ライフサイエンスコーパス: polyamine

1 ich was partially rescued by the addition of polyamine.

2 s, which is rescued by incubating virus with polyamines.

3 over multiple subcultures in the absence of polyamines.

4 mily in the transport of naturally occurring polyamines.

5 m (SMOX, SSAT) and depleted cellular natural polyamines.

6 suppression is inhibited in the presence of polyamines.

7 al intracellular constituents - the cationic polyamines.

8 whereas ATP13A2 dysfunction causes lysosomal polyamine accumulation and rupture.

9 ific transcriptional regulator through local polyamine acetylation.

10 mutants demonstrate the essentiality of the polyamine acetyltransferase activity of SAT1 for its fun

11 ditols) and small organic cations (including polyamines) also lacked consistent effects.

12 named DSS-BEN, which was synthesized from a polyamine analog N(1),N(11)-bisethylnorspermine (BENSpm)

13 The design and biochemical evaluation of polyamine analogues are cornerstones of polyamine resear

14 We reveal a connection between polyamine and lysine metabolism during stress situations

15 hypersensitivity of the transgenic plants to polyamine and paraquat.

16 ndent effects on SAM-dependent metabolism of polyamines and creatine could not be directly attributed

17 UHb plants showed increases in total polyamines and in particular polyamines such as spermidi

18 t for protein synthesis and the formation of polyamines and is involved in the synthesis of many meta

19 on in glycolysis, pentose phosphate pathway, polyamines and nucleotides, but an increase in TCA and u

20 tant to maintain the cellular homeostasis of polyamines and plays a role in stabilizing mRNAs of some

21 d conditions in B. burgdorferi Among several polyamines and polyamine precursors, supplementation of

22 health care, influences the serum pattern of polyamines and related metabolites in subjects at high r

23 B3 (CVB3), are sensitive to the depletion of polyamines and remain a significant public health threat

24 accumulation of the amino acid precursors of polyamines and with the expression of specific polyamine

25 The amino acid, polyamine, and organocation (APC) superfamily is the sec

26 Serum concentrations of arginine, ornithine, polyamines, and acetyl polyamines at baseline and 26 wk

27 d E. faecalis form biofilms normally without polyamines, and exogenous polyamines do not stimulate gr

28 Ozone increased various amino acids, polyamines, and metabolites of gut microbiota in HFD fem

29 of spermine, total biogenic amines and total polyamines; and iii) the highest spermidine levels and t

30 Small molecule polyamines are abundant in all life forms and participat

31 Polyamines are abundant in living cells, where they have

32 Polyamines are classically studied as regulators of ion

33 Polyamines are critical elements in mammals, but it rema

34 We previously demonstrated that polyamines are crucial for RNA viruses; however, the mec

35 Polyamines are involved in the regulation of many host p

36 resence of ruminant serum, exogenously added polyamines are quickly oxidized by the copper-containing

37 We have shown that polyamines are regulators of the host response to H. pyl

38 We posit that polyamines are required to maintain bunyavirus infectivi

39 Polyamines are small host molecules that play diverse ro

40 Polyamines are small polycationic alkylamines involved i

41 Polyamines are small polycationic molecules with flexibl

42 Polyamines are small, positively charged host-derived mo

43 Polyamines are tightly regulated polycations that are es

44 A displays a preference for linear aliphatic polyamines as the amidino acceptor substrate, especially

45 t fails to grow in minimal medium containing polyamines as the sole nitrogen source.

46 erapeutic targets for treating SRS and other polyamine-associated neurological disorders.

47 arginine, ornithine, polyamines, and acetyl polyamines at baseline and 26 wk of intervention were me

48 olleagues provide a mechanistic link between polyamines, autophagy, and aging.

49 ntation of the medium did not circumvent the polyamine auxotrophy of the Deltaarg line.

50 The polyamine auxotrophy, polyamine-independent growth and b

51 ed neuronal protection through an arginase 1-polyamine axis.

52 road regulatory roles due to near ubiquitous polyamine binding.

53 calis represent a new paradigm for bacterial polyamine biology.

54 omyces cerevisiae Yeast strains deficient in polyamine biosynthesis (spe1Delta, lacking ornithine dec

55 pting mitochondrial bioenergetics, increased polyamine biosynthesis and breakdown, as well as abnorma

56 This unique high metabolic flux through polyamine biosynthesis and connected one carbon metaboli

57 that the PGC1alpha/c-MYC/ODC1 axis regulates polyamine biosynthesis and prostate cancer aggressivenes

58 uggests a potential interplay between NO and polyamine biosynthesis during drought response.

59 tion mutations in spermine synthase (SMS), a polyamine biosynthesis enzyme, cause Snyder-Robinson syn

60 lyamines and with the expression of specific polyamine biosynthesis genes.

61 uptake deficiency and resistance to a toxic polyamine biosynthesis inhibitor methylglyoxal bis-(guan

62 Cancers often escape the polyamine biosynthesis inhibitors by increased polyamine

63 a NO-ethylene influenced regulatory node in polyamine biosynthesis linked to drought tolerance/susce

64 ta suggest that pharmacologically inhibiting polyamine biosynthesis may combat virus infection by pre

65 two prozymes described to date reside in the polyamine biosynthesis pathway of the human parasite Try

66 prostate cancer cells via modulation of the polyamine biosynthesis pathway.

67 ge pathway recycles one-carbon units lost to polyamine biosynthesis to the methionine cycle to overco

68 A, PotB, PotC, and PotD), while homologs for polyamine biosynthesis were conspicuously absent.

69 Polyamine biosynthesis-responsive genes, namely ornithin

70 e ADC-box, upstream of ADC genes involved in polyamine biosynthesis.

71 dent decarboxylases that are not involved in polyamine biosynthesis.

72 e, we report that spermine synthase (SMS), a polyamine biosynthetic enzyme, is overexpressed in CRC.

73 n the levels and activity of a rate-limiting polyamine biosynthetic enzyme, ornithine decarboxylase (

74 coccus faecalis have lost either all or most polyamine biosynthetic genes, respectively, and are devo

75 and spermidine synthase, two enzymes of the polyamine biosynthetic pathway, are critical for promast

76 h a PVC membrane containing 12mmol/kg of the polyamine bisnaphthalimidopropyl-4,4'-diaminodiphenylmet

77 Relief of polyamine block in GluK2/GluK5 heteromers results from a

78 M decarboxylase) require externally supplied polyamines, but supplementation with as little as 10(-8)

79 ATP13A2 promotes the cellular uptake of polyamines by endocytosis and transports them into the c

80 The production of metabolites such as polyamines by intestinal-resident bacteria is part of th

81 hibian lymphocyte proliferation, but a third polyamine, cadaverine (CAD), does not.

82 carboxylates lysine and forms an alternative polyamine, cadaverine.

83 d the expression of rate-limiting enzymes in polyamine catabolism (SMOX, SSAT) and depleted cellular

84 ferase (SAT1) is the rate-limiting enzyme in polyamine catabolism and a primary genetic risk factor f

85 ferase 1 (SAT1), the rate-limiting enzyme in polyamine catabolism, has broad regulatory roles due to

86 pressed polyamine oxidase, a gene related to polyamine catabolism, when plants were exposed to Cd.

87 contains a large macrocycle and an appended polyamine component and was shown to be both antimetasta

88 gates were prepared, and the sequence of the polyamine component was varied to optimize the antimigra

89 Based on experimental models, polyamine concentrations may be also influenced by physi

90 The consumption of a MedDiet could increase polyamine concentrations.

91 A series of macrocycle-polyamine conjugates were prepared, and the sequence of

92 Up-regulation of cellular polyamine content in a Mg(2+)-deficient alr1Delta mutant

93 A signaling system may communicate exogenous polyamine content to the cell to control biofilm formati

94 ance and has recently been described to be a polyamine deacetylase, but no studies toward selective H

95 histone deacetylase 10 (HDAC10) is a robust polyamine deacetylase, using recombinant enzymes from Ho

96 single mutants alr1Delta and spe2Delta under polyamine-deficient conditions.

97 t that elevated Mg(2+) can support growth of polyamine-deficient S. cerevisiae mutants.

98 r the up-regulation of the Mg(2+) content in polyamine-depleted cells and suggest that elevated Mg(2+

99 Passaging CVB3 in polyamine-depleted cells generated a mutation in capsid

100 In polyamine-depleted cells, bunyaviruses produce an overab

101 viruses also exhibited reduced attachment to polyamine-depleted cells, suggesting that polyamines may

102 the capsid mutant rescues this inhibition in polyamine-depleted cells.

103 inding amino acid that promotes infection of polyamine-depleted cells.

104 s inform additional mechanisms of action for polyamine-depleting pharmaceuticals, with implications f

105 enveloped viruses are similarly sensitive to polyamine depletion but that a nonenveloped enterovirus

106 d that this methionine-depletion approach to polyamine depletion could not be rescued by exogenous po

107 We found that polyamine depletion did not impact viral RNA or protein

108 rough attachment assays, we demonstrate that polyamine depletion limits CVB3 attachment to susceptibl

109 arged molecules, for robust replication, and polyamine depletion limits infection in vitro and in viv

110 Thus, polyamine depletion promotes the formation of noninfecti

111 to maintain bunyavirus infectivity and that polyamine depletion results in the accumulation of inter

112 In sum, polyamine depletion results in the accumulation of nonin

113 hibited significant Mg(2+) accumulation upon polyamine depletion.

114 how that this mutation confers resistance to polyamine depletion.

115 s precursor, putrescine (PUT), are the major polyamines detected, and SPD is required for growth.

116 The strip was employed for polyamine determination in some of the locally grown fru

117 s normally without polyamines, and exogenous polyamines do not stimulate growth or biofilm formation.

118 et of rapamycin complex 1 (mTORC1) regulates polyamine dynamics, a metabolic route that is essential

119 In contrast, we find polyamine effects on assembly involve the nAChR cytosoli

120 in vitro and in vivo The mechanisms by which polyamines enhance enteroviral replication are unknown.

121 transgenic animal studies find that reducing polyamines enhances cortical neuron nAChR expression and

122 es and we show the deletions extended to the polyamine enzyme methylthioadenosine (MTA) phosphorylase

123 the highest affinity for spermine among the polyamines examined.

124 We found that both polyamines exhibit biphasic effect; enhancement and inhi

125 We present defective lysosomal polyamine export as a mechanism for lysosome-dependent c

126 Here we establish ATP13A2 as a lysosomal polyamine exporter that shows the highest affinity for s

127 terium tumefaciens, which absolutely require polyamines for growth, S. aureus and E. faecalis grow no

128 uncovered that diverse bunyaviruses require polyamines for productive infection.

129 ight a novel means by which bunyaviruses use polyamines for replication and suggest promising means t

130 nd are devoid of any polyamine when grown in polyamine-free media.

131 a mutant or a spe2Delta mutant in a standard polyamine-free minimal medium (SDC) leads to marked incr

132 NA viruses; however, the mechanisms by which polyamines function remain unknown.

133 Spermidine (SPD), a naturally occurring polyamine, has been recognized as a caloric restriction

134 Polyamines have essential roles in cell proliferation, D

135 transport are crucial in the maintenance of polyamine homeostasis.

136 in supporting cell growth while stimulating polyamine homeostatic control mechanisms.

137 Polyamide-polyamine hybrid macrobicycle L is explored with respect

138 in Drosophila recapitulates the pathological polyamine imbalance of SRS and causes survival defects a

139 lyamine biosynthesis inhibitors by increased polyamine import.

140 icity in mechanistic studies of the roles of polyamines in autophagy.

141 Here we show that substituting polyamines in place of elemental counterions significant

142 , we examine the interplay between eIF5A and polyamines in promoting translation elongation.

143 ther, we describe a most unexpected role for polyamines in regulating ion channel assembly, which pro

144 M can functionally substitute for the native polyamines in supporting cell growth while stimulating p

145 We therefore hypothesized that other polyamines in the gastrointestinal tract may control V.

146 Here, we investigated the role of polyamines in the replication of the bunyaviruses Rift V

147 High levels of external polyamines, including norspermidine, eventually inhibit

148 The polyamine auxotrophy, polyamine-independent growth and biofilm formation, and

149 At high concentrations polyamines induce cell toxicity, which is exacerbated by

150 We determined that spermine, an odorous polyamine initially identified from human semen, is inde

151 ng a role for endolysosomes in the uptake of polyamines into cells.

152 lial cells secrete high levels of acetylated polyamines into the prostatic lumen, sensitizing them to

153 Polyamines involve in gene regulation by interacting wit

154 arginase-AdoMetDC/ODC pathway to acquire the polyamines it needs to develop.

155 nel of human cancer cell lines revealed that polyamines L1a and L5a displayed remarkable activity wit

156 ransferase (SSAT) activity, which acetylates polyamines leading to their secretion and drives biosynt

157 sary to maintain intracellular ornithine and polyamine levels in T. brucei, thereby decreasing sensit

158 As a result, Brg11 induces elevated polyamine levels that trigger a defense reaction and lik

159 A decline in polyamine levels with age has been implicated in the pat

160 ate endo-lysosomal transporter ATP13A2 pumps polyamines like spermine into the cytosol, whereas ATP13

161 mbled heterostructures of graphene oxide and polyamine macromolecules, forming a network of ionic cha

162 to polyamine-depleted cells, suggesting that polyamines may facilitate attachment of diverse RNA viru

163 d in SRS, and was associated with changes in polyamine metabolic enzymes.

164 Simultaneous regulation of polyamine metabolism and miR-34a expression by DSS-BEN/m

165 t if increased ODC activity and dysregulated polyamine metabolism contribute to the neurodevelopmenta

166 Dysregulation of polyamine metabolism has been linked to the development

167 ble of simultaneously targeting dysregulated polyamine metabolism in cancer, thereby providing an ele

168 ing miR-34a mimic and targeting dysregulated polyamine metabolism in cancer.

169 The alterations in polyamine metabolism in response to chemotherapy, as wel

170 ng the pathological consequences of abnormal polyamine metabolism in the nervous system and may provi

171 Targeting polyamine metabolism is a proven anticancer strategy.

172 d by reversible acetylation and dysregulated polyamine metabolism is associated with neoplastic disea

173 Intracellular polyamine metabolism is regulated by reversible acetylat

174 ture, tri-carboxylic acid cycle, tocopherol, polyamine metabolism, and bile acids.

175 rboxylase (ODC), the rate-limiting enzyme in polyamine metabolism, has been well studied in epithelia

176 e, production of reactive oxygen species and polyamine metabolism, in response to Cd stress.

177 nes encoding key enzymes of methyl group and polyamine metabolism, including Ornithine Decarboxylase

178 ed to NO signaling and it is also related to polyamine metabolism, we explored this connection.

179 Since NO biosynthesis has been related to polyamine metabolism, we investigated whether the observ

180 cal reactions linked to transmethylation and polyamine metabolism.

181 evidence for a cross-talk between Mg(2+) and polyamine metabolism.

182 Spermidine, an endogenous polyamine metabolite, induces autophagy in vivo and reju

183 , fatty acid acylcarnitines, tryptophan, and polyamine metabolites and decreased levels of steroids,

184 cisplatin and doxorubicin alter arginine and polyamine metabolites.

185 fractionated, we found that amino acids and polyamines, most abundant in Euglena gracilis DOM, were

186 iofilm formation, and presence of functional polyamine N-acetyltransferases in S. aureus and E. faeca

187 eoxyadenosine, and SAM-dependent enzymes for polyamine, neurotransmitter and quorum sensing compound

188 Specifically, the polyamines norspermidine and spermidine enhance and repr

189 Two other related polyamines, norspermidine (NSP) and spermine (SPM), also

190 gnificant changes of serum concentrations of polyamines or related metabolites in comparison with an

191 However, no significant differences in serum polyamines or related metabolites were found between stu

192 r determination of xanthine oxidase (XO) and polyamine oxidase (PAO) activities in milk samples was d

193 By contrast, knockdown of polyamine oxidase (ZmPAO) significantly increased SCMV a

194 asure the growth differences, we developed a polyamine oxidase fvpo1 mutant in this fungus that fails

195 In the present study, polyamine oxidase specific for spermine and spermidine a

196 GABA suppressed polyamine oxidase, a gene related to polyamine catabolis

197 This polyamine oxidation resulted in the production of harmfu

198 Orthogonally protected polyamines (PAs) have been synthesized using alpha,omega

199 ression of the main metabolic enzymes of the polyamine pathway and spermine abundance in 120 well-cha

200 r the other amino acids, is dependent on the polyamine pathway and triggers a reprogramming of redox

201 e of arginase (ARG), the first enzyme of the polyamine pathway in Leishmania, has not been analyzed i

202 role in prostate tumorigenesis and that the polyamine pathway is altered as early as HGPIN.

203 ic reaction in which the first enzyme of the polyamine pathway, Spe1p, decarboxylates lysine and form

204 ved drought-related NO changes could involve polyamine pathway.

205 dysregulation in brain transmethylation and polyamine pathways.

206 region of a CRISPR array suggests that this polyamine plays a potential role in the fidelity of the

207 Depletion of polyamine pools in cells treated with FDA-approved drugs

208 B. burgdorferi Among several polyamines and polyamine precursors, supplementation of spermine or spe

209 first time a pivotal role for Arg-dependent polyamine production during Plasmodium's hepatic develop

210 use these cells lack the first enzyme of the polyamine production pathway, arginase.

211 appeared to be the rate-limiting enzyme for polyamine production.

212 ition to these functions, elevated levels of polyamines promote longevity in various biological syste

213 The polyamines putrescine, spermidine, and spermine are requ

214 ich was accompanied by reduced levels of the polyamines putrescine, spermidine, and spermine in mutan

215 The polyamines putrescine, spermine, and spermidine are abun

216 d anionic polypeptides) and polybases (e.g., polyamines, pyridine and imidazole containing polymers,

217 Combined epigenetic and polyamine-reducing therapy stimulates M1 macrophage pola

218 her, the data demonstrate that gene-specific polyamine removal is a major transcriptional regulatory

219 lized by the arginase pathway to produce the polyamines required for Plasmodium growth.

220 We show that eIF5A can obviate the polyamine requirement for general translation elongation

221 n of polyamine analogues are cornerstones of polyamine research.

222 icles (CS/CF/nZnO) hybrid support to yield a polyamine sensing strip.

223 our carbon spacers revealed that the natural polyamine sequence (norspermidine, a 3,3-triamine) was s

224 A survey of different polyamine sequences containing two, three, or four carbo

225 the 15-membered carbocycle and the appended polyamine showed improved antimigration properties.

226 the Mediterranean diet (MedDiet) are rich in polyamines, small aliphatic amines with potential cardio

227 l viruses has been described to rely on host polyamines, small and abundant positively charged molecu

228 These viruses rely on polyamines, small positively charged molecules, for robu

229 t on the isolation and identification of the polyamine spermidine (SPD) as another significant immuno

230 We aimed to characterize the polyamine spermidine as a modulator of T-cell differenti

231 Ubiquitous polyamine spermidine is not required for normal plankton

232 We show that addition of the ubiquitous polyamine spermidine or of another polyamine, spermine,

233 Deoxyhypusine synthase (DHPS) uses the polyamine spermidine to catalyze the hypusine modificati

234 es, we also assess DNA condensation with the polyamine spermidine.

235 nic amines (tryptamine and tyramine) and two polyamines (spermidine and spermine) were detected in co

236 The biomarker performance of the two polyamines (spermidine/putrescine) was enhanced by ratio

237 We compared the effects of trivalent polyamines, spermidine (SPD) and norspermidine (NSPD), a

238 annuum L.), an exogenous application of two polyamines, Spermidine and Putrescine (SPD-PUT), was tes

239 Interactions between the polyamine spermine and nucleic acids drive important cel

240 ermine oxidase (SMOX), which metabolizes the polyamine spermine into spermidine plus H(2)O(2), is ass

241 w concentrations of divalent cations and the polyamine spermine.

242 of MPS I revealed a marked elevation of the polyamine, spermine, in affected animals, and gene thera

243 biquitous polyamine spermidine or of another polyamine, spermine, significantly alters the ratio betw

244 The biogenic polyamines, spermine (Spm) and spermidine, are organic p

245 Using this polyamine starvation method, we next generated recombina

246 Polyamines stimulate the activity of purified ATP13A2, w

247 cytokinins, abscisic acid, brassinosteroids, polyamines, strigolactones, and ascorbic acid and provid

248 iological processes that constrain or expand polyamine structural and functional diversity.

249 Cationic polyamines such as spermidine and spermine are critical

250 Polyamines such as spermidine and spermine are primordia

251 reases in total polyamines and in particular polyamines such as spermidine.

252 Polyamines, such as putrescine, spermidine, and spermine

253 ut was incapable of growth in the absence of polyamine supplementation, but the auxotrophic phenotype

254 ng methylation reactions, redox maintenance, polyamine synthesis and coupling to folate metabolism, t

255 gulator of mitochondrial metabolism controls polyamine synthesis and prostate cancer aggressiveness,

256 mine transport leads to up regulation of the polyamine synthesis genes speE and cad in vitro.

257 ighly sensitive to inhibition of the de novo polyamine synthesis pathway and that inhibition of this

258 Pharmacological inhibition of intracellular polyamine synthesis with alpha-difluoromethylornithine (

259 arboxylase (AMD1), a rate-limiting enzyme in polyamine synthesis, is required for myeloid leukemia.

260 was found to be essential for ornithine and polyamine synthesis, ornithine decarboxylase appeared to

261 additional branch of metabolism in the cell-polyamine synthesis-that is important for prostate cance

262 ylase 1 (ODC1), the rate-limiting enzyme for polyamine synthesis.

263 arboxylated S-adenosylmethionine (dcSAM) and polyamine synthesis.

264 ite through the modulation of Arg uptake and polyamine synthesis.

265 athione [GSH]: higher in AD, p < 0.001); (3) polyamine synthesis/catabolism (spermidine: higher in AD

266 broad dysregulation of transmethylation and polyamine synthesis/catabolism, including abnormalities

267 Putrescine, a polyamine that is not a sole carbon or nitrogen source f

268 Here, we report the utility of polyamines that have exceptionally high charge-reducing

269 d cells, and an accumulation of intraluminal polyamines that promote epithelial healing.

270 s the urea cycle in keratinocytes increasing polyamines that stabilize RNA-Ag-complexes that upon cel

271 g, with important implications for targeting polyamines therapeutically, as well as for vaccine strat

272 depletion could not be rescued by exogenous polyamines, thereby obviating the need for a PTI.

273 a renders prostate cancer cells dependent on polyamine to promote metastasis.

274 scribe how Coxsackievirus B3 (CVB3) utilizes polyamines to attach to susceptible cells and initiate i

275 Viruses can exploit host polyamines to facilitate nucleic acid packaging, transcr

276 a requirement for DHPS in beta cells to link polyamines to mRNA translation to effect facultative cel

277 e body of eIF5A functionally substitutes for polyamines to promote general protein synthesis and that

278 n and suggest promising means to target host polyamines to reduce virus replication.

279 The polyamine transport activity of ATP13A2 was required for

280 SOS1 and SOS2 synergistically activate the polyamine transport activity of PUT3, and PUT3 also modu

281 ated downregulation of ODC and inhibition of polyamine transport are crucial in the maintenance of po

282 he borrelial genome revealed the presence of polyamine transport components (PotA, PotB, PotC, and Po

283 efore, there is much interest in identifying polyamine transport inhibitors (PTIs) to be used in comb

284 ive polyamine uptake routes and characterize polyamine transport inhibitors for therapy.

285 Additionally, we found that deficiency of polyamine transport leads to up regulation of the polyam

286 nsion, as a major component of the mammalian polyamine transport system that confers sensitivity to M

287 , we reveal a new component of the mammalian polyamine transport system using CHO-MG cells, a widely

288 t on the molecular identity of the mammalian polyamine transport system.

289 The role of the yeast polyamine transporter Tpo1p(3-5) in maintaining oxidant

290 ibitor, and entered into DU145 cells via the polyamine transporter.

291 transport ATPase that represents a candidate polyamine transporter.

292 CHO-MG cells present polyamine uptake deficiency and resistance to a toxic po

293 ls, a widely used model to study alternative polyamine uptake routes and characterize polyamine trans

294 to investigate a potential proviral role for polyamines using a forward screen.

295 However, the minimum requirement for polyamines varies widely, ranging from very high concent

296 Consequently, different forms of polyamines were elevated in Cd-exposed plants following

297 Seven amines were detected; polyamines were predominant before in vitro digestion, w

298 alternative activation-such as ornithine and polyamines-were greatly elevated in the absence of GLUT1

299 c genes, respectively, and are devoid of any polyamine when grown in polyamine-free media.

300 Neurological studies link brain polyamines with neurodegenerative conditions.