ライフサイエンスコーパス: polyketide synthase

1 ase activity missing from two modules of the polyketide synthase.

2 synthase with that of module 2 of rapamycin polyketide synthase.

3 se and an oxygenase, in addition to the core polyketide synthase.

4 ormed by biphenyl synthase (BIS), a type III polyketide synthase.

5 the organization displayed by this singular polyketide synthase.

6 he programming selectivities of the tenellin polyketide synthase.

7 it formation to the ACPs integrated into the polyketide synthase.

8 line skeleton is biosynthesized by a type II polyketide synthase.

9 BonMT2 from module 2 of the bongkrekic acid polyketide synthase.

10 -amino acids and other elements derived from polyketide synthases.

11 quinolone and acridone alkaloid by type III polyketide synthases.

12 e clade of the functionally diverse type III polyketide synthases.

13 onyl-CoA, a common substrate of multimodular polyketide synthases.

14 tituted components from a variety of modular polyketide synthases.

15 chalcone synthase families of fatty acid and polyketide synthases.

16 e mechanism of natural evolution for modular polyketide synthases.

17 d, much like an in vitro version of Nature's polyketide synthases.

18 cillaene, difficidin, and mupirocin trans-AT polyketide synthases.

19 cific lipid branching patterns introduced by polyketide synthase 12 (pks12).

20 toacyl-acyl-carrier protein (ACP) synthases, polyketide synthases, 3-hydroxy-3-methylglutaryl-CoA syn

21 investigation of the model type I iterative polyketide synthase 6-methylsalicylic acid synthase (6-M

22 of ACP domains of the erythromycin precursor polyketide synthase, 6-deoxyerythronolide B synthase (DE

23 ACYL-COA SYNTHETASE, POLYKETIDE SYNTHASE A (PKSA) and PKSB, TETRAKETIDE alpha

24 etic metabolon (ACYL COENZYME A SYNTHETASE5, POLYKETIDE SYNTHASE A [PKSA], PKSB, and TETRAKETIDE alph

25 structural analyses of the TE/CLC domain in polyketide synthase A, the multidomain PKS central to th

26 d by the combined action of a modular Type-I polyketide synthase, a conserved set of enzymes involved

27 It encodes a chimeric multimodular polyketide synthase, a nonribosomal peptide synthetase,

28 The interplay of a dedicated type III polyketide synthase, a prenyl diphosphate synthase, and

29 re is no model available for a fungal type I polyketide synthase ACP.

30 nd CTB3 genes that encode, respectively, the polyketide synthase and a dual methyltransferase/monooxy

31 cluster, followed by characterization of the polyketide synthase and acyltransferase involved in bios

32 alyses identify extensive diversification of polyketide synthase and non-ribosomal peptide synthetase

33 mong differentially expressed transcripts, a polyketide synthase and three lipoxygenases (involved in

34 ne backbone is biosynthesized by the minimal polyketide synthases and an amidotransferase homologue O

35 on and release from six of these nonreducing polyketide synthases and have identified the products.

36 and di-domain ARO/CYCs in bacterial type II polyketide synthases and lays the groundwork for enginee

37 Modular polyketide synthases and non-ribosomal peptide synthetas

38 te pathway that is extended by the action of polyketide synthases and non-ribosomal peptide synthetas

39 2) An important subset of polyketide synthases and nonribosomal peptide synthetase

40 In mycobacteria, polyketide synthases and nonribosomal peptide synthetase

41 ers are converted by thioesterase domains of polyketide synthases and nonribosomal peptide synthetase

42 Structural conservation with type I polyketide synthases and related fatty-acid synthases al

43 lism is shown by gene expression analyses of polyketide synthases and the determination of the second

44 module and intermodule substrate transfer in polyketide synthases, and establishes a new model for mo

45 Highly reducing iterative polyketide synthases are large, multifunctional enzymes

46 Acyltransferase (AT) domains of multimodular polyketide synthases are the primary gatekeepers for ste

47 tegy to identify the low expression of Bik1 (polyketide synthase) as a major bottleneck step in the p

48 role for ABM superfamily proteins in type II polyketide synthase assemblages for maintaining biosynth

49 Type I modular polyketide synthases assemble diverse bioactive natural

50 Polyketide synthases assemble diverse natural products w

51 nt tool for comparative analysis of trans-AT polyketide synthase assembly line architectures.

52 initiating and terminating an unusual type I polyketide synthase assembly line, and discover that mac

53 macrodiolide produced on a bacterial modular polyketide synthase assembly line.

54 e hybrid nonribosomal peptide synthetase and polyketide synthase biosynthetic gene cluster is encoded

55 ibe a pathway to chloroethylmalonyl-CoA as a polyketide synthase building block in the biosynthesis o

56 n the dark: the fermentation products of the polyketide synthase CalE8 (without its cognate thioester

57 Furthermore, in vitro investigations of the polyketide synthase central to cercosporin biosynthesis

58 ction of atrochrysone carboxylic acid by the polyketide synthase ClaG and the beta-lactamase ClaF.

59 id moiety through the activities of both the polyketide synthase ClbO and the amidase ClbL.

60 a shunt product in all related non-reducing polyketide synthase clusters containing homologues of Tp

61 s); each encodes acyltransferase-less type I polyketide synthases commensurate with iso-migrastatin b

62 oding hybrid nonribosomal peptide synthetase/polyketide synthases consistent with thalassospiramide a

63 ation and heterologous expression of type II polyketide synthase-containing eDNA clones is reported h

64 en fluorescent protein (GFP, 27 kDa) and the polyketide synthase DEBS1 (394 kDa).

65 MAL cluster, we identified malleilactone, a polyketide synthase-derived cytotoxic siderophore encode

66 of the biosynthesis of an important group of polyketide synthase-derived mycobacterial lipids, and su

67 Polyketide synthases elongate a polyketide backbone by c

68 Although polyketide synthase encoding genes have been successfull

69 conducted rational domain swaps between the polyketide synthases encoding the biosynthesis of the cl

70 nated when both the tpc and enc non-reducing polyketide synthase-encoding genes, tpcC and encA, respe

71 lly at three specific sites within the giant polyketide synthase-encoding genes.

72 ly required for the release of products from polyketide synthase enzymes, but no such enzyme has been

73 inition: A long-standing paradigm in modular polyketide synthase enzymology, namely the definition of

74 chloroethylmalonyl-CoA, a novel halogenated polyketide synthase extender unit of the proteasome inhi

75 important step toward harnessing these rare polyketide synthase extender units for combinatorial bio

76 A new series of coenzyme A-tethered polyketide synthase extender units were discovered in re

77 rmin, the biosynthesis of which requires the polyketide synthase FgnA.

78 antroquinonol biosynthesis in mycelium, and polyketide synthase for antrocamphin biosynthesis in fru

79 remarkable role of an enoylreductase in the polyketide synthase for azalomycin F biosynthesis.

80 We used this tool to delete a polyketide synthase gene (FUM1) required for fumonisin b

81 The Strongylocentrotus purpuratus polyketide synthase gene (SpPks) encodes an enzyme requi

82 recently a large trans-acyltransferase (AT) polyketide synthase gene cluster responsible for the bio

83 approach by isolating and sequencing type I polyketide synthase gene clusters from an Antarctic soil

84 ow describe a method for rapidly recombining polyketide synthase gene clusters to replace, add or rem

85 One is a cluster of four genes including a polyketide synthase gene, ausA.

86 attenuated mutants is interrupted in pks1, a polyketide synthase gene.

87 tants showed significant upregulation of the polyketide synthase genes ppsA-ppsE and drrA, which cons

88 We also found expansions in reducing polyketide synthase genes specific to the brown-rot fung

89 milarities in key genes such as 16S rRNA and polyketide synthase genes.

90 Many modular polyketide synthases harbor one or more redox-inactive d

91 LovF is a highly reducing polyketide synthase (HR-PKS) from the filamentous fungus

92 Highly reducing polyketide synthases (HR-PKSs) from fungi synthesize com

93 line collaboration between a highly reducing polyketide synthase (HRPKS, Fub1) and a nonribosomal pep

94 Fungal highly reducing polyketide synthases (HRPKSs) biosynthesize polyketides

95 ies, yet the biosynthesis by highly reducing polyketide synthases (HRPKSs) remains enigmatic.

96 teins of several families including type-III polyketide synthases, hydrolases, and cytochrome P450s r

97 e, can be incorporated by the actions of the polyketide synthase III (KSIII) AsuC3/C4 as well as the

98 In this study we show that a bimodular polyketide synthase in conjunction with a fatty acyl-AMP

99 We found that a predicted type III polyketide synthase in the genome of the brown alga Ecto

100 e for the mandatory homodimeric structure of polyketide synthases, in contrast to the monomeric nonri

101 Pks13 is a type I polyketide synthase involved in the final biosynthesis s

102 ciated with defoliation shared homology with polyketide synthases involved in secondary metabolism, w

103 The iterative type I polyketide synthases (IPKSs) are central to the biosynth

104 oxin B1, is one of the multidomain iterative polyketide synthases (IPKSs), a large, poorly understood

105 l polyketide intermediate from the iterative polyketide synthases (iPKSs), most frequently by a thioe

106 Two fungal iterative polyketide synthases (IPKSs), Rdc5, the highly reducing

107 lite gene clusters are anchored by iterative polyketide synthases (IPKSs), which are multidomain enzy

108 s involves a pair of collaborating iterative polyketide synthases (iPKSs): a highly reducing iPKS wit

109 The role of interdomain linkers in modular polyketide synthases is poorly understood.

110 Chalcone synthase (CHS), a type III plant polyketide synthase, is critical for flavonoid biosynthe

111 nge assay directly establishes that specific polyketide synthase ketoreductase domains also have an i

112 eptide synthetase, which resembles iterative polyketide synthases known in fungi.

113 We report expression of a microalgal polyketide synthase-like PUFA synthase system, comprisin

114 The final step in polyketide synthase-mediated biosynthesis of macrocyclic

115 hat encode three acyltransferase-less type I polyketide synthases (MgsEFG), one discrete acyltransfer

116 lly, we introduced the S148C mutation into a polyketide synthase module (PikAIII-TE) to impart increa

117 Every polyketide synthase module has an acyl carrier protein (

118 Thus, this polyketide synthase module showed considerable tolerance

119 e course of the enigmatic iterative use of a polyketide synthase module was deduced from targeted dom

120 yketide natural products produced on modular polyketide synthase multienzymes by an assembly-line pro

121 d substitution (R644W) in an uncharacterized polyketide synthase (MuPKS).

122 We have used a polyketide synthase mutant that accumulates an elevated

123 Pathway engineering of the chartreusin polyketide synthase, mutational synthesis, and molecular

124 ketide/amino acid structure encodes a hybrid polyketide synthase nonribosomal peptide synthetase (PKS

125 c gene cluster contains only a single-module polyketide synthase-nonribosomal peptide synthetase (PKS

126 ay-specific enzyme CpaS, a hybrid two module polyketide synthase-nonribosomal peptide synthetase (PKS

127 CpaS is a hybrid, two module polyketide synthase-nonribosomal peptide synthetase (PKS

128 erial strains and contains an unusual hybrid polyketide synthase-nonribosomal peptide synthetase, whi

129 7, should thus be informative to the modular polyketide synthase novice and expert alike.

130 aced, en masse, the promoters of nonreducing polyketide synthase (NR-PKS) genes, key genes in NP bios

131 A nonreducing polyketide synthase (NR-PKS) PhnA was shown to synthesiz

132 of fungal nonreducing, multidomain iterative polyketide synthases (NR-PKS group of IPKSs) results fro

133 In fungal non-reducing polyketide synthases (NR-PKS) the acyl-carrier protein (

134 Iterative, nonreducing polyketide synthases (NR-PKSs) are multidomain enzymes r

135 Nonreducing iterative polyketide synthases (NR-PKSs) are responsible for assem

136 emplate (PT) domains from fungal nonreducing polyketide synthases (NR-PKSs) are responsible for contr

137 The fungal iterative nonreducing polyketide synthases (NRPKSs) synthesize aromatic polyke

138 by a hybrid nonribosomal peptide synthetase-polyketide synthase (NRPS-PKS) system of the trans-acyl

139 n termination mechanism is described for the polyketide synthase of curacin A, an anticancer lead com

140 n is described for the loading module of the polyketide synthase of curacin A, an anticancer lead der

141 idated this system by expressing nonreducing polyketide synthases of Aspergillus terreus and addition

142 hat employs the final two monomodular type I polyketide synthases of the pikromycin pathway in vitro

143 The mupirocin trans-AT polyketide synthase pathway, provides a model system for

144 re the extent of phosphopantetheinylation of polyketide synthase (PKS) acyl carrier protein (ACP) dom

145 tes and virulence factors biosynthesized via polyketide synthase (PKS) and nonribosomal peptide synth

146 lic fatty acid synthase of type 1 (FAS1) and polyketide synthase (PKS) and the down-regulation of the

147 eaturing an acyltransferase (AT)-less type I polyketide synthase (PKS) and three tailoring enzymes Mg

148 olide B synthase (DEBS) and pikromycin (Pik) polyketide synthase (PKS) are unique multifunctional enz

149 nd sequenced, and shown to possess a type II polyketide synthase (PKS) at its core.

150 ential to both fatty acid synthase (FAS) and polyketide synthase (PKS) biosynthetic pathways, yet rel

151 omain FosDH1 from module 1 of the fostriecin polyketide synthase (PKS) catalyzed the stereospecific i

152 -line like megaenzymes of the type 1 modular polyketide synthase (PKS) class.

153 onribosomal polypeptide synthetase (NRPS) or polyketide synthase (PKS) domains.

154 r nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) enzyme complexes by a conserve

155 of bioactive natural products synthesized by polyketide synthase (PKS) enzyme complexes predominantly

156 n postulated to be synthesized by a type III polyketide synthase (PKS) enzyme, but so far type III PK

157 Polyketide synthase (PKS) enzymes continue to hold great

158 ducts are produced by multifunctional type I polyketide synthase (PKS) enzymes that operate as biosyn

159 athway, we report a differentially expressed polyketide synthase (PKS) gene candidate.

160 son mutagenesis, we identified a stand-alone polyketide synthase (PKS) gene cluster required for the

161 Here, we identified and deleted a polyketide synthase (PKS) gene PfmaE and showed that it

162 Deletion of the polyketide synthase (pks) genotoxic island from E. coli

163 The PLM polyketide synthase (PKS) has the predicted dehydratase

164 ribosomal peptide synthetase (NRPS) and NRPS-polyketide synthase (PKS) hybrid BGCs from Photorhabdus

165 nt antibiotic produced via a trans-AT Type I polyketide synthase (PKS) in Pseudomonas fluorescens, co

166 These techniques were applied to CalE8, the polyketide synthase (PKS) involved in calicheamicin bios

167 Detailed analysis of the modular Type I polyketide synthase (PKS) involved in the biosynthesis o

168 The type II polyketide synthase (PKS) is a complex consisting of 5-1

169 The programming of the fungal polyketide synthase (PKS) is quite complex, with a simpl

170 decouple R*-domain-containing NRPS from the polyketide synthase (PKS) machinery, expanding the parad

171 The polyketide synthase (PKS) mega-enzyme assembly line uses

172 ybrid nonribosomal peptide synthetase (NRPS)/polyketide synthase (PKS) megasynthase followed by the t

173 h nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) modules acting along with cata

174 The potential for recombining intact polyketide synthase (PKS) modules has been extensively e

175 his moiety, the gem-dimethyl group producing polyketide synthase (PKS) modules of yersiniabactin and

176 nits through the use of dedicated initiation polyketide synthase (PKS) modules offers opportunities t

177 mains of cryptic function are often found in polyketide synthase (PKS) modules that produce epimerize

178 , encodes a trans-acyltransferase (trans-AT) polyketide synthase (PKS) multienzyme that was hypothesi

179 by heterologous complementation of enediyne polyketide synthase (PKS) mutants from the C-1027 produc

180 HR) and a non-reducing (NR) iterative type I polyketide synthase (PKS) pair.

181 Metabolic engineering of polyketide synthase (PKS) pathways represents a promisin

182 The virulent gene island polyketide synthase (pks) produces the secondary metabol

183 en 77 and 80 kb and encode five multimodular polyketide synthase (PKS) proteins, a hydroxymethylgluta

184 ad branch of fatty acid synthase- (FAS)-like polyketide synthase (PKS) proteins, which sacoglossan an

185 ns a hybrid type I fatty acid synthase (FAS)-polyketide synthase (PKS) system and an ABC transporter.

186 mains act as interaction hubs within modular polyketide synthase (PKS) systems, employing specific pr

187 f multidomain type I fatty acid synthase and polyketide synthase (PKS) systems.

188 nd the characterization of a highly reducing polyketide synthase (PKS) that acts in both a sequential

189 olyketides are biosynthesized by the type II polyketide synthase (PKS) that consists of 5-10 stand-al

190 antibiotic erythromycin, is synthesized by a polyketide synthase (PKS) that has emerged as the protot

191 core has been predicted to be initiated by a polyketide synthase (PKS) that is distinct from all know

192 g disease, house a nonamodular assembly line polyketide synthase (PKS) that presumably synthesizes an

193 thase (DEBS) is a prototypical assembly line polyketide synthase (PKS) that synthesizes the macrocycl

194 er encoding a cryptic trans-acyl transferase polyketide synthase (PKS) was identified in the genomes

195 mains (DHs) of the iso-migrastatin (iso-MGS) polyketide synthase (PKS) were investigated by systemati

196 ) from Streptomyces coelicolor is a type III polyketide synthase (PKS) with broad substrate flexibili

197 c pathways of the products of type I modular polyketide synthase (PKS) with the focus on providing a

198 a chersina previously identified an enediyne polyketide synthase (PKS), but no anthraquinone PKS, sug

199 The genes tested were polyketide synthase (PKS), Flavin-dependent monooxygenas

200 in, which exhibits a putative combination of polyketide synthase (PKS), non-ribosomal peptide synthet

201 viously identified as a cluster containing a polyketide synthase (PKS)-encoding (FUB1) and four addit

202 Curacin A is a polyketide synthase (PKS)-non-ribosomal peptide syntheta

203 ticancer activity that are biosynthesized by polyketide synthase (PKS)-nonribosomal peptide synthetas

204 tase (NRPS)-acyltransferase (AT)-less type I polyketide synthase (PKS).

205 hesis of lovastatin uses an iterative type I polyketide synthase (PKS).

206 ounds, which are produced by a novel type II polyketide synthase (PKS).

207 chain, which is synthesized by an iterative polyketide synthase (PKS).

208 by using a dissected and reassembled fungal polyketide synthase (PKS).

209 m non-ribosomal peptide synthetase (NRPS) or polyketide synthase (PKS).

210 Our examination of the 27 polyketide synthases (PKS) in A. nidulans revealed that

211 Non-ribosomal peptide synthetases (NRPS) and polyketide synthases (PKS) produce numerous secondary me

212 compounds is proposed to involve two fungal polyketide synthases (PKS) that function collaboratively

213 Engineering polyketide synthases (PKS) to produce new metabolites re

214 line-like multiprotein complexes of modular polyketide synthases (PKS).

215 le that targets the thioesterase activity of polyketide synthase Pks13, an essential enzyme that form

216 gene deletion verified that the F. fujikuroi polyketide synthase PKS13, designated Gpy1, is responsib

217 22) and a 6-domain reducing iterative type I polyketide synthase (Pks15/1) for production of p-hydrox

218 ing the norsolorinic acid anthrone-producing polyketide synthase, PksA, from the aflatoxin biosynthet

219 Previous work identified enediyne-specific polyketide synthases (PKSEs) that can be phylogeneticall

220 tion and functionalization encoded by type I polyketide synthase (PKSs), cascade reactions can take p

221 Insights into how bacterial polyketide synthases (PKSs) acquire new metabolic capabi

222 tural families is determined by the enediyne polyketide synthases (PKSs) alone.

223 id lactone (TAL) is a signature byproduct of polyketide synthases (PKSs) and a valuable synthetic pre

224 enetic analysis of the corresponding melanin polyketide synthases (PKSs) and alignment of melanin BGC

225 The final transformation catalyzed by both polyketide synthases (PKSs) and fatty acid synthases is

226 Modular polyketide synthases (PKSs) and nonribosomal peptide syn

227 Assembly-line polyketide synthases (PKSs) are among the most complex p

228 Nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs) are large enzymes responsibl

229 Iterative polyketide synthases (PKSs) are large, multifunctional e

230 Acyltransferase (AT)-less type I polyketide synthases (PKSs) break the type I PKS paradig

231 The dehydratases (DHs) of modular polyketide synthases (PKSs) catalyze dehydrations that o

232 Ketoreductase (KR) domains from modular polyketide synthases (PKSs) catalyze the reduction of 2-

233 Modular polyketide synthases (PKSs) direct the biosynthesis of c

234 Biochemical characterization of polyketide synthases (PKSs) has relied on synthetic subs

235 Engineering modular polyketide synthases (PKSs) has the potential to be an e

236 Multimodular polyketide synthases (PKSs) have an assembly line archit

237 PKS11 is one of three type III polyketide synthases (PKSs) identified in Mycobacterium

238 Fatty acid synthases (FASs) and polyketide synthases (PKSs) iteratively elongate and oft

239 most of the fatty acid synthases (FASs) and polyketide synthases (PKSs) known to date are characteri

240 Acyltransferase (AT)-less type I polyketide synthases (PKSs) produce complex natural prod

241 The mechanistic details of many polyketide synthases (PKSs) remain elusive due to the in

242 Polyketide synthases (PKSs) represent a powerful catalyt

243 ineering the acyltransferase (AT) domains of polyketide synthases (PKSs) responsible for the incorpor

244 Type III polyketide synthases (PKSs) show diverse cyclization spe

245 e alkylresorcinol synthases (ARSs), type III polyketide synthases (PKSs) that produce 5-alkylresorcin

246 However, manipulation of modular type I polyketide synthases (PKSs) to make unnatural metabolite

247 polyketide intermediates are set by modular polyketide synthases (PKSs) when condensation is not imm

248 Type I polyketide synthases (PKSs), and related fatty acid synt

249 iosynthetic machinery, represented by type I polyketide synthases (PKSs), has an architecture in whic

250 rbon framework is assembled by two iterative polyketide synthases (PKSs), Hpm8 (highly reducing) and

251 To harness the synthetic power of modular polyketide synthases (PKSs), many aspects of their bioch

252 the biosynthesis of polyketide backbones by polyketide synthases (PKSs), post-PKS modifications resu

253 Type I modular polyketide synthases (PKSs), which are responsible for t

254 The plant type III polyketide synthases (PKSs), which produce diverse secon

255 H enzymes in fatty acid synthases (FASs) and polyketide synthases (PKSs).

256 and sequencing of genes encoding a number of polyketide synthases (PKSs).

257 nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs).

258 nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs).

259 roach has been successful for type I modular polyketide synthases (PKSs); however, despite more than

260 a spontaneous point mutation in the putative polyketide synthase PpsD that results in a G44C amino ac

261 of mellein by a partially reducing iterative polyketide synthase (PR-PKS) as a pentaketide product.

262 ar compounds (marginolactones) are formed by polyketide synthases primed not with gamma-aminobutanoyl

263 thase (DEBS) is a prototypical assembly line polyketide synthase produced by the actinomycete Sacchar

264 rmations responsible for converting the post-polyketide synthase product into the exciting anticancer

265 ort the characterization of a novel Type III polyketide synthase, quinolone synthase (QNS), from A. m

266 Two novel type III polyketide synthases, quinolone synthase (QNS) and acrid

267 of programming of iterative highly reducing polyketide synthases remains one of the key unsolved pro

268 The polyketide synthases responsible for the biosynthesis of

269 the hybrid nonribosomal peptide synthetases/polyketide synthase rifamycin biosynthetic cluster of Am

270 ng 3-amino-5-hydroxybenzoic acid (AHBA), the polyketide synthase starter unit of both natural product

271 hioluteus catalyzes the formation of unusual polyketide synthase starter unit p-nitrobenzoic acid (pN

272 ing an extensive literature on assembly line polyketide synthases such as the 6-deoxyerythronolide B

273 ormed by an iterative highly reducing fungal polyketide synthase supported by a hydrolase, together w

274 unctional analysis of three soil DNA-derived polyketide synthase systems in Streptomyces albus reveal

275 , we have constructed pathways involving two polyketide synthase systems, and we show that fluoroacet

276 Type I polyketide synthases (T1PKSs) are one of the most extens

277 re non-ribosomal peptide synthetases, type 1 polyketide synthases, terpenes, and lantipeptides.

278 mediating substrate specificity of bacterial polyketide synthase TEs.

279 by DynE8, a highly reducing iterative type I polyketide synthase that assembles polyketide intermedia

280 Tylactone synthase (TYLS) is a modular polyketide synthase that catalyzes the formation of tyla

281 OTC is synthesized by a type II polyketide synthase that generates the poly-beta-ketone

282 e show that chlorizidine A is assembled by a polyketide synthase that uniquely incorporates a fatty a

283 polyketide biosynthesis mediated by trans-AT polyketide synthases that lack integrated acyl transfera

284 The minimal ssf polyketide synthase together with the amidotransferase S

285 ding frames that encode three modular type I polyketide synthases (TtmHIJ), one type II thioesterase

286 ates tested positive for at least one of the polyketide synthase type I, polyketide synthase type II

287 least one of the polyketide synthase type I, polyketide synthase type II or non-ribosomal peptide syn

288 tory quinones, PkQs are produced by type III polyketide synthases using fatty acyl-CoA precursors.

289 licolor RppA (Sc-RppA), a bacterial type III polyketide synthase, utilizes malonyl-CoA as both starte

290 s of DynE8, fatty acid synthase, and modular polyketide synthases, we overexpressed a 44-kDa fragment

291 quence-specific synthesis by the ribosome to polyketide synthases, where tethered molecules are passe

292 opolone nucleus: tropA encodes a nonreducing polyketide synthase which releases 3-methylorcinaldehyde

293 nsible for chain release from the enacyloxin polyketide synthase, which assembles an antibiotic with

294 hanism for chain release from the enacyloxin polyketide synthase, which assembles an antibiotic with

295 The colinearity of canonical modular polyketide synthases, which creates a direct link betwee

296 y, terpenoid pathways, cytochrome P450s, and polyketide synthases, which may contribute to the produc

297 We also characterized a truncated polyketide synthase with a ketoreductase function that c

298 suggest that Pks15/1 is an iterative type I polyketide synthase with a relaxed control of catalytic

299 ltransferase domain of module 6 of rifamycin polyketide synthase with that of module 2 of rapamycin p

300 gested to be the product of a modular type I polyketide synthase working in trans with two monofuncti