ライフサイエンスコーパス: polycationic

1 We synthesized first- and second-generation polycationic adamantane-based dendrons via a combined pr

2 toplasm susceptible to massive adsorption of polycationic agents once penetration of the membranes oc

3 y potentiate the actions of Ca(2+) and other polycationic agonists on the T903-Rhoc receptor.

4 ic strength could modulate CaR activation by polycationic agonists.

5 o potentially modulate CaR activation by its polycationic agonists.

6 nes putrescine, spermidine, and spermine are polycationic alkylamines commonly found in all living ce

7 Polyamines are small polycationic alkylamines involved in many fundamental ce

8 required stereoelectronic arrangement of the polycationic amines and their basicity requirements to f

9 We subsequently used a polycationic amino acid compound, poly(L-lysine), to con

10 eotides via a new delivery system based on a polycationic amphipathic polymer, PS980.

11 s polypseudorotaxanes with cellulose and its polycationic analogue chitosan.

12 ) because cleavage of the linker between the polycationic and polyanionic domains, typically by a pro

13 tals, we are now targeting complexes bearing polycationic antimony-based Z-type ligands.

14 The polycationic arginine peptide was engineered into the A1

15 otonated at neutrality because of the nearby polycationic backbone.

16 Herein, a novel series of multivalent polycationic beta-cyclodextrin "click clusters" with dis

17 The best small ligands for the polycationic binding site were Lys-Lys and Lys4.

18 ibits PC binding, suggesting that the PC and polycationic binding sites do not overlap.

19 Polyamines (PAs) are ubiquitous, polycationic biogenic amines that are implicated in many

20 A direct ionotropic gelation of the polycationic biopolymer chitosan (CHIT) with the polyani

21 These polycationic blockers traverse a long (>70 A) pore, disp

22 nanoparticles functionalized with synthetic polycationic branched polyethylenimine macromolecules.

23 EVI enhances viral infection by serving as a polycationic bridge that neutralizes the negative charge

24 system composed of polyethylenimine (PEI) as polycationic carrier, transferrin (Tf) as targeting liga

25 n single-molecule trap that fully confines a polycationic carrier-bound amino acid inside the sensing

26 aerolysin nanopore with the help of a short polycationic carrier.

27 (ACPPs), in which the fluorescently labeled, polycationic cell-penetrating peptide (CPP) is coupled v

28 nic acid-containing cleavable linker between polycationic cell-penetrating peptide and polyanionic fr

29 The adhesion strength was modulated by polycationic chain length, electrical stimulation time,

30 The polycationic character of pcPNA pairs, carrying the dupl

31 tained with a photoimmunoconjugate bearing a polycationic charge, mice were treated 3 h after i.v. in

32 vercome by pre-treatment of samples with the polycationic chitosan that was able to agglomerate all n

33 tions, was reduced by surface-coating with a polycationic chitosan-derivative.

34 veal that, upon contact with the hydrophobic polycationic coating, influenza viruses (including patho

35 ed using lipofection, electroporation, and a polycationic compound.

36 competitive blockers (GYKI 53655, SYM 2206), polycationic compounds (spermine, Naspm, philanthotoxin)

37 study, we examined a novel class of nontoxic polycationic compounds initially designed as universal h

38 ve membrane electrodes toward two classes of polycationic dendrimers are examined.

39 Some polycationic dendritic systems, such as the commercially

40 emonstrate how a newly synthesized series of polycationic dendron-MWNT constructs with a precisely ta

41 the design and synthesis of a novel type of polycationic dendrons that are able to penetrate into ce

42 Among non-viral systems, the polycationic derivatives are the most popular gene carri

43 Our experiments suggest that the polycationic domain of PDE6 gamma containing these two p

44 PDE alpha subunit that binds to the central polycationic domain of Pgamma.

45 The effect of polycationic DOSPA:DOPE was dependent upon the viral env

46 iation between the polyanionic DNA helix and polycationic dye stacks.

47 n intact platelets, PIP2 acts as a target of polycationic effectors, including Ca(2+), to promote PS

48 First a polycationic electron-conducting redox polymer is cross-

49 Polycationic enzyme mimics provide not only a hydrophobi

50 elucidate the short- and long-term effect of polycationic factors on the chondrogenesis of MSC and AC

51 e-rich protamine substrate, yielding smaller polycationic fragments that are not sensed by the electr

52 m exploration of the previously investigated polycationic geminoids 4-6.

53 Other degradable polycationic gene carriers such as polyamidoamines (PAA)

54 ass of 25 kDa (PEI25, one of the most potent polycationic gene delivery vectors) with alanine nearly

55 ng the complexation, targeting and uptake of polycationic gene delivery vectors, the molecular mechan

56 s perhaps most prevalent in current nonviral polycationic gene-delivery systems in which the polycati

57 ient than the 25-kDa PEI, one of the premier polycationic gene-delivery vectors.

58 ooptodes either selective for calcium or the polycationic heparin antidote protamine.

59 These results suggest that the polycationic HYDRAmers are potentially interesting as ne

60 Destabilization of immune complexes using polycationic inhibitors might also find a role in manage

61 ign of and manipulation with the DNA-binding polycationic ligands in general and PNA-based drugs in p

62 is RNA site an accommodating target for such polycationic ligands.

63 These vehicles include polyamines, polycationic lipids, and neutral polymers, capable of co

64 In conclusion, polycationic liposome-mediated EC-SOD gene delivery prot

65 Our previous study demonstrated that polycationic liposomes are highly stable in the bloodstr

66 rapeutic efficacy of EC-SOD gene delivery by polycationic liposomes was determined against the toxici

67 Polycationic macrocycles are attractive as they display

68 We present herein the development of novel polycationic macrocycles by introducing organoboronium m

69 Although diverse polycationic macrocycles have been developed, those base

70 EC-SOD has a polycationic matrix-binding domain that binds to polyani

71 to exchange the anionic biopolymer from the polycationic moiety.

72 We present herein the development of a new polycationic molecular receptor, inspired by the ubiquit

73 n, we present a new family of self-assembled polycationic molecular rectangles, derived from our prev

74 Polyamines are biogenic polycationic molecules involved in key cellular function

75 ould be inhibited by biocompatible synthetic polycationic molecules shown previously to dissociate UF

76 Polyamines are polycationic molecules that are crucial in a wide array

77 scine, spermidine, and cadaverine are small, polycationic molecules that are required for optimal gro

78 Polyamines are polycationic molecules with a hydrocarbon backbone and m

79 Polyamines are small polycationic molecules with flexible carbon chains that

80 CaR agonists are polycationic molecules, and charged residues in the extr

81 CaR agonists are polycationic molecules, and our previous studies suggest

82 The confluence of properties imparted by the polycationic MOP architecture and plug-and-play CB[n] co

83 condensation is mediated by TDG's disordered polycationic N-terminal domain, whereas its C-terminal d

84 by electrostatic interactions, and that the polycationic nature of calponin is primarily responsible

85 n of the excellent dispersing properties and polycationic nature of polyhistidine, the stability of t

86 ycationic gene-delivery systems in which the polycationic nature of the delivery system can lead to c

87 tatic attraction between polyanionic RNA and polycationic NCp7 eliminated this immobilization.

88 The mechanism by which the polycationic neomycin enters specific eukaryotic cell ty

89 n are detected using protamine and synthetic polycationic oligopeptides that possess specific cleavag

90 production of a series of positively charged polycationic open-shell cyclophanes.

91 As there is no difference when a polycationic or a polyanionic electrolyte is used to dir

92 ilica spheres through the incorporation of a polycationic peptide (derived from the C. fusiformis sil

93 In this study, we used a membrane-permeant polycationic peptide (RhB-QRLFQVKGRR), derived from the

94 colistin (polymyxin E) and polymyxin B, two polycationic peptide antimicrobial agents, against multi

95 .e., polyanionic pentasaccharide Arixtra and polycationic peptide protamine, to yield the membrane pe

96 Paenilamicins are a group of complex polycationic peptide secondary metabolites with antibact

97 The free energies of binding for polycationic peptide-oligonucleotides were enhanced comp

98 tic polycationic peptides as well as natural polycationic peptides (e.g., protamine) that lack specif

99 med electrostatic interactions between these polycationic peptides and the polyanionic N terminus of

100 Other synthetic polycationic peptides as well as natural polycationic pe

101 gest that the high concentration of adsorbed polycationic peptides forms a dense network of noncovale

102 Following the identification of polycationic peptides from the diatom Cylindrotheca fusi

103 ymer membrane to induce a strong flux of the polycationic peptides from the sample phase into the org

104 The results suggest two design criteria for polycationic peptides that efficiently kill gram-negativ

105 ay be compromised by the general capacity of polycationic peptides to activate mast cell secretion.

106 activities (trypsin and plasmin) that cleave polycationic peptides/proteins such as protamine into sm

107 therapy (PDT) targeted bacteria, by use of a polycationic photosensitizer conjugate, which is designe

108 To understand the role of polycationic PLL in the cellular uptake of bCD-PLL conju

109 We found that a polycationic polyelectrolyte can penetrate through the A

110 this submission we report that biotinylated polycationic polymer can penetrate through the Au overla

111 enhanced dramatically in the presence of the polycationic polymer Polybrene or when centrifugal force

112 the most active precursor to SEVI, and other polycationic polymers to investigate the physical mechan

113 ron-emitting neutral copolymer micelles into polycationic polymers, which are then internalized and r

114 The rational design of PEGylated polycationic PPH integrates the non-ionic nature, inertn

115 particles were prepared from a biodegradable polycationic prodrug, named DSS-BEN, which was synthesiz

116 Furthermore, the polycationic properties of PolyMet permits capture of si

117 We present herein the synthesis of a new polycationic pseudo[1]rotaxane, self-assembled in excell

118 Polycationic PxB binds to anionic vesicles.

119 Yet, traditional polyanionic and polycationic receptors often face performance limitation

120 verrucaria, a polyanion at pH >4.1, and the polycationic redox copolymer of polyacrylamide and poly

121 g electrodes on which an electron-conducting polycationic redox polymer and avidin were coelectrodepo

122 on increases with the surface density of the polycationic redox polymer, its practicality depends on

123 , in which one photoprobe was located in the polycationic region and the other in the C terminus.

124 asymmetry of interaction between the Pgamma polycationic region and the Palphabeta subunits was obse

125 terminal 1-45 segment containing the central polycationic region binds to G alpha t's alpha 3 helix a

126 ically labeled Pgamma identified the central polycationic region of Pgamma interacting with the GAFb

127 results suggest that a direct binding of the polycationic region of Pgamma to the GAFa domains of PDE

128 excitable peptide probe corresponding to the polycationic region of Pgamma, Pgamma-21-45, was specifi

129 The polycationic region of Pgamma, Pgamma-24-45, was mainly

130 and site-directed mutagenesis of the Pgamma polycationic region to identify residues required for th

131 he interaction with Palphabeta are a central polycationic region, Pgamma-24-45, and a C-terminal regi

132 er role of Pgamma has been attributed to its polycationic region.

133 e sequence, PHGGGWGQ, that is flanked by two polycationic residue clusters.

134 cific electrostatic interactions mediated by polycationic residues.

135 A series of "viologen" based dendrimers with polycationic scaffold carrying 10, 18, 26, 42, and 90 ch

136 e, and the docking studies indicate that the polycationic segment of PF4 readily accommodates two Fab

137 pling may provide a promising alternative to polycationic sequences as a means for rendering peptides

138 y sensing macromolecular protamine and other polycationic species are described.

139 reviously reported polyP inhibitors based on polycationic substances, such as polyethylenimine, polya

140 method is based on utilizing a protamine (a polycationic substrate for trypsin-like proteinases)-sen

141 force (EMF) responses toward these and other polycationic substrates at microgram/milliliter levels u

142 The use of patterned, polycationic surfaces also shows great promise for selec

143 thermore, we present a systematic summary of polycationic systems, with an emphasis on their electroc

144 step in translocation and suggests that the polycationic tag binds to a different site.

145 high PF4 affinity, RVT1 readily binds other polycationic targets, indicating a polyreactive nature o

146 e designed oligoanionic molecular sliders on polycationic tracks that exploit Brownian motion and dif

147 The polycationic tracts may bind to anionic sites at the cel

148 Fusion of these polycationic tracts to the amino terminus of the enzymic

149 udy is to present protocols using SPIO and a polycationic transfection agent for magnetic labeling of

150 arged nucleic acids are often complexed with polycationic transfection agents before delivery.

151 derophoric, aminoglycosidic, amphoteric, and polycationic vectors are discussed.

152 Nevertheless, polycationic vectors are often associated with potential

153 the cytoplasmic interactome associated with polycationic vectors based on poly(dimethylaminoethyl me

154 Many synthetic polycationic vectors for non-viral gene delivery show hi

155 factors that may underly a broader impact of polycationic vectors on translation.

156 pointing in this series, aminoglycosidic and polycationic vectors were able for the first time to ach

157 on the long-term transfection efficiency of polycationic vectors.

158 and 9e were the most effective and promising polycationic vehicles to be further optimized for future