ライフサイエンスコーパス: polycytidylic acid

1 ith TLR ligands (Pam3CSK4, LPS, polyinosinic-polycytidylic acid).

2 ced by a synthetic viral mimic, polyinosinic-polycytidylic acid.

3 ulthood to the immune stimulant polyinosinic-polycytidylic acid.

4 inducing viral infections or by polyinosinic:polycytidylic acid.

5 llowing brief pretreatment with polyinosinic:polycytidylic acid.

6 tivation with the TLR3 agonist, polyinosinic:polycytidylic acid.

7 by TNF, lipopolysaccharide and polyinosinic-polycytidylic acid.

8 s by both transfected PRNAs and polyinosinic-polycytidylic acid.

9 n of low doses of a TLR ligand, polyinosinic-polycytidylic acid.

10 eally at gestational day 9 with polyinosinic:polycytidylic acid.

11 opolysaccharide, IFN-gamma, and polyinosinic-polycytidylic acid.

12 h an analogous acycloguanosine derivative on polycytidylic acid.

13 by lipopolysaccharide (LPS) or polyinosinic:polycytidylic acid.

14 ic cells upon inducing Cre with polyinosinic-polycytidylic acid.

15 eurospheres to the viral mimic, polyinosinic:polycytidylic acid.

16 etic MDA5 agonist/(ds)RNA mimic polyinosinic-polycytidylic acid.

17 ogether with anti-CD40 mAbs and polyinosinic-polycytidylic acid.

18 tar Furth) strains induced with polyinosinic:polycytidylic acid.

19 mplex following stimulation with polyinosine-polycytidylic acid.

20 cells following activation with polyinosinic-polycytidylic acid.

21 in response to the viral mimic, polyinosinic:polycytidylic acid.

22 with LPS (a bacterial mimic) or polyinosinic-polycytidylic acid (a viral mimic), M-TRAF3(-/-) mice ex

23 study that TLR3 stimulation by polyinosinic-polycytidylic acid, a double-stranded RNA analog, suppre

24 n response to the dsRNA agonist polyinosinic-polycytidylic acid, a subset of which were modestly regu

25 study, we describe a model of polyinosinic: polycytidylic acid-accelerated lupus nephritis in NZB/W

26 Polyinosinic-polycytidylic acid activated IFN regulatory factor 3 dim

27 50 nucleotides long as well as polyinosinic-polycytidylic acid activated the RNA-dependent protein k

28 diminished the cytotoxicity of polyinosinic-polycytidylic acid-activated natural killer cells agains

29 ty as well as an enhancement of polyinosinic-polycytidylic acid activation of TLR3.

30 iciency in activation following polyinosinic:polycytidylic acid administration in vivo.

31 We found that polyinosinic:polycytidylic acid, aka poly(I:C), exposure induced a sw

32 analogue of viral nucleic acid, polyinosinic-polycytidylic acid, also induced IL-6-dependent glucocor

33 velop IDDM after treatment with polyinosinic:polycytidylic acid and a cytotoxic anti-RT6.1 monoclonal

34 WAG-rnu/rnu rats treated with polyinosinic: polycytidylic acid and a monoclonal antibody to preclude

35 th a peptide subunit mixed with polyinosinic-polycytidylic acid and agonistic anti-CD40 mAb.

36 e diabetes after treatment with polyinosinic:polycytidylic acid and an antibody that depletes ART2(+)

37 ated ex vivo with TLR agonists, polyinosinic-polycytidylic acid and CpG, to prime naive CD4 T cells i

38 ly be induced by treatment with polyinosinic:polycytidylic acid and depletion of RT6+ T-cells.

39 one marrow with the viral mimic polyinosinic:polycytidylic acid and found a significant reduction of

40 We found that TLR3-ligand polyinosinic-polycytidylic acid and human rhinovirus infection induce

41 The synthetic dsRNA analog polyinosinic-polycytidylic acid and infection with live virus were us

42 inflammatory stimuli, including polyinosinic polycytidylic acid and LPS.

43 immunostimulatory nucleic acid polyinosinic:polycytidylic acid and UV light irradiation, linking RNa

44 epitope M282-90, a TLR agonist (polyinosinic-polycytidylic acid), and a costimulatory anti-CD40 Ab.

45 rs upon in vivo activation with polyinosinic:polycytidylic acid, and have poor survival in ex vivo cy

46 on treatment with LPS, E. coli, polyinosinic:polycytidylic acid, and herring sperm DNA.

47 Sendai virus, the dsRNA mimetic polyinosinic-polycytidylic acid, and LPS all activated differentiatio

48 In vivo administration of CpG, polyinosinic-polycytidylic acid, and Pam(3)CSK(4) in combination with

49 ed by crude LPS, peptidoglycan, polyinosinic:polycytidylic acid, and rIFN-gamma in cell lines and pri

50 vaccine with the TLR3 agonist, polyinosinic-polycytidylic acid, and TLR9 agonist, CpG, reduced tumor

51 ral double-stranded RNA (dsRNA) polyinosinic-polycytidylic acid, and type-II interferon-gamma (IFNgam

52 inflammation induced by HDM and polyinosinic-polycytidylic acid, APOE reached a concentration of 32 n

53 odified form of the viral mimic polyinosinic:polycytidylic acid at the end of the first trimester.

54 odified form of the viral mimic polyinosinic:polycytidylic acid at the end of the first trimester.

55 rs of IFN-lambda in response to polyinosinic-polycytidylic acid but are similar to CD1c(+) DC in thei

56 ) DC were strongly activated by polyinosinic-polycytidylic acid but not LPS, and conversely for MoDC.

57 e synthetic double-stranded RNA polyinosinic-polycytidylic acid causes a PPI deficit in the offspring

58 Prenatal exposure to polyinosinic:polycytidylic acid causes an imbalanced expression of th

59 Downregulation upon polyinosinic-polycytidylic acid challenge and expression by crypt cel

60 FN-alpha/beta induced by either polyinosinic-polycytidylic acid complex or by lymphocytic choriomenin

61 -exposed mice intranasally with polyinosinic-polycytidylic acid condensed with poly-l-lysine and carb

62 We demonstrated that polyinosinic:polycytidylic acid consistently up-regulated both B7-2 a

63 ated with lipopolysaccharide or polyinosinic-polycytidylic acid coordinate with constitutively active

64 d the interferon-inducing agent polyinosinic:polycytidylic acid did not induce allograft rejection, s

65 We have recently shown that the polycytidylic acid-directed polymerization of guanosine

66 to the viral mimetic poly I:C (polyinosinic:polycytidylic acid) either on gestational day 9 (early)

67 ycoloyl glycerol liposomes with polyinosinic:polycytidylic acid electrostatically adsorbed to the sur

68 sure to the viral-like adjuvant polyinosinic:polycytidylic acid enhanced anti-FVIII antibody formatio

69 Rather, polyinosinic:polycytidylic acid exposure activates ISGs, and this sti

70 etic resonance (NMR) evidence suggested that polycytidylic acid forms a left-handed helix.

71 le- and single-stranded polynucleotides, but polycytidylic acid greatly enhances activity and also pr

72 with the IFN-alpha/beta inducer polyinosine polycytidylic acid (hereafter 'poly(I:C)') inhibited egr

73 peptide-, double-stranded RNA (polyinosinic-polycytidylic acid)-, HIV-1 Tat-, 1-methyl-4-phenylpyrid

74 ed in macrophages after LPS and polyinosinic:polycytidylic acid in vitro.

75 Treatment of BAFF-RFP mice with polyinosinic:polycytidylic acid increased BAFF expression in splenic

76 ipopeptide-2, or a TLR3 ligand, polyinosinic-polycytidylic acid, increased Cox-2 mRNA and protein and

77 IV-1 Tat, and viral dsRNA mimic polyinosinic-polycytidylic acid, indicating the specificity of the ef

78 tivation by TLR ligands LPS and polyinosinic-polycytidylic acid induced a time-dependent increase of

79 tural killer cell activation by polyinosinic-polycytidylic acid induced cell death to activated hepat

80 Notably, polyinosinic:polycytidylic acid induced nuclear localization of iNOS,

81 In contrast, a synthetic dsRNA, polyinosinic polycytidylic-acid, induced CD11c(+) DC, but not pre-DC2

82 ere markedly less responsive to polyinosinic-polycytidylic acid-induced acute proliferative signals.

83 Polyinosinic-polycytidylic acid-induced antiviral genes were identifi

84 HDM-SLIT resulted in increased polyinosinic:polycytidylic acid-induced expression of IFN-beta at bot

85 nthetic dsRNA-based viral mimic polyinosinic:polycytidylic acid-induced expression of proinflammatory

86 tion receptors was required for polyinosinic-polycytidylic acid-induced IFN-alpha/beta production and

87 Compound II inhibited polyinosinic-polycytidylic acid-induced immune activation in vitro an

88 rtantly, we discovered that the polyinosinic-polycytidylic acid-induced increase in production of IFN

89 e transfused in the presence of polyinosinic:polycytidylic acid-induced inflammation.

90 D138N are resistant to TNF- and polyinosinic-polycytidylic acid-induced necroptosis in vitro, and Rip

91 A defect in polyinosinic-polycytidylic acid-induced TLR3 responses can be detecte

92 rophages; however, priming with polyinosinic-polycytidylic acid induces it and confers needle protein

93 ad, challenge of TM with LPS or polyinosinic-polycytidylic acid induces MAPK, AP-1, and CREB signalin

94 ng anti-CD40 Ab and TLR3 ligand polyinosinic-polycytidylic acid induces protective responses against

95 we show that TLR3 activation by polyinosinic:polycytidylic acid induces up-regulation of microRNA-29b

96 mmatory cytokines in response to polyinosine-polycytidylic acid, influenza A, and reovirus.

97 s infection or after repetitive polyinosinic-polycytidylic acid injection.

98 adult mice that received daily polyinosinic-polycytidylic acid injections, but not in adult mice sub

99 ection of lipopolysaccharide or polyinosinic:polycytidylic acid into mice, mimicking bacterial and vi

100 to respond to stimulation with polyinosinic:polycytidylic acid is abolished when its interaction wit

101 activation (MIA) model in which polyinosinic:polycytidylic acid is injected into pregnant mice, we de

102 TLR3 activation with polyinosinic-polycytidylic acid led to comparable or even higher cyto

103 Treatment with CVB3 and polyinosinic:polycytidylic acid led to higher IFNbeta expression in P

104 with the virus/bacteria mimics polyinosinic:polycytidylic acid/lipopolysaccharide.

105 controls using the viral ligand polyinosinic-polycytidylic acid-low-molecular-weight/LyoVec and LPS t

106 s to stimulation with Pam3CSK4, polyinosinic-polycytidylic acid, LPS, and ODN2006, respectively.

107 cer cells, we demonstrated that polyinosinic:polycytidylic acid-mediated activation of TLR3 induces m

108 y sensitizes cells to cytosolic polyinosinic/polycytidylic acid-mediated induction of type I IFN.

109 ten allograft survival, whereas polyinosinic:polycytidylic acid mediates its effects through a TLR3-i

110 -dependent, m-3M3FBS-activated, polyinosinic:polycytidylic acid-modulated inflammasome driving interl

111 e observed protective effect of polyinosinic-polycytidylic acid on liver fibrosis was diminished thro

112 Treatment with polyinosinic-polycytidylic acid or a combination of monosodium urate

113 and then exposed them to either polyinosinic:polycytidylic acid or a diabetogenic virus to induce dia

114 following the administration of polyinosinic:polycytidylic acid or allogeneic cells (graft versus hos

115 n induced by LPS, as opposed to polyinosinic:polycytidylic acid or cytosine-phosphate-guanine, is rob

116 iet and in mice given low-level polyinosinic:polycytidylic acid or dextran sodium sulfate to induce c

117 eventing PKR phosphorylation by polyinosinic:polycytidylic acid or HIV trans-activation response elem

118 DCs stimulated by polyinosinic acid-polycytidylic acid or IFN-beta, another known inducer of

119 Moreover, treatment with polyinosinic-polycytidylic acid or interferon gamma enhanced the cyto

120 after TLR stimulation with polyinosinic acid-polycytidylic acid or LPS underwent apoptosis, which was

121 sociated Ag upon stimulation by polyinosinic-polycytidylic acid or R848, likewise to what was reporte

122 temically with the TLR3 agonist polyinosinic:polycytidylic acid or were given subcutaneously, activat

123 ning adapter inducing IFN-beta (polyinosinic-polycytidylic acid) or MyD88 (imiquimod), demonstrating

124 engagement of either the TLR3 (polyinosinic-polycytidylic acid) or TLR4 (LPS) receptor.

125 In the absence of polyinosinic:polycytidylic acid, or in the presence of antagonists of

126 t and double-stranded RNA mimic polyinosinic-polycytidylic acid, or poly(I:C), impacted growth in ute

127 infection, cellular exposure to polyinosinic-polycytidylic acid, or TBK1 overexpression.

128 ameliorate lipopolysaccharide, polyinosinic:polycytidylic acid, or tripalmitoyl-S-glyceryl cysteine-

129 phage-activating lipopeptide-2, polyinosinic-polycytidylic acid, or UVB (15 mJ/cm(2)), but it did not

130 mmunogenic tumors, the adjuvant polyinosinic-polycytidylic acid overcomes this failure following radi

131 We show that IFN-alpha and polyinosinic:polycytidylic acid (p-I:C) synergize with the "classical

132 D4(+) T cell epitopes with polyinosinic acid:polycytidylic acid (pI:C) preferentially elicited tumor

133 uction of LMP7 by a low dose of polyinosinic:polycytidylic acid (PI:C) reduced RV-mediated inflammati

134 on with the Th1-biased adjuvant polyinosinic:polycytidylic acid (pI:C).

135 was induced in C57BL/6 mice by polyinosinic-polycytidylic acid (PIC) injected during embryonic days

136 ula Yeast RNA (TYRNA)(640 nm), polyinosinic: polycytidylic acid (pIC)(680 nm), or splice switching ol

137 whether retinoic acid (RA) and polyinosinic:polycytidylic acid (PIC), an inducer of interferons, can

138 eta-cells partially counteracts polyinosinic-polycytidylic acid (PIC)-induced STAT1 and proinflammato

139 Among the compounds tested, polyinosinic:polycytidylic acid (PIC, a Toll-like receptor 3 agonist)

140 Polyinosine-polycytidylic acid [pIC] is a synthetic dsRNA that acts

141 exhibited impaired responses to polyinosine-polycytidylic acid (pIpC) and reduced production of infl

142 ed a MIA rodent model in which polyinosinic: polycytidylic acid (poly (I:C)) was injected into pregna

143 thetic double stranded (ds) RNA polyinosinic-polycytidylic acid (poly (I:C)) widely, but transiently,

144 noviocytes were stimulated with polyinosinic-polycytidylic acid (poly [I-C]) after transfection with

145 (multiplicity of infection 5), polyinosinic:polycytidylic acid (poly I:C) 30 mug/ml, IFN-beta 10 mug

146 double-stranded (ds)RNA mimic, Poly Inosinic-polycytidylic acid (Poly I:C) indicating defective dsRNA

147 Here, by using the polyinosinic-polycytidylic acid (Poly I:C) model of gestational infec

148 reated timed-pregnant mice with polyinosinic:polycytidylic acid (Poly I:C) on gestational day 12.5 to

149 on induced by the viral mimetic polyinosinic:polycytidylic acid (poly I:C) on gestational day 15 of r

150 ate the effect of TLR-3 agonist polyinosinic:polycytidylic acid (Poly I:C) on the expression of infla

151 of TLR3 by the synthetic ligand polyinosine:polycytidylic acid (poly I:C) or by mRNA rapidly causes

152 Polyinosinic-polycytidylic acid (Poly I:C) or IFN-gamma treatment inh

153 Polyinosinic-polycytidylic acid (poly I:C) or IFN-gamma treatment inh

154 We investigated the role of polyriboinosinic:polycytidylic acid (poly I:C), a replication-competent v

155 Polyinosinic:polycytidylic acid (poly I:C), a synthetic analog of dou

156 p diabetes after treatment with polyinosinic:polycytidylic acid (poly I:C), a synthetic double-strand

157 strocyte primary cultures using polyinosinic-polycytidylic acid (poly I:C), a synthetic ds-RNA molecu

158 determines fever severity using polyinosinic:polycytidylic acid (poly I:C), a synthetic form of doubl

159 timulate fish systemically with polyinosinic:polycytidylic acid (poly I:C), a synthetic viral mimic,

160 Polyinosinic-polycytidylic acid (poly I:C), a TLR3 ligand, is current

161 ysaccharide, a TLR4 ligand; and polyinosinic:polycytidylic acid (poly I:C), a TLR3 ligand; but not li

162 prime T cells: the TLR3 ligand, polyinosinic:polycytidylic acid (poly I:C), and immunostimulatory com

163 reated timed-pregnant mice with polyinosinic:polycytidylic acid (Poly I:C), which simulates a viral i

164 t with the synthetic TLR3 ligand polyinosine-polycytidylic acid (poly I:C).

165 imulated with the synthetic RNA polyinosinic-polycytidylic acid (poly I:C).

166 virus or with the viral mimetic polyinosinic:polycytidylic acid (poly I:C).

167 cytokine induction elicited by polyinosinic:polycytidylic acid (poly I:C; a synthetic dsRNA) in mous

168 slets with dsRNA in the form of polyinosinic-polycytidylic acid (poly IC) and IFN-gamma resulted in i

169 d the effect of the TLR3 ligand polyinosinic-polycytidylic acid (poly IC) on CD8 T cell immunity and

170 The synthetic dsRNA molecule polyinosinic-polycytidylic acid (poly IC) stimulates beta-cell DNA da

171 ceptor (TLR) agonists, we found polyinosinic:polycytidylic acid (poly IC) to be the most effective ad

172 sRNA) (in the form of synthetic polyinosinic-polycytidylic acid (poly IC)) on islet expression of ind

173 f the inflammatory viral mimic, polyinosinic:polycytidylic acid (Poly IC), in the late first trimeste

174 dsRNA [polyinosinic:polycytidylic acid (poly IC)]-stimulated inducible nitri

175 cells (MASM) treated with polyinosinic acid-polycytidylic acid (poly(I,C)), a double-stranded RNA th

176 ) nanoparticles adjuvanted with polyinosinic:polycytidylic acid (poly(I:C) as an adjuvant (Vaccine-NP

177 the Toll-like receptor ligands polyinosinic-polycytidylic acid (poly(I:C)) and flagellin.

178 response to TLR3 activation by polyinosinic-polycytidylic acid (poly(I:C)) and related agonists in h

179 6J mouse dams were treated with polyinosinic-polycytidylic acid (Poly(I:C)) at embyronic day 12.5, an

180 ed RNA and the synthetic analog polyinosinic:polycytidylic acid (poly(I:C)) bind and activate TLR3.

181 ia responded to synthetic dsRNA polyinosinic-polycytidylic acid (poly(I:C)) by increasing TLR3 and IF

182 tion of macrophage responses to polyinosinic-polycytidylic acid (poly(I:C)) resulting from three inde

183 IFN-beta expression elicited by polyinosinic-polycytidylic acid (poly(I:C)) treatment or IFN-alpha be

184 imulation by the dsRNA analogue polyinosinic:polycytidylic acid (poly(I:C)) was dependent on TLR3 and

185 asts, the synthetic TLR3 ligand polyinosinic-polycytidylic acid (poly(I:C)), a dsRNA analog, caused d

186 is activated by viral dsRNA and polyinosinic-polycytidylic acid (poly(I:C)), a synthetic mimetic of v

187 Polyinosine-polycytidylic acid (poly(I:C)), a Toll-like receptor 3 (

188 Polyinosinic-polycytidylic acid (poly(I:C)), an analog of viral dsRNA

189 eceptor 3, by the viral mimetic polyinosinic-polycytidylic acid (poly(I:C)), led to disrupted materna

190 igands tested, the TLR3 ligand, polyinosinic/polycytidylic acid (Poly(I:C)), most highly increased fi

191 e induction by a viral mimetic, polyinosinic-polycytidylic acid (poly(I:C)), of the endothelial cell-

192 mice showed reduced responses to polyinosine-polycytidylic acid (poly(I:C)), resistance to the lethal

193 such as LPS, lipoteichoic acid, polyinosinic-polycytidylic acid (poly(I:C)), TNF-alpha, and type I an

194 d in the presence or absence of polyinosinic-polycytidylic acid (poly(I:C)), which elicits RLR accumu

195 or (TNF), lipopolysaccharide or polyinosinic:polycytidylic acid (poly(I:C))-induced necroptosis and i

196 Anti-CD40 also increased polyinosinic-polycytidylic acid (poly(I:C))-inducible IFN-alpha by 5-

197 s by influenza-infected DCs and polyinosinic:polycytidylic acid (poly(I:C))-treated DCs was distingui

198 ge cells stimulated with LPS or polyinosinic-polycytidylic acid (poly(I:C)).

199 ot translocate to lipid rafts by polyinosine-polycytidylic acid (poly(I:C)).

200 stimulated with the viral mimic polyinosinic:polycytidylic acid (poly(I:C)).

201 de (LPS, bacterial antigen) and polyinosinic-polycytidylic acid (poly(I:C), viral antigen) would decr

202 oli (TLR4), lipoprotein (TLR2), polyinosinic-polycytidylic acid (poly-IC) (TLR9), and their combinati

203 e responses upon challenge with polyinosinic-polycytidylic acid (poly-IC).

204 iral immune response activating polyinosinic-polycytidylic acid (poly[I:C]) completely prevented cuta

205 y i.p. injection of alphaPD-L1, polyinosinic:polycytidylic acid (poly[I:C]), or both.

206 As polyinosinic-polycytidylic acid (poly[I:C]), which mimics double-stra

207 e treated with the TLR3 agonist polyinosinic/polycytidylic acid (Poly[I:C]).

208 with the known IFN inducer polyinosinic acid-polycytidylic acid (poly[I]-poly[C]) resulted in an incr

209 at viral-like inflammation with polyinosinic polycytidylic acid [poly (I:C)] significantly enhances R

210 Polyinosinic-polycytidylic acid [Poly (I:C)], a dsRNA receptor ligand

211 nstrate for the first time that polyinosinic-polycytidylic acid [poly (I:C)], a synthetic dsRNA analo

212 synthetic double-stranded RNA (polyinosinic:polycytidylic acid [poly IC] stabilized with poly-L-lysi

213 ha/beta interferon induction by polyinosinic-polycytidylic acid [poly(I-C)] treatment efficiently eli

214 with the IFN-alpha/beta inducer polyinosinic-polycytidylic acid [poly(I-C)].

215 ycan (PGN; a TLR 2 agonist) and polyinosinic-polycytidylic acid [poly(I:C); a TLR3 agonist], modeling

216 smooth muscle cells (VSMCs) to polyinosinic:polycytidylic acid [poly(I:C)] and was necessary for inf

217 ied and cultured overnight with polyinosinic:polycytidylic acid [poly(I:C)] as a viral analog stimulu

218 MIA are induced by injecting Polyinosinic:polycytidylic acid [Poly(I:C)] at 10 mg/kg at E9.5 with

219 t CD8 T-cell function; however, polyinosinic:polycytidylic acid [poly(I:C)] can also suppress autoimm

220 e born to mothers injected with polyinosinic:polycytidylic acid [poly(I:C)] during pregnancy as a mod

221 tion induced by the viral mimic polyinosinic-polycytidylic acid [poly(I:C)] in primary human lung epi

222 like receptor 3 (TLR-3) agonist polyinosinic:polycytidylic acid [poly(I:C)] in the SN of adult rats.

223 ved either saline (control) or polyinosinic: polycytidylic acid [poly(I:C)] injections in the late fi

224 Polyinosinic-polycytidylic acid [poly(I:C)] is a known inducer of IFN

225 was to evaluate the activity of polyinosinic-polycytidylic acid [poly(I:C)] on IL-17A production by C

226 Application of polyinosinic-polycytidylic acid [poly(I:C)] or LPS induces production

227 epitopes and administration of polyinosinic-polycytidylic acid [poly(I:C)] stabilized by lysine and

228 factor 3 in response to LPS and polyinosinic-polycytidylic acid [poly(I:C)] stimulus, corroborating t

229 ) mice primed with TLR3 agonist polyinosinic:polycytidylic acid [poly(I:C)] to induce pro-caspase-11

230 TLR3 signaling through LPS and polyinosinic:polycytidylic acid [poly(I:C)] treatments resulted in ra

231 ) infection and the TLR3 ligand polyinosinic-polycytidylic acid [poly(I:C)] were used to activate inn

232 ioning with the synthetic dsRNA polyinosinic-polycytidylic acid [poly(I:C)], a mimetic of viral RNA,

233 nd was mimicked by injection of polyinosinic-polycytidylic acid [poly(I:C)], an inducer of type I int

234 stration of the synthetic dsRNA polyinosinic:polycytidylic acid [poly(I:C)], but not lipopolysacchari

235 otent inducer of IFN-alphabeta, polyinosinic-polycytidylic acid [poly(I:C)], led to the depletion of

236 ns were resiquimod (R-848) plus polyinosinic-polycytidylic acid [Poly(I:C)], R-848 plus LPS, Pam3CSK4

237 A toll-like receptor 3 agonist, polyinosinic:polycytidylic acid [poly(I:C)], was also encapsulated in

238 of cells or fish with the dsRNA polyinosinic-polycytidylic acid [poly(I:C)], which induces IFNs via t

239 tional regulator STAT3 inhibits polyinosinic:polycytidylic acid [poly(I:C)]-induced cDC1 maturation a

240 double-stranded viral RNA mimic polyinosinic:polycytidylic acid [Poly(I:C)].

241 oligonucleotide [Poly(dT)], and polyinosinic-polycytidylic acid [Poly(I:C)].

242 ide ISA51 with or without TLR3 (polyinosinic-polycytidylic acid [poly-IC]), TLR4 (monophosphoryl lipi

243 n combination, synthetic dsRNA (polyinosinic-polycytidylic acid, poly(I-C)) and interferon (IFN)-gamm

244 he previously employed adjuvant polyinosinic:polycytidylic acid, ((poly(I:C), InvivoGen, San Diego, C

245 dministered in combination with polyinosinic-polycytidylic acid-poly-I-lysine carboxymethylcellulose

246 double-stranded RNA (synthetic polyinosinic-polycytidylic acid; poly(I-C)) on macrophage expression

247 Activation of TLR3 by polyinosinic-polycytidylic acid (polyI:C) leads to induction of multi

248 ng of fetal loss in response to polyinosinic:polycytidylic acid (polyI:C), a viral mimic and an induc

249 tic double-stranded RNA ligand, polyinosinic-polycytidylic acid (polyI:C), leads to decreased acetami

250 nistering the viral dsRNA mimic polyinosinic:polycytidylic acid (PolyI:C).

251 ion (MIA) during pregnancy with polyinosinic:polycytidylic acid (polyI:C).

252 infection or viral mimic [polyinosinic acid:polycytidylic acid (polyI:C)] treatment of human colon M

253 employed the viral RNA mimetic (polyinosinic-polycytidylic acid [polyI:C]) to emulate viral infection

254 Polyinosinic-polycytidylic acid (PolyIC), a "mimic" of double-strande

255 ion and treatment of cells with polyinosinic-polycytidylic acid (polyIC; a dsRNA mimetic that acts as

256 prenatal (E12.5) injection with polyinosinic-polycytidylic acid potassium salt as a mouse MIA model,

257 as CpG oligodeoxynucleotide and polyinosinic:polycytidylic acid primarily stimulated Th1 cells.

258 crease in spleen in response to polyinosinic-polycytidylic acid-promoted hepatitis.

259 Moreover, the IFN inducer polyinosinic:polycytidylic acid promotes fetal resorption and placent

260 clusively upon stimulation with polyinosinic-polycytidylic acid, R848, and CL075 ligands.

261 changes in antivirus-associated polyinosinic:polycytidylic acid response profiles, the bacterial lipo

262 Challenge with polyinosinic-polycytidylic acid results in a rapid and strong downreg

263 nd MyD88-independent receptors (polyinosinic:polycytidylic acid signaling via TLR3 or ds break-DNA si

264 at treatment with radiation and polyinosinic-polycytidylic acid significantly expands the proportion

265 esponses via active delivery of polyinosinic-polycytidylic acid sodium salt (poly I:C) to target Toll

266 gamma, rmIFN-alpha, rmIL-4, and polyinosinic-polycytidylic acid stabilized by lysine and carboxymethy

267 very 3 weeks with intramuscular polyinosinic-polycytidylic acid stabilized by lysine and carboxymethy

268 synthetic double-stranded RNA (polyinosinic:polycytidylic acid stabilized with poly-l-lysine) during

269 synthetic double-stranded RNA (polyinosinic:polycytidylic acid stabilized with poly-L-lysine) was de

270 data indicate that CpG DNA and polyinosinic-polycytidylic acid stimulate different types of cells to

271 w trout RTG-2 and RTS-11 cells, polyinosinic-polycytidylic acid stimulation resulted in early activat

272 In contrast, polyinosinic:polycytidylic acid strongly represses CpG's as well as i

273 monomycolyl glycerol analog and polyinosinic-polycytidylic acid) that efficiently induces CD4 Th cell

274 f the inhaled viral TLR ligands polyinosinic-polycytidylic acid (TLR3) and resiquimod (TLR7/8) on sen

275 the TLR agonists LPS (TLR4) or polyinosinic:polycytidylic acid (TLR3) to mice treated with costimula

276 S (TLR4), peptidoglycan (TLR2), polyinosinic-polycytidylic acid (TLR3), CpG DNA (TLR9), and infection

277 ion, but selectively spared the polyinosinic-polycytidylic acid/TLR3 pathway.

278 cted with TLR2 (Pam3Cys), TLR3 (polyinosinic:polycytidylic acid), TLR4 (LPS), or TLR9 (CpG) agonists.

279 sis after stimulation with LPS, polyinosinic-polycytidylic acid, TNF-alpha, or IFN-beta in the presen

280 in the presence of anti-CD40 or polyinosinic:polycytidylic acid to induce DC maturation.

281 ors and innate immune activator polyinosinic:polycytidylic acid to induce endothelial cells.

282 etic double-stranded RNA analog polyinosinic:polycytidylic acid to mimic viral infection.

283 However, KCs isolated from polyinosinic:polycytidylic acid-treated mice expressed significantly

284 Polyinosinic-polycytidylic acid treatment also ameliorated liver fibr

285 Polyinosinic-polycytidylic acid treatment of RAG(-/-) mice transplant

286 ry head kidney leukocytes after polyinosinic-polycytidylic acid treatment, whereas a moderate increas

287 stress granule aggregates upon polyinosinic:polycytidylic acid treatment.

288 type mice with the IFN-I inducer polyinosine polycytidylic acid triggered HS expression at the B cell

289 in response to the viral mimic polyinosinic-polycytidylic acid using a sensitive PCR assay.

290 cytosine-phosphate-guanine, or polyinosinic:polycytidylic acid) using flow cytometry and measurement

291 DHX9 could specifically bind polyinosine-polycytidylic acid via its double-strand RNA binding mot

292 DHX15 specifically bound polyinosine-polycytidylic acid via its helicase C-terminal domain.

293 s in hDEC205 transgenic mice, if polynocinic polycytidylic acid was coadministered as an adjuvant.

294 he Toll-like receptor 3 ligand, polyinosinic-polycytidylic acid, was used to activate innate immunity

295 polyuridine) and dsRNA viruses (polyinosinic-polycytidylic acid) were significantly weaker (2- to 3-f

296 transfusions in the presence of polyinosinic:polycytidylic acid, whereas anti-hGPA levels increased i

297 leukocytes when stimulated with polyinosinic:polycytidylic acid, whereas group II IFN was up-regulate

298 infected mice with a complex of polyinosinic-polycytidylic acid with poly-L-lysine and carboxymethyl