ライフサイエンスコーパス: polyposis coli

1 th in the context of mutant Apc (adenomatous polyposis coli).

2 -containing protein 2), and APC (adenomatous polyposis coli).

3 synthase kinase 3beta, axin, and adenomatous polyposis coli.

4 ism associated with mutations in Adenomatous Polyposis Coli.

5 urine tumor model of spontaneous adenomatous polyposis coli.

6 a recessive phenotype, multiple adenomas, or polyposis coli.

7 In addition we identified adenomatous polyposis coli 1 (APC1) as an interaction partner of KHC

8 mline specific overexpression of Adenomatous Polyposis Coli 2 (APC2) rescued GSC loss in chic hypomor

9 cells for proper localization of Adenomatous polyposis coli 2 and E-cadherin at the hub-GSC interface

10 centrosomal proteins Ninein and adenomatous polyposis coli abolished this bias.

11 ors of beta-catenin, such as the adenomatous polyposis coli and Axin tumor suppressor proteins.

12 ignaling (RGS) domain that binds adenomatous polyposis coli and Galpha subunits, thereby providing a

13 nsulin-like growth factor 2, and adenomatous polyposis coli) and other solid tumors (e.g., NOTCH3) an

14 attributed to mutations in Axin, adenomatous polyposis coli, and beta-catenin that lead to constituti

15 grafted OPCs differentiated into adenomatus polyposis coli (APC(+)) OLs, and CNTF significantly incr

16 lly expressed a mutant allele of adenomatous polyposis coli (APC(cKO)) in murine uterine stroma cells

17 gmenting CRC tumorigenesis in an adenomatous polyposis coli (APC(Delta14/+)) mouse model.

18 hypoxia-induced PH, we used the adenomatous polyposis coli (Apc(Min/+)) mouse, where reduced APC cau

19 t a cancer causing truncation in adenomatous polyposis coli (APC) (APC(1-1450)) dominantly interferes

20 partner of the tumor suppressor adenomatous polyposis coli (APC) [1]; however, the significance of E

21 titutive Wnt activation upon loss of Adenoma polyposis coli (APC) acts as main driver of colorectal c

22 The tumor suppressor Adenomatous polyposis coli (APC) affects the function of microtubule

23 the rare inheritance of a mutant adenomatous polyposis coli (Apc) allele.

24 LPA to mice heterozygous for the adenomatous polyposis coli (Apc) allele.

25 n of the Wnt-regulating proteins adenomatous polyposis coli (APC) and APC2 in the pathogenesis of hum

26 pecific GSK3 substrates, such as adenomatous polyposis coli (APC) and collapsin response mediator pro

27 t two tumor suppressor proteins, adenomatous polyposis coli (APC) and Dlg1-SAP97, are required for th

28 le plus end-associated proteins, adenomatous polyposis coli (APC) and EB1, providing a potential link

29 nscriptional mechanisms and that adenomatous polyposis coli (APC) and GSK3beta, which are negative re

30 of the gut tumor suppressor gene adenomatous polyposis coli (Apc) and its role in the oligodendroglia

31 that mPar3 forms a complex with adenomatous polyposis coli (APC) and kinesin superfamily (KIF) 3A, p

32 lly, CBC stem cells deficient in adenomatous polyposis coli (Apc) and Math1 were able to promote inte

33 lorectal cancer tumor suppressor adenomatous polyposis coli (APC) and that KLF4 repressed the Wnt/bet

34 d that both the tumor suppressor adenomatous polyposis coli (APC) and the ADP-ribose polymerase Tanky

35 py to image the tumor suppressor adenomatous polyposis coli (APC) and the formin mDia1 during filamen

36 pected loss in the expression of adenomatous polyposis coli (APC) and the transcriptional repressor B

37 ients with germline mutations in adenomatous polyposis coli (APC) are susceptible to stomach polyps a

38 AP) but further study identified adenomatous polyposis coli (APC) as responsible for FAP and the phys

39 As in mammals, loss of adenomatous polyposis coli (APC) causes Drosophila intestinal stem c

40 e find that the tumor suppressor adenomatous polyposis coli (APC) controls microtubule targeting to t

41 mice carrying the Min allele of Adenomatous polyposis coli (Apc) develop numerous adenomas along the

42 Mutations in adenomatous polyposis coli (APC) disrupt regulation of Wnt signaling

43 rs consistently contained mutant adenomatous polyposis coli (APC) DNA molecules in their plasma.

44 hat the tumor-suppressor protein adenomatous polyposis coli (APC) functions in localizing alpha3-nico

45 As Adenomatous Polyposis Coli (APC) functions in many of the same proce

46 g a heterozygote mutation in the adenomatous polyposis coli (APC) gene (Apc(Min/+) mice).

47 geted pigs with mutations in the adenomatous polyposis coli (APC) gene (APC) that are orthologous to

48 The adenomatous polyposis coli (Apc) gene also plays an important role i

49 dels involve modification of the adenomatous polyposis coli (Apc) gene and are excellent models for f

50 n cells with deficiencies in the adenomatous polyposis coli (APC) gene and in cells stimulated with t

51 We show that a deficiency in the adenomatous polyposis coli (APC) gene and subsequent activation of b

52 Mutations in the adenomatous polyposis coli (APC) gene are associated with an early o

53 Patients with mutations in the Adenomatous Polyposis Coli (APC) gene are at increased risk of devel

54 Somatic mutations of the adenomatous polyposis coli (APC) gene are initiating events in the m

55 Mutations in the adenomatous polyposis coli (APC) gene are pivotal in colorectal tumo

56 Genetic mutations in the adenomatous polyposis coli (APC) gene are thought to cause colon ade

57 Mutations in the human adenomatous polyposis coli (APC) gene are thought to initiate colore

58 l lines bearing mutations on the adenomatous polyposis coli (APC) gene as a model of FAP-related mali

59 The adenomatous polyposis coli (APC) gene encodes APC tumour suppressor

60 -LoxP strategy to inactivate the Adenomatous Polyposis Coli (Apc) gene in the murine renal epithelium

61 Since the Adenomatous Polyposis Coli (APC) gene is mutated in the majority of

62 The Adenomatous Polyposis Coli (APC) gene is mutated in the majority of

63 The adenomatous polyposis coli (APC) gene is mutated within specific seq

64 Although beta-catenin and adenomatous polyposis coli (APC) gene mutations are well established

65 Adenomatous polyposis coli (APC) gene mutations have been implicated

66 Mutations in the adenomatous polyposis coli (APC) gene occur in the vast majority of

67 al cancers have mutations of the adenomatous polyposis coli (APC) gene or the beta-catenin gene that

68 The adenomatous polyposis coli (APC) gene plays, among other things, a c

69 The adenomatous polyposis coli (APC) gene product is mutated in the vast

70 ce with inactivating mutation of adenomatous polyposis coli (APC) gene reduces intestinal adenomatous

71 Mutations in the adenomatous polyposis coli (APC) gene result in uncontrolled prolife

72 operate with inactivation of the adenomatous polyposis coli (Apc) gene to accelerate intestinal tumou

73 eta-catenin or defective for the adenomatous polyposis coli (APC) gene to reinvestigated the identity

74 Mutations in the Adenomatous Polyposis Coli (APC) gene up-regulate Wnt signaling by s

75 r as conditional deletion of the adenomatous polyposis coli (Apc) gene within the adult bladder led r

76 The adenomatous polyposis coli (APC) gene, a member of the WNT pathway,

77 arcinogenesis is mutation of the adenomatous polyposis coli (APC) gene, which leads to activation of

78 ar inactivating mutations of the adenomatous polyposis coli (APC) gene, whose product is an important

79 h loss of normal function of the Adenomatous polyposis coli (APC) gene.

80 ular, tumor suppressors TP53 and adenomatous polyposis coli (APC) gene.

81 tions in human CRC occurs in the adenomatous polyposis coli (APC) gene.

82 atic truncation mutations to the adenomatous polyposis coli (Apc) gene.

83 ith heterozygous mutation in the adenomatous polyposis coli (APC) gene.

84 be dominated by mutations in the adenomatous polyposis coli (APC) gene.

85 lasia caused by mutations of the adenomatous polyposis coli (Apc) gene.

86 due to somatic mutations in the adenomatous polyposis coli (APC) gene.

87 mice lacking the beta-catenin or adenomatous polyposis coli (Apc) genes in osteoblasts.

88 The adenomatous polyposis coli (APC) I1307K allele is found in 6% of the

89 nd epigenetic changes induced by adenomatous polyposis coli (Apc) inactivation in intestinal crypts.

90 enin pathway signaling following adenomatous polyposis coli (APC) inactivation.

91 utations in the tumor suppressor adenomatous polyposis coli (APC) initiate most colon cancers and hav

92 The tumor suppressor adenomatous polyposis coli (APC) is a crucial regulator of many stem

93 brain, and the tumor suppressor adenomatous polyposis coli (APC) is a key negative regulator of Wnt/

94 Adenomatous polyposis coli (APC) is a large multidomain protein that

95 Adenomatous polyposis coli (APC) is a microtubule plus-end scaffoldi

96 The tumor suppressor Adenomatous polyposis coli (APC) is a negative regulator of Wnt sign

97 Mutational inactivation of adenomatous polyposis coli (APC) is an early event in colorectal can

98 The tumor suppressor adenomatous polyposis coli (APC) is an essential negative regulator

99 The tumor suppressor adenomatous polyposis coli (APC) is an essential negative regulator

100 ASE of adenomatous polyposis coli (APC) is associated with pathogenesis of

101 Adenomatous polyposis coli (APC) is best known for its crucial role

102 Mutation of the tumor suppressor adenomatous polyposis coli (APC) is considered an initiating step in

103 The tumor suppressor adenomatous polyposis coli (APC) is frequently mutated in colorectal

104 The tumor suppressor adenomatous polyposis coli (APC) is implicated in regulating multipl

105 The tumor suppressor protein adenomatous polyposis coli (APC) is multifunctional - it participate

106 Adenomatous polyposis coli (APC) is mutated in colon cancers.

107 Adenomatous polyposis coli (APC) is one such MAP with a multifunctio

108 ing loss of the tumor suppressor adenomatous polyposis coli (APC) is thought to initiate colon adenom

109 Loss of tumor suppressor adenomatous polyposis coli (APC) is thought to initiate the majority

110 s of heterozygosity rates at the adenomatous polyposis coli (Apc) locus are unaffected by Atm loss.

111 Today, the tumor suppressor adenomatous polyposis coli (APC) may have the same complaint about a

112 stinal epithelial suppression of adenomatous polyposis coli (Apc) mitigates RIGS lethality in vivo af

113 Here, we show that adenomatous polyposis coli (APC) modulates microtubule (MT) severing

114 IP-Tag2 transgenic mouse tumors, adenomatous polyposis coli (apc) mouse adenomas, and implanted MCa-I

115 y oral administration of HFCS in adenomatous polyposis coli (APC) mutant mice, which are predisposed

116 We report that adenomatous polyposis coli (APC) mutant zebrafish harbor an RA-defic

117 itiation of colorectal cancer by adenomatous polyposis coli (APC) mutation is mediated by dysregulati

118 Adenomatous polyposis coli (APC) mutation is the most common genetic

119 er cells even in the presence of adenomatous polyposis coli (Apc) mutation.

120 Adenomatous polyposis coli (APC) mutations are linked to human and m

121 In this study, we show that adenomatous polyposis coli (APC) mutations found in human colorectal

122 nin pathway activation caused by adenomatous polyposis coli (APC) mutations occurs in approximately 8

123 duals with heterozygous germline adenomatous polyposis coli (APC) mutations or familial adenomatous p

124 The tumor suppressor Adenomatous polyposis coli (APC) negatively regulates Wnt signaling

125 pletion of the tumor suppressors adenomatous polyposis coli (APC) or Axin dramatically increased macr

126 nitiating mutation occurs in the adenomatous polyposis coli (APC) or beta-catenin gene, activating th

127 been associated with loss of the adenomatous polyposis coli (APC) or constitutive activation of beta-

128 ynthase kinase 3beta (GSK-3beta)/adenomatous polyposis coli (APC) pathways.

129 The tumor suppressor adenomatous polyposis coli (APC) plays a critical role in the turnov

130 Adenomatous polyposis coli (APC) plays a critical role in the Wnt si

131 The tumor suppressor Adenomatous polyposis coli (APC) plays a key role in regulating the

132 essing NeuN positive neurons and adenomatous polyposis coli (APC) positive mature oligodendrocytes in

133 enin/E-cadherin and beta-catenin/adenomatous polyposis coli (APC) PPIs.

134 In interphase cells, the adenomatous polyposis coli (APC) protein accumulates on a small subs

135 SK-3beta and accumulation of the adenomatous polyposis coli (APC) protein at the plus ends of leading

136 rt that the expression status of adenomatous polyposis coli (APC) protein determines the relative sen

137 The adenomatous polyposis coli (APC) protein functions as a negative reg

138 The role of wild-type adenomatous polyposis coli (APC) protein in native epithelia is poor

139 Loss of the adenomatous polyposis coli (APC) protein is a common initiating even

140 Adenomatous polyposis coli (APC) protein is a large tumor suppressor

141 CtBP interacts with adenomatous polyposis coli (APC) protein, and is stabilized in both

142 Fap1 also interacts with the adenomatous polyposis coli (Apc) protein, but the functional signifi

143 ses, beta-catenin, axin, and the Adenomatous Polyposis Coli (APC) protein.

144 iciencies in mismatch repair and adenomatous polyposis coli (APC) proteins, diet, inflammatory proces

145 ut allele in the gatekeeper gene Adenomatous polyposis coli (Apc) recapitulates familial colon cancer

146 The tumor suppressor protein adenomatous polyposis coli (APC) regulates cell protrusion and cell

147 Adenomatous polyposis coli (APC) regulates the activity of beta-cate

148 lly important for cell migration.Adenomatous polyposis coli (APC) regulates the localization of some

149 ing in mice, we demonstrate that adenomatous polyposis coli (APC) serves an essential function in the

150 The tumor suppressor protein adenomatous polyposis coli (APC) stabilizes microtubules both in vit

151 way the tumor-suppressor protein adenomatous polyposis coli (APC) targets RNAs to cell protrusions, f

152 ave defined a repeat sequence in adenomatous polyposis coli (APC) that binds to EB1's COOH-terminal d

153 responsive cells were defined by adenomatous polyposis coli (APC) time-of-flight mass cytometry (CyTO

154 Binding of adenomatous polyposis coli (APC) to the microtubule plus ends in pol

155 KIF17 participates in localizing adenomatous polyposis coli (APC) to the plus ends of a subset of MTs

156 The adenomatous polyposis coli (APC) tumor suppressor forms a complex wi

157 ed or inherited mutations in the adenomatous polyposis coli (APC) tumor suppressor gene are causally

158 The adenomatous polyposis coli (APC) tumor suppressor gene encodes a mul

159 Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene initiate a ma

160 The Adenomatous Polyposis Coli (APC) tumor suppressor gene is silenced b

161 Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene seem to under

162 with truncating mutations in the adenomatous polyposis coli (APC) tumor suppressor gene through inhib

163 ients harboring mutations in the adenomatous polyposis coli (APC) tumor suppressor gene.

164 The adenomatous polyposis coli (APC) tumor suppressor is a major regulat

165 The Adenomatous Polyposis Coli (APC) tumor suppressor is a multifunction

166 Inactivation of the adenomatous polyposis coli (APC) tumor suppressor is frequently foun

167 The adenomatous polyposis coli (APC) tumor suppressor is inactivated by

168 The adenomatous polyposis coli (Apc) tumor suppressor is involved in the

169 specific allelic deletion of the adenomatous polyposis coli (Apc) tumor suppressor locus, Ikkbeta(EE)

170 The adenomatous polyposis coli (APC) tumor suppressor protein is associa

171 2A) and must be protected by the adenomatous polyposis coli (APC) tumor suppressor protein.

172 Mutation of the adenomatous polyposis coli (APC) tumor suppressor stabilizes beta-ca

173 tain truncating mutations in the adenomatous polyposis coli (APC) tumor suppressor, a negative regula

174 is negatively controlled by the adenomatous polyposis coli (APC) tumor suppressor, which induces pro

175 cleocytoplasmic shuttling of the adenomatous polyposis coli (APC) tumor suppressor.

176 the in vivo mutation rate of the adenomatous polyposis coli (APC) tumor-suppressor gene is presented.

177 etic pathway whereby loss of the adenomatous polyposis coli (APC) tumour suppressor and activation of

178 the granules associate with the adenomatous polyposis coli (APC) tumour suppressor and the fragile X

179 Mutations in the adenomatous polyposis coli (APC) tumour suppressor are the key initi

180 Mutations in Adenomatous polyposis coli (APC) underlie familial adenomatous polyp

181 Mutations in adenomatous polyposis coli (APC) underlie the earliest stages of col

182 dy, the tumor suppressor protein adenomatous polyposis coli (APC) was found to be important for the u

183 found that the tumor suppressor adenomatous polyposis coli (APC) was required for microtubule intera

184 h1 (Atoh1(Deltaintestine)), the adenomatosis polyposis coli (APC)(min) mutation, both mutations (Atoh

185 These mice were crossed with adenomatous polyposis coli (Apc)(min/+) mice, or given azoxymethane

186 ic relationship between MPC1 and Adenomatous polyposis coli (APC), a key tumor suppressor in colorect

187 Inactivating mutations within adenomatous polyposis coli (APC), a negative regulator of Wnt signal

188 Adenomatous polyposis coli (APC), a protein with both tumor suppress

189 uggest that the tumor suppressor adenomatous polyposis coli (APC), a regulator of Wnt signaling and t

190 Adenomatous polyposis coli (APC), a tumor suppressor commonly mutate

191 Adenomatous polyposis coli (Apc), a tumor suppressor gene conserved

192 Adenomatous polyposis coli (APC), a tumor suppressor gene that is co

193 Specific site of CpG islands of adenomatous polyposis coli (APC), a well studied tumor suppressor ge

194 The tumor suppressor adenomatous polyposis coli (APC), an essential negative regulator of

195 uction complex components Axin1, adenomatous polyposis coli (APC), and GSK3beta were also proteolytic

196 containing the proteins axin and adenomatous polyposis coli (APC), both of which bind directly to bet

197 plex with axin (axis inhibitor), adenomatous polyposis coli (APC), casein kinase 1alpha (CK1alpha), a

198 ic exchange factor stimulated by adenomatous polyposis coli (APC), contributing to colorectal cancer

199 with its direct binding partner adenomatous polyposis coli (APC), EB1 can stabilize microtubules.

200 ons in known driver genes [e.g., adenomatous polyposis coli (APC), KRAS, or PIK3CA] found in the prim

201 Individual crypt adenomatous polyposis coli (APC), p53, K-RAS, and 17p loss of hetero

202 y patients induced colon p53 and adenomatous polyposis coli (APC), reversing progrowth GH signals.

203 gainst beta-catenin (Ctnnb1) and adenomatous polyposis coli (Apc), two commonly mutated genes in hepa

204 naling by targeting the gene for Adenomatous Polyposis Coli (Apc), which controls Wnt signaling activ

205 hat the tumor suppressor protein adenomatous polyposis coli (APC), which is a known MT-associated pro

206 ion and activity using models of adenomatous polyposis coli (APC)- and chemotherapy-induced apoptosis

207 Two adenomatous polyposis coli (APC)-dependent proteasomal degradation p

208 beta-catenin through a conserved adenomatous polyposis coli (APC)-like domain.

209 Expression of eIF6 in adenomatous polyposis coli (APC)-mutant colon cancer cells, which ex

210 epithelial over-proliferation in Adenomatous polyposis coli (APC)-mutated intestine.

211 e cortical localizations of the adenomatosis polyposis coli (APC)-related protein APC2/E-APC and the

212 litis-associated and spontaneous adenomatous polyposis coli (APC)-related tumors of the intestinal ep

213 osed the discovery of truncating adenomatous polyposis coli (APC)-selective inhibitor 1 (TASIN-1), a

214 ansducin beta-like 1 (TBL1), and adenomatous polyposis coli (APC).

215 th myelin basic protein (MBP) and adenomatus polyposis coli (APC).

216 tubule plus end binding protein, adenomatous polyposis coli (APC).

217 tations in the tumor suppressor, adenomatous polyposis coli (APC).

218 mutation of the tumor suppressor Adenomatous Polyposis Coli (APC).

219 nthase kinase-3beta, axin-1, and adenomatous polyposis coli (APC).

220 tivation of the tumor suppressor adenomatous polyposis coli (APC).

221 function of the tumor suppressor Adenomatous polyposis coli (Apc).

222 sses beta-catenin activity in an adenomatous polyposis coli (APC)/glycogen synthase kinase-3 (GSK3)-i

223 esses colonic polyp formation in adenomatous polyposis coli (APC)min/+ mice.

224 We analyzed adenomatous polyposis coli (Apc)min/+/Sigirr-/- mice for polyps, mic

225 ve cell imaging, and a mutant of Adenomatous polyposis coli (APC-m4) defective in actin nucleation to

226 EGF1 mice were bred to Min mice (adenomatous polyposis coli [APC] +/-).

227 or suppressor candidate 33, N33; adenomatous polyposis coli, APC; mut-L homolog 1, MLH1; and O(6)-met

228 eted for proteolysis by the Axin/Adenomatous polyposis coli (Apc1 and Apc2)/Zeste-white 3 destruction

229 defect (POP-1)/TCF, APC related/adenomatosis polyposis coli (APR-1)/APC, and LIT-1/NLK (loss of intes

230 lloproteinases 1, 2, and 3, and adenomatosis polyposis coli) are known for their antiangiogenic funct

231 thway mutations, such as loss of adenomatous polyposis coli, are insensitive to this novel hypoxic ef

232 he destruction complex component adenomatous polyposis coli at a similar SLS motif to the effect that

233 lex, consisting of the proteins adenomatosis polyposis coli, Axin and glycogen synthase kinase 3beta

234 ynthase kinase 3beta (GSK3beta)- adenomatous polyposis coli-axin-mediated degradation pathway.

235 Because mutations in adenomatous polyposis coli, beta-catenin and other components of the

236 ted with colon cancer, including adenomatous polyposis coli, beta-catenin, p53, c-myc, cyclin D1, and

237 umors driven by mutations in the adenomatous polyposis coli/beta-catenin pathway and activates AP-1.

238 even harboring mutations in the adenomatous polyposis coli/beta-catenin pathway.

239 lines harboring mutations in the adenomatous polyposis coli/beta-catenin pathway.

240 activated canonical signaling in adenomatous polyposis coli/beta-catenin wild-type colon cancer cells

241 n site family (WNT)/beta-catenin/adenomatous polyposis coli (CTNNB1/APC) pathway has been identified

242 In the context of APC (adenomatous polyposis coli) deficiency (Apc(Min/+) mice), loss of Fb

243 nization and capture dynamics in adenomatous polyposis coli-deficient radial progenitors.

244 Adenomatosis polyposis coli down-regulated 1 (APCDD1) has recently be

245 neoplasia (Min) mutation of the adenomatous polyposis coli gene (Apc) and homozygous for the tumor r

246 e with germline mutations in the adenomatous polyposis coli gene (Apc) and/or DNA mismatch repair gen

247 Mutations in the adenomatous polyposis coli gene (Apc) are a major driver of familial

248 rectal cancers, mutations in the adenomatous polyposis coli gene (APC) or CTNNB1 constitutively activ

249 d with reduced expression of the adenomatous polyposis coli gene (APC).

250 n family 1 gene RASSF1A, and the adenomatous polyposis coli gene APC in tumors and in histologically

251 rrying and non-sense mutation in Adenomatous polyposis coli gene at site R850, which designated Apc (

252 ause of germline mutation of the adenomatous polyposis coli gene is characterized by development of c

253 harboring an identical germline adenomatous polyposis coli gene mutation.

254 gative regulators, such as axin, adenomatous polyposis coli gene product (APC), and glycogen synthase

255 by inhibiting its binding to the adenomatous polyposis coli gene product and subsequent glycogen synt

256 ly rare missense variants in the adenomatous polyposis coli gene, which is responsible for familial a

257 e carrying the Min allele of the adenomatous polyposis coli gene.

258 d to control mice carry wildtype Adenomatous polyposis coli gene.

259 by inactivating mutations in the Adenomatous polyposis coli gene.

260 lineages by deletion of the Apc (adenomatous polyposis coli) gene causes spontaneous T cell activatio

261 through Disheveled (Dvl), Axin, adenomatous polyposis coli, glycogen synthase kinase 3beta, and case

262 hway regulatory genes, including adenomatous polyposis coli, GSK3beta, axin 1, beta-catenin, lymphoid

263 ith the tumor suppressor protein adenomatous polyposis coli in the TJs of epithelial cells.

264 due to inactivating mutations of adenomatous polyposis coli (in colorectal cancer) or activating muta

265 e tumor suppressor protein, APC (adenomatous polyposis coli), in the regulation of base excision repa

266 the Wnt repressor APC (encoding adenomatous polyposis coli) leads to a state of aberrant and unrestr

267 ned mutations in either the APC (adenomatous polyposis coli) locus or in an allele of beta-catenin.

268 g and glycogen synthase kinase-3/adenomatous polyposis coli-mediated beta-catenin activation.

269 al intestinal homeostasis and in adenomatous polyposis coli-mediated tumorigenesis.

270 Crossing Tfam(+/-) mice to the adenomatous polyposis coli multiple intestinal neoplasia (APC(Min/+)

271 Here, we demonstrate that adenomatous polyposis coli mutant APC(Min/+) mice, which have increa

272 ted and somatic mutations in the adenomatous polyposis coli occur in most colon cancers, leading to a

273 g functional mutations in either adenomatous polyposis coli or beta-catenin.

274 by loss of the tumor suppressor adenomatous polyposis coli or casein kinase 1alpha uncovered new reg

275 xamination of one or more of the adenomatous polyposis coli, p14ARF, p16INK4a, or death associated pr

276 formation about the roles of the adenomatous polyposis coli protein (APC) and its binding partner EB1

277 ated depletion of two kMAPs, the adenomatous polyposis coli protein (APC) and its binding partner, EB

278 in Axin and the tumor suppressor adenomatous polyposis coli protein (APC) are critical components of

279 We recently identified adenomatous polyposis coli protein (APC) as a key regulator of inter

280 eport that the tumour suppressor adenomatous polyposis coli protein (APC) directs the localization an

281 We propose that adenomatous polyposis coli protein (APC) is a key coordinator of pre

282 elic mutations in APC2, encoding adenomatous polyposis coli protein 2.

283 des with both beta4-spectrin and adenomatous polyposis coli protein in the cytosol.

284 f a region similar to one in the adenomatous polyposis coli protein involved in EB1 binding blocks Ml

285 actin-nucleating ability of the adenomatous polyposis coli protein is required for disassembly of fo

286 We had shown that the APC (adenomatous polyposis coli) protein controls localization of some RN

287 i of the beta-catenin antagonist adenomatous polyposis coli results in the regeneration of a tail at

288 However, little is known about adenomatous polyposis coli's (APC's) role in the mammalian brain.

289 tably transformed with wild-type adenomatous polyposis coli showed decreased beta-catenin protein and

290 -catenin, a component of the Wnt-adenomatous polyposis coli signaling pathway, contribute to the deve

291 ifferent autoantigen, except for adenomatous polyposis coli that was recognized by sera of two patien

292 s the tumor suppressor gene APC (adenomatous polyposis coli), thereby affecting Wnt (Wingless-related

293 sed by germline mutations in the adenomatous polyposis coli tumor suppressor gene.

294 le motor cytoplasmic dynein, the adenomatous polyposis coli tumor suppressor protein (APC), and glyco

295 Mutations in the APC (adenomatous polyposis coli) tumor suppressor gene cause uncontrolled

296 The APC gene encodes the adenomatous polyposis coli tumour suppressor protein, germline mutat

297 enin activation or loss of APC - adenomatous polyposis coli) upon expression of CRE recombinase in th

298 All patients were tested for the adenomatous polyposis coli variants I1307K and E1317Q, and variants

299 tivation of the tumor suppressor adenomatous polyposis coli, with the resultant activation of beta-ca

300 Disruption of Apc (adenomatous polyposis coli) within hepatocytes activates Wnt signall