ライフサイエンスコーパス: polyadenylation

1 th hFip1 binding sites in CPSF30 can support polyadenylation.

2 ng decisions and Chtop regulates alternative polyadenylation.

3 ncluding intron splicing and 3' cleavage and polyadenylation.

4 modifications such as capping, splicing, and polyadenylation.

5 isoforms in vivo is generated by alternative polyadenylation.

6 lar mechanisms required for polo alternative polyadenylation.

7 itive and negative regulators of alternative polyadenylation.

8 g RNAs (lncRNAs), undergo trans-splicing and polyadenylation.

9 through alternative splicing and alternative polyadenylation.

10 in mediating PAS-dependent RNA cleavage and polyadenylation.

11 RNA binding proteins, or during alternative polyadenylation.

12 ed from the unc-44 locus through alternative polyadenylation.

13 onses relative to its interactions with mRNA polyadenylation.

14 oding RNAs, which undergo trans-splicing and polyadenylation.

15 uencing alternative splicing and alternative polyadenylation.

16 ession, potentially regulated by alternative polyadenylation.

17 ivity that can repress proximal cleavage and polyadenylation.

18 identify prominent alternative splicing and polyadenylation abnormalities in infant CDM muscle, and,

19 he proteins share metal ion-dependent RNA 3' polyadenylation activities that are greatly stimulated b

20 iral capsid gene via its role in alternative polyadenylation and alternative splicing of the single M

21 nucleus and rescue ELAV-mediated alternative polyadenylation and alternative splicing.

22 ously unappreciated link between alternative polyadenylation and chromatin signaling.

23 NP1 suppresses polyadenylation and cleavage at its internal site, terme

24 ects of RNA processing including alternative polyadenylation and intron retention.

25 ions involving RNase R treatment followed by Polyadenylation and poly(A)+ RNA Depletion (RPAD), which

26 access via its role in alternative internal polyadenylation and splicing.

27 mely low mRNA abundance(14-16), lack of mRNA polyadenylation and thick cell walls(17).

28 generate these isoforms (such as alternative polyadenylation) and RNA surveillance.

29 ses, including transcription, deadenylation, polyadenylation, and degradation.

30 between alternative splicing and alternative polyadenylation, and it is their concerted actions that

31 nal processes such as splicing, cleavage and polyadenylation, and the editing, localization, stabilit

32 e control of chromatin dynamics, cytoplasmic polyadenylation, and translation.

33 lmost 70% of human genes undergo alternative polyadenylation (APA) and generate mRNA transcripts with

34 ethylation and mRNA alternative cleavage and polyadenylation (APA) are both prevalent in cancer and h

35 The recent emergence of alternative polyadenylation (APA) as an engine driving transcriptomi

36 CFIm regulates global alternative polyadenylation (APA) by specifically binding and activa

37 Alternative cleavage and polyadenylation (APA) can occur at more than half of all

38 Alternative polyadenylation (APA) contributes to transcriptome compl

39 Alternative splicing (AS) and alternative polyadenylation (APA) generate diverse transcripts in ma

40 Alternative cleavage and polyadenylation (APA) generates mRNA isoforms with diffe

41 Alternative cleavage and polyadenylation (APA) generates mRNAs with different 3'

42 Alternative polyadenylation (APA) has emerged as a prevalent feature

43 , p63beta, and p63delta, whereas alternative polyadenylation (APA) in coding sequence creates two mor

44 The physiological role of alternative polyadenylation (APA) in controlling hematopoietic stem

45 e impact of genetic variation on alternative polyadenylation (APA) in the nuclear and total mRNA frac

46 de alternative splicing (AS) and alternative polyadenylation (APA) in the rhizome system.

47 Alternative polyadenylation (APA) is a gene regulatory process that

48 Alternative polyadenylation (APA) is a major driver of transcriptome

49 Alternative polyadenylation (APA) is a widespread gene regulatory me

50 Alternative polyadenylation (APA) is a widespread mechanism that gen

51 Alternative polyadenylation (APA) is a widespread post-transcription

52 Alternative polyadenylation (APA) is an RNA-processing mechanism on

53 Alternative polyadenylation (APA) is increasingly recognized to regu

54 (PASs), leading to expression of alternative polyadenylation (APA) isoforms with distinct functions.

55 Most eukaryotic genes produce alternative polyadenylation (APA) isoforms.

56 A regulation and neural-specific alternative polyadenylation (APA) of a single locus controls complex

57 Here, we show that the alternative polyadenylation (APA) of mRNA is important for root deve

58 Alternative polyadenylation (APA) plays a key post-transcriptional r

59 Alternative polyadenylation (APA) produces isoforms with distinct 3'

60 Alternative polyadenylation (APA) produces mRNA isoforms with differ

61 multiple polyadenylation sites, alternative polyadenylation (APA) produces three major PolH transcri

62 Alternative polyadenylation (APA) produces transcript 3' untranslate

63 (PAT) sequencing approach, mRNA alternative polyadenylation (APA) profiles after auxin treatment wer

64 action landscape and changed the alternative polyadenylation (APA) profiles and/or transcript levels

65 Alternative polyadenylation (APA) regulates diverse developmental an

66 hypothesis that cannabis targets alternative polyadenylation (APA) sites within hypothalamic transcri

67 l, a comprehensive comparison of alternative polyadenylation (APA) was performed to understand the ro

68 transcription initiation (ATI), alternative polyadenylation (APA), alternative splicing (AS), and fu

69 especially intron retention) and alternative polyadenylation (APA), display circadian rhythmicity res

70 al 3' UTR isoforms, generated by alternative polyadenylation (APA), is a broad and conserved feature

71 udes comprehensive assessment of alternative polyadenylation (APA), which is subject to broad tissue-

72 Alternative polyadenylation (APA)-mediated 3'-untranslated region (U

73 ne-like protein CPSF6, regulates alternative polyadenylation (APA).

74 ry of regulators of alternative cleavage and polyadenylation (APA).

75 he transcriptome as instances of alternative polyadenylation (APA).

76 en used for testing differential alternative polyadenylation (APA).

77 th alternative splicing (AS) and alternative polyadenylation (APA).

78 ate causes widespread changes in alternative polyadenylation (APA).

79 netic factors potentially affect alternative polyadenylation (APA).

80 sms by which completion of mRNA splicing and polyadenylation are recognized, together with how they a

81 we observed no general shift in alternative polyadenylation associated with PE, the EO-PE and LO-PE

82 Generated by 3' end cleavage and polyadenylation at alternative polyadenylation (poly(A))

83 ernative RNA processing, by both suppressing polyadenylation at an internal site, termed the proximal

84 Specifically, alternative polyadenylation at Intron-2 of OXT6 produces a transcrip

85 riptional read-through by promoting proximal polyadenylation at many sites in the Arabidopsis genome(

86 fect in eukaryotes is probably inappropriate polyadenylation at near-cognate sites within the coding

87 ntalize 3'-end processing factors to enhance polyadenylation at specific sites.

88 ger RNA precursors must undergo cleavage and polyadenylation at their 3'-end for maturation.

89 lice sites and poly(A) signals were mutated, polyadenylation became the preferred mode of OXT6 proces

90 Reduced levels of the polyadenylation binding protein nucleus 1 (PABPN1), a mu

91 FLL2 was required to promote this proximal polyadenylation, but not the binding of FCA to target RN

92 tein that is essential for mRNA cleavage and polyadenylation (C/P).

93 tiple sites at which RNA 3' end cleavage and polyadenylation can occur, enabling the expression of di

94 P II) and in the recruitment of the cleavage/polyadenylation complex, both of which could cause the o

95 poly(A) binding element of the mitochondrial polyadenylation complex.

96 ges the 5' end-bound PPsome and 3' end-bound polyadenylation complexes.

97 mutants display defects in polo alternative polyadenylation concomitant with a striking reduction in

98 y player in this process is the cleavage and polyadenylation (CPA) factor PCF11, which directly binds

99 metalloproteinase 3 (TIMP3) and cytoplasmic polyadenylation element binding protein 3 (CPEB3) were i

100 prion-like RNA-binding protein, cytoplasmic polyadenylation element-binding (CPEB) protein, is a put

101 The translational regulator cytosolic polyadenylation element-binding protein 2 (CPEB2) has tw

102 The cytoplasmic polyadenylation element-binding protein 3 (CPEB3) regula

103 Orb2 is a cytoplasmic polyadenylation element-binding protein homolog in Droso

104 instead via binding of CPEB4 to cytoplasmic polyadenylation elements within the 3'-untranslated regi

105 hort PolH transcript produced by alternative polyadenylation escapes repression by miR-619 and confer

106 in this manner inhibits downstream cleavage/polyadenylation events through a splicing-independent me

107 methodologies designed to assess genome-wide polyadenylation events.

108 per se is lethal in the absence of cleavage-polyadenylation factor (CPF) subunits Ppn1 and Swd22 and

109 ho1 de-repression by IP8 depends on cleavage-polyadenylation factor (CPF) subunits, termination facto

110 y the 1-megadalton multiprotein cleavage and polyadenylation factor (CPF).

111 Cleavage and polyadenylation factor (CPF/CPSF) is a multi-protein com

112 -containing RNA binding protein, kinetoplast polyadenylation factor 3 (KPAF3), and demonstrate its ro

113 th morpholino technology or silencing of the polyadenylation factor CPSF1 caused a splice switch that

114 c post-mortem controls were analysed for the polyadenylation factor CPSF4 and inflammatory markers.

115 including an association of PAF1-C with the polyadenylation factor CstF.

116 of this intronic PAS depends on the nuclear polyadenylation factor SYDN-1, which inhibits the RNA po

117 on the roles played by general cleavage and polyadenylation factors (CPA factors).

118 y pentatricopeptide repeat (PPR) Kinetoplast Polyadenylation Factors (KPAFs).

119 e inflammatory transcription factor NFkB and polyadenylation factors (WDR33 and CPSF4).

120 Knockdown of polyadenylation factors also prevented nuclear localisat

121 This is supported by the finding that polyadenylation factors are required for inflammation in

122 stone pre-mRNA processing in the presence of polyadenylation factors from nuclear extracts.

123 The increased expression of polyadenylation factors in OA synovia indicates a new ta

124 tone cleavage complex (HCC), and a subset of polyadenylation factors including the endonuclease CPSF7

125 independently of THO, Sub2, or cleavage and polyadenylation factors, and enhances mRNA export via TR

126 ges induced nuclear localisation of NFkB and polyadenylation factors, effects inhibited by cordycepin

127 ey recruit the endonuclease CPSF73 and other polyadenylation factors, forming catalytically active ho

128 t-translational modifications of splicing or polyadenylation factors, leading to splicing events that

129 iated via THO and Sub2 of TREX, cleavage and polyadenylation factors, or Sus1 (that regulates mRNA ex

130 Alternative polyadenylation generates transcriptomic diversity, alth

131 anscription termination and stimulates early polyadenylation genome-wide.

132 n in humans, the role of HDACs in regulating polyadenylation has not been uncovered.

133 re-mRNA alternative splicing and alternative polyadenylation have been implicated to play important r

134 These results indicate that HDA6 regulates polyadenylation in a histone deacetylation-dependent man

135 Here, we report that HDA6 affects mRNA polyadenylation in Arabidopsis Poly(A) sites of up-regul

136 dy and probe principles of mRNA cleavage and polyadenylation in C. elegans The worm 3' UTRome v2 repr

137 ding of the role of alternative splicing and polyadenylation in cell migration.

138 pmentally regulated alternative splicing and polyadenylation in congenital myotonic dystrophy (CDM).

139 t that poly(A) polymerase I (PAP I)-mediated polyadenylation in Escherichia coli is highly prevalent

140 leosomes have been reported to regulate mRNA polyadenylation in humans, the role of HDACs in regulati

141 Herein, a role of polyadenylation in OA synovial samples was investigated,

142 evious work suggested a role for alternative polyadenylation in target selection, but this proved not

143 cle kinase Polo is controlled by alternative polyadenylation in the 3' untranslated region (3'UTR), w

144 CLIP, which can be used to study alternative polyadenylation in the CNS.

145 processing pathways and the implications of polyadenylation in tRNA metabolism in E. coli.

146 ex and factors involved in mRNA splicing and polyadenylation, including an association of PAF1-C with

147 ly(A) polymerases that regulates cytoplasmic polyadenylation-induced translation, but its target mRNA

148 s was investigated, and the potential of the polyadenylation inhibitor cordycepin (3' deoxyadenosine)

149 tion in macrophages and by the fact that the polyadenylation inhibitor cordycepin attenuates pain and

150 Polyadenylation is a critical step for gene expression r

151 3' polyadenylation is a key step in eukaryotic mRNA biogene

152 To assess the full panoply of mRNAs whose polyadenylation is controlled by GLD4, we performed an u

153 gene expression at the level of cytoplasmic polyadenylation is important for many biological phenome

154 data indicate that FIP1-mediated alternative polyadenylation is important for plant development and s

155 elationship between DNA methylation and mRNA polyadenylation isoform expression in vivo.

156 By elucidation of a genome-wide polyadenylation landscape of EBV in JSC-1, Raji, and Aka

157 ing poly(A) polymerase from the cleavage and polyadenylation machinery could signal completion of mRN

158 Mutations in FIP1, a component of polyadenylation machinery, affects plant development, ce

159 II termination via depletion of the cleavage/polyadenylation machinery, circular RNA levels were simi

160 avage module with the canonical cleavage and polyadenylation machinery.

161 miR-379 and ABCC2 However, alternative mRNA polyadenylation may result in expression of 3'-untransla

162 Thus, premature polyadenylation-mediated reduction in stathmin-2 is a ha

163 s transcription elongation, termination, and polyadenylation, must also be considered as potential me

164 Since polyadenylation occurs co-transcriptionally, and specifi

165 at Pax3 levels are controlled by alternative polyadenylation of its transcript, which is regulated by

166 These data point to a role for alternative polyadenylation of LDLR mRNA as a potent regulator of LD

167 to such challenges involves the alternative polyadenylation of mRNA.

168 1 and requires the factors essential for the polyadenylation of mRNAs.

169 Polyadenylation of nascent RNA by poly(A) polymerase (PA

170 he newly discovered alternative cleavage and polyadenylation of NaV1.8 mRNA.

171 We show that Nudt21 directs differential polyadenylation of over 1,500 transcripts in cells acqui

172 Polyadenylation of pre-mRNAs is one important step in th

173 mutations in genes involved in stability and polyadenylation of RNA.

174 The dual polyadenylation of snoRNA intermediates is carried out b

175 ilure of 5'-end maturation elicits increased polyadenylation of some pre-tRNAs by poly(A) polymerase

176 The lack of PDE12 results in a spurious polyadenylation of the 3' ends of the mitochondrial (mt-

177 Proximal polyadenylation of the antisense transcripts by FCA, an

178 WDR33), thus linking activities for proximal polyadenylation of the antisense transcripts to FLD/LD/S

179 The dual polyadenylation of the precursor snoRNAs by PAPs may fun

180 scriptome-wide analysis revealed alternative polyadenylation of thousands of genes, most of which res

181 motes pluripotency by regulating alternative polyadenylation of transcripts encoding pluripotency fac

182 diated TATase activity is involved in the 3' polyadenylation of viral plus-strand RNAs.IMPORTANCE Pre

183 Alternative polyadenylation often regulates mRNA isoform usage.

184 e via epigenetic modifications, and altering polyadenylation (pA) sites at which precursor mRNA is cl

185 ion at an internal site, termed the proximal polyadenylation (pA)p site, and by facilitating splicing

186 ge at its internal site, termed the proximal polyadenylation (pA)p site, to allow accumulation of RNA

187 Polyadenylation patterns of many genes are sensitive to

188 s were constructed to alter the splicing and polyadenylation patterns of OXT6.

189 ion defects, inducing premature cleavage and polyadenylation (PCPA) and loss of expression of long (>

190 on-terminating premature 3' end cleavage and polyadenylation (PCPA) from cryptic polyadenylation sign

191 Polyadenylation plays a key role in producing mature mRN

192 Differential mRNA polyadenylation plays an important role in shaping the n

193 In eukaryotes, polyadenylation (poly(A)) is an essential process during

194 Using a poly(A)-tag sequencing approach, polyadenylation (poly(A)) site profiles were investigate

195 cleavage and polyadenylation at alternative polyadenylation (poly(A)) sites, alternative terminal ex

196 s have generated comprehensive catalogues of polyadenylation (poly(A)) sites; their analysis using in

197 y described modulation of co-transcriptional polyadenylation (polyA) site choice.

198 Alternative polyadenylation (polyA) sites near the 3' end of a pre-m

199 s, suppressing the use of early, alternative polyadenylation (polyA) sites.

200 c pre-mRNAs must undergo 3'-end cleavage and polyadenylation prior to their export from the nucleus.

201 nerated by spliced leader trans-splicing and polyadenylation, processes that are functionally linked.

202 red genes, a full transcription map with EBV polyadenylation profiles remains unknown.

203 d normal Pol II elongation rates have normal polyadenylation profiles.

204 cting signals necessary for the cleavage and polyadenylation reaction and splicing of the adjacent up

205 esource to investigate the mRNA cleavage and polyadenylation reaction, 3'-UTR biology, and miRNA targ

206 or transposable elements within the intronic polyadenylation region.

207 such as alternative splicing and alternative polyadenylation result in greater transcript and protein

208 age of nascent transcripts, generally during polyadenylation, resulting in degradation of the residua

209 Further analysis of intronic polyadenylation revealed that LTR/Gypsy and LTR/Copia we

210 s of dsDNA, ssRNA and dsRNA viral markers of polyadenylation-selected RNA sequences from microbial co

211 silenced transcription and read through its polyadenylation sequence.

212 es transcriptional readthrough of downstream polyadenylation sequences.

213 tes (pA sites) using our previously reported polyadenylation sequencing (PA-seq) technology.

214 ranscription complexes pass the cleavage and polyadenylation signal (CPS) and increases upon PP1 depl

215 nd decrease abruptly around the cleavage and polyadenylation signal (CPS).

216 vidence that evolutionary divergence in core polyadenylation signal (PAS) and downstream sequence ele

217 his process is the recognition of the AAUAAA polyadenylation signal (PAS), and the molecular mechanis

218 hexanucleotide AAUAAA motif in the pre-mRNA polyadenylation signal by the cleavage and polyadenylati

219 Next, mice with a floxed polyadenylation signal causing premature transcriptional

220 e development of new therapies targeting the polyadenylation signal in AR intron 3 as a strategy to p

221 AR-V9 is regulated coordinately by a single polyadenylation signal in AR intron 3.

222 pulohumeral muscular dystrophy-specific DUX4 polyadenylation signal is surprisingly inefficient, and

223 mutations near the CEP135(mini) alternative polyadenylation signal reduces the CEP135(full:mini) rat

224 3' UTR, which contains a conserved, precise polyadenylation signal, a robust transient transfection

225 , which likely represents a new cleavage and polyadenylation signal.

226 HLA-A alleles indicated the presence of two polyadenylation signals (PAS).

227 mRNA isoforms due to usage of more proximal polyadenylation signals (PASs) in introns and last exons

228 vage and polyadenylation (PCPA) from cryptic polyadenylation signals (PASs) in introns.

229 rentially localized upstream of noncanonical polyadenylation signals in Drosophila melanogaster genes

230 apply APARENT to forward engineer functional polyadenylation signals with precisely defined cleavage

231 ered sites that are closely spaced and share polyadenylation signals, as these are likely the result

232 riptome-wide gene expression and alternative polyadenylation signatures associated with early-onset P

233 Here, we identify a key role for an intronic polyadenylation site (PAS) in temporal- and tissue-speci

234 transcripts, through inhibition of proximal polyadenylation site (PAS) usage.

235 ion or loss of CDK12/CDK13 triggers intronic polyadenylation site cleavage that suppresses the expres

236 In the present study, we mapped a polyadenylation site for both mouse and human MOR-1Bs th

237 matin and transcripts at a critical proximal polyadenylation site of RPP7, where they suppress proxim

238 Here we used polyadenylation site sequencing (PAS-Seq) of RNA from no

239 molecule long-read sequencing technology and polyadenylation site sequencing (PAS-seq) to re-annotate

240 EF-RNA interactions upon RNA cleavage at the polyadenylation site triggers disassembly of the elongat

241 we compared genome-wide DNA methylation and polyadenylation site usage between DNA methylation-compe

242 hosphorylated CPSF6 largely supported normal polyadenylation site usage, a significant number of mRNA

243 Loss of CFIm function results in proximal polyadenylation site usage, shortening mRNA 3' untransla

244 1 cohesin complex protein can recover distal polyadenylation site usage.

245 , form chromatin loops that promote proximal polyadenylation site usage.

246 thmin-2 pre-messenger RNA, uncover a cryptic polyadenylation site whose utilization produces a trunca

247 intron immediately upstream of the internal polyadenylation site, (pA)p, and that generation of thes

248 end of the gene, thereby using the canonical polyadenylation site, and associate to polyribosomes.

249 serted into intron 35 exposes an alternative polyadenylation site, resulting in a truncated Pkhd1 tra

250 hen all protein factors come together at the polyadenylation site.

251 ed the first comprehensive analysis of viral polyadenylation sites (pA sites) using our previously re

252 nscription start sites (TSS) or cleavage and polyadenylation sites (PAS).

253 tematically mapped and compared cleavage and polyadenylation sites (PASs) in two yeast species, S. ce

254 Most mammalian genes harbor multiple polyadenylation sites (PASs), leading to expression of a

255 ally facilitate usage of distal cleavage and polyadenylation sites (PASs), leading to long 3' UTR iso

256 In addition, we characterized 25 069 polyadenylation sites from 11 450 genes, 6311 of which h

257 of numerous transcripts at cryptic cleavage/polyadenylation sites in first introns.

258 inding protein that promotes use of proximal polyadenylation sites in genes targeted by IBM2, includi

259 mice, this mutation was sufficient to alter polyadenylation sites in over 1300 genes critical for br

260 ion changes using RNA-seq data and annotated polyadenylation sites in the PolyA_DB database.

261 cupancy markedly increased near cleavage and polyadenylation sites in xrn1Delta cells, whereas its ac

262 nd processing and directly binds to proximal polyadenylation sites of target mRNAs in vivo.

263 methylation resulted in a shift of upstream polyadenylation sites to annotated 3' ends.

264 3'-UTR of NRT1.1 showed that the pattern of polyadenylation sites was altered in the cpsf30 mutant.

265 relates with an increased number of intronic polyadenylation sites, a feature especially prominent am

266 e found that due to the presence of multiple polyadenylation sites, alternative polyadenylation (APA)

267 hin protein-coding sequences, acquisition of polyadenylation sites, structural rearrangements, and in

268 f RNA polymerase II, and terminates at their polyadenylation sites, thereby ensuring global co-direct

269 lower ratios of U1 snRNP binding to intronic polyadenylation sites.

270 llele, which disrupts the most distal of two polyadenylation sites.

271 d in transcription termination downstream of polyadenylation sites.

272 y detect and assess differential alternative polyadenylation specifically from 3'Seq data.

273 F100 is a core component of the cleavage and polyadenylation specificity factor (CPSF) complex for 3'

274 A polyadenylation signal by the cleavage and polyadenylation specificity factor (CPSF) complex.

275 is 3'-end processing, including cleavage and polyadenylation specificity factor (CPSF) in mammals.

276 rocessing machinery consists of cleavage and polyadenylation specificity factor (CPSF), cleavage stim

277 eract with Fip1, a component of cleavage and polyadenylation specificity factor (CPSF).

278 ng to the 30-kDa subunit of the cleavage and polyadenylation specificity factor (CPSF30), a cellular

279 tinct modules: a cleavage factor (mCF) and a polyadenylation specificity factor (mPSF).

280 eased the binding of NS1 to the cleavage and polyadenylation specificity factor 30 (CPSF30).

281 nt whose mutation mapped to the Cleavage and Polyadenylation Specificity Factor 30 gene (CPSF30-L).

282 te that CPSF4 (cellular protein cleavage and polyadenylation specificity factor 4) independently and

283 ian (CFIm) complex, composed of cleavage and polyadenylation specificity factor 5 (CPSF5) and serine/

284 Cleavage and polyadenylation specificity factor 6 (CPSF6) is a cellul

285 n myxovirus resistance B (MxB), cleavage and polyadenylation specificity factor 6 (CPSF6), and cyclop

286 interactions with host protein cleavage and polyadenylation specificity factor 6 (CPSF6), complete r

287 f the capsid proteins with host cleavage and polyadenylation specificity factor 6 (CPSF6), which is a

288 EAH-box helicase 15 (DHX15) and cleavage and polyadenylation specificity factor 6 (CPSF6; also known

289 ncodes a homologue of mammalian cleavage and polyadenylation specificity factor subunit 3 (CPSF-73 or

290 , such as cleavage factor I and cleavage and polyadenylation specificity factor, as well as by other

291 he 73-kilodalton subunit of the cleavage and polyadenylation specificity factor, poised for cleavage.

292 tholog of 30 kDa subunit of the Cleavage and Polyadenylation Specificity Factor.

293 The host protein cleavage-and-polyadenylation-specificity-factor-6 (CPSF6) has been im

294 Polyadenylation tests (PAT) on endogenous mRNAs determin

295 factors required for specific and efficient polyadenylation, to help coordinate mRNA 3'-end processi

296 r of translation control through alternative polyadenylation usage required to fine-tune the timing o

297 Alternative polyadenylation was largely independent from the relativ

298 mination of mRNAs is coupled to cleavage and polyadenylation while noncoding transcripts are terminat

299 ular mechanisms involved in polo alternative polyadenylation, with remarkable physiological functions

300 Cryptic polyadenylation within coding sequences (CDS) triggers r