ライフサイエンスコーパス: polygenic risk

1 explored the interplay between monogenic and polygenic risk.

2 acceptable range and in the lowest decile of polygenic risk.

3 ith inclusion of newer risk factors, such as polygenic risk and mammographic density.

4 re highly heritable and arise from a complex polygenic risk architecture.

5 but we argue that the advent of genome-wide polygenic risk assessment now makes an empirical evaluat

6 onnectome-wide associations of schizophrenia polygenic risk at the systems level and suggest that dis

7 ted variants in hundreds of genes and common polygenic risk at thousands of loci.

8 llomics and proteomics approach to show that polygenic risk can be disentangled by searching for shar

9 We conclude that some measures of polygenic risk, cognition, and neuroimaging show signifi

10 imary prevention patients (n = 33,251), high polygenic risk did not correspond with increased recomme

11 Shared polygenic risk exists between ALS and educational attain

12 However, the relationships between polygenic risk factors and connectome-wide neural mechan

13 esbycusis is shaped by not only well-studied polygenic risk factors of small effect size revealed by

14 es may be related to shared environmental or polygenic risk factors rather than MITF(E318K).

15 higher when the 22q11.2 deletion and common polygenic risk factors that contribute to schizophrenia

16 enotyped cohort, we delineate a pathway from polygenic risk for ADHD to hyperactive-impulsive symptom

17 We found that polygenic risk for ADHD was associated with symptoms of

18 By studying a cohort of 362 youth, we ask if polygenic risk for ADHD, combined with baseline neural a

19 with worsening symptoms carried the highest polygenic risk for ADHD, followed by those with stable s

20 agnostically specific and were not found for polygenic risk for ASD or schizophrenia.

21 son comorbidity index and is associated with polygenic risk for coronary heart disease and type 2 dia

22 vidence for these observations, GWAS-derived polygenic risk for depression was enriched for genes exp

23 Each standard deviation increase in polygenic risk for depressive symptoms, schizophrenia, a

24 Furthermore, we stratified the polygenic risk for Japanese PCa patients by using 82 SNP

25 DNA from 51 members of 21 families with low polygenic risk for melanoma identified a CDKN2A p.G101W

26 reterm infants are associated with increased polygenic risk for psychiatric illness.

27 Finally, we demonstrate that polygenic risk for PTSD is significantly predictive of r

28 Attachment style may moderate polygenic risk for PTSD symptoms, and a novel locus impl

29 Higher polygenic risk for schizophrenia associated with a great

30 microarray data enabled direct comparison of polygenic risk for schizophrenia between 22q11.2DS and i

31 ame connectivity was adversely influenced by polygenic risk for schizophrenia in healthy subjects.

32 The effect of polygenic risk for schizophrenia on connectivity was exa

33 Polygenic risk for schizophrenia within 22q11.2DS was si

34 rgic function and the expression profiles of polygenic risk for schizophrenia.

35 rd connectivity, and delusional thinking and polygenic risk for schizophrenia.

36 lationships with clinical diagnosis and with polygenic risk for schizophrenia.

37 neurodevelopmental processes associated with polygenic risk for SCZ and ASD across the allelic freque

38 Polygenic risk for SCZ and ASD converged on partially ov

39 networks in the brain and clinical state and polygenic risk for SCZ and provides a strategy for using

40 reatments for PTSD for individuals with high polygenic risk for this disorder.

41 lain the association between common variant (polygenic) risk for ADHD and its core symptoms.

42 mune vitiligo is a complex disease involving polygenic risk from at least 50 loci previously identifi

43 quilibrium score regression, that ALS shares polygenic risk genetic factors with a number of traits a

44 The practical applications of polygenic risk information for stratified screening or f

45 uropsychiatric disorders is how to translate polygenic risk into disease biology.

46 Schizophrenia polygenic risk is plausibly manifested by complex transc

47 whether primary prevention patients at high polygenic risk might be distinguished on the basis of gr

48 evidence for transmission of common variant polygenic risk of BD in our full sample (pTDT p = 2.21 x

49 proaches, using previous genetic studies for polygenic risk, or other PTSD-related literature.

50 may be countered, at least in part, by a low polygenic risk potentially representing other innate mec

51 erful and practical approach for multi-trait polygenic risk prediction in large cohorts.

52 applications, it is absolutely critical that polygenic risk prediction is applied with appropriate me

53 Here, we propose a polygenic risk prediction method that does not require e

54 phenotype data from biobank-linked EHRs for polygenic risk prediction.

55 east one copy of the APOE e4 allele and b) a polygenic risk score (AD-PRS) estimated from AD-GWAS.

56 iet, physical activity, and body fatness), a polygenic risk score (based on 90 single-nucleotide poly

57 Applying the major depressive disorder polygenic risk score (MDD-PRS) derived from the most rec

58 ty was measured using a previously described polygenic risk score (N=929 single-nucleotide polymorphi

59 t gastric cancer across the quintiles of the polygenic risk score (p(trend)<0.0001).

60 Finally, we perform phenome-wide polygenic risk score (PRS) analyses on 67 complex traits

61 We performed polygenic risk score (PRS) analyses to investigate share

62 s interactions between an established 77-SNP polygenic risk score (PRS) and non-genetic risk factors

63 investigate the relationship between an IOP polygenic risk score (PRS) and short-term IOP profile.

64 A polygenic risk score (PRS) based on a GWAS of risk-toler

65 A polygenic risk score (PRS) composed of these SNPs (RT-in

66 Toward that end, we showed that an AD polygenic risk score (PRS) could identify mild cognitive

67 A polygenic risk score (PRS) derived from genome-wide asso

68 A glaucoma polygenic risk score (PRS) enables effective risk strati

69 We built a 201-variant polygenic risk score (PRS) for CAD and tested for intera

70 To determine the incremental value of polygenic risk score (PRS) for coronary artery disease,

71 In this study, we developed a polygenic risk score (PRS) for DILI by aggregating effec

72 e combined Magnetic Resonance Imaging with a polygenic risk score (PRS) for five psychiatric patholog

73 Calculating polygenic risk score (PRS) has become widely used due to

74 ease risk we test the extent to which higher polygenic risk score (PRS) identifies the affected sibli

75 A polygenic risk score (PRS) including 123 known risk vari

76 A polygenic score (PGS) or polygenic risk score (PRS) is an estimate of an individu

77 ized sequence kernel association testing and polygenic risk score (PRS) methods to examine rare and c

78 sk by using summarized GWAS results to build polygenic risk score (PRS) models in three PTC study gro

79 In addition, a polygenic risk score (PRS) of 188 prostate cancer varian

80 We constructed one polygenic risk score (PRS) per lipid trait (total choles

81 The authors sought to assess polygenic risk score (PRS) prediction of subsequent psyc

82 , we examined gene-diet interactions using a polygenic risk score (PRS) that combined the effects of

83 iac arterial beds, and derived a genome-wide polygenic risk score (PRS) to identify a subset of the p

84 A polygenic risk score (PRS) was strongly associated with

85 schizophrenia risk alleles, as indexed by a polygenic risk score (PRS), carried by 139,679 participa

86 e a cumulative estimation of risk known as a polygenic risk score (PRS).

87 history of breast cancer (N = 49,674) and a polygenic risk score (PRS, N = 9,365).

88 ted genetic variants used in a prototype QTc-polygenic risk score (QTc-PRS).

89 Polygenic risk score analyses showed that the combined e

90 attempt in these independent samples through polygenic risk score analysis (t = 4.02, p = 5.75 x 10(-

91 Phenome-wide polygenic risk score analysis in an independent biobank

92 Polygenic risk score and D:A:D score contributed to CKD.

93 We then compared the contribution of AF polygenic risk score and LOF variants to AF risk.

94 much lower but still varied according to the polygenic risk score and the healthy lifestyle score (me

95 absolute risk of CRC varied according to the polygenic risk score and the healthy lifestyle score (me

96 This analysis was followed by a polygenic risk score approach to test for associations b

97 ody mass index) subscores, and a genome-wide polygenic risk score based on 1.1 million variants.

98 sceptibility to esophageal adenocarcinoma (a polygenic risk score based on 18 recognized genetic vari

99 by meta-analysis with an independent cohort, polygenic risk score calculation, and cross-phenotype an

100 esearch should validate our findings using a polygenic risk score constructed from historical data.

101 formed in FOURIER to determine whether a VTE polygenic risk score could identify high-risk patients w

102 The polygenic risk score derived from 112 single-nucleotide

103 The polygenic risk score did not significantly improve calib

104 ulation-specific variants, fine-mapping, and polygenic risk score estimation.

105 In contrast, the AF polygenic risk score explained 4.7% of the variance in A

106 In total, polygenic risk score explained 8.07% [confidence interva

107 A polygenic risk score for AF was estimated using the LDpr

108 urrence after ablation using a comprehensive polygenic risk score for AF.

109 We constructed a polygenic risk score for aortic valve area, which in a s

110 men; and as a continuous variable) and an AF polygenic risk score for association with incident AF.

111 wins with genome-wide data, we constructed a polygenic risk score for BMI (PRSBMI) using almost 1 mil

112 rs with obesity, we calculated a genome-wide polygenic risk score for BMI (PRSBMI).

113 to optimize the predictive performance of a polygenic risk score for CAD based on summary statistics

114 The addition of a polygenic risk score for CAD to pooled cohort equations

115 Polygenic risk score for CAD, pooled cohort equations, a

116 d for sex, age, family socioeconomic status, polygenic risk score for cognitive function, adolescent/

117 We used a polygenic risk score for cutaneous melanoma to compare f

118 d significantly negatively correlated with a polygenic risk score for educational attainment.

119 We therefore tested whether a polygenic risk score for heel quantitative ultrasound sp

120 We further show that a polygenic risk score for hypertension associates with pr

121 ment and apathy were associated with reduced polygenic risk score for intelligence.

122 Polygenic risk score for major depression was associated

123 A higher polygenic risk score for obesity significantly correlate

124 A polygenic risk score for SCAD was associated with (1) hi

125 We investigated whether a high polygenic risk score for schizophrenia (PGRS-SCZ) is ass

126 A polygenic risk score for SOS was trained and selected in

127 We developed a genome-wide polygenic risk score for venous thromboembolism that ide

128 low-density lipoprotein cholesterol (LDL-C) polygenic risk score further increased CVD risk in patie

129 A polygenic risk score identified patients who were at >2-

130 Our results suggest that the use of a polygenic risk score in fracture risk screening could de

131 This scientific commentary refers to 'Polygenic risk score increases schizophrenia liability t

132 The remainder of the polygenic risk score influence (3.93%, CI 2.37-4.48%) re

133 The heritability explained by polygenic risk score is the highest for educational atta

134 These findings suggest that a polygenic risk score may not enhance risk prediction in

135 g individuals in the highest 0.44% of the AF polygenic risk score only 9.3% had AF.

136 can subjects in either cohort, nor did an AD polygenic risk score or genetic skin pigment score expla

137 r meta-GWAS hit replication rates and poorer polygenic risk score predictive performance in survivor

138 A polygenic risk score predicts disease with up to 90% acc

139 Polygenic risk score profiling revealed improved predict

140 Polygenic risk score quantifying the risk across multipl

141 summarizes clinical CKD risk factors, and a polygenic risk score that summarizes genetic information

142 anding of EoE and provides a framework for a polygenic risk score to be validated in future studies.

143 ng a risk threshold of 7.5%, addition of the polygenic risk score to pooled cohort equations resulted

144 Addition of the polygenic risk score to the pooled cohort equations did

145 risk threshold of 7.5%, the addition of the polygenic risk score to the pooled cohort equations did

146 Polygenic risk score using variants rs2230288 and rs2291

147 among participants at the 95th percentile of polygenic risk score was 88.2% (95% CI, 71.8-95.7).

148 When this polygenic risk score was applied to the CKB cohort, we f

149 redictive accuracy of a previously validated polygenic risk score was assessed among 4847 adults of w

150 An AF polygenic risk score was associated with AF (hazard rati

151 this analysis of 2 cohorts of US adults, the polygenic risk score was associated with incident corona

152 The performance of the polygenic risk score was compared with that of the 2013

153 The polygenic risk score was significantly associated with 1

154 2DS and population-based cohorts showed that polygenic risk score was significantly greater in indivi

155 The genetic extended model included a polygenic risk score with 313 single nucleotide polymorp

156 rait meta-analysis, Mendelian randomization, polygenic risk score, and functional analysis.

157 In models including both alcohol and the AF polygenic risk score, each remained associated with AF.

158 CAD discrimination for polygenic risk score, pooled cohort equations, and both

159 d to evaluate the predictive accuracy of the polygenic risk score, pooled cohort equations, and both

160 stimate associations between 135 SNPs (and a polygenic risk score, PRS) and LCADs among 6345 individu

161 enotype identified by these four models are: polygenic risk score, sex, age, and education.

162 y lifestyle factors and family history and a polygenic risk score, the model identified women at high

163 riking ability of genetics, in the form of a polygenic risk score, to identify those individuals at h

164 These have been combined into a vitiligo polygenic risk score, which has allowed various aspects

165 be identified by use of our newly developed polygenic risk score.

166 tes family history, and genome-wide diabetes polygenic risk score.

167 nic risk score], and high [quintile 5 of the polygenic risk score]).

168 sk score], intermediate [quintile 2-4 of the polygenic risk score], and high [quintile 5 of the polyg

169 fied by genetic risk (low [quintile 1 of the polygenic risk score], intermediate [quintile 2-4 of the

170 Through genome-wide polygenic-risk-score prediction, more than 6% of the phe

171 (GWAS) on delta age, combined into distinct polygenic risk scores (PRS(cis-eQTL) and PRS(GWAS)), and

172 ne-out analyses generated highly significant polygenic risk scores (PRS) (explained variance of up to

173 014 FWE corrected), as were their respective polygenic risk scores (PRS) (r = 0.17, n = 874, p = 6.5

174 Polygenic risk scores (PRS) aggregate the effects of man

175 as to evaluate the associations between ADHD polygenic risk scores (PRS) and a broad range of childho

176 study, we explore the association between MS polygenic risk scores (PRS) and brain imaging outcomes f

177 Polygenic risk scores (PRS) based on an individual's gen

178 We used data from the UK Biobank to combine polygenic risk scores (PRS) for 13 diseases and 12 morta

179 Polygenic risk scores (PRS) for breast cancer have poten

180 Recent studies indicate high polygenic risk scores (PRS) for coronary artery disease

181 Polygenic risk scores (PRS) for coronary artery disease

182 Psychiatric risk alleles were indexed by polygenic risk scores (PRS) for schizophrenia using geno

183 Finally, we test whether polygenic risk scores (PRS) for self-harm ideation and s

184 Polygenic risk scores (PRS) for the 22 risk factors were

185 Using polygenic risk scores (PRS) from a European-ancestry gen

186 ifferent approaches to generating predictive polygenic risk scores (PRS) from genome-wide association

187 Polygenic risk scores (PRS) have been shown to predict b

188 Polygenic risk scores (PRS) have shown promise in predic

189 Polygenic risk scores (PRS) may soon be used to predict

190 Polygenic risk scores (PRS) provide a personalized genet

191 opulations, which limits the use of existing polygenic risk scores (PRS) to identify subpopulations a

192 We also analyzed the impact of polygenic risk scores (PRS), calculated using genetic va

193 ts at the 99th risk percentile of underlying polygenic risk scores (PRS), compared to average risk, r

194 mple, comparing their predictive accuracy to polygenic risk scores (PRS).

195 e genetic liability of complex disease using polygenic risk scores (PRS).

196 tologies, for association with schizophrenia polygenic risk scores (PRSs) and with diagnosis, and als

197 Genome-wide approaches including polygenic risk scores (PRSs) are now widely used in medi

198 While polygenic risk scores (PRSs) are poised to be translated

199 e we developed an alternative approach using polygenic risk scores (PRSs) based on genome-wide associ

200 The mean polygenic risk scores (PRSs) between study subjects with

201 Previous research has shown that polygenic risk scores (PRSs) can be used to stratify wom

202 There is growing evidence that polygenic risk scores (PRSs) can identify individuals wi

203 ding to their risk of breast cancer based on polygenic risk scores (PRSs) could improve screening and

204 Polygenic risk scores (PRSs) denoting the sum of an indi

205 The authors investigated the role of polygenic risk scores (PRSs) derived from a TS genome-wi

206 This study examined the association of polygenic risk scores (PRSs) for a broad depression phen

207 n The Netherlands (2002-2006), we calculated polygenic risk scores (PRSs) for ASD and attention-defic

208 Psychiatric genetic risk was indexed by polygenic risk scores (PRSs) for attention deficit hyper

209 SUA in 6,881 Korean individuals, calculated polygenic risk scores (PRSs) for common variants, and va

210 Because polygenic risk scores (PRSs) for coronary heart disease

211 Polygenic risk scores (PRSs) for major depression, bipol

212 stream mechanistic investigation or yielding polygenic risk scores (PRSs) for prognostication.

213 Polygenic risk scores (PRSs) for schizophrenia were calc

214 Polygenic risk scores (PRSs) have become the standard fo

215 Polygenic risk scores (PRSs) have been applied to many c

216 Polygenic risk scores (PRSs) have been consistently asso

217 Polygenic risk scores (PRSs) have shown promise in predi

218 To facilitate scientific collaboration on polygenic risk scores (PRSs) research, we created an ext

219 We constructed polygenic risk scores (PRSs) using external weights and

220 ividual risk prediction based on genome-wide polygenic risk scores (PRSs) using millions of genetic v

221 o, high psoriasis, and low atopic dermatitis polygenic risk scores (PRSs) were associated with longer

222 Additionally, 3 polygenic risk scores (PRSs) were generated with 97 BMI

223 We derived polygenic risk scores (PRSs) with ~6M variants separatel

224 Relationships between Tourette's polygenic risk scores (PRSs), other tic disorders, ascer

225 y complex traits, the non-transferability of polygenic risk scores across populations suggests the pr

226 d with an increased PTSD risk and had higher polygenic risk scores and a greater methylation compared

227 risk scores and ED symptoms, and between AN polygenic risk scores and ADHD symptoms, in a genotyped

228 further tested the associations between ADHD polygenic risk scores and ED symptoms, and between AN po

229 regions that were associated with increased polygenic risk scores and enriched risk gene expression

230 We show for height how polygenic risk scores based on summary statistics from a

231 Polygenic risk scores comprising millions of single-nucl

232 ared genetic etiology and whether Tourette's polygenic risk scores correlate with worst-ever tic seve

233 ADHD polygenic risk scores correlated positively with ED symp

234 he performance of several different vitiligo polygenic risk scores derived from GWAS data.

235 ur bipolar disorder sample, which shows that polygenic risk scores explain a higher proportion of the

236 hat could allow selection of those with high polygenic risk scores for clinical trials and precision

237 m (PGC) datasets as a reference, we estimate polygenic risk scores for depression (depression-PRS) in

238 linkage disequilibrium score regression and polygenic risk scores for depressive symptoms, schizophr

239 Finally, we tested how polygenic risk scores for HIV-1 acquisition influence bl

240 Polygenic risk scores for major depression were signific

241 Polygenic risk scores for prostate cancer were higher in

242 Polygenic risk scores for psychiatric disorders, particu

243 lso significantly positively correlated with polygenic risk scores for schizophrenia, alcohol use dis

244 t updates to the role of genetic testing and polygenic risk scores for the prediction of stroke and c

245 d in increased trans-ancestry portability of polygenic risk scores from Europeans to East Asians acro

246 in the general population by 1) constructing polygenic risk scores from large genome-wide association

247 Polygenic risk scores had reduced performance when trans

248 monogenic FH and superimposed elevated LDL-C polygenic risk scores have the greatest risk of prematur

249 (PGx) markers, blood antigen serotyping, and polygenic risk scores in 100 individuals (50 with cardio

250 g by testing the association between partner polygenic risk scores in 34,987 couple pairs from the UK

251 from the meta-analysis, we constructed five polygenic risk scores in a range of thresholds (p=5 x 10

252 The incremental value of polygenic risk scores in addition to well-established ri

253 ew opportunities for developing and applying polygenic risk scores in the clinic, to systematically e

254 iderations relevant to the implementation of polygenic risk scores in the health care setting.

255 Poor trans-ancestry portability of polygenic risk scores is a consequence of Eurocentric ge

256 Second, we created polygenic risk scores of DBP and systolic blood pressure

257 s for incident depression were identified by polygenic risk scores or by reported traumatic life even

258 EO-IBD patients have, on average, higher IBD polygenic risk scores than population controls (99 patie

259 Polygenic risk scores that provide an overall estimate o

260 The utility of polygenic risk scores to stratify coronary artery diseas

261 Polygenic risk scores were computed for each individual

262 No significant association between partner polygenic risk scores were observed.

263 Project, we found that higher schizophrenia polygenic risk scores were significantly correlated with

264 Polygenic risk scores were used to assess the collective

265 ches, including genomics approaches (such as polygenic risk scores), microbiome profiling and, potent

266 Twenty percent had high polygenic risk scores, 60% had intermediate risk scores,

267 as micro-ribonucleic acid (miRNA) genetics, polygenic risk scores, environmental pollutants, and som

268 Models without using hazard weights, i.e. polygenic risk scores, showed lower predictive power tha

269 and, although it generates highly predictive polygenic risk scores, the predictive power can be expla

270 The odds ratios of polygenic risk scores, which included 330 variants, for

271 In clinical research, the application of polygenic risk scores-the cumulative sum of associated a

272 pairment and used these results to construct polygenic risk scores.

273 artery disease have been leveraged to create polygenic risk scores.

274 anels could be clinically more relevant than polygenic risk scores.

275 l inform the development of subtype-specific polygenic risk scores.

276 the accumulation of AD genetic risk through polygenic risk scores.

277 e genetic risk variants can be combined into polygenic risk scores.

278 tudies, single nucleotide polymorphisms, and polygenic risk scores.

279 roader polygenic architecture, estimated via polygenic risk scoring (AD-PRS).

280 ssociation analysis, (v) meta-analysis, (vi) polygenic risk scoring and (vii) replication analysis.

281 genome-wide association testing, followed by polygenic risk scoring and phenome-wide screening, to id

282 P-chip heritability estimates of 7.29%, with polygenic risk scoring capturing 4.4% of the variance in

283 Polygenic risk scoring was used to investigate the genet

284 Linkage disequilibrium score regression, polygenic risk scoring, and two-sample Mendelian randomi

285 We show that a common variant polygenic risk significantly contributes to ID.

286 case subjects carrying risk CNVs had a lower polygenic risk than case subjects without risk CNVs but

287 antly less overtransmission of schizophrenia polygenic risk than did non-carriers, which provides a s

288 athway with large effect on disease and (ii) polygenic risk that involves many variants of small effe

289 , clinicians will have an opportunity to use polygenic risk to predict perioperative complications.

290 is and probed aggregated Tourette's syndrome polygenic risk to test whether Tourette's and related ti

291 mediation was found, mapping a pathway from polygenic risk, to white matter microstructure of the an

292 ven more pronounced among those with extreme polygenic risk (top 1% of the distribution, odds ratio,

293 High polygenic risk (top 20% of PRS) conferred 1.9-fold odds

294 complex relationship of penetrant and weaker polygenic risk variants to ASD, 'isogenic' iPSC-derived

295 years, probability of cirrhosis with extreme polygenic risk was 13.7%, 20.1%, and 48.2% among individ

296 cceptable range and in the highest decile of polygenic risk was 2.33% (95% CI, 2.07-2.59), compared w

297 ilarly, probability among those with extreme polygenic risk was 6.5%, 10.3%, and 19.5% among individu

298 The impact of extreme polygenic risk was substantially more pronounced in thos

299 vailable, schizophrenia and bipolar disorder polygenic risk were significantly overtransmitted to pro

300 This study sought to intersect polygenic risk with guideline-based recommendations and