ライフサイエンスコーパス: polyfunctional

1 d CD4(+)T cell responses that were broad and polyfunctional.

2 ition to long-lived memory cells but are not polyfunctional.

3 lls than WT mice, and these T cells are more polyfunctional.

4 c CD8 T cells, a high fraction of which were polyfunctional.

5 T cells were broadly reactive and polyfunctional.

6 C4) expression, persisted long-term and were polyfunctional.

7 nd they point to the potential importance of polyfunctional Ab responses.

8 Overall, these data show that the polyfunctional abilities of HIV-specific CD8(+) T cells

9 Our results showed that the polyfunctional abilities of HIV-specific CD8(+) T cells

10 HIV vaccine capable of eliciting V2-focused, polyfunctional Abs that effectively bind HIV and trigger

11 ion, quantification, and characterization of polyfunctional Ag-specific T cells.

12 hey are traditionally prepared by condensing polyfunctional aldehydes and amines at elevated temperat

13 erent electrophiles are possible and lead to polyfunctional amide derivatives of the biuret type whic

14 important intermediates for the synthesis of polyfunctional amino derivatives and natural products an

15 Polyfunctional analysis revealed a pattern of TNFalpha a

16 alone or with IL2, those induced by DCs are polyfunctional and coexpress IL17 and IFNgamma (Th17-1 c

17 These T cells are polyfunctional and cytotoxic and can inhibit mycobacteri

18 CD8(+) T cells, of monofunctional, polyfunctional and cytotoxic phenotypes, were also induc

19 higher frequencies of mycobacterial-specific polyfunctional and cytotoxic T cells and higher concentr

20 in the T-cell-intact SHIV-immunized animals, polyfunctional and degranulating SIV-specific CD8(+) T c

21 scent-phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotyp

22 rior driver of autoimmune processes due to a polyfunctional and high cytokine expression combined wit

23 m, the NS3-specific TCR-redirected CTLs were polyfunctional and inhibited HCV RNA replication through

24 L1 pathway dramatically reduces apoptosis of polyfunctional and interferon gamma(+)/granzyme B(-) mem

25 nates under conditions mild enough to modify polyfunctional and late-stage molecules.

26 These T cells were polyfunctional and lysed peptide-pulsed target cells in

27 CD8(+) T cells from infected mice were polyfunctional and mediated cytotoxicity.

28 Vaccine-induced T cells were polyfunctional and persisted at high frequencies for at

29 nt of new methods and strategies to assemble polyfunctional and polycyclic molecular architectures.

30 y, we found that anti-5T4 CD4(+) T-cells are polyfunctional and that their PFRs are essential for TCR

31 TriVax vaccination generated robust, polyfunctional, and protective CD8(+) T cell responses i

32 nizes the potential importance of generating polyfunctional antibodies (Abs).

33 f vaccines, including DeltagD-2, that elicit polyfunctional antibody responses.IMPORTANCE Herpes simp

34 ften the synthetic precursors of traditional polyfunctional aryl amine monomers and are more stable,

35 -dependent activation remained as potent and polyfunctional as with younger adults.

36 ion of coinhibitory molecules, and they were polyfunctional based on cytokine production.

37 infected mice, CD4 T cells are not cytokine polyfunctional, but there is a division of labor in the

38 In contrast, CMV-specific CD8(+) T cell polyfunctional capacities were similar across all memory

39 tracellular TNF-alpha, which impact on their polyfunctional capacities.

40 Thus, the polyfunctional capacity and increased survival potential

41 f Chlamydia-specific CD4 TCR-Tg T cells with polyfunctional capacity offers a powerful approach for a

42 The unique stereocontrol by the polyfunctional catalyst system is also demonstrated with

43 ticle, the development of a novel artificial polyfunctional catalyst type is described, in which an i

44 Enzymes are Nature's polyfunctional catalysts tailor-made for specific bioche

45 ne boronate ester-linked COFs from protected polyfunctional catechols and bis(boronic acids).

46 After in vitro stimulation with T27K, polyfunctional CD4 and CD8 lymphocytes of PBMC from immu

47 High-magnitude, polyfunctional CD4 and CD8(+) T cells were detected duri

48 Polyfunctional CD4 lymphocytes, defined as producing int

49 The frequency of Pf-specific polyfunctional CD4 memory T cells was associated with pr

50 The presence of mycobacterial-specific polyfunctional CD4 T cells measured by flow cytometry 10

51 response appeared to be most associated with polyfunctional CD4 T cells raised against the SseI pepti

52 s immunodominant among lipid Ags tested, and polyfunctional CD4 T cells specific for this lipid simul

53 The proportion of polyfunctional CD4 T cells was significantly higher in i

54 d for antigen presentation, the frequency of polyfunctional CD4 T lymphocytes did not significantly i

55 ne response revealed strong antigen-specific polyfunctional CD4(+) and CD8(+) T cell responses.

56 Vaccine-induced polyfunctional CD4(+) and CD8(+) T cells targeted 58 (60

57 as maintained and cure became prevalent when polyfunctional CD4(+) effector cells were prevented from

58 motherapy with cyclophosphamide gave rise to polyfunctional CD4(+) effector cells, which in turn inte

59 Among patients, a high quality, polyfunctional CD4(+) T cell response was associated wit

60 ecific T-cell response that was dominated by polyfunctional CD4(+) T cells and that targeted multiple

61 T-cell responses, including splenic and lung polyfunctional CD4(+) T cells expressing the three cytok

62 +)) with a significantly higher frequency of polyfunctional CD4(+) T cells producing IFN-gamma, TNF-a

63 nduced robust and durable response of mostly polyfunctional CD4(+) T cells, coexpressing IFN-gamma, t

64 esponses, and protection was associated with polyfunctional CD4(+) T-cell responses 2 wk after primin

65 sue of Blood, Mahnke and colleagues identify polyfunctional CD4(+) T-cell responses directed against

66 ontrast, BAL and blood mycobacteria-specific polyfunctional CD4(+) T-cell responses were impaired in

67 Rapid expansion of tuberculosis-specific polyfunctional CD4(+) T-cell responses, likely linked to

68 ted significantly greater monofunctional and polyfunctional CD4+ and CD8+ T-cell responses against in

69 binant IL-7 markedly amplified and sustained polyfunctional CD4+ effector cells, resulting in improve

70 a expression, giving rise to IL-7-responsive polyfunctional CD4+ effector cells.

71 The frequency of polyfunctional CD4+ T cells in rectal mucosa positively

72 , median vaccine-elicited influenza-specific polyfunctional CD4+ T cells were higher in recipients of

73 mean fold-increases of influenza HA-specific polyfunctional CD4+ T-cells compared to IIV3-HD or RIV4.

74 We identified multiple polyfunctional CD4-restricted T-cell epitopes within a h

75 n large responses, as did the proportions of polyfunctional CD8 (IFN-gamma(+) IL-2(+/-) TNF-alpha(+))

76 multiparameter flow cytometry revealed that polyfunctional CD8 cells were less prevalent in children

77 eath, leading to activation and expansion of polyfunctional CD8 CTLs and tumor regression.

78 asis of how alphaPD-L1 therapy reinvigorates polyfunctional CD8 response during chronic infections.

79 oid tissues as a heterogeneous population of polyfunctional CD8 T cells.

80 esponses associated with a high frequency of polyfunctional CD8 T cells.

81 lerated and induced cytomegalovirus-specific polyfunctional CD8 T-cell and neutralizing Ab responses

82 ation to the Gag vaccine insert mounted less polyfunctional CD8 T-cell responses at the protein level

83 tors and suggest the functional relevance of polyfunctional CD8(+) and CD4(+) T-lymphocyte responses.

84 e; induced CCL1 production identifies highly polyfunctional CD8(+) and CD4(+)T(M) subsets; long-term

85 individuals, the most frequent, robust, and polyfunctional CD8(+) T cell responses, as assessed by a

86 There was an increased proportion of polyfunctional CD8(+) T cells after antigen stimulation

87 ced assessment of the importance of inducing polyfunctional CD8(+) T cells by vaccination.

88 rol of viral load, and only antigen-specific polyfunctional CD8(+) T cells correlated with protection

89 CD8(+) interferon (IFN) gamma(+) T cells and polyfunctional CD8(+) T cells producing IFN-gamma, tumor

90 The generation of polyfunctional CD8(+) T cells, in response to vaccinatio

91 Polyfunctional CD8(+) T cells, producing IFN-gamma, TNF-

92 icited cellular responses were predominantly polyfunctional CD8(+) T cells.

93 gene expression and elicited high-frequency, polyfunctional CD8(+) T lymphocytes that trafficked broa

94 a synergistic effect in generating frequent polyfunctional CD8(+) T(RM) cells that infiltrated both

95 esearch revealed that VACV is able to induce polyfunctional CD8(+) T-cell responses after immunizatio

96 moDC, LC, and idDC, can prime multispecific, polyfunctional CD8(+) T-cell responses to HIV-1 and othe

97 Polyfunctional CD8(+) T-cell responses, defined as singl

98 To determine whether the presence of polyfunctional CD8+ T cell responses distinguishes prote

99 cells, directly influences the generation of polyfunctional CD8+ T cells and that the number of CD4+

100 ikewise, vaccine-elicited influenza-specific polyfunctional CD8+ T cells were higher in recipients of

101 e that was greatest in the lungs and yielded polyfunctional CD8+ T cells, including a subset that exp

102 In a recent study, we observed a dominant polyfunctional CD8+ T-cell response after natural mumps

103 For example, polyfunctional cells increased from 21 to 782 and from 1

104 In both CD8 + and CD4 + cells, polyfunctional cells with high cytotoxic potential accou

105 suggesting increased antigen sensitivity in polyfunctional cells.

106 immunology space that survey vaccine-induced polyfunctional cellular activity by flow cytometry, tran

107 ce adsorption is jointly associated with the polyfunctional character of the nanoparticles, analogous

108 dditionally, activated DN1 T cells exhibited polyfunctional characteristics, accumulated in lung gran

109 RZV induced strong humoral and polyfunctional CMI responses that persisted above pre-va

110 NA-loaded DCs would enhance the frequency of polyfunctional CMV pp65-specific CD8(+) T cells after AT

111 These increases in polyfunctional CMV-specific CD8(+) T cells correlated (R

112 Polyfunctional CMV-specific immunity was assessed by sti

113 In summary, our findings show that polyfunctional CMV-specific T cells were not superseded

114 ies of IFNgamma(+), TNFalpha(+), and CCL3(+) polyfunctional, CMV-specific CD8(+) T cells.

115 t efficiently and stereoselectively generate polyfunctional compounds.

116 transformations essential to building their polyfunctional cores can be achieved, and (4) that a sin

117 l loads (VLs) harbored higher frequencies of polyfunctional CXCR5+ SIV-specific CD8+ T cells in vario

118 zyme-linked immunosorbent spot (ELISpot) and polyfunctional cytokine assays.

119 e but were still capable of antigen-specific polyfunctional cytokine expression and cytotoxicity in r

120 t Lys27 and, consequently, stimulated T cell polyfunctional cytokine expression and promoted their su

121 CD14(hi) monocytes exhibited the most polyfunctional cytokine expression patterns, with more t

122 Twp CD8(+) T cells showed impaired polyfunctional cytokine production, whereas cytotoxicity

123 Trm cells must initiate a rapidly diffusing, polyfunctional cytokine response with activation of byst

124 + effector frequencies, immunodominance, and polyfunctional cytokine responses predominating in the l

125 Gag-specific CD4(+) and CD8(+) T lymphocyte polyfunctional cytokine responses were more robust in mi

126 derate IL-17 and affect differentiation into polyfunctional cytokine-producing cells.

127 e vaccine mixture improves the generation of polyfunctional cytolytic CD8(+) T cell responses as char

128 A wide range of polyfunctional diaryl- and diheteroarylzinc species were

129 toward the ex vivo quantification of T cell polyfunctional diversity via the simultaneous measuremen

130 y are the DNA end binding protein Ku and the polyfunctional DNA ligase LigD.

131 and sulfoxide functionalities in protonated polyfunctional drug metabolites.

132 ative set of 17 organozinc pivalates with 18 polyfunctional druglike electrophiles (informers) in Neg

133 -type response, and it tended to become less polyfunctional during the course of this transition.

134 ody to OX40 strongly enhanced development of polyfunctional effector CD8 T cells that were induced af

135 individuals, the most frequent, robust, and polyfunctional effector CD8(+) T cell responses, as asse

136 mory phenotype as well as characteristics of polyfunctional effector cells such us IFN-gamma and TNF-

137 and from chronic hepatitis B patients became polyfunctional effector cells when grafted with HBV-spec

138 tigen-specific Teff:Treg ratios and inducing polyfunctional effector cells.

139 of vaccine recipients) and were mediated by polyfunctional effector memory CD4(+) T cells, with the

140 lly derived help, this population acquired a polyfunctional effector phenotype and antitumor immunity

141 3 costimulation results in a more robust and polyfunctional effector response to TCR signals, compare

142 Tumor-infiltrating Th17 cells exhibit a polyfunctional effector T-cell phenotype, are positively

143 bjects maintained high levels of humoral and polyfunctional effector/memory CD4(+) T cells responses,

144 lass I-restricted transgenic TCR function as polyfunctional effectors that can exhibit a helper as we

145 ation shows that recombinant viruses induced polyfunctional Env-specific CD4 or Gag-specific CD8 T ce

146 the first protein boost, a greater number of polyfunctional Env-specific CD4 T cells (those with > or

147 CD8(+) TEM cell epitopes induced robust and polyfunctional epitope-specific CD8(+) TEM cells that we

148 7 cells cultured in IL1beta were also highly polyfunctional, expressing high levels of effector molec

149 gnize peptide-loaded targets and demonstrate polyfunctional features such as IL-2, IFN-gamma, and TNF

150 ward, providing ready access to libraries of polyfunctional fluorophores with long Stokes shifts base

151 fied functional subsets including quiescent, polyfunctional fully activated, partially activated popu

152 nificantly associated with a high-magnitude, polyfunctional Gag-specific CD8(+) T-cell response but n

153 responses and the correlation between them, polyfunctional gE-specific CD4 T-cell responses, safety,

154 after administration of entecavir, developed polyfunctional, HBV-specific CD8(+) T cells, and HBV was

155 tion has demonstrated induction of broad and polyfunctional HCV-specific CD8(+) T cells in healthy vo

156 Transcriptional analysis revealed a polyfunctional helper and cytotoxic phenotype characteri

157 oselective catalysis, as building blocks for polyfunctional heterocycles, and in photoluminescent mat

158 C-H functionalization method gives access to polyfunctional heterocyclic zinc and magnesium reagents,

159 erized by the robust increase of preexisting polyfunctional, highly differentiated effector CD4(+) T-

160 ties appears to contribute to maintenance of polyfunctional HIV-1-specific CD8+ T cells from HIV-1 co

161 of programmed death-1, and the emergence of polyfunctional HIV-specific CD8 T cells.

162 SHIV(KU2)) induced long-lasting, potent, and polyfunctional HIV-specific CD8(+) T-cell responses.

163 five immunized macaques developed broad and polyfunctional HIV-specific T-cell IR that persisted for

164 es from ASYMP individuals induced robust and polyfunctional HSV-specific CD8(+) T cells associated wi

165 es from ASYMP individuals induced robust and polyfunctional HSV-specific CD8(+) TEM cells associated

166 Frequent polyfunctional HSV-specific IFN-gamma(+)CD107(a/b+)CD44(

167 CD4 and CD8), T-helper type 1 polarized, and polyfunctional (ie, they produced interferon gamma, tumo

168 es in the frequency of tuberculosis-specific polyfunctional IFN-gamma(+)/IL-2(+)/TNF-alpha(+) CD4(+)

169 roportions of interleukin-2(+) (IL-2(+)) and polyfunctional IFN-gamma(+)/TNF-alpha(+)/IL-2(+) T-lymph

170 with cryptic epitopes, induced HSV-specific polyfunctional IFN-gamma-producing CD107(ab+) CD4(+) T c

171 A significant increase in polyfunctional IFN-gamma/tumor necrosis factor alpha (TN

172 were potent cytokine producers, exhibiting a polyfunctional (IFN-gamma(+) IL-2(+) TNF-alpha(+)) profi

173 CMV reactivation had a reduced proportion of polyfunctional (IFN-gamma+/tumor necrosis factor alpha-p

174 e the capacity of DCs to induce expansion of polyfunctional IL17-producing T cells in humans, and sug

175 We report here polyfunctional immune activation associated with increas

176 omprise an immune correlate-thus implicating polyfunctional immune control of HIV-1 transmission.

177 ata suggest early ART initiation to maintain polyfunctional immune memory responses.

178 rotection would most likely correlate with a polyfunctional immune response involving several effecto

179 T lymphocyte response was significantly more polyfunctional in SM compared with RM, and granzyme B-po

180 of IL-17 expression, ex-Th17 cells were more polyfunctional in terms of cytokine production than eith

181 3) These memory cells were polyfunctional in terms of degranulation and production

182 n metathesis is increasingly incorporated in polyfunctional industrial processes.

183 o estimate the magnitude of sorption for any polyfunctional ionogenic compound of interest.

184 Polyfunctional ionogenic compounds are unique in that th

185 a synergistic effect in generating frequent polyfunctional Ki-67(+), IFN-gamma(+), CD107(+), and CD8

186 brid that combines Ca(2+) ions and the rigid polyfunctional ligand 5-(dihydroxyphosphoryl)isophthalic

187 Instead, fragmentation produces polyfunctional low molecular weight carboxylic acids aft

188 differentiation, with decreased formation of polyfunctional lymphoid memory cells.

189 nd its broad application in the synthesis of polyfunctional materials demonstrated.

190 ate that PD-1 is preferentially expressed on polyfunctional memory CD8(+) T cells, which renders them

191 the patient ultimately developed long-term, polyfunctional memory T-cell responses to Lassa virus.

192 CD4(+) and CD8(+) T cells with HCV-specific polyfunctional memory were expanded in all 5 individuals

193 c cells that were found in the LNs resembled polyfunctional memory-type cells.

194 h the grapes at crushing, extra increases in polyfunctional mercaptans were observed.

195 ances at 420 nm, remarkable increases in the polyfunctional mercaptans, 3-mercaptohexanol (3MH) and i

196 n sensory profiles, even with high levels of polyfunctional mercaptans.

197 infected animals induced high frequencies of polyfunctional MML-specific CD4+ T cells.

198 Polyfunctional molecules and a range of previously elusi

199 erforming selective modifications of complex polyfunctional molecules through the use of tailoring en

200 in films, surface-mediated polymerization of polyfunctional monomers, and solid-state topochemical po

201 y used to prepare complex architectures from polyfunctional monomers, species formed out of equilibri

202 A blood polyfunctional, Mtb DosR latency antigen specific, regul

203 both HLA-DRB1*13 and HLA-DQB1*06 had highly polyfunctional mucosal CD4+ T cells compared to individu

204 The frequency of polyfunctional mucosal CD4+ T cells was also higher in c

205 Previous studies have suggested that polyfunctional mucosal CD8(+) T-cell responses may be a

206 Polyfunctional MVA-specific CD8(+) T cells were detected

207 s aspect is substantiated by applications to polyfunctional (natural) products.

208 ents with glioblastoma-generated circulating polyfunctional neoantigen-specific CD4(+) and CD8(+) T c

209 Inflated cells were polyfunctional, not senescent, and displayed high ex viv

210 ly, immunization with the coNS5A gene primed polyfunctional NS5A-specific CD8(+) T cell responses.

211 classical phenotypic memory markers and are polyfunctional, only Flu-TM protects against a lethal vi

212 There was no difference in the polyfunctional or memory profile of Ag-specific CD4(+) T

213 HLA-DR, and PD-1 expression), phenotype, and polyfunctional pathogen-specific cellular immune respons

214 ractive intermediates for the preparation of polyfunctional phenazines and extended polyheteroacenes.

215 that latency-associated T cells exhibited a polyfunctional phenotype and could secrete a range of ef

216 ty to produce interleukin-2, indicative of a polyfunctional phenotype as found in controlled chronic

217 ro numerical expansion of a clonally diverse polyfunctional population of Ag-specific CD8(+) T cells

218 iles react by ring opening to afford a novel polyfunctional product.

219 ct elicited larger numbers of T cells with a polyfunctional profile and a good Env-GagPolNef balance,

220 specific CD4 and CD8 T cell responses with a polyfunctional profile.

221 ecific T cells, we analyzed the kinetics and polyfunctional profiles of Gag-specific CD4(+) and CD8(+

222 lls exhibited pathogenic features, including polyfunctional proinflammatory cytokine production, an a

223 azides has been developed in order to access polyfunctional pseudopeptides.

224 high yielding protocol for the synthesis of polyfunctional pyrazoles has been developed through one-

225 method very versatile for the preparation of polyfunctional pyridines.

226 with an in situ bromination gives access to polyfunctional pyrrole scaffolds.

227 equency virus-specific T-cell responses with polyfunctional repertoires.

228 that describe the quality of an individual's polyfunctional response and can be correlated directly w

229 f SPRY2 expression enhanced the HIV-specific polyfunctional response independently of the PD-1 pathwa

230 ty during anti-CTLA-4 treatment, revealing a polyfunctional response pattern of IFN-gamma, MIP-1beta

231 Candida albicans displayed microbe-specific polyfunctional response profiles, antigen sensitivity, a

232 e identified and validated a specific T-cell polyfunctional response to CMV antigen stimulation that

233 h in turn translated to a stronger, and more polyfunctional, response of engineered T cells to their

234 re, we demonstrate higher magnitude and more polyfunctional responses for HLA alleles associated with

235 lls and a decrease in functional avidity and polyfunctional sensitivity were evident in emerging epit

236 In addition, polyfunctional SIV-specific CD8+ T cells were consistent

237 on after live attenuated SHIV infection have polyfunctional SIV-specific CD8+ T cells with an increas

238 ation, converting aromatic hydrocarbons into polyfunctional species widely found in tropospheric aero

239 int measurements have obscured whether these polyfunctional states arise from the simultaneous or suc

240 ve CD8 + and CD4 + T cells contained similar polyfunctional subsets, and the level of polyfunctionali

241 Cu-catalyzed protocols; in cases involving a polyfunctional substrate, unique profiles in chemoselect

242 The applicability of the new catalysts to polyfunctional substrates was demonstrated by two C-C bo

243 ached to the pyridazinone ring, a variety of polyfunctional systems can be readily accessed by sequen

244 While a cytotoxicity response from a polyfunctional T cell activation caused hepatotoxicity a

245 roduction of cytokines and results in a more polyfunctional T cell phenotype.

246 omes results in an enhanced antigen-specific polyfunctional T cell response.

247 We additionally show that DC reveal polyfunctional T cell responses after many years of trea

248 endogenous retrovirus-K Gag and Env, induced polyfunctional T cell responses to all Ags, and Ab respo

249 d T cells consist of a smaller proportion of polyfunctional T cells and require more peptide ligands

250 Recently, investigators have shown that polyfunctional T cells correlate best with long-term pro

251 had an 11-fold increase in frequency of CD8+ polyfunctional T cells expressing multiple cytokines, as

252 The use of NKTR-214 increases the number of polyfunctional T cells in murine spleens and tumors comp

253 Moreover, ICB drove optimal generation of polyfunctional T cells in this "cold" tumor model, inste

254 ighlight the measurement of vaccine-induced, polyfunctional T cells may not reflect the extent or deg

255 We sought to determine whether polyfunctional T cells secreting multiple cytokines simu

256 as associated with increased accumulation of polyfunctional T cells that secreted multiple effector c

257 Polyfunctional T cells were predominantly of the effecto

258 R2 costimulation increases the percentage of polyfunctional T cells, a hallmark of potent T cell resp

259 In particular, ET were enriched in polyfunctional T cells.

260 of VACV as a vaccine platform able to induce polyfunctional T cells.

261 evel BK viremia expressed low frequencies of polyfunctional T cells.

262 to type I interferon, gave rise to activated polyfunctional T helper cells with high interleukin-7 re

263 These data demonstrate the presence of polyfunctional T lymphocytes in the peripheral blood of

264 ic flow cytometry, the in vitro frequency of polyfunctional T lymphocytes in the peripheral blood of

265 However, the proportion of T(H)1 and polyfunctional T(H) cells (producing multiple cytokines

266 Polyfunctional T(H)1 and T(H)17 cell subsets were underr

267 f TIL containing about 25% mutation-specific polyfunctional T(H)1 cells, the patient achieved a decre

268 The epitopes inducing polyfunctional T-cell activities were highly conserved a

269 pilot trial in patients with GBM implicates polyfunctional T-cell responses as a biomarker for effec

270 Our data implicate polyfunctional T-cell responses as a potential biomarker

271 re, whereas control patients had rejuvenated polyfunctional T-cell responses by 3 months after ART, I

272 DNA vaccine alone to induce long-lasting and polyfunctional T-cell responses in the nonhuman primate

273 ed region of membrane protein, which induced polyfunctional T-cell responses, which may be critical f

274 ort, we identified a specific combination of polyfunctional T-cell subsets to pp65 that predicted pro

275 nflammation-induced conversion of Tregs to a polyfunctional T-helper phenotype similar to proinflamma

276 Our hypothesis was that "polyfunctional" T cells producing multiple antiviral fac

277 Polyfunctional Tg Th1 effectors demonstrated enhanced IF

278 igrate to the infected tissue, and acquire a polyfunctional Th1 phenotype in infected mice.

279 cterized by the production of IFN-gamma, and polyfunctional Th1 responses are associated with enhance

280 and consequently prevented the generation of polyfunctional Th1/17 effector cells.

281 evoked as well, which suggests the onset of polyfunctional Th17 cells.

282 (-) patients, but also in the frequencies of polyfunctional Th2-like (CD4(+)IL-4(+)IL-5(+) and CD4(+)

283 The latter was a result of exaggerated polyfunctional Th22-cell expansion that was reversed by

284 tribution; and (iv) BAL CD4 T cells are more polyfunctional than CD4 T cells in blood, and their func

285 adapted epitope-specific responses were less polyfunctional than nonadapted epitope-specific response

286 e CD4 T-cell response to HSV-2 was much more polyfunctional than was the response to CMV.

287 s induced by both MVA and Dryvax were highly polyfunctional; they degranulated and produced interfero

288 re shown to contain very high amounts of two polyfunctional thiol precursors (3-S-glutathionylhexan-1

289 1, the capacity of CD8 T cells to attain the polyfunctional trait of IL-2 production is consistently

290 27(-) (but not gammadelta27(+)) cells become polyfunctional upon IL-1beta plus IL-23 stimulation, cos

291 ne regimen that induces a highly durable and polyfunctional V2-focused Ab response in rhesus macaques

292 cination regimens, higher frequency and more polyfunctional vaccine-elicited virus-specific CD8(+) T-

293 iated immune suppression to massively expand polyfunctional Vgamma2Vdelta2 T cells, and whether such

294 Blockade of IL-10 in vitro rescued polyfunctional virus-specific CD8 T cell responses.

295 markedly enhanced the number of high-quality polyfunctional virus-specific CD8 T cells with a nonexha

296 educed apoptosis, increased the abundance of polyfunctional virus-specific CD8 T cells, and improved

297 These responses were highly polyfunctional, with 64.5% of responses having 3 to 5 fu

298 the adenoviral-primed T cells markedly more polyfunctional, with the number of gamma interferon (INF

299 ells in particular, were fully activated and polyfunctional, yet associated with relatively narrow tr

300 Polyfunctional zinc and magnesium organometallic reagent