ライフサイエンスコーパス: ploidy

1 ma Staging System [INSS] stage, MYCN status, ploidy).

2 tients according to 14q32 translocations and ploidy.

3 pes upon biomarker expression and chromosome ploidy.

4 yll cells and, in some cases, increased leaf ploidy.

5 sis, resulting in an increase in nuclear DNA ploidy.

6 creasing function of the average chromosomal ploidy.

7 oduction by 50% and had significantly higher ploidy.

8 tely spawning proliferative cells of reduced ploidy.

9 amage in diploid daughter cells and elevated ploidy.

10 ce each lost cell with multiple PCs of lower ploidy.

11 association with hybridisation and shifts in ploidy.

12 d are rarely scalable to genomes with higher ploidy.

13 of cell lines with experimentally determined ploidy.

14 rst scalable polyplotyping method for higher ploidy.

15 kably, loss of FLVCR increased megakaryocyte ploidy.

16 nhanced K accumulation of plants with higher ploidy.

17 ble to account for unknown tumour purity and ploidy.

18 talytic subunit results in rapid increase in ploidy.

19 gene expression profiles, and increased DNA ploidy.

20 th enhanced cell proliferation and increased ploidy.

21 osity and not further enhanced by increasing ploidy.

22 t they become essential in cells with higher ploidy.

23 the ability of MKs to achieve high levels of ploidy.

24 ounting for aberrant cell fraction and tumor ploidy.

25 DNA copy number relative to overall genomic ploidy.

26 ases whose overexpression leads to increased ploidy.

27 t proteins in a cell increases linearly with ploidy.

28 bserved to be associated with differences in ploidy.

29 cell number per leaf blade with incrementing ploidy.

30 additional unobserved factor, rather than by ploidy.

31 ed with distinct genetic aberrations and DNA ploidies.

32 st cells of different sizes due to different ploidies.

33 fferent copy numbers, resulting in different ploidies.

34 y reduced numbers of MKs in culture of lower ploidy (2N and 4N) than wild-type controls, implicating

35 ls are produced by increasing DNA content or ploidy, a developmental strategy employed throughout the

36 romotes ICL repair in a manner that controls ploidy, a role that we show is not shared by the Fanconi

37 Mice with knockdown of ANLN had hepatocyte ploidy above physiologic levels and developed significan

38 taxa, we know very little about how elevated ploidy above the diploid level might affect plasticity.

39 new generation, and meiosis thus stabilizes ploidy across generations.

40 ion between metabolic rate and cardiomyocyte ploidy across species, linking whole-body metabolic cont

41 psy, estimating cancerous cell purity, tumor ploidy, allele-specific copy number, and clonality and r

42 of individual blastomeres are diagnostic of ploidy, amenable to automated tracking algorithms, and l

43 multiparameter analysis of apoptosis and DNA ploidy analysis in human hematopoietic cancer cells.

44 ity in USARCs by integrating DNA sequencing, ploidy analysis, gene expression, and methylation profil

45 simple and robust algorithm to infer purity, ploidy and absolute copy numbers in whole numbers for tu

46 In particular, we describe ConPADE (Contig Ploidy and Allele Dosage Estimation), a probabilistic me

47 We used the bioinformatics tools 'expanding ploidy and allele frequency on nested subpopulations' (E

48 iomarkers (low-grade dysplasia, abnormal DNA ploidy and Aspergillus oryzae lectin) can identify patie

49 y, and also predicted a relationship between ploidy and cell size that was observed in yeast and aneu

50 key cell cycle regulatory factor influencing ploidy and cell-size depending on external nitrate.

51 While ploidy and chromatin architecture appear unaffected, S22

52 opy number calls corrected for tumor purity, ploidy and clonal heterogeneity, with comprehensive outp

53 has been implicated in proliferation of MKs, ploidy and deposition of fibers.

54 ocytes from these mice were blocked at 2N/4N ploidy and did not survive ex vivo.

55 Pdk1-/- BM-MKs developed increased ploidy and exhibited an abnormal ultrastructure with dis

56 can be divided into two groups according to ploidy and hyperdiploidy versus nonhyperdiploidy.

57 oracic gland cells, a process that increases ploidy and is rate limiting for the expression of ecdyso

58 Arabidopsis mutants whose pollen has higher ploidy and larger volume develop four or more apertures.

59 nuclear localization and rescues defects in ploidy and mitosis.

60 in mice by sustaining Yap-P27-mediated cell ploidy and P62-HDAC6-controlled autophagy maturation.

61 The decrease in megakaryocyte ploidy and platelet counts of DKO mice is more severe th

62 nd ploidy, suggesting that CCL5 increases MK ploidy and proplatelet formation in a CCR5-dependent man

63 potential to improve the estimation of tumor ploidy and purity.

64 and because crop plants have highly variable ploidy and repeat content, the performance of GBS analys

65 lineages of Mercurialis that differ in their ploidy and sexual system to ascertain the extent to whic

66 s of the mean (modes) to identify underlying ploidy and the contamination level, and finally we perfo

67 Megakaryocyte ploidy and the generation of pre/proplatelets are both i

68 hts that cohesin is required for maintaining ploidy and the repair of spontaneous DNA damage in place

69 to the accumulation of MKs with low nuclear ploidy and to decreased platelet production.

70 igen, phosphorylated histone 3, mitosis, and ploidy), and regeneration-associated molecules.

71 iology of eusocial species, independently of ploidy, and add support to the idea that haplodiploidy h

72 erating hepatocytes can increase or decrease ploidy, and animal models with healthy diploid-only live

73 Low-grade dysplasia, abnormal DNA ploidy, and AOL can be used to identify patients with BE

74 comprising low-grade dysplasia, abnormal DNA ploidy, and AOL most accurately identified progressors a

75 ed maturation, decreased survival, decreased ploidy, and developmental abnormalities, including abnor

76 ularly for dispersal ability, mating system, ploidy, and environmental heterogeneity.

77 MYCN, 11q, mitosis-karyorrhexis index (MKI), ploidy, and lactate dehydrogenase were independently sta

78 Tumor purity, ploidy, and subclonality were reliably inferred from dif

79 reatment decisions, accurate, tumor purity-, ploidy- and clonal heterogeneity-adjusted integer copy n

80 Alteration of normal ploidy (aneuploidy) can have a number of opposing effect

81 artners distinguishable by their morphology, ploidy, antigens, biochemical traits, gene expression, a

82 B1 expression whereas megakaryocytes of high ploidy are inhibited by lamin suppression.

83 Estimates of tumor purity and ploidy are necessary to correctly infer copy number, and

84 Megakaryocyte number and ploidy are normal in all 3 mouse lines, but platelet rec

85 Hence GS and ploidy are significant traits affecting biomass growth u

86 We investigate ploidy as a candidate biomarker of this phenotypic heter

87 dy identifies the double-edged sword of high ploidy as a prerequisite to personalize combination ther

88 Ploidy assessed by DI was also a favorable factor: the h

89 the best indicator for excellent outcome was ploidy assessed by karyotype because patients with 58-66

90 ogeographic impacts of reproductive mode and ploidy because it is composed of diploid sexual and both

91 inction rate differences are associated with ploidy, breeding system, and the interaction between the

92 lication programme, increasing their nuclear ploidy, but subsequently reinitiate mitotic division cou

93 ovided feedback on the correctness of sample ploidy calls and also detected data quality issues.

94 es of polyploids, especially those with high ploidies, can reveal fundamental processes in speciation

95 cancer cells, suggesting that the reversible ploidy change itself could provide a general mechanism f

96 uence for cotton (Gossypium spp.) revealed a ploidy change of a complexity unprecedented to date, ind

97 e and dosage responses immediately following ploidy change.

98 Age-related accumulation of ploidy changes is associated with decreased expression o

99 c principles of sex are conserved, including ploidy changes, the formation of gametes via meiosis, ma

100 ce given CCl(4) had significant increases in ploidy compared with livers from uninjured mice.

101 ed the presence of alterations in hepatocyte ploidy compared with tissue from control individuals.

102 arch of molecular factors that regulate this ploidy consistency, we isolated an Arabidopsis thaliana

103 role in consolidating the male gametophytic ploidy consistency.

104 and increased abnormal mitoses and cellular ploidy, consistent with on-target activity.

105 providing direct evidence of the hepatocyte ploidy conveyor model.

106 me aneuploid in a dynamic process called the ploidy conveyor.

107 when assessing copy number changes; however, ploidy-corrected copy number states suggest good agreeme

108 Unexpectedly, higher ploidy correlated with reduced tumor-forming capacity.

109 We also discover that ploidy correlates with Stentor's cell size.

110 OS-induced DNA damage could have facilitated ploidy cycling prior to a conventional meiosis in eukary

111 ivity inhibition by blebbistatin rescued the ploidy defect of FPD/AML MKs.

112 mediated GEF-H1 knockdown alone rescues this ploidy defect.

113 and abnormal spindle polarity, resulting in ploidy defects.

114 ion of nodule-specific genes correlated with ploidy-dependent opening of the chromatin as well as, in

115 The reasons for this ploidy-dependent reproductive isolation remain unknown.

116 ication stress, early events associated with ploidy dictate the repair pathway choice.

117 Ploidy (diploid vs polyploid states) and breeding system

118 that infers tumor purity and malignant cell ploidy directly from analysis of somatic DNA alterations

119 We detected high ploidy diversity in Allium and a polyploidy-related dive

120 We quantified intraspecific ploidy diversity, heterogeneity in diversification rates

121 thesis that blastomere behaviour may reflect ploidy during the first two cleavage divisions.

122 This ploidy effect is independent of mating type heterozygosi

123 lation accompanying changes in lifestyle and ploidy, especially in carbon metabolism.

124 ogous chromosomes during meiosis I to reduce ploidy for gamete production.

125 Production of gametes of halved ploidy for sexual reproduction requires a specialized ce

126 Importantly, DNA repair, ploidy formation, and cell fusion were not implicated in

127 benchmark methods for estimating purity and ploidy from tumor-normal pairs.

128 It is concluded that ploidy gave less variation than temperature.

129 For triploid and higher ploidy genomes, we demonstrate that HapTree substantiall

130 ion of sexual reproduction, mutational load, ploidy, genomic complexity, speciation, and the origin o

131 Three tumours with the highest ploidy had little genome-wide LOH, yet one of these had

132 ivergent allelic-imbalance profiles and with ploidy heterogeneity in two of four tumors.

133 ced by tumor sample characteristics, such as ploidy, heterogeneity, and purity.

134 Challenges in sequencing any genome include ploidy, heterozygosity and paralogy, all which are ampli

135 t megakaryocytes had partial blocks at 2N/4N ploidy; however, only the latter exhibited reduced propl

136 We examined ploidy in a naturally multinucleate fungus, Ashbya gossy

137 during development could affect mitosis and ploidy in post-mitotic differentiated tissue.

138 CitK, Ephrin/Eph signaling controls neuronal ploidy in the developing neocortex.

139 om mitotic progression led to altered genome ploidy in the liver.

140 fusion of two gametes restores the original ploidy in the new generation, and meiosis thus stabilize

141 by simultaneously altering nuclear size and ploidy in X. laevis embryos.

142 maturation of neonatal MKs without affecting ploidy, in contrast to the synchronous inhibition of pol

143 Here we show that an abrupt five- to sixfold ploidy increase approximately 60 million years (Myr) ago

144 uard cell nuclear size did not justify for a ploidy increase.

145 an additional mechanism of cyclin E-mediated ploidy increase.

146 es in trichome nuclear size likely reflected ploidy increases while the moderate increases in guard c

147 xpression was associated with an increase of ploidy, intratumor heterogeneity, copy-number alteration

148 nds on the intact SAC as well as increase in ploidy (Ipl1)/Aurora kinase and a centromere-associated

149 We conclude that ploidy is a substantially stronger and more common drive

150 Elevated ploidy is associated with enhanced cell size, metabolic

151 bperineurial glia (SPG) to be polyploid, and ploidy is coordinated with brain mass.

152 ng coverage is available, or the true contig ploidy is low.

153 Significant phenotypic variation including ploidy is present across the two primary ecotypes of swi

154 The difference in nuclear ploidy is the likely result of an autosomal polymorphism

155 These data suggest that mixed ploidy is tolerated in these syncytia; however, there ma

156 ta vs. Arabica) may be due to differences in ploidy level (2n = 22 vs. 2n = 4x = 44).

157 ass of angiosperm species with different GS, ploidy level and Grime's C-S-R (competitive, stress-tole

158 biosynthesis in the argan seed, the anatomy, ploidy level and lipid composition of mature seed tissue

159 Their unusual ploidy level and pattern of inheritance imply that sex c

160 situations where asexual taxa are of higher ploidy level and phosphorus availability limits importan

161 Ploidy level differences have not been investigated in t

162 Overall, we found that an increase in ploidy level from 4x to 6x in M. annua is associated wit

163 ides no support for the idea that increasing ploidy level increases the ability to express different

164 acterization revealed that the basic somatic ploidy level negatively correlated with lignin and cellu

165 iosynthesis are required for maintaining the ploidy level of the premeiotic germ lineage and that sub

166 MK ploidy level was low and mature MKs displayed a major de

167 one allele was also observed irrespective of ploidy level, but not transcriptome wide as previously s

168 fascinating example of the interplay between ploidy level, hybridisation and alien plant invasion.

169 iated with model crops, including changes in ploidy level, loss of shattering, multiple origins, and

170 nd 5S rDNA amounts increased with increasing ploidy level.

171 ica that occupy diverse habitats and vary in ploidy level.

172 NA units, chromosome number, genome size and ploidy level.

173 Here, we ask whether different ploidy levels > 2x express different plasticity in the r

174 psis thaliana) plants with different somatic ploidy levels (2n, 4n, 6n, and 8n) and performed rigorou

175 ntrols cotyledon and leaf size by increasing ploidy levels and cell expansion but that cell division

176 transcriptional waves correlate with growing ploidy levels and have investigated how the epigenome ch

177 hepatocytes were able to dynamically resolve ploidy levels and return to normal by the end of regener

178 ot growth kinematics, G2/M phase cell count, ploidy levels and ribosome polysome profiles.

179 screens, scaling down a tetraploid to lower ploidy levels and swapping of nuclear and cytoplasmic ge

180 ow cytometry analyses allowed us to evaluate ploidy levels and to monitor cell cycle progression in l

181 genes DNA methylation was unaffected by the ploidy levels and was independent of the genes' active o

182 Plants of different ploidy levels are separated by a strong postzygotic hybr

183 Nevertheless, taxa within ploidy levels could be largely distinguished according t

184 mosomes, thereby enabling the restoration of ploidy levels during fertilization.

185 In quiescent liver, normally high ploidy levels in adult mice increased with loss of p53.

186 ly the approach to systems of known variable ploidy levels in the Meloidogyne genus and the extreme c

187 Ploidy levels increased during regeneration of both wild

188 sex ratios, respectively, regardless of the ploidy levels involved (diploid, tetraploid or hexaploid

189 Hybridisation among taxa with different ploidy levels is often associated with hybrid sterility.

190 Chromosomal markers on three diverse ploidy levels reflecting different stages of rediploidiz

191 wing) regions of 3-day-old hypocotyls showed ploidy levels to be lower in abcb19 mutants compared wit

192 stem hydraulic efficiency and safety across ploidy levels underlies niche differentiation among diff

193 ensities increased concurrent with increased ploidy levels, and H3K27me2 peaks were colocalized with

194 e phenotypes, including thick leaves, higher ploidy levels, and larger palisade mesophyll cells.

195 S) morphological aspect and exhibited higher ploidy levels, as compared with MKs in liquid culture.

196 ng of CYCD5;1 were effective in changing DNA ploidy levels, confirming CYCD5;1 to be a previously und

197 ly stable among wheat species with different ploidy levels, H3K27me2 intensities increased concurrent

198 found increased mesophyll cell size and leaf ploidy levels, suggesting that endoreduplication underpi

199 gh polymorphism is extensively shared across ploidy levels, there is strong ploidy-specific different

200 ated with adaptation to hosts with different ploidy levels.

201 at differentiation among plants of different ploidy levels.

202 e analyzed using flow cytometry to determine ploidy levels.

203 for maintenance of chromosome stability and ploidy levels.

204 usually higher, basic chromosome numbers and ploidy levels.

205 af size and cell area, and resulted in lower ploidy levels.

206 olves endoreduplication leading to increased ploidy levels.

207 their overexpression triggers increased DNA ploidy levels.

208 e found that the same Caph2 mutation impairs ploidy maintenance to a different extent in different he

209 ecessary to correctly infer copy number, and ploidy may itself be a prognostic factor in cancer progr

210 w approaches to experimentally manipulate CM ploidy may resolve some of these long-standing and funda

211 lastoma factors, including age, MYCN status, ploidy, mitosis-karyorrhexis index, and histologic grade

212 low) mice, where there is an increase in low ploidy MKs, augmented levels of PDGF-BB, and an extensiv

213 d that, in a system with an abundance of low ploidy MKs, LOX could be highly expressed and with funct

214 ional belief, are more mature than adult low-ploidy MKs.

215 in different hematopoietic cell types, with ploidy most severely perturbed at the CD4(+)CD8(+) T-cel

216 n the present study, we demonstrate that low-ploidy neonatal MKs, contrary to traditional belief, are

217 H-PoP might be applied to help determine the ploidy of an organism.

218 ), a probabilistic method that estimates the ploidy of any given contig/scaffold based on its allele

219 spondingly altered metaphase progression and ploidy of daughter nuclei.

220 rform this estimation and supports a maximum ploidy of eight.

221 dasatinib-treated mice was increased and the ploidy of MKs derived from bone marrow progenitor cells

222 erile grain sorghum and johnsongrass and the ploidy of their progeny, cytoplasmic (CMS), genetic (GMS

223 d SMR1 play different roles in affecting the ploidy of trichome and leaf cells, respectively.

224 e different combinations of tumor purity and ploidy often explain the sequencing data equally well.

225 , transcriptional plasticity and the role of ploidy on the interactions.

226 DIT cells can produce progeny with increased ploidy or aneuploid genomes that drive aggressive diseas

227 or sequences adjacent to the polyQ, altering ploidy or chaperone dosage, or deleting anti-aging facto

228 me sequencing precluded inferences about its ploidy or sexual cycle.

229 tion and maintenance of meiotically unstable ploidy or structural variants and provides an alternativ

230 To achieve this reduction in ploidy, organisms must devise strategies to couple siste

231 We find that ploidy per se has little effect.

232 In addition, higher ploidy plants displayed altered sugar composition.

233 atterns observed in the wild-type and higher-ploidy pollen.

234 Despite the widespread failure to increase ploidy prior to entering meiosis, the fecundity of parth

235 Allelic composition and ploidy profiling analysis revealed extensive intratumor

236 uencing, chromosome aberration analysis, and ploidy profiling on multiple spatially separated samples

237 infers genome-wide parameters such as cancer ploidy, purity and heterogeneity.

238 he creation of tumour samples with different ploidy, purity and polyclonality features.

239 rance to antifungal drugs and for nonmeiotic ploidy reduction after mating.

240 ure and as xenografts, hybrids underwent DNA ploidy reduction and morphological reversal to breast ca

241 Multicolored polyploid hepatocytes undergo ploidy reduction and subsequent re-polyploidization afte

242 dom homologous chromosome segregation during ploidy reduction can expose deleterious mutations throug

243 iggers cryptococcal polyploidization and how ploidy reduction is achieved remain open questions.

244 a midgut are replaced by spindle-independent ploidy reduction of cells in the enterocyte lineage thro

245 ies of the polyploidization and meiosis-like ploidy reduction process in cancer cells, suggesting tha

246 Marker segregation revealed that ploidy reduction rarely involves chromosome missegregati

247 Importantly, ploidy reduction was seen in all injury models studied.

248 activated in C. neoformans and contribute to ploidy reduction, both in vitro and during infection in

249 in a pathway responsible for a component of ploidy-related hypocotyl growth.

250 Ploidy represents the number of chromosome sets in a cel

251 hat p53 plays a role in mitotic fidelity and ploidy resolution in hepatocytes of normal and regenerat

252 Analysis of mutants that alter cell size or ploidy revealed that SAC strength is determined primaril

253 epatocytes become polyploid and then undergo ploidy reversal and become aneuploid in a dynamic proces

254 ploid hepatocytes and can result in one-step ploidy reversal to generate offspring with halved chromo

255 cell, while rendering the genome size of the ploidy-sensitive central cell unaffected.

256 Hence, in the Oh43 ploidy series, expression for most proteins in a cell in

257 This ploidy shift coincided with anisogamous mating, during w

258 At the stem level, cytotypes of higher ploidy showed consistently lower leaf-specific hydraulic

259 ndependently of beneficial mutations through ploidy-specific changes in cell physiology.

260 Two major ploidy-specific cutoffs in LST distributions were suffic

261 shared across ploidy levels, there is strong ploidy-specific differentiation in 39 regions spanning 4

262 control in tissue-, grain development-, and ploidy-specific manners.

263 eproductive modes of the same species, (iii) ploidy-specific niche differentiation within and among s

264 This study reports an unusual ploidy-specific response to replication stress presented

265 ts in meiotic cell division and reproductive ploidy stability occur in Arabidopsis plants depleted of

266 with different parental genomes or different ploidy states in a single individual, respectively.

267 tions between cellular morphology and genome ploidy states.

268 of NDJ in meiosis II is associated with the ploidy status of an egg.

269 We tested the ploidy status of available chromosomal markers after the

270 onfirming the association of CIN rather than ploidy status with multidrug resistance, tetraploid isog

271 te-committed progenitor cells, megakaryocyte ploidy status, and thrombocytosis.

272 s, irrespective of their lobular location or ploidy status.

273 of urothelial proliferation, cell cycle, and ploidy status.

274 t is cell line specific and dependent on the ploidy status.

275 rsed the augmented proplatelet formation and ploidy, suggesting that CCL5 increases MK ploidy and pro

276 ture, survivin expression, cytokinesis, cell ploidy, symmetrical cell division, and tissue architectu

277 ve and give rise to MKs smaller and of lower ploidy than adult MKs.

278 and are more sensitive to changes in genome ploidy than the consistent contacts.

279 s review is to evaluate assumptions about CM ploidy that are commonly discussed, even if not experime

280 izing gene diversity in samples of arbitrary ploidy that contain related or inbred individuals.

281 because it is distinct from the increase in ploidy that is inherited through the germline and presen

282 ivation, there was an increase in hepatocyte ploidy that was accompanied by hyperphysiological assemb

283 They tended to evolve towards normal ploidy through chromosomal DNA loss and gene expression

284 g from cell cycle organization to chromosome ploidy to replication mode and nature of the replicative

285 t to CN changes that are more common in high-ploidy tumors and thus support altered selection pressur

286 ify true copy numbers, and calculate average-ploidy value.

287 Ploidy-variable species allow direct inference of the ef

288 d, and thus there is incomplete buffering of ploidy variation despite a common cytosol.

289 The consequences of ploidy variation in syncytia are difficult to predict be

290 The degree of ploidy variation increases as cells age.

291 Ploidy variation is found in contexts as diverse as soli

292 y several specific genomic features as broad ploidy variation, high chromosome numbers, presence of n

293 Ploidy variations such as genome doubling are frequent i

294 etions (InDels), structural variants, and/or ploidy variations.

295 The term 'ploidy' was subsequently derived to describe the total c

296 rate of mitosis in hepatocytes of differing ploidies, we found no lagging chromosomes or micronuclei

297 To examine the effect of ploidy, we autotetraploidized the Arabidopsis (Arabidops

298 ts can lead to asexual lineages of increased ploidy when favorable combinations of parental genomes a

299 exhibit genome instability and reduce their ploidy when grown on a glucose-rich "pre-sporulation" me

300 ons for how cell size responds to changes in ploidy, which are particularly important in plant develo