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1 arians can regenerate their entire CNS using pluripotent adult stem cells, and this process is robust
2 ) sGRP78 promotes cellular functions in both pluripotent and breast cancer cells (3) overexpression o
4 ation (ZGA) genes (2-cell-specific genes) in pluripotent and differentiated cells, and pre-depleting
5 trategies during stepwise conversion between pluripotent and rare totipotent two-cell embryo (2C)-lik
9 between GBA and CTSB and GBA p.N370S induced pluripotent cell-derived neurons were shown to have decr
12 ning gene 9 (Sox9) is expressed initially in pluripotent cells and subsequently in ectodermal, endode
13 the major binding partner of Id proteins in pluripotent cells as the basic helix-loop-helix (bHLH) t
14 use epiblast stem cells, which correspond to pluripotent cells at a late post-implantation stage of e
16 CX43) gap junction communication in cultured pluripotent cells from human dental follicles (hDFC).
17 oincides with loss of epiblast pluripotency, pluripotent cells in development and in vitro can adopt
18 the insights into telomere end protection in pluripotent cells mean for the t-loop model of end prote
19 mbryos, where EPHA receptors are enriched in pluripotent cells whilst surrounding lineage-specified t
20 ficient to drive robust neural commitment in pluripotent cells, even under non-permissive conditions.
21 PRC2-bound elements function as silencers in pluripotent cells, they can transition into active tissu
27 undergoes lumenogenesis and forms the primed pluripotent egg cylinder, which is able to generate the
28 dispensable for telomere protection in mouse pluripotent embryonic stem (ES) and epiblast stem cells.
33 osphorylation reduces decay of m(6)A-labeled pluripotent factor transcripts and traps mouse embryonic
34 mbryo first specifies two cell lineages: the pluripotent inner cell mass that forms the fetus, and th
38 , OXPHOS), which in turn triggers reversible pluripotent quiescence specifically in the ground-state
39 c stem cells can propagate indefinitely in a pluripotent state, able to differentiate into all types
47 euronal cells (iNs) from seven human-induced pluripotent stem (iPS) cell lines from subjects of Europ
48 w that intracortically grafted human induced pluripotent stem (iPS) cell-derived cortical neurons sen
49 scribe a medulloblastoma model using Induced pluripotent stem (iPS) cell-derived human neuroepithelia
50 ed-9 (Cas9)-mediated genome editing in human pluripotent stem (PS) cells mainly employ plasmids or ri
53 thy using DMD patient-specific human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes and
54 odeling cardiac disorders with human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes is
55 cell cultures generated from multiple human pluripotent stem cell (hPSC) myogenic differentiation pr
58 We report a 96-well-based array of 3D human pluripotent stem cell (hPSC)-derived cardiac microtissue
59 pidly-expanding therapeutic potential, human pluripotent stem cell (hPSC)-derived cell therapies cont
62 s, are differentially spliced during induced pluripotent stem cell (iPSC) differentiation and in tumo
64 ene networks dysregulated in a human induced pluripotent stem cell (iPSC) disease model of a common f
65 emonstrate complete correction of an induced pluripotent stem cell (iPSC) line derived from a C9orf72
69 ar envelope invaginations in patient induced pluripotent stem cell (iPSC) neurons and postmortem tiss
70 e, we report the generation of human induced pluripotent stem cell (iPSC) reporter lines in which flu
71 seases and conditions in which human induced pluripotent stem cell (iPSC)-based regenerative medicine
72 n this study, we established a human induced pluripotent stem cell (iPSC)-derived air-liquid interfac
74 0 nM - 100 muM) for effects in human induced pluripotent stem cell (iPSC)-derived cardiomyocytes (CMs
77 Armed with patient-derived cell lines and pluripotent stem cell (iPSC)-derived kidney organoids, i
78 therefore used highly enriched human induced pluripotent stem cell (iPSC)-derived motor neurons and a
79 creased 5-HT concentrations in human induced pluripotent stem cell (iPSC)-derived neuron culture medi
80 ast lines and generated six lines of induced pluripotent stem cell (iPSC)-derived neurons covering a
82 genome sequencing (WGS) with patient-induced pluripotent stem cell (iPSC)-derived retinal organoids (
84 ere, we report the generation of two induced pluripotent stem cell (iPSC)-lines from patients with ra
90 re we evaluate if transplantation of induced pluripotent stem cell derived TM like cells (iPSC-TM) re
91 type specification, with broad relevance for pluripotent stem cell differentiation and disease modeli
92 e of 'cross-antagonistic' signalling to trap pluripotent stem cell intermediates with different linea
93 mutations engineered in subclones of a human pluripotent stem cell line can be investigated in parall
94 Under these conditions, we derive several pluripotent stem cell lines that express pluripotency-as
96 on 3 of FMR1, we generated an isogenic human pluripotent stem cell model of FXS that shows complete l
101 t that reprogramming to a stable naive human pluripotent stem cell state may effectively erase dysfun
102 riventricular endothelial cells, using human pluripotent stem cell technology, and extensively charac
103 cularly powerful in combination with induced pluripotent stem cell technology, which enables the deri
104 e of high-throughput assays in human induced pluripotent stem cell-based neurodevelopmental models to
106 ntitative phosphoproteomic survey of induced pluripotent stem cell-derived AT2s (iAT2s) infected with
107 epithelium with SARS-CoV-2 by using induced pluripotent stem cell-derived AT2s that have been adapte
109 reduced FcRn engagement across human induced pluripotent stem cell-derived brain endothelial-like cel
110 characterization conducted in human induced pluripotent stem cell-derived cardiac myocytes (hiPSC-CM
111 impacted by recent advances in human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) t
112 his process and lead to better maturation of pluripotent stem cell-derived cardiomyocyte and novel th
113 on recently due to the maturation defects in pluripotent stem cell-derived cardiomyocyte, its antagon
114 c kidney (HEK293) cells and in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)
115 these signaling modulators to human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)
117 ventricular cardiomyocytes and human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)
118 s for creating cardioprotective drugs, human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs)
119 signals on human cardiomyocytes, using human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs)
124 Accumulating evidence suggests that human pluripotent stem cell-derived cardiomyocytes can affect
125 iac pathogenesis in patient-specific induced pluripotent stem cell-derived cardiomyocytes from NS pat
133 s cultured primary human hepatocytes (PHHs), pluripotent stem cell-derived hepatocyte-like cells (HLC
134 , they received either endobronchial induced pluripotent stem cell-derived human MSCs (hMSCs) (n = 7)
135 lomerular function in the transplanted human pluripotent stem cell-derived kidney tissue 1, 2, and 3
136 systems from primary mouse and human induced pluripotent stem cell-derived lung epithelial cells to m
137 we used genetically engineered human induced pluripotent stem cell-derived microglia-like cells to sh
138 ovo in schizophrenia, and studies of induced pluripotent stem cell-derived neural progenitor cells.
139 both the prefrontal cortex (PFC) and induced pluripotent stem cell-derived neuronal cultures from pat
140 Truncated STMN2 accumulated in human induced pluripotent stem cell-derived neurons depleted of TDP-43
144 ockout (CISH(-/-)) NK cells using an induced pluripotent stem cell-derived NK cell (iPSC-NK cell) pla
145 n, we optimized a protocol to generate human pluripotent stem cell-derived Purkinje cells (hPSC-PCs)
147 cessible Chromatin using sequencing on human pluripotent stem cell-derived SAN-like pacemaker cells a
149 ioink to 3-dimensionally print human induced pluripotent stem cell-laden structures with 2 chambers a
150 tem cells (WA-01, passage 27-40) and induced pluripotent stem cells (GM23338) with a series of chemic
151 of EpCAM(+) cells derived from human induced pluripotent stem cells (hiPSC) at the physiological air-
152 nd disease-primed conventional human induced pluripotent stem cells (hiPSC) can be significantly impr
153 ) retinal organoids (ROs) from human induced pluripotent stem cells (hiPSCs) derived from an LCA4 pat
154 Towards this, patient-derived human induced pluripotent stem cells (hiPSCs) have demonstrated consid
157 be a protocol to differentiate human induced pluripotent stem cells (hiPSCs) into oogonia in vitro.
158 itor cells (NPCs) derived from human induced pluripotent stem cells (hiPSCs) of ASD individuals with
159 blastocysts were injected with human induced pluripotent stem cells (hiPSCs) or hiPSCs overexpressing
162 paradigm using genetically engineered human pluripotent stem cells (hiPSCs) that captures authentic
163 ation of SALL4 was examined in human induced pluripotent stem cells (hiPSCs) that were differentiated
164 re of brain tissue.We employed human induced pluripotent stem cells (hiPSCs) to compare patterns of A
165 IMPORTANCE This study employed human induced pluripotent stem cells (hiPSCs) to model the interaction
166 these phenotypes, 65 clones of human induced pluripotent stem cells (hiPSCs) were generated from 13 i
167 splice regulatory elements in human induced pluripotent stem cells (hiPSCs), and develop a software
168 nt gene expression profiles in human induced pluripotent stem cells (hiPSCs), indicating isoform-spec
173 ranscriptomics between differentiating human pluripotent stem cells (hPSCs) and developing mouse neur
180 stablished method to generate ECs from human pluripotent stem cells (hPSCs), and then we overexpresse
181 a CLDN5-P2A-GFP stable cell line from human pluripotent stem cells (hPSCs), directed their different
186 ells and cardiomyocytes derived from induced pluripotent stem cells (iPSCs) and used a monomeric Fc-l
187 to produce cardiomyocytes from human induced pluripotent stem cells (iPSCs) are capable of generating
188 NA sequencing in both mice and human induced pluripotent stem cells (iPSCs) derived from bipolar pati
189 chizophrenia (SCZ) when matured-from induced pluripotent stem cells (iPSCs) derived from healthy cont
190 al muscle models were developed from induced pluripotent stem cells (iPSCs) derived from healthy indi
191 ng a time course experiment of human induced pluripotent stem cells (iPSCs) differentiating into card
192 differential response, we generated induced pluripotent stem cells (iPSCs) from full responders and
193 IMPA1 deficiency in ID, we generated induced pluripotent stem cells (iPSCs) from patients and neuroty
194 rogramming of human somatic cells to induced pluripotent stem cells (iPSCs) generates valuable resour
195 derived from embryonic stem cells or induced pluripotent stem cells (iPSCs) has been considered.
198 Cardiomyocytes derived from human induced pluripotent stem cells (iPSCs) provide a unique opportun
201 velop cerebral organoid models using induced pluripotent stem cells (iPSCs) with APOE epsilon3/epsilo
202 issue-specific stem cells from human induced pluripotent stem cells (iPSCs) would have broad reaching
203 p formed by HGPS-SMCs generated from induced pluripotent stem cells (iPSCs), to study their vulnerabi
205 se 2 (LRRK2) gene identified patient induced pluripotent stem cells (iPSCs), which were used to isola
206 es AD-related lysosomal defects in inducible pluripotent stem cells (iPSCs)-derived brain cells of Ap
213 d a model of CSCs by culturing mouse induced pluripotent stem cells (miPSCs) for four weeks in the pr
214 r epidermal vulnerabilities, patient-derived pluripotent stem cells (PSCs) conditional for the FA pat
216 binding for chromatin localization in human pluripotent stem cells and in turn for defining cellular
218 dification that specifies the basic state of pluripotent stem cells and regulates the developmental t
219 e the conversion of somatic cells to induced pluripotent stem cells and rejuvenation of the germline
220 how single-cell technologies, human-induced pluripotent stem cells and systems pharmacogenomics acce
221 single DNA molecules in the genome of mouse pluripotent stem cells and using CRISPR/Cas9-mediated en
222 like cells differentiated from human induced pluripotent stem cells are further induced into M-prospe
223 e brain organoids and assembloids from human pluripotent stem cells are increasingly utilized to mode
225 emergence of brain organoids generated from pluripotent stem cells as a model to compensate for the
228 on of developmental transcription factors in pluripotent stem cells by methylating lysine 27 on histo
229 re, we tackle this question in human induced pluripotent stem cells by using multiple complementary a
230 ement based on generating neurons from human pluripotent stem cells could effectively treat in the fu
233 ic lineage cells differentiated from induced pluripotent stem cells derived from an affected individu
235 lex and coordinated pathway originating from pluripotent stem cells during embryogenesis and continui
236 hus, we identify chromosome-bound factors in pluripotent stem cells during mitosis and reveal that PR
238 ates the usefulness of using patient-induced pluripotent stem cells for targeted discovery and valida
240 ultures containing dopamine neurons, induced pluripotent stem cells from patients with YOPD showed in
242 patient-specific model, we generated induced pluripotent stem cells from three patients with missense
243 as their recapitulation in vitro from human pluripotent stem cells has the potential to generate aut
245 subtelomeres, and at higher levels in mouse pluripotent stem cells in comparison with mouse embryoni
248 man development, we examine the potential of pluripotent stem cells in the context of bioprinting tow
249 ith improved protocols differentiating human pluripotent stem cells into beta-like cells has opened u
250 otocols have been published to differentiate pluripotent stem cells into RPE cells suitable for disea
253 that provide a selective growth advantage in pluripotent stem cells is of concern for their clinical
254 Dopaminergic neurons derived from induced pluripotent stem cells of PD patients carrying LRRK2 G20
256 man somatic cells to primed or naive induced pluripotent stem cells recapitulates the stages of early
258 A sequencing (RNA-seq) data from human naive pluripotent stem cells reported multiple point "mutation
259 model nuclear shape changes of human-induced pluripotent stem cells resulting from drug treatments.
261 de in producing mature beta-cells from human pluripotent stem cells that respond appropriately to dyn
262 reated by the use of patient-derived induced pluripotent stem cells to generate both the motor neuron
263 also used cardiomyocytes derived from human pluripotent stem cells to model the contribution of TRPM
264 ortical spheroids derived from human induced pluripotent stem cells to replicate this neurodevelopmen
265 e cells differentiated in vitro from induced pluripotent stem cells to show that these cells exhibit
267 human pancreatic alpha (SC-alpha) cells from pluripotent stem cells via a transient pre-alpha cell in
268 poietic potential of patient-derived induced pluripotent stem cells was skewed toward the myeloid lin
271 onic stem cells, and patient-derived induced pluripotent stem cells) to investigate the mechanism thr
272 n pneumocyte-like cells derived from induced pluripotent stem cells, and apilimod also demonstrated a
273 cortical neurons differentiated from induced pluripotent stem cells, as well as post-mortem tissue fr
274 redible advances in cell biology, namely, in pluripotent stem cells, have also contributed to the lat
275 tem and progenitor cells, stromal cells, and pluripotent stem cells, have been investigated over the
276 recursors, including patient-derived induced pluripotent stem cells, we further demonstrated that MCM
278 tive strategy is to print with human induced pluripotent stem cells, which can proliferate to high de
279 comprise dopamine neurons derived from human pluripotent stem cells, which have several advantages ov
280 ial for the long-term proliferation of human pluripotent stem cells, while their telomere length set
281 the nucleus utilizing isogenic human-induced pluripotent stem cells-derived neurons from PD patients
295 ifferentiation protocol for generating human pluripotent stem-cell-derived beta (SC-beta) cells with
298 ing a model of chronic HIF1a accumulation in pluripotent-stem-cell-derived oligodendrocyte progenitor
300 eive the necessary regulatory cues to remain pluripotent until the appropriate time when they are sti