ライフサイエンスコーパス: poly ADP-ribosylation

1 trations required to maximally activate auto-poly(ADP-ribosylation).

2 CTCF participate in DNA damage response via poly(ADP-ribosylation).

3 ng to the lesions where it catalyses protein poly(ADP-ribosylation).

4 e stress in IDH-mutant cells is dependent on poly-(ADP-ribosylation).

5 tes the crosstalk between ubiquitination and poly-ADP-ribosylation.

6 e role in the cell or is just a byproduct of poly-ADP-ribosylation.

7 This modification can occur as mono- or poly-ADP-ribosylation.

8 ver, histone phosphorylation is modulated by poly(ADP-)ribosylation.

9 The dsDNAs activated trans-poly(ADP-ribosylation) about 5 times more effectively th

10 P-ribose may not be unique to PARPs and that poly(ADP-ribosylation), an established nuclear activity,

11 erent domains that interpret either mono- or poly-ADP-ribosylation and the implications for cellular

12 Mg2+ inhibited trans-poly(ADP-ribosylation) and so did dcDNA at concentration

13 NAD(+) is a substrate for PARP-enzymes (mono/poly-ADP-ribosylation) and sirtuins (deacetylation).

14 increase in GAPDH activity, decreased GAPDH poly-ADP-ribosylation, and nuclear translocation of GAPD

15 These data implicate intra-mitochondrial poly(ADP-ribosylation) as an important therapeutic targe

16 at SSB sites, possibly reflecting PARP1 auto-poly-ADP-ribosylation at non-serine residues.

17 tion, HPF1-deficient cells maintained robust poly-ADP-ribosylation at SSB sites, possibly reflecting

18 ar concentrations of ATP inhibit PARP-1 auto(poly-ADP-ribosylation) but less so the transfer of oligo

19 Activation of auto-poly(ADP-ribosylation) by dcDNA was 10 times greater tha

20 An allosteric activation of auto(poly-ADP-ribosylation) by physiologic cellular component

21 Axin turnover is controlled by its poly-ADP-ribosylation catalyzed by tankyrase (TNKS), whi

22 Poly-ADP-ribosylation, catalyzed by PARP1, is a post-tra

23 Collectively these data suggest that poly(ADP-ribosylation) compartmentalized to the mitochon

24 se DTX2 is rapidly mobilized to lesions in a poly ADP-ribosylation-dependent manner.

25 regulated kinase (ERK) signaling, Parp1 auto-poly ADP-ribosylation enhances Sox2-Parp1 interactions,

26 While poly-ADP-ribosylation has been established as a protein

27 nction of the DLK regeneration pathway, that poly-(ADP ribosylation) inhibits axon regeneration acros

28 Poly-ADP-ribosylation is a post-translational modificati

29 Poly-ADP-ribosylation is a unique post-translational mod

30 While the overall impact of PARP1-dependent poly-ADP-ribosylation is heavily investigated, very litt

31 While histone poly-ADP-ribosylation is required to trigger this switch

32 n) was at least 100-fold lower than in trans-poly(ADP-ribosylation) (K(a) = 1400 versus 3-15, respect

33 We found reduced poly(ADP)ribosylation levels in nic2-1 seed, which were

34 dues of target proteins, leading to mono- or poly-ADP-ribosylation (MARylation or PARylation).

35 catalyze post-translational modification by poly-ADP-ribosylation of a plethora of target proteins.

36 PDH activity/intracellular localization, and poly-ADP-ribosylation of GAPDH.

37 ed for the regulation of mtDNA integrity via poly-ADP-ribosylation of mtLIG3, the rate-limiting enzym

38 function, stimulating NAD(+)-dependent auto-poly-ADP-ribosylation of poly(ADP-ribose) polymerase 1 (

39 PARP1 mediates poly-ADP-ribosylation of proteins on chromatin in respon

40 merase (PARP) activity and posttranslational poly-ADP-ribosylation of several regulatory proteins inv

41 In contrast, poly-ADP-ribosylation of Spt16 by PARP1 significantly in

42 is reduced shortly after viral infection via poly-ADP-ribosylation of the RNA-induced silencing compl

43 We also found that tankyrase1-mediated poly-ADP-ribosylation of TRF1 is important for both the

44 Functionally, poly(ADP-ribosylation) of CycT1 promotes DNA repair and

45 Mg2+ activated auto-poly(ADP-ribosylation) of PARP I.

46 ed SSB level, gamma-H2AX foci formation, and poly(ADP-ribosylation) of PARP-1, which were associated

47 (mono-ADP-ribosylation) or polymeric chains (poly-ADP-ribosylation) of ADP-ribose are conjugated to p

48 ansfer to histone H(1) is 1% of that of auto(poly-ADP-ribosylation) of PARP-1, and this trans(ADP-rib

49 und that MDM2-deficient cells have increased poly-ADP-ribosylation on chromatin which supports the po

50 ose from NAD to histone H1 (defined as trans-poly(ADP-ribosylation)) or to PARP I (defined as auto-po

51 ns of oxidative stress and energy depletion, poly(ADP-ribosylation) paradoxically contributes to mito

52 Here we report that both BRCA1 poly-ADP ribosylation (PARsylation) and the presence of

53 Enzymes involved in poly(ADP-ribosylation) participate in several critical p

54 ys a crucial role to regulate PARP1-mediated poly ADP-ribosylation (PARylation) and the choice of DSB

55 polymerases (PARPs) catalyze massive protein poly ADP-ribosylation (PARylation) within seconds after

56 Poly(ADP) ribosylation (PARylation) is important for sub

57 Poly(ADP)-ribosylation (PARylation) regulates chromatin

58 RTD1/PARP1) and erasers (e.g. PARG, ARH3) of poly-ADP-ribosylation (PARylation) are relatively well d

59 Here, we found unlike PARP1-mediated Poly-ADP-Ribosylation (PARylation) at genomic damage sit

60 ed on the basis of their ability to catalyze poly-ADP-ribosylation (PARylation) or mono-ADP-ribosylat

61 PARP1-dependent poly-ADP-ribosylation (PARylation) participates in the r

62 id not alter in vitro PARP1 enzyme activity, poly-ADP-ribosylation (PARylation), nor did inhibition o

63 ional modification in particular for protein poly-ADP-ribosylation (PARylation).

64 dentify a DPC repair pathway orchestrated by poly-ADP-ribosylation (PARylation).

65 y(ADP-ribose) polymerase 1 (Parp1) catalyzes poly(ADP-ribosylation) (PARylation) and induces replicat

66 ntial role in the PARP1- and PARP2-dependent poly-(ADP-ribosylation) (PARylation) of histones, by for

67 abase chromatin domains surrounding DSBs via poly-ADP-ribosylation, phosphorylation, acetylation, and

68 Furthermore, inhibition of poly(ADP-ribosylation) prevented intranuclear localizati

69 Poly(ADP-ribosylation), primarily via poly(ADP-ribose) p

70 ribosylation)] or to PARP-1 [defined as auto(poly-ADP-ribosylation)] requires binding of coenzymic DN

71 Our data reveal the mechanism of poly-ADP-ribosylation reversal, with ADP-ribose as the d

72 for PARP I and catalyze preferentially trans-poly(ADP- ribosylation), thereby opening the possibility

73 However, the direct involvement of poly ADP-ribosylation was also apparent as 3-AB was able

74 Treatment with inhibitors of poly-ADP-ribosylation was also strongly protective, with

75 of PARP I toward dcDNA or dsDNA in the auto-poly(ADP-ribosylation) was at least 100-fold lower than

76 ribosylation)) or to PARP I (defined as auto-poly(ADP-ribosylation)) was studied with respect to the

77 To this end, the presence of PARP-1 and poly(ADP-ribosylation) were verified within mitochondria

78 cts of H2O2 can be overcome by inhibitors of poly(ADP)-ribosylation, which also preserve cellular ATP

79 Rates of auto(poly-ADP-ribosylation) with dsDNAs as coenzymes were nea

80 Inhibition of poly(ADP-ribosylation) within the mitochondrial compartm

81 Although it has been presumed that poly(ADP-ribosylation) within the nucleus mediates this