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3 highlight a drastic conformational change in plasmodial ADA upon substrate binding that has not been
6 is natural difference in specificity between plasmodial and mammalian ADA has not been well understoo
7 MP potency and selectivity toward bacterial, plasmodial, and cancerous cells while enabling the targe
8 , T cells from infected mice stimulated with plasmodial antigen triggered 5-10-fold increases in p24
11 e need a deeper understanding of fundamental plasmodial bioregulatory mechanisms to successfully subv
13 Physarum polycephalum, when transplanted, by plasmodial coalescence, into an S-phase plasmodium, fail
16 for folding of falcipain-2 and four related plasmodial cysteine proteases was inclusion of a 14-15-r
17 es represent the first crystal structures of plasmodial cysteine proteases with small molecule inhibi
18 ned in silico against the homology models of plasmodial cysteine proteases, falcipain-2, and falcipai
20 DSM265 is a novel antimalarial that inhibits plasmodial dihydroorotate dehydrogenase, an enzyme essen
24 was genetically modified to secrete two anti-plasmodial effector peptides, MP2 (midgut peptide 2) and
28 s, we propose a specific role for one of the plasmodial enzymes, aminopeptidase P, in the catabolism
31 strategy may be widely applicable to modify plasmodial genes and perform structure-function analyses
32 ort the relative susceptibility of human and plasmodial GRs to a series of tricyclic inhibitors as we
33 yte modification by the parasite may involve plasmodial heat shock proteins and be vastly more comple
34 rties of Hs-18Pf-SAHH, the human enzyme with plasmodial helix 18, and Tc-18Hs-SAHH, the trypanosomal
36 ms in the pfmdr1 gene, the gene encoding the plasmodial homologue of mammalian multidrug resistance t
37 m-infected RBCs appeared to be suppressed by plasmodial infection, as both increased after antimalari
39 treatments are available to prevent or cure plasmodial infections, but genetic mutations in the caus
41 Recently, we discovered and validated the plasmodial l-lactate transporter, PfFNT, as a novel anti
42 consistent with recent observations that the plasmodial MAPKs are not true orthologues of the ERK1/2,
45 , epoxyazadiradione inhibited both huMIF and plasmodial MIF, thus bearing an immense therapeutic pote
47 insight into this process, we have studied a plasmodial ortholog of the lysosomal exopeptidase cathep
50 alytic domain with extensions from six other plasmodial proteases folded normally and had kinetic par
51 Recent advances in the characterization of plasmodial proteases should facilitate the analysis of t
53 nose) and FP2(arm) are found only in related plasmodial proteases, suggesting that they confer malari
55 re we report the characterization of a novel plasmodial protein kinase, PfPK7, whose top scores in bl
59 Because they occur in almost all families of plasmodial proteins, the occurrence of LCRs cannot be as
62 stent with the differences between human and plasmodial sequences in the Q2 pocket receiving this gro
67 ty to ions and nutrients, as mediated by the plasmodial surface anion channel (PSAC) and recently lin
76 n unusual voltage-dependent ion channel, the plasmodial surface anion channel (PSAC), which may accou
77 ll patch-clamp indicate direct action on the plasmodial surface anion channel, a channel linked to pa
78 echanism involving genes responsible for the plasmodial surface anion channel, a nutrient channel tha
83 sident proteins are detected as rafts in the plasmodial vacuole, (2) a voltage-gated channel in the i