ライフサイエンスコーパス: pole

1 d laterally in the direction of the temporal pole.

2 istent hexagonal flow pattern near its north pole.

3 rogen peroxide at the egg's future posterior pole.

4 sured on all glomeruli containing a vascular pole.

5 t separate and did not move toward a spindle pole.

6 activate Tfp machines at the bacterial cell pole.

7 thus cells, T4P localize at the leading cell pole.

8 t inferior temporal gyrus, and right frontal pole.

9 eading pole and then form at the new leading pole.

10 lateral cortex but retained at the posterior pole.

11 grity vulnerability exploitable by targeting POLE.

12 hibition of T4P formation at the new lagging pole.

13 s family GTPase MglA localizes to the second pole.

14 otein aggregates are located at the cellular pole.

15 leading to random furrows through the animal pole.

16 paired and oriented toward the same spindle pole.

17 or away from the geomagnetic north or south pole.

18 f DNA replication is sequestered to the cell pole.

19 s across the cell to the opposite (or 'new') pole.

20 reater at the cenexin-positive older spindle pole.

21 PG growth and stabilizes at one future cell pole.

22 organizing centers (MTOCs) located at either pole.

23 to divide, with centrioles clustered at each pole.

24 uld be symmetric between the north and south poles.

25 inding partner polo-like kinase 1 at spindle poles.

26 and preventing FtsZ-ring misassembly at the poles.

27 break but do not detach from kinetochores or poles.

28 o bind to microtubules from opposite spindle poles.

29 o sequesters cI(VP882), localizing it to the poles.

30 eting of Dot/Icm components to the bacterial poles.

31 in animal cells naturally become two spindle poles.

32 , including strongly at AP-axis ends and the poles.

33 species having between three and eight xylem poles.

34 at is, on the region between chromosomes and poles.

35 s cortical concentration gradients from cell poles.

36 and the Rod PG synthesis complexes away from poles.

37 ein mediates ER concentration around spindle poles.

38 tude further at the equator than towards the poles.

39 and centriole mis-positioning at the spindle poles.

40 1 kinase forms gradients with maxima at cell poles.

41 s by clustering centrosomes into two spindle poles.

42 sponse time after an external electric field poling.

43 m Saturn, which has only one cyclone at each pole?

44 pendent dielectric relaxation is seen in the poled [001] crystal around 100 K.

45 cross-linking kinesin-5 motor Eg5 at spindle poles [3].

46 1%), computer station (37%), and intravenous pole (32%).

47 (mRNAs) are first transported to the vegetal pole a few minutes after fertilization and then to the f

48 independently evaluated images for posterior pole abnormality (normal, preplus, plus), with discrepan

49 chemical process of an analyte occurs at one pole, accompanied by a complementary process at the seco

50 on lead to segregation of chromosomes to the poles after anaphase onset.

51 r of Von Karman crater (VK) inside the South Pole-Aitken (SPA).

52 nct subgroups dependent on the nature of the POLE allele, its expression level, and MMR status.

53 ER redistribution to spindle poles also did not require non-claret disjunctional (ncd

54 rhages (RH) typically found in the posterior pole and around the peripheral retina in AHT.

55 ndation for T4P formation at the new leading pole and inhibition of T4P formation at the new lagging

56 at SpmX localizes along one side of the cell pole and its extent closely matches that of the PopZ reg

57 t nucleus accumbens as well as right frontal pole and left caudate.

58 POLE and mismatch repair protein-encoding genes were mut

59 scherichia coli that oscillates from pole to pole and regulates the spatial position of the cell divi

60 ent, T4P are disassembled at the old leading pole and then form at the new leading pole.

61 achine with centrosomes at two opposing cell poles and chromosomes at the equator.

62 emonstrate that BB0270 localizes at the cell poles and controls the number and position of PF via reg

63 an effector gradient that is highest at the poles and diminishes toward the chromatin, which is oppo

64 s of the contact binary have closely aligned poles and equators, constraining their accretion mechani

65 asmic flagella (PF) that arise from the cell poles and extend toward the midcell as a flat-ribbon, wh

66 glycan (PG) cell wall that caps the daughter poles and prevents osmotic lysis of the newborn cells.

67 enitor cells that contribute to both cardiac poles and provide new insights into the pathogenesis of

68 Atrophy of the bilateral temporal poles and the fusiform gyrus were associated with prosop

69 r a precise cortical region (lateral frontal pole) and a structural pathway (the ventral amygdalofuga

70 ich dynamically relocalises between the cell poles) and a GTPase, MglA(Mx), previously postulated as

71 om their normal positions at the basolateral pole, and auditory-nerve terminals extend towards the ha

72 ollowed by early involvement of the temporal pole, and eventually encompassing additional temporal an

73 Furthermore, low levels of POLA1, POLE, and POLE2 protein expression in NSCLC and colorect

74 s of the B-family of DNA polymerases (POLA1, POLE, and POLE2) whose silencing sensitized the human A5

75 o aggregation and no longer localizes to the pole, and redirecting HspX to the septum radically disru

76 icrotubules (KMTs) connect directly with the poles, and countering forces are supplied either by inte

77 ider the timing of origin of angiosperms are poles apart in their estimates.

78 nthesis and identify DNA polymerase epsilon (POLE) as an ISC-containing protein that underlies this p

79 n form T4P at both poles but engage only one pole at a time in T4P formation.

80 prevents spindle bending that can lock both poles at the cortex.

81 he angular dispersion of virtual geomagnetic poles at the equator and the median axial dipole dominan

82 Their distinct localizations at spindle poles (AtAurora1), spindle microtubules (AtEDE1), phragm

83 NEIL3, ERCC6, BRCA2, BRCA1, XPC, JAG1, RPA1, POLE, ATM, and LIG1 in African American men, and POLQ, N

84 29 male, 63+/-9 years) were recorded with 64-pole basket catheters and simultaneous 57-lead body surf

85 e can bind soil iron under alkaline pH; (ii) pole bean, common bean, and tomato plants can uptake mim

86 Second, to study mimosine uptake in plants, pole bean, common bean, and tomato plants were supplied

87 escribe how scaffolding the MEN onto spindle pole bodies (SPB-centrosome equivalent) allows the MEN t

88 Centrosomes and spindle pole bodies (SPBs) are membraneless organelles whose dup

89 Here we show that yeast spindle pole bodies (SPBs, yeast centrosomes) differentially con

90 s insertion of centrosomes (known as spindle pole bodies [SPBs]) into fenestrated regions of the nucl

91 ause of dynamic microtubule bundles, spindle-pole bodies, the nuclear envelope, and passive cross-lin

92 ugh the nuclear envelope (NE) at the spindle pole body (SPB) and other sites.

93 The Saccharomyces cerevisiae spindle pole body (SPB) serves as the sole microtubule-organizin

94 the yeast centrosome equivalent, the spindle pole body (SPB), and disruption of this motif prevents b

95 the invariant inheritance of the old spindle pole body (SPB, the yeast centrosome) by the bud.

96 e that microtubule nucleators at the spindle pole body help coordinate cytokinetic furrow formation i

97 nuclei appeared predominantly after spindle pole body separation, suggesting that nuclear envelope e

98 xcept for an intruder that visited the south pole briefly, have occurred at either pole since Juno ar

99 ow necrotic borders, involving the posterior pole but not the fovea.

100 Thus, cells can form T4P at both poles but engage only one pole at a time in T4P formatio

101 ther, pulled kinetochore-fibers pivot around poles but not chromosomes, retaining their orientation w

102 Furrows form within 30 degrees of the animal pole, but typically, not through the ICSI injection site

103 stimulation of T4P formation at the leading pole by MglA-GTP and SgmX and indirect inhibition of T4P

104 t inhibition of T4P formation at the lagging pole by MglB due to its MglA GAP activity.

105 ole, indirectly blocks T4P formation at this pole by stimulating the conversion of MglA-GTP to MglA-G

106 ospital, using auto-regressive modelling and pole cancellation.

107 ite mutant that we previously characterized, POLE cancer mutants readily drive signature mutagenesis

108 r mRNAs required for germline development to pole cells, the germ cell progenitors.

109 uring oogenesis, we show that it is toxic to pole cells.

110 embryogenesis to minimize its inheritance by pole cells.

111 e, and they divided them into four sensorial poles (characterized by 36 different descriptors) attrib

112 ales, and improved motor coordination during pole climbing in male mice.

113 s act as a physical barrier blocking spindle pole coalescence and bipolarity.

114 by improving both centrosome clustering and pole coalescence.

115 leakage index (P < 0.0001) in the posterior pole compared with eyes without DME.

116 Although this structure is not pole-connected, its organization suggests that it can su

117 Fusiform gyrus and temporal pole cortical thickness was also lower in children with

118 dies seeking explanations for the equator-to-poles decline in richness of most groups of organisms, n

119 glandular architecture with an inward apical pole delineating a luminal cavity.

120 Metaphase spindles exert pole-directed forces on still-connected sister kinetocho

121 Furthermore, Pole-driven cancers exhibited a continuous and stochasti

122 provide insights into the carcinogenesis of POLE-driven tumors and valuable information for genetic

123 yosin-V wins over kinesin-1 at the posterior pole due to low microtubule density at this site, while

124 og pair moved together with the same spindle pole during anaphase B spindle elongation.

125 t restrict peptidoglycan biosynthesis to the pole during elongation and re-direct peptidoglycan biosy

126 misaligned chromosomes at the oldest spindle pole during metaphase.

127 calization as a hexameric ring at the growth pole during polar growth.

128 red paths of the Earth's virtual geomagnetic poles during reversals(8) that might not reflect the geo

129 In addition, maximizing contact between pole dynein and cortical dynein stabilizes flattened pol

130 romosome shortening (anaphase A) and pole-to-pole elongation (anaphase B).

131 olar growth is terminated and ectopic growth poles emerge from mid-cell.

132 of extrinsic correction systems that remove Pole errors.

133 ll known geysers concentrated over the south pole, even though the expected pattern of tidal forced d

134 1R is at least ten times more mutagenic than Pole-exo- at each location analyzed.

135 e show that both exonuclease-deficient Pole (Pole-exo-) and Pole-P301R generate mutations in a strict

136 mutator effects far exceeding the effect of Pole exonuclease deficiency.

137 epair (MMR) proteins, and DNA sequencing for POLE exonuclease domain were done to classify tumors as

138 a non-polar solvent, placed between two like-poles-facing NdFeB magnets, allowed separation of seven

139 Pole figures constructed from a combination of GIWAXS an

140 The background intensity in the pole figures is also comparable to the background from t

141 diffraction patterns and their reconstructed pole-figures determined here.

142 rotubule cross-linking to help focus spindle poles for efficient bipolar spindle assembly.

143 of prefrontal cortex - with lateral frontal pole (FPl) supporting the context-dependent mapping from

144 fined frontal regions to the lateral frontal pole (FPl), an anatomically defined portion of the aPFC

145 chromatin thus ended up at opposite spindle poles, giving the appearance of successful anaphase.

146 d grows by polar growth from a single growth pole (GP), while the old cell compartment and its old po

147 in the gene encoding DNA polymerase epsilon (POLE) have incredibly high mutation burdens.

148 ars ago (Ma), a time when greater equator-to-pole heat transport led to a warmer Northern Hemisphere(

149 were assigned using DNA polymerase epsilon (POLE) hotspot mutations and immunohistochemistry-based p

150 a rise in sulfate ca. 1458 C.E. in the South Pole ice core (SPICEcore) indicate that the tephra depos

151 ce was eligible for inclusion (eg, posterior pole imaging vs ultrawidefield imaging).

152 s tend to misalign toward the oldest spindle pole in a cenexin- and PLK1-dependent manner.

153 RCC6, ATR, RBBP8, BRCA1, ATM, JAG1, XPC, and POLE in Caucasians.

154 sigma(X) and DprA stably co-localize at one pole in competent cells, with sigma(X) physically convey

155 ased activity on the strand-specific role of Pole in DNA replication and the action of extrinsic corr

156 ein and cortical dynein stabilizes flattened poles in a perpendicular orientation, and spindle rigidi

157 f three-dimensional microdomains at the cell poles in Caulobacter crescentus, where it functions as a

158 astral MTs and concentration around spindle poles in early M-phase.

159 ised to be precisely localized at new growth poles in sibling cells.

160 Qtip can localize to the poles independently of cI(VP882).

161 , which localizes mainly to the lagging cell pole, indirectly blocks T4P formation at this pole by st

162 fundamental understanding of the electrical-poling-induced ion migration, accounting for many unusua

163 Such electrical-poling-induced polarization potential is responsible for

164 ied by a complementary process at the second pole, inducing an optical (fluorimetric) analytical sign

165 Importantly, restoring mitotic spindle pole integrity following centromere inactivation lead to

166 centromere function impacts mitotic spindle pole integrity.

167 ereby the final coalescence of supernumerary poles into a bipolar array is inhibited.

168 Subsequently, the electrical poling invokes the ion migration within perovskite cryst

169 of Cdc15-scaffolded septum formation at cell poles is a key Pom1 mechanism that ensures medial divisi

170 In addition to posterior pole leakage index and microaneurysm count, DME was asso

171 hows spatiotemporal oscillation between cell poles, leaving a mid-cell zone for division.

172 that is required for anterior- and posterior-pole localization to axis extremes.

173 be inhibited by an evolutionarily conserved pole-localized protein that we have named SpbR.

174 We find that pole-localized SpbR is normally cleared by ClpXP-mediate

175 of whisker bending were informative cues to pole location.

176 Checkpoint blockade did not prevent Pole lymphomas, but rather likely promoted lymphomagenes

177 ersity for most planktonic groups toward the poles, mainly driven by decreasing ocean temperatures.

178 By leveraging the Tara Oceans pole-to-pole metagenomic data set, we investigated the distribut

179 tly with macular leakage index and posterior pole microaneurysm count (P = 0.0002 and P = 0.03, respe

180 OCTA 12- x 12-mm scans to create a posterior pole montage, and 5 eyes also underwent SS-OCTA imaging

181 SS OCTA 12 x 12-mm scans to create posterior pole montages.

182 ntus, c-di-GMP works as a major regulator of pole morphogenesis and cell development.

183 tion of the Z-ring is to govern nascent cell pole morphogenesis by directing the spatiotemporal distr

184 d in prediction, diagnosis, and treatment of Pole-mutant tumors.See related article by Galati et al.,

185 These results suggest that different POLE mutants have previously unappreciated differences i

186 amples derived from formalin-fixed tumors, a POLE mutated cell line and standard DNA by WES and five

187 No patient with POLE-mutated tumor was enrolled in the MMRD cohort, and

188 he MMRD cohort, and all MMRP tumors were not POLE-mutated.

189 red mouse models harboring cancer-associated Pole mutations and examine the effects of these mutation

190 POLE mutations are a major cause of hypermutant cancers,

191 n correlates enabled novel stratification of POLE mutations into three groups based on clinical pheno

192 ish mouse models harboring cancer-associated POLE mutations P286R and S459F, which cause rapid albeit

193 fects of cancer-associated DNA polymerase e (Pole) mutations on tumorigenesis and response to immune

194 re were no differences in AHN at the rostral pole, nor were there differences in expression of geneti

195 ompare to experimental observations of xylem pole number across a range of species, as well as in tra

196 1-3], cortical rotation to generate a dorsal pole of beta-catenin activity [4-8], and the release of

197 ing division, peptidoglycan assembles at the pole of dividing Chlamydia trachomatis cells where daugh

198 ateral wings and those at the rostral-dorsal pole of DR nucleus.

199 concentration provide a non-zero singularity pole of inverse Laplace transform.

200 During these movements, a pole of Nodal signaling emerges that is required for exp

201 ealed immunopuncta clustered at the synaptic pole of outer hair cells.

202 protein popZ (PopZ) microdomain at the cell pole of the asymmetrically dividing bacterium Caulobacte

203 upon anatomy, we hypothesise that the caudal pole of the avian Hippocampal Formation (HF) presents a

204 heromone-promoted polarity cue in the distal pole of the cells.

205 e Drosophila oocyte determines the posterior pole of the future embryo.

206 normally reside within the SHF and arterial pole of the heart.

207 ) and beaded axons (p = 0.021) at the caudal pole of the HF than controls.

208 by chronic stress, primarily at the ventral pole of the hippocampus.

209 intercollicular tegmentum (ICt), the rostral pole of the inferior colliculus (ICrp), and the nucleus

210 om the secondary source towards the arterial pole of the linear heart tube, resulting in a constricte

211 ssel bifurcations, followed by the posterior pole of the retina.

212 a cell bridge between the NG and the cranial pole of the SCG.

213 stering occurs when chromosomes approach the poles of anaphase spindles, and is mediated by a microtu

214 elongation disrupts the shaping of opposing poles of BMP and Wnt/TCF activity and the anterior-poste

215 methodology which allows correlating sensory poles of chocolate to their chemical characteristics and

216 ng and patterning submicron particles at two poles of each pillar in an array embedded in a microflui

217 ic vortices in polygonal patterns around the poles of Jupiter.

218 ions of concatenated nuclei and at the outer poles of nuclear chains in human skeletal myotubes.

219 hemical information to predict the sensorial poles of samples.

220 inward growth of the septum to form the new poles of the daughter cells(4).

221 field (SHF) cardiac progenitor cells to the poles of the heart tube results in congenital heart defe

222 toskeleton of most animal cells and form the poles of the mitotic spindle.

223 ze the microtubule cytoskeleton and form the poles of the mitotic spindle.

224 mutant forms two pore-like apertures at the poles of the pollen grain.

225 ent-exposed pocket between the extracellular poles of TM-I, TM-II, and TM-VII.

226 dex and microaneurysm count in the posterior pole on UWFA images were associated with the presence an

227 , while the old cell compartment and its old pole (OP) do not elongate.

228 From its pole-to-pole orbit, the Juno spacecraft discovered arrays of cyc

229 xchange in and out of the 200 nm cytoplasmic pole-organizing protein popZ (PopZ) microdomain at the c

230 ral lingual (p = 0.04), ipsilateral temporal pole (p = 0.007), ipsilateral pars opercularis (p = 0.03

231 arietal (p = 0.04) and contralateral frontal pole (p = 0.04).

232 reases in the mutation rate, indicating that Pole-P301R errors are corrected by Poldelta proofreading

233 h exonuclease-deficient Pole (Pole-exo-) and Pole-P301R generate mutations in a strictly strand-speci

234 Yeast Pole-P301R has increased DNA polymerase activity, which

235 ns in a strictly strand-specific manner, yet Pole-P301R is at least ten times more mutagenic than Pol

236 ease to prevent catastrophic accumulation of Pole-P301R-generated errors on the leading strand.

237 nce by supplying healthy mitochondria to the pole plasm.

238 con, we show that both exonuclease-deficient Pole (Pole-exo-) and Pole-P301R generate mutations in a

239 ackage geometrically determines the anterior pole position, the equatorial diameter, and three-dimens

240 UWF-FA in defined retinal regions [posterior pole (PP), mid-periphery (MP), far-periphery (FP)].

241 between left angular gyrus and left frontal pole predicted better response to CBT in the OCD group.

242 NCA, FANCD2, MLH1, MSH2, MSH6, PALB2, POLD1, POLE, PRKDC, and RAD50) and caretaker genes (BAP1, CDK12

243 Herein, the electrical-poling-promoted polarization potential is reported for r

244 ng the approach by recovering animal-vegetal-pole proteomic asymmetry in the frog zygote, the technol

245 is tethering of parental mitochondria to the poles results in uniparental inheritance of mitochondria

246 retofore unknown protein that we name GROWTH POLE RING (GPR) due to its striking localization as a he

247 oma tumor that was detected on OCT posterior pole screening.

248 ues of genes patterning the anthozoan aboral pole, secondary axis and endomesoderm support simplifica

249 rotubule-dependent motors that drive spindle pole separation during mitosis.

250 glass substrate - connected to the negative pole side of the DMFC - with a conductive poly (3,4-ethy

251 ranches and longer paths form on the urinary pole side.

252 ferent and efferent branches on the vascular pole side; connections here would allow blood to exit wi

253 south pole briefly, have occurred at either pole since Juno arrived at Jupiter in 2016.

254 acking isotherm shifts, and move towards the pole six times faster than terrestrial species.

255 ize and is present primarily on the vascular pole size.

256 Posterior pole structural OCT had the best detection rate for NV,

257 rnal pangolin transcript at the anterior egg pole, suggesting that pangolin functioned as ancestral a

258 formed mammary cells maintain viability upon POLE suppression but become dependent upon an ATR/CHK1/C

259 In BLBC cells, POLE suppression leads to replication fork stalling, DNA

260 actic cocci with two flagella bundles on one pole swim faster than 500 um.s(-1) along a double helica

261 Earth's equator-to-pole temperature gradient drives westerly mid-latitude j

262 global average(4), decreasing the Equator-to-pole temperature gradient to values comparable with thos

263 weight loss and worsened performance on the pole test.

264 more effective for genes located at the cell poles than for genes located on the chromosome.

265 r membrane protein secreted at the bacterial pole that is required for S. flexneri actin-based motili

266 discernable, PopZ fills a region at the cell poles that is devoid of electron-dense ribosomes.

267 ndles, particularly those without structured poles, the origin of extensive forces is less obvious.

268 s prevents the relocation of PopZ to the new pole, thereby eliminating a positional cue for centromer

269 icantly thinning the ice shell at one of the poles, thereby allowing fracture formation there.

270 lly, the degree of left frontal and temporal pole thinning, and clinical score at the time of the MRI

271 sively branched and accumulate growth active poles through tip splitting events.

272 dionally, allowing moist air near the summer pole to be rapidly transported to lower latitudes during

273 the membrane too transiently to diffuse from pole to mid-cell.

274 ase in Escherichia coli that oscillates from pole to pole and regulates the spatial position of the c

275 ned Spn cells vertically oriented onto their poles to image the division plane at the high lateral re

276 icrotubules and molecular motors connect the poles to kinetochores, specialized protein assemblies on

277 s, which targets the enzyme to the bacterial poles to recognize YcbB-edited peptidoglycan.

278 otes chromosome congression from the spindle poles to the metaphase plate.

279 We find spermatocytes exhibit simultaneous pole-to-chromosome shortening (anaphase A) and pole-to-p

280 le-to-chromosome shortening (anaphase A) and pole-to-pole elongation (anaphase B).

281 By leveraging the Tara Oceans pole-to-pole metagenomic data set, we investigated the d

282 From its pole-to-pole orbit, the Juno spacecraft discovered array

283 rk presents new insights into the electrical-poling-triggered ion migration and, in turn, polarizatio

284 Cas9 to engineer human cell lines expressing POLE tumor variants, with and without mismatch repair (M

285 Eleven new invisible posterior pole tumors in 7 eyes of 5 children were treated by this

286 abundance of mutation signatures partitions POLE tumors into distinct subgroups dependent on the nat

287 to classify tumors as p53 abnormal (p53abn), POLE-ultramutated (POLEmut), MMR-deficient (MMRd), or no

288 LK1 asymmetrically localizes between spindle poles under conditions of chromosome misalignment, and c

289 erior cingulate cortex and anterior temporal pole was associated with baseline global cognition in co

290 the underlying vasculature of the posterior pole was visible on en face projections.

291 ng ECL of luminol and H(2)O(2) at the anodic poles was monitored using a photomultiplier tube (PMT) o

292 -ends are anchored by centrosomes at spindle poles, we hypothesized that the MT minus-end motor dynei

293 bR exhibits aberrant accumulation at the old pole, where it physically interacts with PopZ.

294 er anterosuperior areas toward the occipital pole, whereas alpha in somatosensory cortex propagates f

295 tity is determined by anterior and posterior poles, which are putative organizers.

296 ates the assembly of the two mitotic spindle poles, which are required for the formation of the micro

297 o dynamic microtubules from opposite spindle poles, which exerts forces to bring kinetochores under t

298 d(33) |) of 18 pmV(-1) at 9 wt% BNNT without poling, which is competitive with commercial piezoelectr

299 successive TMS pulses around their occipital pole while the stimuli were presented.

300 ng is due to nuclear repulsion from the cell poles, while the third, most robust, model poses that th

301 f p~25.8 muC m(-2) K(-1) were achieved after poling, with high pyroelectric figure of merits for sens