ライフサイエンスコーパス: polycistronic

1 tails, and the fact that the messages can be polycistronic.

2 The late mRNAs of simian virus 40 (SV40) are polycistronic.

3 Bacterial and viral mRNAs are often polycistronic.

4 d that the ahpCF genes were transcribed as a polycistronic 2.4-kb mRNA and that ahpC also was present

5 A) against ctfB (the second CoAT gene on the polycistronic aad-ctfA-ctfB message) was used in order t

6 of inwardly rectifying potassium channels in polycistronic adenoviral vectors.

7 n of protein-coding genes in trypanosomes is polycistronic and gene expression is primarily regulated

8 present evidence for the production of both polycistronic and monocistronic transcripts from A. cart

9 We have additionally characterised polycistronic and monocistronic transcripts from two pla

10 The polycistronic and non-canonical gene tarsal-less encodes

11 anisms because they exhibit almost exclusive polycistronic, and unregulated, transcription.

12 The polycistronic approach enables efficient construction an

13 6 is conserved across fungi and reflects the polycistronic arginine operon in prokaryotes.

14 parasites where genes are co-transcribed in polycistronic arrays but not necessarily co-regulated.

15 The active VSG is transcribed from 1 of 15 polycistronic bloodstream-form VSG expression sites (ESs

16 Our strategy employed a polycistronic cassette containing a non-fused GFP protei

17 red for the translation of internal genes in polycistronic chloroplast mRNAs.

18 gulated miRNA transcripts, including a large polycistronic cluster of brain-specific miRNAs, are DNA-

19 We demonstrate that a polycistronic cluster of engineered synthetic small RNAs

20 We recently demonstrated that a polycistronic cluster of miRNAs, miR-17-92, is oncogenic

21 However, miR-17~92 is a polycistronic cluster that encodes microRNAs (miRNAs) be

22 ein-coding genes into long, strand-specific, polycistronic clusters and lack of general transcription

23 genes are organized into large (>100-300 kb) polycistronic clusters of adjacent genes on the same DNA

24 anscribed at an equivalent rate within large polycistronic clusters.

25 cripts carrying subsets of miRNAs encoded by polycistronic clusters.

26 to HCV genes delivered intramuscularly as a polycistronic construct capsid/E1/E2/NS2/NS3 (pRC/C-NS3)

27 eprogramming factors are carried on a single polycistronic construct, the mice can be easily maintain

28 Polycistronic copies of multiple p28 genes were not dete

29 Bacterial chromosomes are organized into polycistronic cotranscribed operons, but the evolutionar

30 characterized the site of termination of the polycistronic distal gene transcript beyond the D-loop r

31 , we propose a model in which both mono- and polycistronic ESs are controlled by a similar mechanism

32 ases upstream of the vsg, in contrast to the polycistronic ESs in which the promoters are located 45-

33 Here, we show that it is possible to drive polycistronic expression from a single pol III promoter

34 -cleaving" peptides, which support efficient polycistronic expression from a single promoter.

35 sociated proteins (NAPs), possibly through a polycistronic expression of a clustered group of genes.

36 n (VSG) genes found adjacent to telomeres in polycistronic expression sites (ESs).

37 malian genes for which there is evidence for polycistronic expression via translation through an inte

38 , subsequent transcription into the opposing polycistronic gene cluster does not lead to downregulati

39 Strain DHT3 genome contains a polycistronic gene cluster, emtABCD, differentially tran

40 rimarily organized into two large convergent polycistronic gene clusters (i.e. transcribed from the t

41 s in transcription termination at the end of polycistronic gene clusters and the generation of antise

42 reduction of base J at specific sites within polycistronic gene clusters in L. major leads to read th

43 n termination and expression of genes within polycistronic gene clusters in trypanosomatids.

44 ever, the loss of J at specific sites within polycistronic gene clusters led to altered transcription

45 'divergent junction' region between the two polycistronic gene clusters may be a candidate for an or

46 genomes of kinetoplastids are organized into polycistronic gene clusters that are flanked by the modi

47 s of Trypanosoma cruzi are arranged in large polycistronic gene clusters transcribed by polymerase II

48 in-coding genes organized into two divergent polycistronic gene clusters with the mRNAs transcribed t

49 ating transcriptional uncoupling of genes in polycistronic gene clusters.

50 oteome of about 6200 genes in large syntenic polycistronic gene clusters.

51 and gene expression at specific sites within polycistronic gene clusters.

52 tegy to produce numerous gRNAs from a single polycistronic gene.

53 Identification of additional polycistronic genes may provide new insights into diseas

54 Polycistronic genes were annotated in the same manner wi

55 gradual recognition that a growing number of polycistronic genes, originally discovered in viruses, a

56 ng complexes associate preferentially with a polycistronic gRNA over non-processed RNAs.

57 I are gRNA processing complexes that cleave polycistronic gRNA transcripts into monocistrons.

58 followed by reprogramming with loxP-flanked polycistronic (human Oct4, Klf4, Sox2, and c-Myc) STEMCC

59 HI had a 20-fold higher transcription of the polycistronic hydrogenase mRNA encoding SHI, and the spe

60 Although primary transcripts are polycistronic in the mitochondria of Trypanosoma brucei,

61 the generation of human iPSCs using a single polycistronic lentiviral vector (pLM-fSV2A) coexpressing

62 actors FOXA3, GATA4, HNF1A, and HNF4A from a polycistronic lentiviral vector converts mouse myofibrob

63 NF1A), MODY5 (HNF1B), and MODY8 (CEL) with a polycistronic lentiviral vector expressing a Cre-excisab

64 system for the rapid engineering of complex polycistronic lentiviruses, allowing combinatorial gene

65 The Drosophila let-7-Complex (let-7-C) is a polycistronic locus encoding three ancient microRNAs: le

66 opposing functions encoded by genes within a polycistronic locus of the human cytomegalovirus (HCMV)

67 n signal and studied first in the context of polycistronic luciferase reporter constructs.

68 e mce1 genes can be transcribed as a 13-gene polycistronic message encompassing Rv0166 to Rv0178.

69 iptase PCR analysis, we have found that this polycistronic message extends downstream of prgH to incl

70 plementary to the mgtC portion of the mgtCBR polycistronic message from Salmonella enterica.

71 of Pig, pigA-O, are transcribed as a single polycistronic message in an N-AHL-dependent manner.

72 Furthermore, invA was cotranscribed in a polycistronic message with rrp, a gene encoding the resp

73 gene of R. rickettsii is cotranscribed in a polycistronic message with the putative nuoF (encoding N

74 in the coding region of the first gene of a polycistronic message, manXYZ.

75 nscribed as a large ( approximately 16.7-kb) polycistronic message.

76 s that the operon is transcribed as a single polycistronic message.

77 Although a few examples exist, the use of polycistronic messages in mammalian cells is not widely

78 rnative splicing, alternative translation of polycistronic messages is a mechanism to generate protei

79 nd significantly higher folding potential in polycistronic messages than in monocistronic messages in

80 Many viral mRNAs encode polycistronic messages where programmed -1 ribosomal fra

81 To identify other polycistronic messages, we carried out genome-wide ribos

82 ion, including alternative monocistronic and polycistronic messages.

83 tion from the second open reading frame of a polycistronic messenger RNA, which would not be translat

84 a means of regulating protein synthesis on a polycistronic messenger RNA.

85 ning at least 19 genes distributed over four polycistronic messenger RNAs, appears to be regulated by

86 miR-17 approximately 92 is a polycistronic microRNA (miR) cluster (consisting of miR-

87 Polycistronic microRNA (miRNA) clusters are a common fea

88 The polycistronic miR-183/96/182 cluster is preferentially a

89 erized by high expression of miRNAs from the polycistronic miR17-92 cluster and its paralogs, miR-106

90 genome-wide view of how the components of a polycistronic miRNA cluster affect gene expression in vi

91 fferential expression characteristic of many polycistronic miRNA clusters.

92 The structural complexity of mir-17-92 as a polycistronic miRNA oncogene, along with the complex mod

93 pt produces one protein, mir-17-92 encodes a polycistronic miRNA transcript that yields six individua

94 nucleotide modifications after release from polycistronic mitochondrial RNA precursors, which is ess

95 ts dynamic regulation, and its impact on the polycistronic mitochondrial transcript processing.

96 3'-Extended forms of this mRNA, including a polycistronic mRNA ADI1-YMR010W mRNA, also accumulate in

97 We also identified a polycistronic mRNA for RID-alpha and RID-beta.

98 This polycistronic mRNA is induced by paraquat in a wild-type

99 under the control of a single promoter to a polycistronic mRNA molecule, and the operon's gene produ

100 ated roles and are transcribed into a single polycistronic mRNA molecule.

101 sly, we have shown that MSP2 is encoded on a polycistronic mRNA transcript in erythrocyte stages of A

102 . pyogenes, mutS and mutL are organized on a polycistronic mRNA under control of a common promoter.

103 lated as a downstream gene from the ORF35-37 polycistronic mRNA via a unique mechanism involving shor

104 In this experiment a long polycistronic mRNA was sampled repeatedly.

105 different heterologous operons revealed that polycistronic mRNA was the predominant transcript produc

106 of the Gr64 gene family are transcribed as a polycistronic mRNA, providing a mechanism for the coexpr

107 he ompB promoter and transcribed as a single polycistronic mRNA, the expression of envZ is known to b

108 Despite being part of the same polycistronic mRNA, the relative levels of transcription

109 tical protein) and RT0216 (TolC) as a single polycistronic mRNA.

110 t the remaining hut genes are expressed as a polycistronic mRNA.

111 hort intergenic region, and transcribed as a polycistronic mRNA.

112 anscription of both pvuIIC and pvuIIR into a polycistronic mRNA.

113 otein of A. marginale, MSP2, is encoded on a polycistronic mRNA.

114 crete open reading frames (ORFs) in a single polycistronic mRNA.

115 onfirmed that M2-1 enhances the synthesis of polycistronic mRNAs and that the magnitude of this effec

116 of translational control in prokaryotes, but polycistronic mRNAs are not usable (and usually not prod

117 ene expression of single genes or even large polycistronic mRNAs as a function of environmental chang

118 ctural outcome, not unlike operons and their polycistronic mRNAs do in prokaryotic organisms.

119 iral mRNA and suggests a widespread role for polycistronic mRNAs in the innate immune system.

120 internal translational initiation on latent polycistronic mRNAs is the principal source of v-FLIP in

121 ulosomal cbpA gene cluster is transcribed as polycistronic mRNAs of 8 and 12 kb.

122 Genes are transcribed as polycistronic mRNAs that are dissected by the concerted

123 codon readthrough, 125 new candidate ORFs of polycistronic mRNAs, and several candidate translational

124 that enables predictable protein output from polycistronic mRNAs, expanding the toolkit of plant synt

125 f adjacent genes co-transcribed on bacterial polycistronic mRNAs, translation of the first coding reg

126 The synthesis of polycistronic mRNAs, which presumably involves antitermi

127 relies on the plastid's ability to translate polycistronic mRNAs.

128 to express more than one protein from bi- or polycistronic mRNAs.

129 their structural and enzymatic proteins from polycistronic mRNAs.

130 t this approach can also be used to regulate polycistronic mRNAs; such regulation has rarely been ach

131 titatively monitored via direct injection of polycistronic MuLE lentiviruses into mouse tissues.

132 s have garnered increased interest for their polycistronic nature, small size and high "cleavage" eff

133 adigm whereby the unique gene structure of a polycistronic oncomir confers an intricate balance betwe

134 mir-17-92, a potent polycistronic oncomir, encodes six mature miRNAs with co

135 termined that fhuD and fhuG are members of a polycistronic operon comprised of four genes, fhuCDBG, t

136 secreted Esp molecules are part of a fourth polycistronic operon designated LEE4.

137 ding 203 aa and was transcribed as part of a polycistronic operon, consisting of orfY-fumC-orfX-sodA.

138 ducreyi flp gene cluster was likely to be a polycistronic operon.

139 atelet binding locus consists of an apparent polycistronic operon.

140 some, they can be monocistronic or part of a polycistronic operon.

141 ified pathway for the maturation of tRNAs in polycistronic operons (valV valW and leuQ leuP leuV) whe

142 c island was found to be organized into five polycistronic operons along with eight individual genes

143 Genes were divided into putatively polycistronic operons and those predicted to be monocist

144 secretion system are transcribed from three polycistronic operons designated LEE1, LEE2 and LEE3.

145 etected overrepresented uPSS and iPSS in the polycistronic operons encoding ribosomal proteins, and t

146 about 864 monocistronic transcripts and 533 polycistronic operons from the protein-encoding genes in

147 Efficient transcription of long polycistronic operons in bacteria frequently relies on a

148 rtance in post-transcriptional regulation of polycistronic operons in Escherichia coli, little is kno

149 Thus, the four polycistronic operons of the LEE that encode type III se

150 ator), which activates expression of several polycistronic operons within the 35.6-kb LEE pathogenici

151 The LEE is comprised of multiple polycistronic operons, most of which are controlled by t

152 lytic activity starts the processing of both polycistronic operons, such as glyW cysT leuZ, argX hisR

153 5' UTR and a long 3' UTR similar to those of polycistronic ORF60 and ORF62.

154 as a decrease in polysome association of the polycistronic petA mRNA in the DeltapetB and DeltapetD m

155 the entire HCV protein coding genome in two polycistronic plasmids encoding HCV capsid-E1-E2-NS2-NS3

156 tobacco plants transformed with a prototype polycistronic plastid vector, pPRV110L, designed to expr

157 onreplicating canarypox booster encoding HCV polycistronic pRC/C-NS3 genes appears to diversify and e

158 r results indicate that mice that received a polycistronic pRC/C-NS3 with canarypox booster had enhan

159 ated multigene transcription units, in which polycistronic pre-messenger RNA (pre-mRNA coding for mul

160 promoter upstream of another gene creates a polycistronic pre-mRNA that receives SL2, whereas transc

161 pecificity information is encoded within the polycistronic pre-mRNA, and that trans-splicing specific

162 ocessing of a heat shock-induced gpd-2-gpd-3 polycistronic pre-mRNA.

163 lates E6 and E7 expression of the early E6E7 polycistronic pre-mRNA.

164 In Caenorhabditis elegans, polycistronic pre-mRNAs are processed by cleavage and po

165 tion and trans-splicing in the processing of polycistronic pre-mRNAs from C. elegans operons.

166 Polycistronic pre-mRNAs from Caenorhabditis elegans are

167 rhabditis elegans operons are transcribed as polycistronic pre-mRNAs in which downstream gene product

168 ated in downstream positioned genes in these polycistronic pre-mRNAs is critical for their expression

169 8 encodes two major (one early and one late) polycistronic pre-mRNAs that are regulated by alternativ

170 gulated by alternative RNA splicing of viral polycistronic pre-mRNAs to produce a repertoire of viral

171 of genes that are co-transcribed to produce polycistronic pre-mRNAs, is a trait found in a wide rang

172 chosen C. elegans operons are transcribed as polycistronic pre-mRNAs.

173 C/D and box H/ACA) and are transcribed as a polycistronic pre-snoRNA transcript from an upstream pro

174 deficiency resulted in reduced abundance of polycistronic precursor transcripts and mature counterpa

175 ex that cleaves the 5' ends of mt-tRNAs from polycistronic precursor transcripts.

176 t-transcriptionally processed from a stable, polycistronic precursor.

177 sm in dinoflagellate chloroplasts where long polycistronic precursors are processed to form mature tr

178 tes trans-splicing of spliced leader (SL) to polycistronic precursors conveys a hypermethylated cap 4

179 (small nucleolar RNAs) that are excised from polycistronic precursors or from mRNA introns is also a

180 are valine and lysine tRNAs encoded by three polycistronic precursors that follow a recently discover

181 pping transcripts derived by processing from polycistronic precursors.

182 endogenous miRNA-17-92 cluster to generate a polycistronic primary miRNA that is processed into five

183 together with 11 mRNAs and 2 rRNAs from long polycistronic primary transcripts with almost no spacers

184 of these potential enoplean operons confers polycistronic processing activity when expressed as part

185 The virus displayed increased levels of polycistronic readthrough mRNAs resulting from failure o

186 length mRNAs as well as for the synthesis of polycistronic readthrough mRNAs, which are characteristi

187 ulted in decreased production of the related polycistronic readthrough mRNAs, which normally arise du

188 e strain with a single copy of an inducible, polycistronic reprogramming cassette, allowing for the i

189 f hematopoietic stem cells transduced with a polycistronic retrovirus expressing both human ferrochel

190 Polycistronic rgg-gtfG as well as rgg- and gtfG-specific

191 We also define a class of short, polycistronic ribosome-associated coding RNAs (sprcRNAs)

192 ter-driven transcription, with the resultant polycistronic RNA being processed (5' and 3') and excise

193 tionation assays, which allowed detection of polycistronic RNA in lower fractions of the sucrose grad

194 to be sites of translation from the CaMV 35S polycistronic RNA intermediate, the precise role of thes

195 l as overlapping transcripts and alternative polycistronic RNA molecules.

196 ice variants, as well as between overlapping polycistronic RNA molecules.

197 r (SL) upstream of protein-coding regions in polycistronic RNA precursors through trans splicing.

198 criptional and involves the orchestration of polycistronic RNA processing, 3'-terminal maturation, RN

199 Consistent with the mechanism of polycistronic RNA resolution in other nematodes, the mRN

200 is transcribed from both strands, producing polycistronic RNA species that are immediately processed

201 expressed through alternative splicing of a polycistronic RNA to yield four major splice isoforms (E

202 ly transcribed from both strands, generating polycistronic RNA units that are processed and matured.

203 uster are transcribed in an unusual way as a polycistronic RNA.

204 tion between genes prevents the formation of polycistronic RNAs and anti-sense RNAs, which are genera

205 liced leader RNAs, and we are able to detect polycistronic RNAs derived from these operons.

206 As a result, the polycistronic rpsL-bmpD mRNA level increased from 3 to 1

207 I catalyzes several processing events of the polycistronic rRNA precursor.

208 The processing of the initial polycistronic rRNA transcript is also a conserved proces

209 To produce mature ribosomal RNAs (rRNAs), polycistronic rRNA transcripts are cleaved in an ordered

210 protein was shown to bind monocistronic and polycistronic RS virus mRNAs during infection.

211 Among these, we identified a polycistronic, sensory organ-specific paralogous miRNA c

212 dification sites, initial gene organization (polycistronic, single gene and intronic) and the number

213 The polycistronic structure of mRNAs is an important aspect

214 iguity with other dap genes, suggestive of a polycistronic structure.

215 NAs generated from a cluster of tRNA-related polycistronic structures located at the left end of the

216 The UL138 transcripts are polycistronic, such that each transcript expresses pUL13

217 ook advantage of the inherent feature of the polycistronic system and generated all possible combinat

218 Finally, we developed a polycistronic system to simultaneously express multiple

219 he coordination of multiple events including polycistronic transcript cleavage, polyadenylation, RNA

220 gene, mille-pattes, that encodes an unusual polycistronic transcript predicted to produce four conse

221 aseZ activity display impaired mitochondrial polycistronic transcript processing, increased reactive

222 mitochondrial transcript abundance and also polycistronic transcript processing.

223 rious stages of mt-RNA metabolism, including polycistronic transcript production, its processing into

224 Our results demonstrate how a variable polycistronic transcript provides an evolutionary altern

225 ing of these different snoRNAs from the same polycistronic transcript suggests that the processing ma

226 ly downstream of the fatA gene, is part of a polycistronic transcript that also includes the iron tra

227 ual genes are regulated from a mitochondrial polycistronic transcript to have variable expression rem

228 s of a synthetic miRNA can be expressed in a polycistronic transcript to increase the inhibition of a

229 or the expression of an approximately 200-kb polycistronic transcript within the imprinted Dlk1-Dio3

230 pri-miR-100, the first miRNA in this let-7-C polycistronic transcript, leads to enhanced miRNA proces

231 Mir-17-92 encodes 6 miRNAs inside a single polycistronic transcript, the proper expression of which

232 n the expression of multiple products from a polycistronic transcript, under the control of a single

233 ich HER2 and Cre are expressed from a single polycistronic transcript, we showed that palpable tumor

234 on morphogenesis are expressed from the same polycistronic transcript.

235 cifically cleaving stem-loop segments of its polycistronic transcript.

236 nannotated short ORFs as the first gene of a polycistronic transcript.

237 etabolism is non-conventional exemplified by polycistronic transcription and mRNA processing by trans

238 ms for control of gene expression, including polycistronic transcription and trans-splicing.

239 Trypanosomatids utilise polycistronic transcription for production of the vast m

240 ssion sites" (ESs), each of which contains a polycistronic transcription unit that includes ES-associ

241 of base J at regions flanking polymerase II polycistronic transcription units (Pol II PTUs) througho

242 In Trypanosoma brucei, genes are arranged in Polycistronic Transcription Units (PTUs), which are dema

243 , the fractionation behavior of ribosomes in polycistronic transcription units encoding both membrane

244 The long polycistronic transcription units of trypanosomes do not

245 BESs are polycistronic transcription units, containing a variety

246 ol II) in Trypanosoma brucei are arranged in polycistronic transcription units.

247 ssion because their genome is organized into polycistronic transcription units.

248 found no evidence to support the proposal of polycistronic transcription, including a marked underrep

249 osomatids, eukaryotic parasites that perform polycistronic transcription, this phenomenon and its con

250 features of kinetoplastid biology, including polycistronic transcription, trans-splicing, and a glyco

251 an organism with widespread and constitutive polycistronic transcription.

252 As a polycistronic transcriptional unit of one or more adjace

253 reading frames MPN140 to MPN142 constitute a polycistronic transcriptional unit.

254 hat the ery gene cluster contains four major polycistronic transcriptional units, the largest one ext

255 f all seven valine tRNAs from three distinct polycistronic transcripts (valV valW, valU valX valY lys

256 on impaired mitochondrial RNA processing and polycistronic transcripts accumulated.

257 , which cause quantitative variation between polycistronic transcripts and accumulation of transcript

258 ed polynucleotide tails in the rpsJ and rpsM polycistronic transcripts and the lpp monocistronic tran

259 he processing intermediates of mitochondrial polycistronic transcripts and their products including t

260 organized in operons that are coexpressed as polycistronic transcripts and then often are processed f

261 Polycistronic transcripts are common in prokaryotes but

262 In animals, protein-coding polycistronic transcripts are rare.

263 'UTRs has identified several bicistronic and polycistronic transcripts as the novel targets of viral

264 ed transcripts in A. carterae, and show that polycistronic transcripts can be terminally polyuridylyl

265 Polycistronic transcripts from such operons are trans-sp

266 ere identified by their inability to silence polycistronic transcripts in enhanced RNAi (Eri) mutant

267 siae are consistent with the near absence of polycistronic transcripts in eukaryotes.

268 of the 5' proximal genes of bicistronic and polycistronic transcripts offer additional regulatory ta

269 Trans-splicing of trypanosomatid polycistronic transcripts produces polyadenylated monoci

270 The UL138 polycistronic transcripts serve to coordinate the expres

271 leuU and metT leuW glnU glnW metU glnV glnX polycistronic transcripts takes place through a differen

272 ssential initial cleavages by RNase E within polycistronic transcripts to generate pre-tRNAs that sub

273 sion of functionally related genes as single polycistronic transcripts.

274 NAs that are likely to be encoded as part of polycistronic transcripts.

275 s and encodes many genes with bicistronic or polycistronic transcripts.

276 s locus involves both classical and atypical polycistronic transcripts.

277 snoRNAs processed from pre-mRNA introns and polycistronic transcripts.

278 were identified; four of these would produce polycistronic transcripts.

279 onally related proteins encoded by bacterial polycistronic transcripts.

280 transcription terminators for both mono- and polycistronic transcripts.

281 by which RNase P processes the valU and lysT polycistronic transcripts.

282 r role in the processing of all three valine polycistronic transcripts.

283 3'UTRs has revealed abundant bicistronic and polycistronic transcripts.

284 ime that the processing of RNase P-dependent polycistronic tRNA operons to release pre-tRNAs is the e

285 report that the 3'ETS of the glyW-cysT-leuZ polycistronic tRNA precursor is highly and specifically

286 r the processing and maturation of mono- and polycistronic tRNA precursors in Escherichia coli involv

287 In Escherichia coli, processing of polycistronic tRNA precursors involves separation into i

288 unnecessary for the initial cleavage of some polycistronic tRNA precursors.

289 However, recently we identified two polycistronic tRNA transcripts whose endonucleolytic pro

290 NAs that target different genomic sites, the polycistronic tRNA-gRNA gene (PTG) strategy enables mult

291 Murid herpesvirus 4 (MuHV-4) contains eight polycistronic tRNA-microRNA encoded RNA (TMER) genes tha

292 J) is present within sequences flanking the polycistronic units (PTUs) in T. cruzi.

293 RNA genes or as gene clusters transcribed as polycistronic units.

294 CRISPR-associated (Cas) proteins on a single polycistronic vector and the guide RNA (gRNA) on a separ

295 ased on this analysis, we developed a single polycistronic vector encoding the five pentamer genes se

296 Using a polycistronic vector we misexpress Pdx1, Ngn3, and MafA

297 n keratinocytes, demonstrating that a single polycistronic virus can reprogram human somatic cells.

298 Inclusion of Mycn and Meis1 and use of polycistronic viruses increase reprogramming efficacy.

299 he procyclic stage, in contrast to the known polycistronic vsg ESs which undergo abortive transcripti

300 Chromosomal norD expression is polycistronic with the upstream oligopeptide permease ge