ライフサイエンスコーパス: polycation

1 dent on the identity and charge state of the polycation.

2 ing 12 times more potent than the unmodified polycation.

3 aPPE, and poly(allylamine hydrochloride) PAH polycation.

4 DNA molecules bind electrostatically to this polycation.

5 NAs via electrostatic interactions with the polycation.

6 gative charge and forms a stable EC with the polycation.

7 NA in the presence of spermine, a biological polycation.

8 eglycol and a tetraethylenepentamine-grafted polycation.

9 al lipids, gemini surfactants, or lipophilic polycations.

10 poly(2-ethyl-2-oxazoline), yielding the pure polycations.

11 ious agents including glycosaminoglycans and polycations.

12 ed by a variety of condensing agents such as polycations.

13 previously studied minor groove binders, and polycations.

14 and some other inorganic cations and organic polycations.

15 ere abrogated by preincubation of cells with polycations.

16 alency in titration experiments with various polycations.

17 horylated Tau that is condensed by cytosolic polycations.

18 dramatically improved by treating cells with polycations.

19 protein toxin architecture that is devoid of polycations.

20 hallenging owing to the high cytotoxicity of polycations.

21 a gold surface via an intermediate layer of polycations.

22 After deprotection, three water-soluble polycations (9a, 9b, or 9c) were obtained with similar d

23 We propose that in the absence of polycations, access of target proteins to their binding

24 Polycations accumulate to a higher degree in hyperpolari

25 shift depends on the amount of biotinylated polycation added to the etalon, which can subsequently b

26 tails configuration, accompanied by greater polycation adsorption.

27 with natural polyelectrolytes (chitosan as a polycation and a mixture of manuka honey with essential

28 Planar potentiometric polycation and polyanion PSEs are prepared by incorporat

29 -lysine (PLL) and succinylated PLL (SPLL) as polycation and polyanion, respectively, we demonstrated

30 bited by divalent inorganic cations, soluble polycations and amphipathic organic cations.

31 Competing influences of polycations and monovalent cations suggest a significant

32 ndensation to be driven by electrostatics of polycations and not hydration, and the concentration of

33 evidence that gene complexes, consisting of polycations and plasmid DNA enter cells via binding to m

34 ver, the enhancing and inhibitory effects of polycations and polyanions on HIV-1 infection are largel

35 icles composed of equimolar charge ratios of polycations and polyanions, we demonstrate that increasi

36 Moreover, combining VSV with polycations and ruxolitinib (which inhibits antiviral si

37 articles formed with cyclodextrin-containing polycations and siRNA.

38 the effects of the interactions between the polycations and the hydrogel microspheres over time in v

39 N-terminal domains of MyBPC may act as small polycations and therefore bind actin via nonspecific ele

40 Combined treatment of polycations and vemurafenib diminishes the metabolic fle

41 atic complexes (ECs) comprised of insulin, a polycation, and glucose oxidase (GOx).

42 Here, by using polycation- and polyanion-directed intrafibrillar minera

43 ence-defined xenopeptides, to macromolecular polycations applied in polyplexes and polymer micelles.

44 However, the impact of polycation architecture and solution assembly on the bio

45 not to small inorganic cations because only polycations are able to form cooperative ion pairs with

46 midoamines (PAA) and cyclodextrin (CD)-based polycations are also in a significant interest because o

47 Complexes formed from DNA and polycations are of interest because of their potential u

48 of DNA sequence-mediated isomer preference, polycations are the major contributor to biasing strand

49 Organic polycations are used as zeolite crystal shape modifiers

50 electron microcopies data indicate that the polycations are wrapped around NTs forming a uniform coa

51 Polyamines, small organic polycations, are essential for cell viability, and their

52 the resulting gelled spheres are coated with polycations as a cross-linker; and (iii) these complexes

53 o a conformational change in the presence of polycations as demonstrated by its increased trypsin cle

54 developments on these three major degradable polycations as promising carriers for deoxyribonucleic a

55 ms of ds-DNA and polydiallyldimethylammonium polycations assembled layer-by-layer.

56 or can be employed for FIA detection of both polycations at levels >/=10 mug/mL and polyanions at lev

57 through nanoporous membranes and showed that polycations at the trans side accelerated the translocat

58 void renal clearance, many cationic polymer (polycation)-based siRNA nanoparticles that are used for

59 we compared the phosphorylcholine (PC)- and polycation-based binding activities of human CRP.

60 Although PC inhibits both PC- and polycation-based binding, none of the amines that inhibi

61 Here we develop a polycation-based nanomedicine polyamidoamine generation

62 egies to be evaluated using a single type of polycation-based vector.

63 oquine (CQ) enhances transgene expression in polycation-based, nonviral gene delivery systems, a numb

64 particles were coated with a polyanion and a polycation bearing thymine chromophores.

65 is is restricted to alpha-Syn PFFs and other polycation-bearing cargos that enter cells via HSPGs.

66 indicate that the negative charges to which polycations bind are multiple and mobile.

67 The tobramycin polycation binds to loops in tRNA (Asp) and induces RNA

68 VIPER is composed of a polycation block for condensation of nucleic acids, and

69 and spermine, are physiologically important polycations, but the transporters responsible for their

70 sed on peptide-modified low molecular weight polycations can possess versatile properties including e

71 Experiment has shown that polycations can turn electrostatic self-repulsion of DNA

72 olumes containing siRNAs in complexes with a polycation carrier.

73 NA duplex d(CGCGAATTCGCG) in the presence of polycation chains are carried out to shed light on the s

74 the polyamines decreased with a decrease of polycation charge: spermine(4+) > spermidine(3+) >>> cad

75 ositional correlations between polyanion and polycation charges has not been confirmed experimentally

76 The polycation chitosan (pKa 6.4) has been used to efficient

77 tion with confocal microscopy shows that the polycation chitosan coadsorbs to interfacial layers of b

78 Hybrid polycation-clay composites, based on methylated poly vin

79 led membranes featuring channels composed of polycation clusters are sandwiched between two layers of

80 However, anions transport across polycation clusters is amplified.

81 Cation flux across the polycation clusters is greatly inhibited because of inte

82 n strategies are the inclusion of additional polycation coatings and the covalent bonding of the semi

83 achment in alginate microspheres with double polycation coatings.

84 eparation of approximately 50 A, the DNA and polycation come together and form a stable complex withi

85 anding of the structure and formation of DNA-polycation complexes at atomic scale.

86 etic vectors involves the endocytosis of DNA-polycation complexes, escape from endosomes, and diffusi

87 s were labeled by incubation with ferumoxide:polycation complexes.

88 etween nanosphere size, surface charge, PLGA-polycation composition, and protein loading is also inve

89 s, cross-linking density, voltage amplitude, polycation concentration, and perimeter-to-area ratio of

90 s, we developed a non-viral lipid-entrapped, polycation-condensed delivery system (LPD) for central n

91 ated i.v. administration of lipid-entrapped, polycation-condensed RB complementary DNA.

92 Synthetic vectors based on reducible polycations consisting of histidine and polylysine resid

93 which one end of a long-chained hydrophobic polycation containing antimicrobial monomers is attached

94 tra(ethylene glycol) chains to PLL abrogated polycation cytotoxicity in a charge density and PEG depe

95 his relatively simple microtiter plate-based polycation detection system.

96 Mechanistic insight into how polycations disrupt and cross cell membranes is needed f

97 nanoparticle formulations, cationic liposome-polycation-DNA (LPD) and anionic liposome-polycation-DNA

98 me-polycation-DNA (LPD) and anionic liposome-polycation-DNA (LPD-II), for systemic co-delivery of dox

99 thetic nucleic acid delivery vectors such as polycation/DNA or polycation/siRNA complexes (polyplexes

100 PC-based binding required calcium, whereas a polycation (e.g. poly-l-lysine) was bound in the presenc

101 ber, transduction time, and concentration of polycation (e.g., Polybrene).

102 The severity of polycation effect on bioenergetic crisis follows with th

103 Surprisingly, polycations enhance titers 20- to 30-fold by stabilizing

104 refore, other techniques based on the use of polycations, enzymes, nanomaterials, and photoactive age

105 spermidine, and spermine) are major organic polycations essential for a wide spectrum of cellular pr

106 Polyamines are organic polycations essential for a wide variety of cellular fun

107 Polyamines are organic polycations essential for cell growth and differentiatio

108 Thus, polycations exert considerable detrimental effects on me

109 involves electrostatic interactions with the polycation forming a poorly fitting "plug" in the mouths

110 Polyamines are primordial polycations found in most cells and perform different fu

111 ar-type ion pair complex between the analyte polycation from aqueous sample phase and the deprotonate

112 in endocytic vesicles, (ii) displacement of polycations from the nucleic acids in polyplexes, and (i

113 Introduction of pNTs in a polycation-gene complex (polyplex) enhanced the extent o

114 The polycations have been designed to contain repeated oligo

115 ylene argininylaspartate diglyceride) (PEAD) polycation, heparin, and cargo insulin-like growth facto

116 ing an injectable polyvalent coacervate of a polycation, heparin, and fibroblast growth factor-2 (FGF

117 siRNA into a core-membrane structured lipid-polycation-hyaluronic acid (LPH) nanoparticle for system

118 -directed RNA polymerization is sensitive to polycation identity, with polydiallyldimethylammonium ch

119 atechol-functionalized weak polyanion with a polycation in dimethyl sulphoxide (DMSO), the solution w

120 block copolymer of polyethylene glycol and a polycation in solvents of different polarity.

121 lar uptake and mitochondrial accumulation of polycations in melanoma cells compared with epidermal me

122 impairs activation by metal ions and organic polycations in the presence of NPS 568 but not the syner

123 Combining both photoreactive and inert polycations in the same film yielded additional control

124 activity in vivo based on its requirement of polycations in vitro.

125 in is induced to form bundles by a number of polycations including divalent metal ions, Co(NH3)63+, a

126 Thus certain polycations, including polyhistidine and wall glycoprote

127 views of the structures that are formed when polycations interact with lipid membranes that will be i

128 ine, spermidine, and spermine, are essential polycations, intimately involved in the regulation of ce

129 amine to eliminate addition of the indicator polycation into the sample.

130 A, immune-stimulatory RNA, and biodegradable polycations into the immune-cell-rich epidermis, using m

131 These polycations introduced little change in DNA superhelicit

132 nly interact with DNA phosphate groups, with polycation intrusion into the major and minor grooves de

133 Biogenic polyamines are small organic polycations involving in a variety of biological process

134 A threshold concentration of polycation is required to form lateral aggregates of act

135 ions of the 14-3-3 isoforms in regulation by polycations is not clear.

136 Surprisingly, optical response toward polycations is shown to result from the extraction of th

137 ments of polyanions and their attractions to polycations, is even more pronounced in the calculated c

138 In the presence of DEAE-dextran, the polycation known to enhance HIV-1 infectivity in cell cu

139 oped polyanionic SPAN layer, grown on a 2-nm polycation layer, was conductive between about 0.1 and -

140 id of a poly(allylamine hydrochloride) (PAH) polycation layer.

141 y, we developed tetraethylenepentamine-based polycation liposomes (TEPA-PCL) as a vector for the deli

142 med complex, the charged amine groups of the polycation mainly interact with DNA phosphate groups, wi

143 Beyond the classical single coating with polycations, many other different coating designs have b

144 ption of certain amine side chain-containing polycations may become continuous, i.e., asymptotically

145 polyamine disulfides as preferred agents for polycation-mediated controlled condensation and function

146 vidence supports a role for proteoglycans in polycation-mediated gene delivery.

147 is needed for understanding and controlling polycation-membrane interactions, yet such information i

148 branes that will be important for predicting polycation-membrane interactions.

149 they substantiate the use of polycation/PEG-polycation mixtures for facile product evaluation in ord

150 We have examined the effect of covalent polycation modification with lipophobic and hydrophobic

151 Pyrene removal by polycation-montmorillonite (MMT) composites and granulat

152 tocols for the synthesis of the microbicidal polycation N,N-dodecyl,methyl-polyethylenimine and coati

153 Here we report the engineering of PLGA-polycation nanoparticles with a core-shell structure tha

154 e nanosphere complexes contain multiple PLGA-polycation nanoparticles, surrounded by large amounts of

155 The polycation neomycin (250-500 microM) reduced the PIP(2)-

156 n of D4938 and D4945 was confirmed using the polycation neomycin.

157 role for head group charge was supported by polycations (neomycin, spermine, and polylysine) reversi

158 of the zinc finger structures, NC acts as a polycation, neutralizing the highly negative phosphodies

159 rtunity to expand this new class of group IV polycations, obtained by peroxide reactivity and ligatio

160 e attractive force between dsDNA mediated by polycations of valence >/= 3.

161 scine, spermidine, and spermine are abundant polycations of vital importance in mammalian cells.

162 ts toward heparin (polyanion) and protamine (polycation) of at least 1 order of magnitude (to 0.01 un

163 The delivery of nucleic acids with polycations offers tremendous potential for developing h

164 by sequentially chemisorbing polyanions and polycations on miniature (5 x 10(-4) cm2) enzyme electro

165 deposit alternating layers of polyanions and polycations on the surface surrounding the core of conde

166 Electrostatic binding of polycations or basic polypeptides to the DNA phosphate b

167 Yet the counterions for these polycations or polyanions are often ignored, even though

168 targeting, and they substantiate the use of polycation/PEG-polycation mixtures for facile product ev

169 294002 stimulated TRPC6 activity, as did the polycation PIP(2) scavenger poly-L-lysine.

170 lfonate), PSS, to layer alternately with the polycation poly(allyamine hydrochloride), PAH, is shown

171 nanoparticles (DNPs) functionalized with the polycation poly(allylamine HCl) in a manner that depends

172 The osmium bipyridil redox relay sites on polycation poly(allylamine) backbone efficiently work as

173 mproved by a coating of alternated shells of polycation poly(diallyldimethylammonium chloride) and of

174 he cross-linked polyion complex of SOD1 with polycation poly(ethylene glycol) (PEG)-polylysine (singl

175 ofmeister series of counterions for a common polycation, poly(diallyldimethylammonium), enthalpy chan

176 romising DNA vector candidates, and a second polycation, poly-L-lysine, are compared.

177 hway for symmetric polyelectrolyte mixtures: polycation-polyanion complexation and polyion pair-pair

178 Polycation/polyanion pairs are tested for coacervation,

179 d virus, as for virus used alone or with the polycation Polybrene, showed first-order dependence on v

180 spectrographic graphite electrodes with the polycation polyethyleneimine (PEI) prior to adsorption o

181 we developed a novel formulation between the polycation polyethyleneimine and DNA that mediates high-

182 n using a sample probe surface modified by a polycation (polyethylenimine or poly(acrylic acid) compl

183 However, another polycation, polyhistidine, strongly promoted RG-II dimer

184 In contrast, polycations (polylysine and polyethylenimine) and low-mo

185 , spermine (Spm) and spermidine, are organic polycations present in millimolar concentrations in all

186 While ion-selective electrodes for the polycation protamine have been reported, for instance, a

187 The polycations protect pDNA against nuclease degradation, w

188 Calcium/polycation receptor proteins (CaRs) enable cells in the

189 hing of the formal charge of a photoreactive polycation resulted in repulsive interlayer electrostati

190 nium linkers (represented by g) provides the polycation ribonucleic guanidine (RNG).

191 lamine), poly(lysine), and poly(arginine) in polycation/RNA coacervates.

192 coating (painting) of glass slides with this polycation's butanol solution are described.

193 -angle neutron scattering profiles where the polycation scattering length density is matched to that

194 ppropriate current pulse is applied across a polycation-selective polymer membrane to induce a strong

195 A polycation-sensitive membrane electrode based on the ion

196 decrease in the potentiometric response of a polycation-sensitive membrane electrode toward protamine

197 e potentiometric response characteristics of polycation-sensitive membrane electrodes toward two clas

198 It is further shown that the rotating polycation sensor can be used as an end-point detector t

199 d delivery vectors such as polycation/DNA or polycation/siRNA complexes (polyplexes) will be facilita

200 physicochemical properties of self-assembled polycation/siRNA nanoparticles affect their IP delivery

201 etal in both the presence and absence of the polycation spermine.

202 lent metals (Mg(2+), Gd(3+)) and the organic polycations spermine and poly-l-Arginine.

203 The effects of Mg2+ and the polycations spermine and spermidine are partially additi

204 ot seem to involve intracellular Mg2+ or the polycations spermine and spermidine.

205 ese oligopeptides as well as another type of polycation, spermine, shifted the equilibrium toward H-D

206 Polycations such as polylysine, polyarginine, histone H1

207 s exhibit sensitive colorimetric response to polycations such as protamine but not to small inorganic

208 Small polycations such as spermine and a cationic decapeptide

209 Here we show that synthetic polycations, such as polyethylenimines and poly(l-lysine

210 to the skin and hair; this process produces polycation-surfactant anion coacervates that entrain the

211 Similarly, organic polycations synergistically activate T903-Rhoc with di-

212 delivery platform is presented, in which the polycation synthesis and pDNA complexation occur in situ

213 o this targeting agent, polyethyleneimine (a polycation that binds DNA and enhances transfection) was

214 Polyamines are small organic polycations that are absolutely required for cell growth

215 Polyamines are small organic polycations that are essential for DNA replication, tran

216 Polyamines are tightly regulated polycations that are essential for life.

217 Polyamines are small, organic polycations that are ubiquitous and essential to all for

218 ch as spermidine and spermine are primordial polycations that are ubiquitously present in the three d

219 ly(ethylenimine) (PEI) is one of a number of polycations that has been used successfully to transfer

220 he allosteric modulators NPS 568 and organic polycations that may play important roles in the regulat

221 rst incorporated into a polyion complex with polycation, then coated by anionic block copolymer, PEG-

222 livery system uses a cyclodextrin-containing polycation to bind and protect siRNA and transferrin as

223 The ability of the polycation to effectively neutralize the charge of the D

224 art of a gate that opens with the binding of polycations to loop 8.

225 that uses a linear, cyclodextrin-containing polycation, transferrin (Tf) protein targeting ligand, a

226 ide polyionic clusters that include aluminum polycations, transition-metal polyoxometalates, and the

227 nical shortcomings, we developed a synthetic polycation, Universal Heparin Reversal Agent (UHRA), whi

228 Indeed, the polycation used to counteract heparin-associated bleedin

229 neimine (PEI) represents a family of organic polycations used as nucleic acid transfection reagents i

230 ltiple passages, a degradable version of the polycation was observed to make E. coli cells more susce

231 Using a model polycation, we conducted molecular dynamics simulations

232 tly functionalized with a representative BCN polycation were also able to repetitively kill bacteria

233 Bicyclo[3.3.1]nonane (BCN) polycations were synthesized by the reaction of the biva

234 er a thousand combinations of polyanions and polycations were tested to search for new polymer candid

235 e surface occurs only on the addition of the polycation, whereas PSS merely compensates the PDADMAC.

236 Polycations, which enhance the infectivity of several ot

237 amino groups of 2-kDa PEI yields a nontoxic polycation whose transfection efficiency in the presence