ライフサイエンスコーパス: polyene

1 polyene, ideal polymethine, and zwitterionic polyene.

2 ission in aggregates of astaxanthin, a small polyene.

3 ctly over each face of a linear heptamethine polyene.

4 cess attractive for the synthesis of complex polyenes.

5 atalyst resulted in the formation of soluble polyenes.

6 and tandem oxidation reactions of conjugated polyenes.

7 rnation resulting from Peierls distortion in polyenes.

8 re compared to these data for cyclacenes and polyenes.

9 r systems such as donor-acceptor-substituted polyenes.

10 articularly in the construction of bioactive polyenes.

11 th the allenyne to give the cross-conjugated polyenes.

12 ion afforded functionalized cross-conjugated polyenes.

13 electrophilic addition to aromatic rings and polyenes.

14 e pigments belong to xanthomonadin-like aryl polyenes.

15 second structural modification yielded a new polyene, AM-2-19, that is renal sparing in mice and prim

16 cluster dihydrides can thus be considered as polyene analogues, or "polyboroenes".

17 on the substitution pattern of the starting polyene and could be rationalized through DFT calculatio

18 Butadiene is the simplest polyene and has long served as a model system for many c

19 Diphenylamine (DPA), a known inhibitor of polyene and isoprene biosynthesis, is shown to inhibit f

20 ic nitrogen heterocycles were prepared using polyene and polyenyne metathesis cascades.

21 e structures featured layers with all carbon polyene and polyphenylene arrays.

22 ization reactions incorporated the sensitive polyene and provided the protected roxaticin seco-acid,

23 f Ru(II)-based electron donor-acceptor (D-A) polyene and some closely related chromophores.

24 ration of a variety of (Z)-alkene-containing polyenes and application to a concise total synthesis of

25 d in previous studies of intermediate length polyenes and carotenoids.

26 ure on the radiative properties of all-trans polyenes and carotenoids.

27 nd are remarkably similar to those of simple polyenes and carotenoids.

28 Azoles, polyenes and echinocandins constitute the mainstay of an

29 icacy of other classes of drugs, such as the polyenes and echinocandins, was not affected by the pres

30 s to both of their conjugated relatives, the polyenes and polyynes.

31 ave smaller band gaps than the corresponding polyenes and triplet ground states for nine or more benz

32 reodivergent synthesis of unbranched 1,5,9,n-polyenes (and -polyynes) was investigated.

33 uce toxicity (e.g. new lipid formulations of polyenes), and new derivatives of drugs have been develo

34 ille cross-coupling reaction to assemble the polyene, and an intramolecular Horner-Wadsworth-Emmons o

35 ly for the analogues of this state in longer polyenes, and consequently studies of longer polyenes ar

36 In a second step, the effects of the polyene antibiotic MS-8209, the polyanion dextran sulfat

37 ng domain of Ncr1p conferred temperature and polyene antibiotic sensitivity without changes in sterol

38 Nystatin isolated from Streptomyces is a polyene antibiotic that is frequently used in the treatm

39 led with the fluorescent cholesterol-binding polyene antibiotic, filipin, although there are differen

40 These mutant cells are also resistant to the polyene antibiotic, nystatin.

41 In previous studies, the polyene antibiotics amphotericin B (AmB) and MS-8209 pro

42 The polyene antibiotics are the only group of antifungal ant

43 In contrast to other polyene antibiotics that form pores in the membrane, the

44 new method for studying the interactions of polyene antibiotics with sterol-containing membranes, an

45 teins is a general mode of action of all the polyene antibiotics, of which some have been shown addit

46 t cells when administering nystatin or other polyene antibiotics.

47 ction of a cholesterol-binding compound, the polyene antifungal antibiotic amphotericin B methyl este

48 2 and IZH3 gene dosage affects resistance to polyene antifungal drugs.

49 of previous efforts to develop renal-sparing polyene antifungals were misguided by the classic membra

50 rgosterol can yield potent and renal-sparing polyene antifungals.

51 y against the ergosterol-active triazole and polyene antifungals.

52 Aryl polyene (APE) pigments are a widely distributed class of

53 polyenes, and consequently studies of longer polyenes are very limited.

54 Five bivalent homodimeric polyenes based on stipiamide linked with polyethylene gl

55 A combinatorial library of polyenes, based on (-)-stipiamide, has been constructed

56 explored collection of structurally diverse, polyene-based metabolites.

57 nazole (n = 39), caspofungin (n = 16), and a polyene-based product (n = 12).

58 nt relationship to a third subfamily of aryl polyene BGCs, and together the three subfamilies represe

59 lated macrocyclic lactone (+)-aspicillin and polyene bioactive natural product beta-parinaric acid an

60 y metabolite production (colibactin and aryl polyene biosynthesis).

61 tive to its Huckel isomer is confined to the polyene bridge and is not due to a delocalized pi circui

62 on of uncorrected ISE(II) values of just the polyene bridge portion of 1 and its Huckel counterpart s

63 eous in vitro production of three octaketide polyenes by biosynthetic enzymes for the 10-membered ene

64 ssemble terpene natural products and complex polyenes by using simple modular building blocks.

65 The polyene C22 hydrocarbon chain, bearing a methoxyl group

66 The conjugated n-system in polyenes can be interrupted by electrocyclic ring-closur

67 ericyclic reactions meet again to expand the polyene-carbonyl manifold.

68 egio- and stereocontrolled catalytic radical polyene cascade cyclization from preoleanatetraene oxide

69 ared to their neutral forms as, for example, polyene cations and dyes such as indigo and the cyanines

70 static and vulnerable to resistance, whereas polyenes cause serious host toxicity.

71 roups) and into the adjoining segment of the polyene chain (at C8).

72 inding pocket are straightening of retinal's polyene chain and separation of its beta-ionone ring fro

73 he three different planes that represent the polyene chain and the beta-ionone ring of retinal.

74 -cis-retinal shows torsional twisting of the polyene chain and the beta-ionone ring.

75 steric interactions between Ala-117 and the polyene chain at the C13 position, torsion of the polyen

76 thermal reactions in which relaxation of the polyene chain back to all-trans is coupled to various ch

77 ate NMR, we were able to analyze the retinal polyene chain between positions C10 and C15 as well as t

78 yl Batho, even though the C8-hydrogen of the polyene chain cannot interact with a ring C5-methyl grou

79 s double bonds and s-cis single bonds in the polyene chain determine the topology space of the carote

80 ne chain at the C13 position, torsion of the polyene chain due to steric constraints in the binding p

81 hyl retinal, where the 9-methyl group on the polyene chain has been deleted.

82 e orientation of the beta-ionone ring to the polyene chain has both modest barrier heights and a tors

83 The polyene chain is rigidly locked into a single, twisted c

84 a twisted 6-s-cis conformation, whereas the polyene chain is twisted 12-s-trans.

85 atures central to toxin function, namely the polyene chain length.

86 orientation of the beta-ionone ring and the polyene chain of the chromophore 11-Z-retinylidene of rh

87 The other dihedral angles along the polyene chain of the chromophore, although having lower

88 The planarity of the polyene chain of the retinal chromophore in bacteriorhod

89 data indicate that the methyl groups on the polyene chain point toward the cytoplasmic side of the m

90 cient steric bulk at the terminal end of the polyene chain to mimic the trimethylcyclohexenyl ring of

91 pward movement of the C(5)-C(13) part of the polyene chain toward the cytoplasmic surface or with inc

92 ature of the analogues and the length of the polyene chain with all-trans-C17 aldehyde and all-trans-

93 olves a shift of electron density within the polyene chain, and it does not involve participation of

94 ined rotation about each bond in the retinal polyene chain, for both the protonated and deprotonated

95 and electrostatic changes along the retinal polyene chain, ionone ring, and within the binding pocke

96 beta-ionone ring can rotate relative to the polyene chain, thereby populating both positively and ne

97 ence of an electron-withdrawing group on the polyene chain, which would inhibit carbocation formation

98 -s-cis conformation between the ring and the polyene chain.

99 181, points toward the center of the retinal polyene chain.

100 ii) changes in tilt and slant of the retinal polyene chain.

101 f the beta-ionone ring or carbon C(9) of the polyene chain.

102 yl, ethyl, propyl) at the C9 position of the polyene chain.

103 hen the pulling positions are located on the polyene chain.

104 orce at the terminal ends of the interrupted polyene chain.

105 pagating away from the Schiff base along the polyene chain.

106 rotation about the long-axis of the retinal polyene chain.

107 s containing keto units positioned along the polyene chain.

108 sing number of cis and/or s-cis bonds in the polyene chain.

109 order reversal in the central portion of the polyene chain.

110 tical insight into the reactivity of cyanine polyene chains and elucidate the truncation mechanism an

111 tic electrode potential, the low affinity of polyene chains without hydrophilic groups to the substra

112 proximity and favorable geometry for the two polyene chains, but from the heptahelical crystallograph

113 garding the effects of extension of bridging polyene chains.

114 85 as a photochemical reaction pathway for a polyene chromophore imbedded in a protein binding cavity

115 and produces amphidinols, a family of polyol-polyene compounds with antifungal and antimycoplasmal ac

116 nt reaction pathway for a diene, or a longer polyene confined in a rigid (relative to isomerization r

117 By analogy to conjugated polyenes, conjugative stabilization of polyynes with the

118 t can be appended to the rest of the skipped polyene core by Wittig condensation.

119 An asymmetric polyene cyclization (92% ee) strategy has been successfu

120 Bronsted acid (chiral LBA) mediated cationic polyene cyclization and a titanocene-mediated radical cy

121 erated in 12 steps underwent a nonbiomimetic polyene cyclization mediated by ferric chloride to gener

122 systematic investigation of acetal-initiated polyene cyclization of epoxy polyenes has been conducted

123 e syntheses begin with a biomimetic cationic polyene cyclization of epoxy-polyene, yielding the natur

124 A new polyene cyclization strategy exploiting beta-ionyl deriv

125 ovel dearomatization methodology followed by polyene cyclization to access DMOA-derived meroterpenoid

126 A novel Co(II) -catalyzed polyene cyclization was developed that is uniquely effec

127 This process features a reductive radical polyene cyclization, an unprecedented oxidative Rautenst

128 biosynthetic pathways: the multibond-forming polyene cyclizations catalyzed by the yet poorly underst

129 nd 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP), polyene cyclizations using allylic alcohols as initiator

130 rpene synthesis, particularly in the area of polyene cyclizations, much remains to be learned if the

131 many reagent combinations that can initiate polyene cyclizations, simple electrophilic halogen sourc

132 ectronic factors hinder the much-anticipated polyene cyclizations.

133 Herein, we examine a series of a short-chain polyene, dithienohexatriene (DTH), with tailored materia

134 Combination lipid polyene-echinocandin therapy is the most promising of su

135 Metatricycloene is a tricyclic polyene encoded by a reductive, iterative polyketide-lik

136 itions agrees with theoretical treatments of polyene excited-state energies and is consistent with th

137 Fragmentation of polyene FAME yields major diagnostic ions resulting from

138 cell surface Y2 sites could be activated by polyene filipin III through complexing of membrane chole

139 he power of cation-initiated cyclizations of polyenes for the synthesis of polycyclic terpenoids cann

140 eck reaction for selective complex diene and polyene formation.

141 Several methods for the generation of the polyene fragment were explored, and the side-chain was u

142 cetal-initiated polyene cyclization of epoxy polyenes has been conducted using bicyclic epoxonium ion

143 se of antifungal drugs, primarily azoles and polyenes, has increased in parallel.

144 periments imply that the S1 states of longer polyenes have local energy minima, corresponding to a ra

145 resistance to the azoles, echinocandins, and polyenes have occurred in several Candida species, most

146 polymers adopt a stretched and almost planar polyene helix, where the OPE units are arranged describi

147 Polyene hydrocarbons and epoxides are used as pheromone

148 erplay of the three virtual states: nonpolar polyene, ideal polymethine, and zwitterionic polyene.

149 FR256523 are a family of potent macrocyclic polyene immunosuppressive agents with a novel mode of ac

150 ty can be used to furnish complex dienes and polyenes in good yields and excellent selectivities (gen

151 n = 2, in marked contrast to other known D-A polyenes in which beta(0) increases steadily with n.

152 0.89, 0.81.0.89; p<0.0001) with ratio of PI (polyene index) to PRs - suggesting the plausible signifi

153 leaving chemically similar sites within the polyene intact.

154 ular understanding of how Lsd18 transforms a polyene into a bisepoxide during lasalocid A biosynthesi

155 Charge is moved from the allenic side of the polyene into the furanic ring region and is accompanied

156 highly substituted and stereodefined skipped polyenes is described from the reductive cross-coupling

157 The finding that fluorescence from linear polyenes is so strongly dependent on molecular symmetry

158 plication in total synthesis, regioselective polyene isomerization, and spatiotemporal control of pre

159 oximately a 1/N dependence) to a common long polyene limit at approximately 16,000 cm(-1).

160 the Proteobacteria; their products are aryl polyenes, lipids with an aryl head group conjugated to a

161 These compounds are members of polyene macrocycles, pyrroloindole alkaloids, angucyclin

162 of a new class of bis-salicylate-containing polyene macrodiolides, which have potent antibiotic acti

163 ritical for the structure elucidation of the polyene macrolactam salinilactam A, but its structural a

164 A total synthesis of the oxo-polyene macrolide (+)-roxaticin is achieved in 20 steps

165 ues recently identified a new broad-spectrum polyene macrolide active against many fungal pathogens,

166 The total synthesis of the potent polyene macrolide antibiotic pentamycin was accomplished

167 C8 oxidation of 8-deoxyamphotericin B to the polyene macrolide antibiotic, amphotericin B.

168 Polyene macrolide antibiotics are naturally occurring an

169 n (NYT), an antifungal drug of the family of polyene macrolide antibiotics, elevated YFP expression b

170 On the other hand, natamycin, a polyene macrolide antifungal agent, exhibits strong effi

171 y will be applicable to other members of the polyene macrolide natural products.

172 ents the most concise preparation of any oxo-polyene macrolide reported to date, is achieved in the a

173 discovered selvamicin, an unusual antifungal polyene macrolide, in bacterial isolates from two neighb

174 t the opposite end of selvamicin's shortened polyene macrolide.

175 Two new polyene macrolides, marinisporolides A and B (1, 2), wer

176 to prepare polyol chains associated with the polyene macrolides.

177 Although polyenes, marinisporolides A (1) and B (2) showed weak t

178 The combination of a triazole and polyene may be antagonistic in the treatment of invasive

179 mutants abolished the production of an aryl polyene metabolite causing the yellow colony morphotype

180 tres at the central positions of the skipped polyene motif.

181 apeptide amide from an antimicrobial peptide polyene natural product and a lipopeptide, digested into

182 able for the synthesis of various unbranched polyene-natural products with 1,5,9,n-(Z)-configured dou

183 A series of cyclobutanes substituted 1,2- by polyenes of increasing radical-stabilizing power has bee

184 This paper reports the synthesis of polyene oligomers ("oligoenes") that contain up to 15 do

185 dy nonlinear photoexcitation dynamics in the polyene oligomers by using a quantum-chemical method sui

186 cal bond between the protein and the retinal polyene only slightly affected the main electron transpo

187 owever, quite different from those of either polyenes or polyynes.

188 Selective polyene oxidation provides an archetypical example of th

189 The use of cyclic polyene perimeter-model approaches, such as Gouterman's

190 mands a re-evaluation of current theories of polyene photophysics and highlights the robustness of ca

191 the first example of Type II PKS-synthesized polyene pigments and show that the metabolites serve as

192 rot feathers contain red, orange, and yellow polyene pigments called psittacofulvins.

193 Remarkably, this aryl polyene PKS complex only contains the KS (ORF17), but no

194 Finally, we incubated the polyene-PKS with the NRPS module in the presence of orni

195 Other options include combination lipid polyene plus deferasirox or posaconazole therapy.

196 sis of monensin A involves construction of a polyene polyketide backbone, subsequent epoxidation of t

197 In lasalocid A biosynthesis, a polyene polyketide intermediate is converted into a bise

198 r can provide access to other members of the polyene-polyol macrolides, including stereoisomers of RK

199 X = NO(2), CN, Cl, H, OH, NH(2); spacers R = polyene, polyyne, acene with n = 1-5 repeatable units) s

200 photochemical transformations from a common polyene precursor are described.

201 s constructed from four principal modules: a polyene precursor for carbons 3-9, and three alkyne-term

202 prepared via valence bond isomerization of a polyene precursor.

203 ules (tricyclic to pentacyclic) from achiral polyene precursors by enantioselective proton-initiated

204 ntra-thermodynamic polycyclizations of their polyene precursors.

205 Their predicted polyene product matches the proposed pre-prymnesin precu

206 ity chemical 1,3-butadiene to afford skipped polyene products is reported.

207 Alongside these two polyene products, we have additionally detected a hydroc

208 n, and acid-sensitive moieties, particularly polyenes prone to cyclization.

209 The results indicate that both ends of the polyene reversal agent are involved in Pgp interaction a

210 tivation pathway: excited-state trans-to-cis polyene rotation.

211 ring the energy change for hydrogen loss for polyene series 2 (n double bonds) with polyene series 3

212 s for polyene series 2 (n double bonds) with polyene series 3 (n double bonds), which are combined in

213 For three different polyene series, the intense, visible d-->pi* metal-to-li

214 (2)H NMR structure shows a reduction of the polyene strain, while torsional twisting of the beta-ion

215 esymmetrization of readily available achiral polyene substrates, 5,6-, 5,7-, and 5,8-bicyclic amides

216 useful site selectivities can be obtained in polyene substrates.

217 ve cation-olefin cyclization/fluorination of polyene substrates.

218 contribution of a cyclopropyl ring linked to polyene systems.

219 pids with an aryl head group conjugated to a polyene tail.

220 triphosphate (ATP), and we detected the same polyene tetramate as that in Streptomyces transformed wi

221 howed the production of HSAF analogues and a polyene tetramate intermediate.

222 e chromophores unveils a contrathermodynamic polyene that engages in a Heck bicyclization to afford [

223 alkenylidene units, giving cross-conjugated polyenes that are challenging to prepare otherwise.

224 mical methods for the preparation of skipped polyenes that contain varied stereochemistries and subst

225 Skipped polyenes (that is, 1,4-dienes and higher homologues) are

226 hydrocarbons built from geminally connected polyenes; the resulting arrangement of conjugated C=C bo

227 lective access to a diverse array of skipped polyenes through a process that establishes one C-C bond

228 rge substrate-binding pocket that allows the polyene to adopt different conformations within the enzy

229 This method converts linear polyenes to functionalized polycyclic systems bearing up

230 Polyene-type polyketides are known to be biosynthesized

231 d also becomes exergonic in all investigated polyenes under these force conditions.

232 the stabilization of conjugated ground-state polyenes vs polyynes.

233 de adenine dinucleotide phosphate (NADPH), a polyene was detected in the tryptic acyl carrier protein

234 Construction of the polyene was realized using two successive Heck couplings

235 elease HCl gas and decompose into conjugated polyenes, we envisioned a dual role for PVC plastics.

236 cture, and excited-state properties of model polyenes, we propose a molecular mechanism that accounts

237 erved for cis/trans isomerization in acyclic polyenes, which occurs via singlet diradical transition

238 gy is applicable to the synthesis of 1,5,9,n-polyenes with any possible double bond configuration acc

239 s a strategy for the synthesis of conjugated polyenes with at least one Z-configured C=C bond.

240 upted fatty acid methyl esters (NMI-FAME) of polyenes with three and more double bonds.

241 tional groups resulted in soluble telechelic polyenes with up to 20 double bonds.

242 imetic cationic polyene cyclization of epoxy-polyene, yielding the natural product beta-hydroxy-8,11,