ライフサイエンスコーパス: polyketide

1 ed that FMO3 is an essential modifier of the polyketide.

2 duct is not a sesquiterpenoid but a phenolic polyketide.

3 (PKS) that presumably synthesizes an unknown polyketide.

4 nd enable the trans MT to access the growing polyketide.

5 are a widely distributed class of bacterial polyketides.

6 ycin represents a novel subclass of aromatic polyketides.

7 nzymatic partners to produce fatty acids and polyketides.

8 he asymmetric synthesis of a wide variety of polyketides.

9 vitamins, methionine, lycopene, squalene and polyketides.

10 ly of natural products for human health, the polyketides.

11 new members of a rapamycin-related family of polyketides.

12 eltolide, are a key functional group in many polyketides.

13 in future combinatorial biosynthesis of new polyketides.

14 ipid-like molecules, and phenylpropanoid and polyketides.

15 that animals also make complex, microbe-like polyketides.

16 rom streptomycetes in the discovery of novel polyketides.

17 t method for the synthesis of the privileged polyketide 1,3-dienyl-6-oxy motif.

18 The structures of the new polyketides 2-5 were elucidated by analysis of spectrosc

19 ester and performs a direct amidation of the polyketide, a reaction typically catalyzed by nonribosom

20 ementation assays, we demonstrate that these polyketides act as chemical triggers of sporulation and

21 idation of the NOCAP (nocardiosis-associated polyketide) aglycone by first fully reconstituting the N

22 al assignments of the previously undescribed polyketide analogues.

23 mily represents an uncharacterized branch of polyketide and fatty acid metabolism, encoding a large d

24 been identified as the source of almost all polyketide and modified peptides families reported from

25 he role of editing thioesterases involved in polyketide and non-ribosomal peptide synthase synthases.

26 yl carrier protein, essential to fatty acid, polyketide and various specialized metabolite biosynthes

27 , and two of them produced bioactive allenic polyketides and citreodiols as end products, respectivel

28 belong to carboxylic acids and derivatives, polyketides and fatty acyls.

29 rm the largest family of polycyclic aromatic polyketides, and have been studied extensively.

30 etabolites, including nonribosomal peptides, polyketides, and ribosomally synthesized and post-transl

31 Kalimantacin is a polyketide antibiotic with selective activity against st

32 incorporated into the stambomycin family of polyketide antibiotics are assembled by direct carboxyla

33 ic gene cluster encodes two groups of type 2 polyketide antibiotics: the formicamycins and their bios

34 Polyketides are a class of specialised metabolites synth

35 Polyketides are a large family of bioactive natural prod

36 Polyketides are an important class of bioactive small mo

37 While numerous polyketides are known to be derived from aerobic organis

38 Complex polyketides are typically associated with microbial meta

39 Key steps involved polyketide aromatization of a trans, trans-farnesol-deri

40 The thioester intermediates in polyketide assembly are covalently tethered to acyl carr

41 These findings afford a view of a polyketide "atom-replaced" mimetic in a NR-PKS active si

42 We identified the gamma-pyrone polyketides Aureothin/Neoaureothin as potent hits by ant

43 itrogen atom, which is incorporated into the polyketide backbone, remained unknown.

44 l 17 natural derivatives share the same C-14 polyketide backbone, they exhibit a fairly broad structu

45 Finally, polyketide-based macrolides similar to peloruside A and

46 inspiring the development of methodology for polyketide bio-orthogonal tagging via incorporation of 6

47 acellular metabolites that are funneled into polyketide biosynthesis has proven elusive.

48 thy-3-ketoacyl-ACP products during bacterial polyketide biosynthesis mediated by trans-AT polyketide

49 s targeting either ketosynthase domains from polyketide biosynthesis or adenylation domains from nonr

50 Here, we report on a versatile polyketide biosynthesis pipeline, based on identificatio

51 d cycle, non-ribosomal peptide synthesis and polyketide biosynthesis point towards thioester-dependen

52 alytic domains play an important role during polyketide biosynthesis through the dehydration of the n

53 During de novo fatty acid and polyketide biosynthesis, beta-ketoacyl-acyl carrier prot

54 lular TAGs and extracellular substrates into polyketide biosynthesis.

55 ion reminiscent of malonyl-CoA reactivity in polyketide biosynthesis.

56 ddTAG) to mobilize the TAG pool and increase polyketide biosynthesis.

57 arbon ketide units in de novo fatty acid and polyketide biosynthesis.

58 hemical characterization of an intact animal polyketide biosynthetic enzyme opens the door to underst

59 Our observations broaden the polyketide biosynthetic landscape and identify a non-cat

60 s, a promising strategy aims at transferring polyketide biosynthetic pathways from their native produ

61 Polyketide biosynthetic pathways have been engineered to

62 t isoprenoid, alkaloid, phenylpropanoid, and polyketide biosynthetic pathways in microbial systems.

63 elective access to stereotriads as important polyketide building blocks is reported on the basis of t

64 proposed deprotonation at C4 of the nascent polyketide by the catalytic His1345 and the role of a pr

65 describe an unusual family of spirotetronate polyketides, called streptaspironates, which are produce

66 ates that the biosynthesis of complex fungal polyketides can be established and efficiently engineere

67 hat the covalent linkage between the growing polyketide chain and the enzyme is lost in these cases,

68 yl and methylmalonyl-CoA building blocks for polyketide chain assembly.

69 are required to accomplish twenty cycles of polyketide chain elongation.

70 elongating ketosynthase domain transfers the polyketide chain from the final acyl carrier protein dom

71 hate, thus indicating it plays a key role in polyketide chain release and butenolide formation.

72 Several mechanisms for polyketide chain release are known, contributing to natu

73 which was likely produced from an incomplete polyketide chain, together with an intriguing decarboxyl

74 is essential for methylation of the growing polyketide chain.

75 tions beta to the thiol ester in the growing polyketide chain.

76 producer mutant, produces high levels of the polyketide compounds aspinolides (Asp) B and C.

77 The antibacterial polyketide compounds described in the present study may

78 revealed that hydrophobic descriptor of the polyketide compounds significantly contribute towards it

79 papillosa was used to isolate antibacterial polyketide compounds.

80 Desertomycin A is an aminopolyol polyketide containing a macrolactone ring.

81 genetic features delineating spirotetronate polyketides could be identified in streptaspironates A (

82 product template (PT) domain that catalyzes polyketide cyclization, we developed the first mechanism

83 ore unveiled new routes and biocatalysts for polyketide cyclization.

84 ins, providing an unrivaled model system for polyketide dehydration.

85 led to isolation of three unprecedented aryl polyketide derivatives, characterized as (E)-12-(17-ethy

86 noids exhibits a substitution pattern of the polyketide-derived aromatic core that seemingly contradi

87 Solanapyrones are polyketide-derived secondary metabolites produced by div

88 Fungal polyketides display remarkable structural diversity and

89 Nogalamycin, an aromatic polyketide displaying high cytotoxicity, has a unique st

90 logenated and then elaborated by peptidic or polyketide extensions.

91 ion to bacterial pathways for three distinct polyketide families comprising microtubule-inhibiting pe

92 ) reductase (BKR) putatively associated with polyketide fatty acid starter unit synthesis and alkyl s

93 rinol and mupirocin are assembled on similar polyketide/fatty acid backbones and exhibit potent antib

94 The cladosins are rare examples of hybrid polyketides featuring a 3-enamine tetramic acid group de

95 The potential of hitherto undescribed polyketides from P. malabarica as natural antioxidative

96 ucts, particularly nonribosomal peptides and polyketides, from sequence data.

97 uinones are a family of structurally related polyketide fungal toxins with nearly universal toxicity.

98 nome sequencing revealed the putative type I polyketide gene cluster responsible for selvamicin's bio

99 udies of site-selective alteration including polyketides, glycopeptides, terpenoids, macrolides, alka

100 m aerobic organisms, only a single family of polyketides has been identified from anaerobic organisms

101 ahuoic acid Ci(Bii) (3), a novel cis-decalin polyketide, has been achieved.

102 Fungal polyketides have significant biological activities, yet

103 that both HRPKS-TEs synthesize aminoacylated polyketides in an ATP-independent fashion.

104 production of new and diversified bioactive polyketides in an automated, rapid, and versatile fashio

105 emonstrating the existence and importance of polyketides in anaerobes, and showcases a strategy of ma

106 ition potential (IC50 0.76-0.92mg/mL) of the polyketides in consonant with significantly greater anti

107 dol addition of an acyl donor to a beta-keto-polyketide intermediate acceptor.

108 We show that nor-toralactone is the key polyketide intermediate and the substrate for the unusua

109 Alkyl branching at the beta position of a polyketide intermediate is an important variation on can

110 yl-carrier protein (ACP) carries the growing polyketide intermediate through iterative rounds of elon

111 hesis through the dehydration of the nascent polyketide intermediate to provide olefins.

112 sponsible for beta-alkylation of the growing polyketide intermediates in AT-less type I PKSs.

113 on of the beta-hydroxy groups of the nascent polyketide intermediates, DH10 acts in a long-range mann

114 The structural diversity of type II polyketides is largely generated by tailoring enzymes.

115 produces a class of isoprenylated resorcinyl polyketides known as cannabinoids, a subset of which are

116 Mandelalides A-D (1-4) are macrocyclic polyketides known to have an unusual bioactivity profile

117 ic polyene encoded by a reductive, iterative polyketide-like gene cluster.

118 tein secretion system ESX-1, biosynthesis of polyketide lipids, and utilization of sterols.

119 in part due to WhiB3-dependent production of polyketide lipids.

120 nd in vivo studies with archazolids, complex polyketide macrolides, which present the most potent V-A

121 teins involved in synthesis of the cytotoxic polyketide malleilactone; trimethoprim does so by increa

122 Four cyclopentenone-containing ansamycin polyketides (mccrearamycins A-D), and six new geldanamyc

123 ses to infectious diseases and terpenoid and polyketide metabolism were enriched in subjects with hal

124 has been made on the synthesis of repetitive polyketide motifs through the iterative application of a

125 rylenequinones are a class of photoactivated polyketide mycotoxins produced by fungal plant pathogens

126 Here we uncover a family of polyketides native to the anaerobic bacterium Clostridiu

127 The polyketide natural product (+)-SCH 351448, a macrodiolid

128 Recent work has demonstrated that the polyketide natural product Aurodox from Streptomyces gol

129 diate is an important variation on canonical polyketide natural product biosynthesis.

130 The polyketide natural product cryptocaryol A is prepared in

131 The nonaromatic polyketide natural product zincophorin methyl ester has

132 Polyketide natural products are an important class of bi

133 The kinamycin family of aromatic polyketide natural products contains an atypical angucyc

134 hould inspire future efforts to discover new polyketide natural products from AT-less type I PKSs.

135 relevant biological activities, nonaromatic polyketide natural products have for decades attracted a

136 ermectin and rapamycin are clinically useful polyketide natural products produced on modular polyketi

137 l representatives of the tetracyclic type II polyketide natural products that are widely used in canc

138 Phenalenones are polyketide natural products that display diverse structu

139 o the structural diversification of aromatic polyketide natural products via unusual redox tailoring

140 The total syntheses of several iconic type I polyketide natural products were undertaken using these

141 now allows access to a much wider family of polyketide natural products with stereochemistry being d

142 nthesis of all possible stereoisomers of two polyketide natural products, avocadyne, avocadene, and t

143 ns essential for the formation of olefins in polyketide natural products.

144 in numerous non-ribosomal peptide and hybrid polyketide-non-ribosomal peptide synthetases, including

145 roduce structurally and functionally diverse polyketides, nonribosomal peptides and their hybrids.

146 Antitubercular agent levesquamide is a new polyketide-nonribosomal peptide (PK-NRP) hybrid marine n

147 The colibactins are hybrid polyketide-nonribosomal peptide natural products produce

148 e belonging to the chemical family of hybrid polyketide/nonribosomal peptide compounds.

149 Complex polyketides of bacterial origin are biosynthesised by gi

150 cally labeled precursors clearly supported a polyketide origin for the formal monoterpenoid gibepyron

151 E)-pent-2-enyl)-2H-chromene-6-carboxylate of polyketide origin, with activity against human opportuni

152 arbocycle fused to an anthraquinone, both of polyketide origin.

153 droxy-6-methylacetophenone is derived from a polyketide pathway, we report a differentially expressed

154 etic origins-derived from both terpenoid and polyketide pathways-with a wealth of biological activiti

155 adicts the established reactivity pattern of polyketide phenol nucleophiles and terpene diphosphate e

156 Natural product classes include polyketides (PKs), nonribosomal peptides (NRPs), and rib

157 tricyclic ring system cyclized from a linear polyketide precursor via an unresolved mechanism.

158 rary to previous studies suggesting a single polyketide precursor.

159 acyls, glycerolipids, phosphoglycerolipids, polyketides, prenols, saccharolipids, sphingolipids, and

160 very of lugdunomycin, an angucycline-derived polyketide, produced by Streptomyces species QL37.

161 osynthetic machinery, alkaloid, terpene, and polyketide-producing organisms have all evolved pathways

162 influence of protein-protein interactions on polyketide product outcome.

163 the cAT domain is capable of esterifying the polyketide product with polyalcohol nucleophiles.

164 h as erythromycin and josamycin, are natural polyketide products harboring 14- to 16-membered macrocy

165 T engineering provided the first full-length polyketide products incorporating two non-natural extend

166 benzoic acid, a combinatorial library of six polyketide products is readily accessed.

167 g of assembly lines that construct primarily polyketide products, structural aspects of the assembly-

168 The synthesis of a linear polyketide resembling a biosynthetic precursor was achie

169 d enables convergent construction of type II polyketide ring systems of the angucycline class.

170 nt asymmetric access to anti,syn and syn,syn polyketide stereotriads from the same alpha-chiral start

171 ration mechanism that could be exploited for polyketide structural diversity by combinatorial biosynt

172 cal characterization of DH10 in vitro, using polyketide substrate mimics with varying chain lengths.

173 llenged them with both native and non-native polyketide substrates.

174 es enable convergent construction of type II polyketide substructures.

175 Pharmaceutically important polyketides such as avermectin are mainly produced as se

176 sing microalga as a substrate, including the polyketide sugar unit, lipopolysaccharide, peptidoglycan

177 Here, we provide evidence that polyketides support this unusual photosynthetic partners

178 ble construction of the actin-binding marine polyketide swinholide A in only 15 steps (longest linear

179 line collaboration between a highly reducing polyketide synthase (HRPKS, Fub1) and a nonribosomal pep

180 d substitution (R644W) in an uncharacterized polyketide synthase (MuPKS).

181 A nonreducing polyketide synthase (NR-PKS) PhnA was shown to synthesiz

182 lic fatty acid synthase of type 1 (FAS1) and polyketide synthase (PKS) and the down-regulation of the

183 omain FosDH1 from module 1 of the fostriecin polyketide synthase (PKS) catalyzed the stereospecific i

184 -line like megaenzymes of the type 1 modular polyketide synthase (PKS) class.

185 of bioactive natural products synthesized by polyketide synthase (PKS) enzyme complexes predominantly

186 Polyketide synthase (PKS) enzymes continue to hold great

187 athway, we report a differentially expressed polyketide synthase (PKS) gene candidate.

188 Here, we identified and deleted a polyketide synthase (PKS) gene PfmaE and showed that it

189 ribosomal peptide synthetase (NRPS) and NRPS-polyketide synthase (PKS) hybrid BGCs from Photorhabdus

190 Detailed analysis of the modular Type I polyketide synthase (PKS) involved in the biosynthesis o

191 decouple R*-domain-containing NRPS from the polyketide synthase (PKS) machinery, expanding the parad

192 The potential for recombining intact polyketide synthase (PKS) modules has been extensively e

193 mains of cryptic function are often found in polyketide synthase (PKS) modules that produce epimerize

194 , encodes a trans-acyltransferase (trans-AT) polyketide synthase (PKS) multienzyme that was hypothesi

195 HR) and a non-reducing (NR) iterative type I polyketide synthase (PKS) pair.

196 The virulent gene island polyketide synthase (pks) produces the secondary metabol

197 ad branch of fatty acid synthase- (FAS)-like polyketide synthase (PKS) proteins, which sacoglossan an

198 ns a hybrid type I fatty acid synthase (FAS)-polyketide synthase (PKS) system and an ABC transporter.

199 mains act as interaction hubs within modular polyketide synthase (PKS) systems, employing specific pr

200 g disease, house a nonamodular assembly line polyketide synthase (PKS) that presumably synthesizes an

201 thase (DEBS) is a prototypical assembly line polyketide synthase (PKS) that synthesizes the macrocycl

202 er encoding a cryptic trans-acyl transferase polyketide synthase (PKS) was identified in the genomes

203 mains (DHs) of the iso-migrastatin (iso-MGS) polyketide synthase (PKS) were investigated by systemati

204 c pathways of the products of type I modular polyketide synthase (PKS) with the focus on providing a

205 a chersina previously identified an enediyne polyketide synthase (PKS), but no anthraquinone PKS, sug

206 The genes tested were polyketide synthase (PKS), Flavin-dependent monooxygenas

207 viously identified as a cluster containing a polyketide synthase (PKS)-encoding (FUB1) and four addit

208 ticancer activity that are biosynthesized by polyketide synthase (PKS)-nonribosomal peptide synthetas

209 m non-ribosomal peptide synthetase (NRPS) or polyketide synthase (PKS).

210 ounds, which are produced by a novel type II polyketide synthase (PKS).

211 investigation of the model type I iterative polyketide synthase 6-methylsalicylic acid synthase (6-M

212 alyses identify extensive diversification of polyketide synthase and non-ribosomal peptide synthetase

213 mong differentially expressed transcripts, a polyketide synthase and three lipoxygenases (involved in

214 role for ABM superfamily proteins in type II polyketide synthase assemblages for maintaining biosynth

215 nt tool for comparative analysis of trans-AT polyketide synthase assembly line architectures.

216 Furthermore, in vitro investigations of the polyketide synthase central to cercosporin biosynthesis

217 ction of atrochrysone carboxylic acid by the polyketide synthase ClaG and the beta-lactamase ClaF.

218 id moiety through the activities of both the polyketide synthase ClbO and the amidase ClbL.

219 a shunt product in all related non-reducing polyketide synthase clusters containing homologues of Tp

220 en fluorescent protein (GFP, 27 kDa) and the polyketide synthase DEBS1 (394 kDa).

221 Although polyketide synthase encoding genes have been successfull

222 inition: A long-standing paradigm in modular polyketide synthase enzymology, namely the definition of

223 rmin, the biosynthesis of which requires the polyketide synthase FgnA.

224 remarkable role of an enoylreductase in the polyketide synthase for azalomycin F biosynthesis.

225 We used this tool to delete a polyketide synthase gene (FUM1) required for fumonisin b

226 approach by isolating and sequencing type I polyketide synthase gene clusters from an Antarctic soil

227 ow describe a method for rapidly recombining polyketide synthase gene clusters to replace, add or rem

228 milarities in key genes such as 16S rRNA and polyketide synthase genes.

229 lly, we introduced the S148C mutation into a polyketide synthase module (PikAIII-TE) to impart increa

230 yketide natural products produced on modular polyketide synthase multienzymes by an assembly-line pro

231 7, should thus be informative to the modular polyketide synthase novice and expert alike.

232 The mupirocin trans-AT polyketide synthase pathway, provides a model system for

233 le that targets the thioesterase activity of polyketide synthase Pks13, an essential enzyme that form

234 gene deletion verified that the F. fujikuroi polyketide synthase PKS13, designated Gpy1, is responsib

235 ormed by an iterative highly reducing fungal polyketide synthase supported by a hydrolase, together w

236 ates tested positive for at least one of the polyketide synthase type I, polyketide synthase type II

237 least one of the polyketide synthase type I, polyketide synthase type II or non-ribosomal peptide syn

238 tegy to identify the low expression of Bik1 (polyketide synthase) as a major bottleneck step in the p

239 Chalcone synthase (CHS), a type III plant polyketide synthase, is critical for flavonoid biosynthe

240 nsible for chain release from the enacyloxin polyketide synthase, which assembles an antibiotic with

241 hanism for chain release from the enacyloxin polyketide synthase, which assembles an antibiotic with

242 nated when both the tpc and enc non-reducing polyketide synthase-encoding genes, tpcC and encA, respe

243 We report expression of a microalgal polyketide synthase-like PUFA synthase system, comprisin

244 BonMT2 from module 2 of the bongkrekic acid polyketide synthase.

245 Fungal highly reducing polyketide synthases (HRPKSs) biosynthesize polyketides

246 ies, yet the biosynthesis by highly reducing polyketide synthases (HRPKSs) remains enigmatic.

247 lite gene clusters are anchored by iterative polyketide synthases (IPKSs), which are multidomain enzy

248 In fungal non-reducing polyketide synthases (NR-PKS) the acyl-carrier protein (

249 emplate (PT) domains from fungal nonreducing polyketide synthases (NR-PKSs) are responsible for contr

250 Engineering polyketide synthases (PKS) to produce new metabolites re

251 enetic analysis of the corresponding melanin polyketide synthases (PKSs) and alignment of melanin BGC

252 Modular polyketide synthases (PKSs) and nonribosomal peptide syn

253 Assembly-line polyketide synthases (PKSs) are among the most complex p

254 Modular polyketide synthases (PKSs) direct the biosynthesis of c

255 Fatty acid synthases (FASs) and polyketide synthases (PKSs) iteratively elongate and oft

256 Acyltransferase (AT)-less type I polyketide synthases (PKSs) produce complex natural prod

257 Polyketide synthases (PKSs) represent a powerful catalyt

258 ineering the acyltransferase (AT) domains of polyketide synthases (PKSs) responsible for the incorpor

259 However, manipulation of modular type I polyketide synthases (PKSs) to make unnatural metabolite

260 To harness the synthetic power of modular polyketide synthases (PKSs), many aspects of their bioch

261 nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs).

262 roach has been successful for type I modular polyketide synthases (PKSs); however, despite more than

263 Type I polyketide synthases (T1PKSs) are one of the most extens

264 Modular polyketide synthases and non-ribosomal peptide synthetas

265 te pathway that is extended by the action of polyketide synthases and non-ribosomal peptide synthetas

266 lism is shown by gene expression analyses of polyketide synthases and the determination of the second

267 Type I modular polyketide synthases assemble diverse bioactive natural

268 Polyketide synthases assemble diverse natural products w

269 ciated with defoliation shared homology with polyketide synthases involved in secondary metabolism, w

270 ar compounds (marginolactones) are formed by polyketide synthases primed not with gamma-aminobutanoyl

271 The polyketide synthases responsible for the biosynthesis of

272 polyketide biosynthesis mediated by trans-AT polyketide synthases that lack integrated acyl transfera

273 teins of several families including type-III polyketide synthases, hydrolases, and cytochrome P450s r

274 re non-ribosomal peptide synthetases, type 1 polyketide synthases, terpenes, and lantipeptides.

275 quence-specific synthesis by the ribosome to polyketide synthases, where tethered molecules are passe

276 The colinearity of canonical modular polyketide synthases, which creates a direct link betwee

277 e mechanism of natural evolution for modular polyketide synthases.

278 d, much like an in vitro version of Nature's polyketide synthases.

279 cillaene, difficidin, and mupirocin trans-AT polyketide synthases.

280 Putative biosynthetic route by means of polyketide synthatase biocatalyzed pathways unambiguousl

281 ISPR-Cas system, quorum quenching lactonase, polyketide synthesis and arsenic resistance makes this s

282 ed 1,3-dienyl-6-oxy motif and enable complex polyketide synthesis in a rapid and asymmetric fashion.

283 domains of type II thioesterases involved in polyketide synthesis.

284 dies integrated with the outcome obtained by polyketide synthetase (pks) coding genes established tha

285 Natural products of mixed polyketide/terpenoid origins (meroterpenes) are a partic

286 ein are syntheses of the naturally occurring polyketides (-)-tetrapetalones A and C and their respect

287 Hippolachnin A (1) is an antifungal polyketide that bristles with ethyl groups mounted onto

288 Mensacarcin is a highly oxygenated polyketide that was first isolated from soil-dwelling St

289 The lasonolides are novel polyketides that have displayed remarkable biological ac

290 resence of beta-branches in the structure of polyketides that possess potent biological activity unde

291 ation and structural characterization of six polyketides (three known compounds and new streptoketide

292 Our strategy could improve polyketide titers for pharmaceutical production.

293 pret this result as FMO3 modifies the parent polyketide to contribute to the normal brown/green color

294 t interest in diversifying the structures of polyketides to create new analogues of these bioactive m

295 polyketide synthases (HRPKSs) biosynthesize polyketides using a single set of domains iteratively.

296 -play combinatorial biosynthesis of aromatic polyketides using bacterial type II PKSs in E. coli, pro

297 he biosynthesis of nonribosomal peptides and polyketides, we found that urban park soil microbiomes a

298 The structures of the polyketides were assigned by extensive spectroscopic exp

299 Homodimericin A is a hexacyclic polyketide with a carbon backbone containing eight conti

300 ynthetic pathway of bikaverin, a tetracyclic polyketide with antibiotic, antifungal and anticancer pr