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1 sylceramides, dehydrocholesteryl esters, and plasmalogens).
2 to hydrolyse plasmenylcholine phospholipids (plasmalogens).
3 s) and a nearly 35% decrease in ethanolamine plasmalogen.
4  is specific for the sn-2-deacylated form of plasmalogen.
5  neutrophils, attack the vinyl ether bond of plasmalogens.
6 s of the vinyl ether linkage of arachidonoyl-plasmalogens.
7 s present in the sn-1 position of neutrophil plasmalogens.
8 ty acids in plasma and deficient erythrocyte plasmalogens.
9  single step in the biosynthetic pathway for plasmalogens.
10  the introduction of the ether bond found in plasmalogens.
11 tent of the peroxisome-derived lipids called plasmalogens.
12 tein (MtbYhhN), despite having no endogenous plasmalogens.
13 including 8 phosphatidylcholines (PCs) and 2 plasmalogens.
14 classes, with the latter being also known as plasmalogens.
15 arbon receptor (AhR) ligands, bile acids and plasmalogens.
16 89-deficient mice may be caused by a lack of plasmalogens.
17 orous acid targeting the vinyl ether bond of plasmalogens.
18 egraded in response to the cellular level of plasmalogens.
19 m reactive chlorinating species targeting of plasmalogens.
20 d eosinophils attack the vinyl ether bond of plasmalogens.
21  in arachidonic acid-containing ethanolamine plasmalogens.
22                             The discovery of plasmalogens (1-alk-1'-enyl, 2-acyl phospholipids) in an
23 iosynthesis, resulted in decreased levels of plasmalogens (16-30%).
24  in sphingomyelin (78.3 and 117.5mug/ml) and plasmalogens (27.3 and 24mug/ml), possibly important for
25 lysis consistently detected a decrease in PC-plasmalogens (36:4, 36:6, 38:6) and highly unsaturated P
26  the interaction between M.tb and macrophage plasmalogens, a subclass of glycerophospholipids with a
27 not only from PAF to lysoplasmalogen forming plasmalogen analogs of PAF, but also to sphingosine prod
28 n; and validate a novel association of serum plasmalogen and TMEM229B, which was predicted as causal
29 sociations between ratios containing choline-plasmalogens and single-nucleotide polymorphisms in the
30  3 phosphatidylethanolamines (PEs) (C38:3 PE plasmalogen) and lysophosphatidylethanolamines (C18:2, C
31  composed of highly saturated triglycerides, plasmalogens, and acylcarnitines were associated with un
32 vels of tryptophan metabolites, eicosanoids, plasmalogens, and fatty acids.
33 ids with putative health benefits, including plasmalogens, and should aid in selecting appropriate in
34 ing progressive accumulation of cholesterol, plasmalogens, and sphingolipids.
35                                              Plasmalogens are a phospholipid molecular subclass that
36                                              Plasmalogens are a subclass of glycerophospholipids that
37         The present studies demonstrate that plasmalogens are attacked by MPO-derived reactive chlori
38                           We determined that plasmalogens are crucial for Schwann cell development an
39 rative strategies for the total synthesis of plasmalogens are enabled by this simple transformation.
40 s evidence for an anaerobic process in which plasmalogens are formed from their corresponding diacyl
41                                              Plasmalogens are present in mitochondria and decreased w
42 iosynthesis of ether phospholipids, of which plasmalogens are the most abundant form in nervous tissu
43 spholipid causes neuropathology, implicating plasmalogens as regulators of membrane and cell signalin
44 ng negative spontaneous curvature, including plasmalogens, as a hallmark of deep-adapted membranes th
45 on in the rate of biosynthesis and levels of plasmalogens, as determined using short- and long-term l
46                                          The plasmalogen-based pathway is consistent with previous st
47 This study illustrates the plausibility of a plasmalogen-based pathway through synthesis of the plasm
48 oteins, including the peroxisomal enzymes of plasmalogen biosynthesis and peroxisomal 3-ketoacyl thio
49 clinical features associated with defects in plasmalogen biosynthesis to include FAR1 deficiency as a
50 ation of a mutant CHO cell line defective in plasmalogen biosynthesis which contains intact, function
51 ansferase (DHAP-AT), a peroxisomal enzyme of plasmalogen biosynthesis, and we identify the mutations
52 entification of mutations in another gene in plasmalogen biosynthesis, fatty acyl-CoA reductase 1 (FA
53  AGPS and FAR1, encoding enzymes involved in plasmalogen biosynthesis.
54 e acyltransferase (DHAP-AT), first enzyme in plasmalogens biosynthesis, resulted in decreased levels
55 n PEX7, GNPAT, and AGPS, all involved in the plasmalogen-biosynthesis pathway, have been described in
56 s to their respective fatty alcohols for the plasmalogen-biosynthesis pathway.
57              Lysoplasmalogens, produced from plasmalogens by hydrolysis at the sn-2 carbon by phospho
58 ate the targeting of the vinyl ether bond of plasmalogens by the reactive brominating species produce
59 ate the targeting of the vinyl ether bond of plasmalogens by the reactive brominating species produce
60 ime the targeting of the vinyl ether bond of plasmalogens by the reactive chlorinating species produc
61  (C36:4 PC-A, C34:3 PC plasmalogen, C36:3 PC plasmalogen, C34:2 PC plasmalogen, C36:2 PC) and lysopho
62  plasmalogen, C36:3 PC plasmalogen, C34:2 PC plasmalogen, C36:2 PC) and lysophosphatidylcholines (C18
63  phosphocholines (PCs) (C36:4 PC-A, C34:3 PC plasmalogen, C36:3 PC plasmalogen, C34:2 PC plasmalogen,
64                                              Plasmalogen concentrations were lower in VAT than in SAT
65 ery-long-chain fatty acid beta-oxidation and plasmalogen concentrations, and a decrease in very-long-
66                                              Plasmalogens constitute a significant fraction of cardia
67                                              Plasmalogens contain a characteristic 1-O-alk-1'-enyl et
68                                              Plasmalogens contain a vinyl ether bond linking the sn-1
69      The rearing system had no effect on the plasmalogen content but influenced aldehyde composition,
70 s confirmed 34- and 20-fold increases in the plasmalogen cooxidation products, unsaturated lysophosph
71 ell development and differentiation and that plasmalogen defects impaired radial sorting, myelination
72 dels of RCDP and analyzed the consequence of plasmalogen deficiency in peripheral nerves.
73  Schwann cell defects, effectively bypassing plasmalogen deficiency.
74 viving population, we have isolated a unique plasmalogen-deficient Chinese hamster ovary (CHO) cell l
75       The method was validated using a novel plasmalogen-deficient mouse model, which lacks plasmanyl
76                  Unlike previously described plasmalogen-deficient mutants, NZel-1 contained peroxiso
77 ion between peroxisomes and mitochondria and plasmalogen-dependent localization of TMEM135 in mitocho
78 transmembrane domain of Far1 is required for plasmalogen-dependent modulation of Far1 stability.
79 y human coronary artery endothelial cells to plasmalogen-derived lysophosphatidylcholine molecular sp
80 chanism that targets the vinyl ether bond of plasmalogens during neutrophil activation resulting in t
81 demonstrated that sphingomyelin-ceramide and plasmalogen dysmetabolism are associated with FSGS and t
82                                 Synthesis of plasmalogens enhanced pressure tolerance in Escherichia
83  such as in asthma, might selectively target plasmalogens for oxidation.
84   Our results demonstrate the requirement of plasmalogens for the correct and timely differentiation
85  an inability of these cells to form labeled plasmalogens from labeled alkylglycerols.
86  2-chlorooctadecanal, respectively, from the plasmalogen glycerol backbone.
87                 Lysophosphatidic acid (LPA), plasmalogen-glycerophosphate (alkenyl-GP) and, cyclic-ph
88   Arachidonic acid was observed primarily in plasmalogen glycerophosphoethanolamine (GPE), whereas li
89 sed to examine the fate of diacyl, ether, or plasmalogen glycerophosphoethanolamine (GPEtn) species a
90 way of oxidative degradation of arachidonoyl plasmalogen GPE suggesting a unique role for this plasma
91 iliverdin and C36:5 phosphatidylcholine (PC) plasmalogen had inverse associations; C16:0 ceramide and
92  pseudouridine and C36:2 phosphatidylcholine plasmalogen had the strongest statistical associations (
93        The latter compounds, better known as plasmalogens, harbor a vinyl ether double bond conferrin
94                                              Plasmalogens (i.e. plasmenylcholines or plasmenylethanol
95 ials, to generate glycerophosphocholine-type plasmalogens in 4% overall yield.
96 n and the biosynthesis of LC-PUFA-containing plasmalogens in BAT.
97                     We also observed reduced plasmalogens in red blood cells in one individual to a r
98 vous tissue and myelin; however, the role of plasmalogens in the peripheral nervous system is poorly
99 rected the in situ levels of fatty acids and plasmalogens in these mutant cell lines.
100                 Dietary supplementation with plasmalogens increased mitochondrial copy number, improv
101                                              Plasmalogen insufficiency resulted in defective protein
102 dy demonstrates that the vinyl ether bond of plasmalogens is a molecular target of the reactive chlor
103 at the enzyme may be important in regulating plasmalogen levels in animal cells.
104 turase activity and had dramatically lowered plasmalogen levels in their tissues.
105                                    The total plasmalogen levels were significantly decreased in NASH
106 mine desaturase activity, strongly decreased plasmalogen levels, and accumulation of plasmanylethanol
107 by a mechanism that is dependent on cellular plasmalogen levels.
108 cies promote selective oxidative cleavage of plasmalogens, liberating alpha-chloro fatty aldehydes an
109 lactate, methionine sulfone, indole lactate, plasmalogen lipids, pristanate and fumarate.
110 ondrial function correlated with antioxidant plasmalogens, long-chain ceramides, lyso-phosphatidylcho
111 ts lacked all ether phospholipids, including plasmalogens, LPG, and GIPLs.
112 eroxidase target the vinyl ether bond of the plasmalogen, lysoplasmenylcholine (1-O-hexadec-1'-enyl-s
113 ds) and lack of products (like bile acids or plasmalogens), many peroxisomal defects lead to detrimen
114 decanal was dependent on the presence of the plasmalogen masked aldehyde (i.e. the vinyl ether) in th
115 ct of FABP on plasmalogen mass, ethanolamine plasmalogen mass was reduced 30% in gene-ablated mice.
116 Consistent with a reported effect of FABP on plasmalogen mass, ethanolamine plasmalogen mass was redu
117              Dysregulation of adipose tissue plasmalogen metabolism is associated with obesity-relate
118 e, is arrhythmogenic, but the effects of the plasmalogen metabolite, lysoplasmenylcholine (LPLC), are
119     FSGS was also associated with individual plasmalogen metabolites and the subpathway.
120 alogen GPE suggesting a unique role for this plasmalogen molecular species glycerophospholipid.
121 s found that the abundant arachidonoyl GPEtn plasmalogen molecular species were uniquely reduced in r
122 vely associated, whereas phosphatidylcholine plasmalogens (NES, -1.91), lysophosphatidylcholines (NES
123  lenta that revealed a plasmalogen-triggered plasmalogen pair that forms a single molecule signal tra
124 ospholipids in the human body is composed of plasmalogens, particularly in the brain, cardiac, and im
125 , where very long chain ceramide species and plasmalogen PE decreased, then normalising in late-stage
126 vide a universal scan for diacyl, ether, and plasmalogen PE lipids that cannot be readily observed ot
127                                           PE plasmalogen, PE with two unsaturated fatty acids, and ly
128 Concentrations of 2 phosphatidylethanolamine plasmalogens, PE(18:2/P-18:0) and PE(18:2/P-16:0), were
129  are acid sensitive suggestive that they are plasmalogen PEs possessing a double bond at the 1-positi
130  undertaken to define the role of PLA(2) and plasmalogen phospholipid hydrolysis in PAF synthesis in
131  resulted in inhibition of iPLA(2) activity, plasmalogen phospholipid hydrolysis, production of choli
132 d by its use in syntheses of an anti-oxidant plasmalogen phospholipid, found in electrically active t
133 kD CaIPLA2 with preferential activity toward plasmalogen phospholipids has been recently purified fro
134 tion of iPLA(2) and associated hydrolysis of plasmalogen phospholipids was accompanied by increased l
135 sary for peroxisome growth, the synthesis of plasmalogen phospholipids, and the maintenance of cellul
136 active chlorinating species (RCS) target the plasmalogen pool of LDL isolated from peripheral human b
137 rinated aldehydes from both LDL and monocyte plasmalogen pools that may have important effects during
138 -mediated targeting of both monocyte and LDL plasmalogen pools was demonstrated in phorbol myristate
139 logen-based pathway through synthesis of the plasmalogen precursor (2) and triggering the plasmalogen
140                                              Plasmalogen rather than diacyl phospholipids are the pre
141 p ratio were inversely associated with total plasmalogens relative to total phospholipids in both sex
142 eactive chlorinating species attack membrane plasmalogens releasing alpha-chloro fatty aldehydes incl
143                      The vinyl ether bond of plasmalogens renders them susceptible to oxidation.
144 ivated neutrophils targeted endothelial cell plasmalogens resulting in 2-chlorohexadecanal production
145 il peroxidase target the vinyl ether bond of plasmalogens resulting in the production of a neutral li
146 eloperoxidase target the vinyl ether bond of plasmalogens, resulting in the production of a neutral l
147 plasmalogen precursor (2) and triggering the plasmalogen's electron-rich vinyl ether with small elect
148  of inflammatory environments react with the plasmalogen's sensitive vinyl ether moiety to create a l
149 ates RORgammat through a triggered mammalian plasmalogen signal, 1-18:0-lysophosphatidylethanolamine.
150 phosphatidylcholines, lysophospholipids, and plasmalogens, some of which may mediate the effect of TG
151                                              Plasmalogen subclass masses were also reduced, suggestin
152 risks of PPV use, while metabolites from the plasmalogen subpathway were associated with lower risks.
153 K 293T cells resulted in decreased levels of plasmalogens, suggesting that the enzyme may be importan
154 ositioned either side of enzymes involved in plasmalogen synthesis and degradation showed positive an
155                 Expression of Far1 increased plasmalogen synthesis in wild-type Chinese hamster ovary
156 nylethanolamine desaturase, a key enzyme for plasmalogen synthesis.
157 tabolism, including fatty acid oxidation and plasmalogen synthesis.
158 ting that Far1 is a rate-limiting enzyme for plasmalogen synthesis.
159 ed, suggesting that H-FABP may augment brain plasmalogen synthesis.
160 ochondrial copy number, but knockdown of the plasmalogen synthetic enzyme glyceronephosphate O-acyltr
161  of very long-chain fatty acids (VLCFAs) and plasmalogens, the ER also plays a role in peroxisome bio
162 l targets tissue- and lipoprotein-associated plasmalogens to generate alpha-chlorinated fatty aldehyd
163 ly, 2-BrHDA was preferentially produced from plasmalogen treated with hypochlorous acid in the presen
164 ry metabolites from E. lenta that revealed a plasmalogen-triggered plasmalogen pair that forms a sing
165                     An improved synthesis of plasmalogen type lipids is described.
166 ng species targeting the vinyl ether bond of plasmalogens utilizing a cell-free system.
167 oduced by eosinophil peroxidase attacked the plasmalogen vinyl ether bond at acidic pH.
168 s, reactive brominating species attacked the plasmalogen vinyl ether bond at neutral pH.
169                         Targeting of the LDL plasmalogen vinyl ether bond was dependent on the presen
170                  The vinyl ether bond of LDL plasmalogens was targeted by MPO-derived RCS, resulting
171                                           PE plasmalogens were positively correlated with saturated f
172 ment analyses, phosphatidylethanolamine (PE) plasmalogens were positively enriched for association wi
173 her phospholipids also known as ethanolamine plasmalogen whose functions are not well characterized.
174 e A2 (PLA2) or by "triggering" of a suitable plasmalogen with accompanying 1,2-acyl migration from th

 
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