrombin-catalyzed conversion of a soluble plasma protein, fibrinogen, into a polymeric fibrin clot

149 The heat-labile plasma protein, fibronectin, inhibited PF4 binding to pl

150 itative trait locus variants associated with plasma proteins followed by Mendelian randomization to i

151 However, the concept of using plasma proteins for individualized health assessment acr

152 The mean +/- SEM plasma protein fractional synthesis rate was 0.13 +/- 0.

153 ureus had sufficiently high solubility, high plasma protein free fraction, and favorable pharmacokine

154 gram increased the fraction unbound to human plasma protein from below minimum detection levels, i.e.

155 We measured 2,925 plasma proteins from 4,263 young adults to nonagenarians

156 4, MGAT3 and MGAT5) and a known regulator of plasma protein fucosylation (HNF1A).

157 We show that the plasma protein haptoglobin prevents the fatty acid-promo

158 Treatment with the naturally occurring human plasma proteins haptoglobin or hemopexin may have benefi

159 face area and high pore volume towards human plasma proteins has been investigated.

160 alibration, MagLev showed that the levitated plasma proteins have a measured density in solution of 1

161 As plasma proteins have become a major thrust in the field

162 Recently, the liver-derived plasma protein, histidine-rich glycoprotein (HRG), was d

163 ing affinity of ASO fatty acid conjugates to plasma proteins improved with fatty acid chain length an

164 of a comparison of the quantification of 100 plasma proteins in >1500 LC-MS runs, the SD range of the

165 yed an aptamer-based method to examine 1,305 plasma proteins in 12 participants before and after exer

166 We aimed to reveal the differential plasma proteins in 272 CHD patients with or without PAH.

167 We performed multianalyte profiling of 50 plasma proteins in 28 patients with persistent HCV infec

168 assay was used for targeted profiling of 145 plasma proteins in 29 patients with CVID.

169 aracterize binding constants with individual plasma proteins in a reliable and high throughput manner

170 hat coatings prepared with GOx repelled more plasma proteins in all cases than their GOx-free counter

171 We identified 117 and 41 differentiating plasma proteins in Cbs(-/-) mice and CBS(-/-) humans, re

172 We analyzed a broad range of plasma proteins in children with well-characterized asth

173 h by serving as a comprehensive reference of plasma proteins in humans and accelerate biomarker disco

174 ized that formation of a fibrin mesh retains plasma proteins in NPs.

175 Plasma proteins in patients who responded to standard tr

176 It bound strongly to plasma proteins in rats (97%), and its labeled metabolit

177 Here, turnover rates of plasma proteins in rats were measured in vivo using a pu

178 ay), to determine statin effects on over 350 plasma proteins in relevant ASCVD pathways among HIV and

179 ndergo changes in morphology and internalize plasma proteins in response to this disorder.

180 The major plasma proteins in the animal plasmas were identified us

181 ociations between type 2 diabetes and >1,000 plasma proteins in the Cooperative Health Research in th

182 r, the mechanisms underlying NP retention of plasma proteins in the submucosa remain unclear.

183 r, the mechanisms underlying NP retention of plasma proteins in their submucosa remain unclear.

184 The presence of plasma proteins in urine is difficult to interpret quant

185 We detected changes to 418 plasma proteins in vivo, and detected changes to 262 pro

186 changes in the level of a broad spectrum of plasma proteins including serine protease/endopeptidase

187 luenced by interaction of the particles with plasma proteins, including coagulation factor X (FX), wh

188 mass spectrometry (MS) targeted detection of plasma proteins, including post-translational modificati

189 One-quarter of plasma proteins increased in GPS are known to be synthes

190 stinal digestion, intestinal permeation, and plasma protein interaction of polyphenols from a single

191 tness range 0.3-1.5 x 10(4) M(-1) x cm(-1)), plasma protein interactions (range 85.0% +/- 2.3%-90.7%

192 High abundance plasma proteins interfere with detection of potential pr

193 red at sites of inflammation, converts blood plasma proteins into chaperone-like holdases that protec

194 ide chains is the major factor that converts plasma proteins into efficient activators of immune cell

195 Albumin is the most abundant plasma protein involved in the transport of many compoun

196 glass-based microarray, able to measure >600 plasma proteins involved in cell-to-cell communication,

197 dema or formation of a pseudocyst containing plasma proteins is a prominent characteristic of nasal p

198 C-reactive protein (CRP), an acute-phase plasma protein, is a major component of inflammatory rea

199 Serum AA protein (SAA), an acute phase plasma protein, is deposited extracellularly as insolubl

200 hange the thermal behavior of specific human plasma proteins, leading to an elevation of the heat-res

201 However, VA1 induced less plasma protein leakage and myeloid inflammatory cell rec

202 Microvascular plasma protein leakage is an essential component of the

203 cle or dorsal skin, but neutrophil-dependent plasma protein leakage was abolished.

204 loci explained up to 66% of interindividual plasma protein-level variation and, on average, accounte

205 esponsible for inter-individual variation in plasma protein levels are poorly understood.

206 lyses with gene expression in 47 tissues and plasma protein levels implicate genes potentially operat

207 Integrating RNA profiles and plasma protein levels revealed known as well as previous

208 with cell-type-specific gene expression and plasma protein levels sheds light on potential disease m

209 ithin a gene were analyzed for corresponding plasma protein levels using genome-wide association stud

210 Plasma protein levels were higher in patients than HDs (

211 as performed, to evaluate the association of plasma protein levels with dopaminergic system integrity

212 profiles (MATN3, MDGA1 and NEP), and altered plasma protein levels.

213 ation defined by tumour mutational status or plasma protein levels.

214 ciation between ARDS-associated genotype and plasma protein levels.

215 n of the causal consequences of variation in plasma protein levels.

216 ecovery of body weight, reduced glycosylated plasma proteins levels, and long-term survival without s

217 yndrome (ARDS) have been identified based on plasma protein markers in four previous studies.

218 fic for C5a, suggesting that this ubiquitous plasma protein may have a more significant role in neutr

219 Although plasma proteins may serve as markers of neurological dis

220 markers for MPV and PLT among 71 CVD-related plasma proteins measured in FHS (Framingham Heart Study)

221 Third Generation cohorts, who had 85 fasting plasma proteins measured using Luminex xMAP platform.

222 mechanisms, and supports the use of MRI and plasma protein measures as RmTBI biomarkers.

223 ween platelet glycoprotein (Gp) IIb/IIIa and plasma proteins mediate platelet cross-linking in arteri

224 ents, we recovered at least 82% of the blood plasma proteins, more than with state-of-the-art filters

225 d a specific reduction of only serum Mn, and plasma protein N-glycome profiling revealed reduced comp

226 ion and their preferential adsorption to the plasma protein-occupied oil-water interface.

227 Protein S (PS) is a multifunctional plasma protein of the hemostatic and inflammatory pathwa

228 od inflammation markers, antibodies, and 101 plasma proteins of hospitalized COVID-19 patients who di

229 io (a test showing relative amounts of major plasma proteins) of 0.92 (reference range, 0.8-2.0), a u

230 Two plasma proteins, OSM and HGF, were also associated with

231 in a mean 70% reduction in circulating PCSK9 plasma protein (p<0.0001) and a mean 40% reduction in LD

232 ysiologic conditions, significant amounts of plasma protein pass the renal filter and are reabsorbed

233 ally modified nucleic acid therapeutics with plasma proteins play an important role in facilitating d

234 ) hydrogel particles for removal of abundant plasma proteins, prior to proteome analysis by MS.

235 that each individual has a unique and stable plasma protein profile throughout the study period and t

236 Clustering based on plasma protein profiles delineated a subgroup of patient

237 Unsupervised clustering of plasma protein profiles identified 2 distinct groups of

238 l-to-cell communication, was used to measure plasma protein profiles in 96 HIV-infected, treatment-na

239 isease (CHD-PAH) has serious consequence and plasma protein profiles in CHD-PAH are unknown.

240 These data suggest that plasma protein profiles might improve the prediction of

241 We compared plasma protein profiles with ex vivo islet secretome and

242 In the present study, plasma protein profiling was compared among NEC, sepsis

243 We find that plasma proteins readily permeate the healthy brain paren

244 -feet from cerebral microvessels, leakage of plasma proteins, reduction in expression of endothelial

245 nce of neutrophils mediated by HOCl-modified plasma proteins, resulting in the increased and prolonge

246 The plasma protein serum amyloid P (SAP) reduces neutrophil

247 differentiation is strongly inhibited by the plasma protein serum amyloid P (SAP), and healthy tissue

248 dosis always contain the nonfibrillar normal plasma protein, serum amyloid P component (SAP).

249 Our aim was to find out whether the plasma protein signature in CVID is associated with clin

250 aminase-specific labeling to identify FXIIIa plasma protein substrates and their reactive residues.

251 , even in the presence of 'matrix' and other plasma proteins such as albumin and globulin.

252 lation of highly expressed genes involved in plasma protein synthesis and metabolism, a concomitant c

253 Acute phase proteins (APPs), plasma proteins synthesized in the liver, are increased

254 d protein-1 (MAP-1) is a recently discovered plasma protein that acts as an upstream inhibitor of the

255 more active in the presence of properdin, a plasma protein that acts to stabilize C3bBb.

256 Serum amyloid A (SAA) is an acute-phase plasma protein that functions in innate immunity and lip

257 Complement factor H (fH) is a plasma protein that regulates activation of the alternat

258 a receptor for vitronectin (Vn), an abundant plasma protein that regulates the terminal pathway of th

259 Serum amyloid A (SAA) is a plasma protein that transports lipids during inflammatio

260 In univariable analyses, the only plasma protein that was associated with overall survival

261 Interestingly, plasma proteins that become heat-resistant following tre

262 -capture low-molecular-weight, low-abundance plasma proteins that cannot be detected by conventional

263 ue to the blocking of radioligand binding to plasma proteins that elevated the free fractions of the

264 includes a predominant contribution of blood plasma proteins that is conserved with human SF.

265 cquisition, assimilation and/or recycling of plasma proteins that predicted overwinter survival.

266 Further, we identified 98 plasma proteins that still foul current "protein-resista

267 was a significant increase in the number of plasma proteins that were related to endocrine system di

268 profiling of a larger portion of circulating plasma proteins (the plasma proteome) will provide oppor

269 o bind, absorb, and load their granules with plasma proteins, this report is one of the first to expl

270 during inflammatory responses, citrullinates plasma proteins, thus affecting thrombus formation.

271 ults were explained by the pre-adsorption of plasma proteins to an oil-water interface (lowering cont

272 a list of proteins or peptides against known plasma proteins to assess novelty of their data set.

273 oss-talk couples transendothelial leakage of plasma proteins to the cytokine circuitry that coordinat

274 The plasma protein transthyretin (TTR) is linked to human am

275 studies, creating a reference dataset of 496 plasma protein turnover rates from 4 healthy adults.

276 This study is the first to measure global plasma protein turnover rates in rats in vivo, measure v

277 Unlike IgG antibody, plasma protein uptake diminishes in the aged brain, driv

278 f our new technique, we have levitated human plasma proteins using MagLev.

279 es the blood flow through its binding to the plasma protein von Willebrand factor (VWF) and transmits

280 The plasma protein von Willebrand factor (VWF) is essential

281 A core signature of 46 plasma proteins was commonly modulated in all three infe

282 Here, a proteomic analysis of 1301 plasma proteins was conducted in 997 individuals between

283 Normal sialylation of plasma proteins was observed in spite of NANS deficiency

284 ween groups, and biochemical profiling of 40 plasma proteins was performed to identify proteins that

285 ng the corresponding effects on inflammatory plasma proteins, we identified cathepsin S as a lead ind

286 Using flow cytometry, these plasma proteins were also confirmed to be acquired to th

287 Differential plasma proteins were first detected by iTRAQ proteomic t

288 tabolic enzymes, some myofibrillar and blood plasma proteins were identified, which were characterise

289 he CDCS cohort, 212 differentially expressed plasma proteins were significantly associated with subse

290 ecific differences in their association with plasma proteins which likely rationalizes their behavior

291 shing the binding affinity between drugs and plasma proteins, which is a critical factor to develop e

292 ted to improve the fraction unbound to human plasma protein while retaining biochemical potency.

293 Human alpha-1-antitrypsin (A1PI) is a plasma protein with the function of protecting lung tiss

294 We studied the association of plasma proteins with AD in the overall sample and strati

295 , and turnover rates were quantified for 157 plasma proteins with half-lives ranging 0.3-103 days.

296 poproteins, 135 lipid species, and 211 other plasma proteins with incident CVD (91 events), defined a

297 We then correlated plasma proteins with left ventricular ejection fraction

298 The interaction of plasma proteins with metal oxide nanoparticles (NPs) is

299 ing constants for the 25 most abundant human plasma proteins with phosphorothioate (PS) modified anti

300 In addition to promoting the uptake of plasma proteins, Yap/Taz also promoted the scavenging of