ライフサイエンスコーパス: polysorbate

1 trometry (LC-MS) for the characterization of polysorbates.

2 d in the presence of two common emulsifiers: polysorbate 20 (P20) and polysorbate 80 (P80).

3 food grade surface active compounds, namely, Polysorbate 20 (PS20), sodium caseinate (SC), gum Arabic

4 The detergent polysorbate 20 (Tween 20) was used successfully to facil

5 , and quantify the multiple ester species in polysorbate 20 and also to monitor the change of their c

6 polysorbate in the formulation sample, while polysorbate 20 esters were trapped online and then analy

7 the molecular heterogeneity and stability of polysorbate 20 in mAb formulations as polysorbate can gr

8 the characterization and stability study of polysorbate 20 in the presence of mAb formulation sample

9 Polysorbate 20 is a nonionic surfactant commonly used in

10 nto the heterogeneous stability behaviors of polysorbate 20 subspecies in real-time stability samples

11 as developed using elevated temperatures and polysorbate 20, rather than chaotropic and reducing agen

12 ation is 0.25% monocaprin in 1% HPMC with 1% polysorbate 20.

13 loped to analyze the degradation products of polysorbate 20.

14 his is especially true for the common NISEs, polysorbates 20 and 80 (PS20 and PS80, respectively) and

15 , agar dilution, broth microdilution without polysorbate 80 (BMD), and the TREK Gram-negative extra M

16 ve bacilli (GNB) by broth microdilution with polysorbate 80 (BMD-T), broth macrodilution (TDS), and t

17 mulsifiers carboxylmethylcellulose (CMC) and polysorbate 80 (P80) alter the composition of the intest

18 , including carboxymethylcellulose (CMC) and polysorbate 80 (P80), perturb gut microbiota composition

19 common emulsifiers: polysorbate 20 (P20) and polysorbate 80 (P80).

20 s conducted to polyethylene glycol (PEG) and polysorbate 80 (P80).

21 cyanoacrylate) dextran polymers coated with polysorbate 80 (PBCA nanoparticles) to deliver BBB-imper

22 mAb and the presence of excipients, such as polysorbate 80 (PS80) and methionine.

23 can accurately estimate the concentration of polysorbate 80 (PS80) in intact pharmaceutical samples o

24 -knockout mice in the presence or absence of polysorbate 80 (PS80) or Kolliphor EL (formerly Cremopho

25 FO and conventional emulsions stabilized by polysorbate 80 (PS80).

26 ncern in the AstraZeneca COVID-19 vaccine is polysorbate 80 (PS80).

27 nd Fmoc-FF/C18-(GK)3 NGs were obtained using polysorbate 80 (TWEEN 80) and sorbitane monooleate 80 (S

28 taxel (Taxotere) and its formulation vehicle polysorbate 80 (Tween 80) in human plasma samples is des

29 NA, and a diagnostic reaction mix containing polysorbate 80 (Tween 80).

30 ine/excipients (polyethylene glycol[PEG] and polysorbate 80 [PS]) has been recommended, but has unkno

31 Cross-sensitization to polysorbate 80 and poloxamer 407 was assessed.

32 ric series differences in the two batches of polysorbate 80 and the presence of one compound and thre

33 us phase (W(2)) composed of distilled water, polysorbate 80 and xanthan gum.

34 In addition to the use of Gelucire 44/14 and polysorbate 80 as excipients in drugs, they are also wid

35 port of a project to assess the influence of polysorbate 80 concentrations on the disposition and tox

36 on a full-length spike protein formulated in polysorbate 80 detergent.

37 s consuming either carboxymethylcellulose or polysorbate 80 for 12-weeks.

38 d to measure concentrations of docetaxel and polysorbate 80 in plasma samples in support of a project

39 he inclusion of 0.002% of the mild detergent polysorbate 80 in the MIC assay.

40 , magnesium, zinc, potassium, thymidine, and polysorbate 80 levels were tested by BMD and DD.

41 propylene glycol, soya lecithin, water, and polysorbate 80 micelles.

42 Incorporating polysorbate 80 resulted in 3 twofold and 2 twofold modal

43 the quality controls (QCs) with and without polysorbate 80 supports the use of Escherichia coli stra

44 Polysorbate 80 was found to have the greatest influence

45 Detection of docetaxel and polysorbate 80 was performed using tandem MS detection w

46 l polyethylene glycol 1000 succinate (TPGS), Polysorbate 80, and poly(methyl methacrylate) (PMMA) as

47 ting and basophil activation testing to PEG, polysorbate 80, and the BNT162b2 (Pfizer) and AZD1222 (A

48 their formulation vehicles Cremophor EL and polysorbate 80, as well as serum binding proteins on tax

49 formulation variables, such as the amount of polysorbate 80, glycerin, and carbomer copolymer as well

50 ng/ml) and 1.00 microg/ml for docetaxel and polysorbate 80, respectively.

51 cyl sulfate, SDS) and non-ionic surfactants (polysorbate 80, Tween 80) at varied concentrations on th

52 tive conditions were 100rpm in water with 2% polysorbate 80, which showed profile differences between

53 be diminished by adding a surfactant, i.e., polysorbate 80.

54 two different batches of Gelucire 44/14 and polysorbate 80.

55 ulsified systems containing squalene oil and polysorbate 80.

56 ross-sensitization to poloxamer 407 and 3 to polysorbate 80.

57 hould include PEG 4000 or 3500, PEG 2000 and polysorbate 80.

58 v hydroxypropyl-methylcellulose and 0.1% w/v polysorbate 80; Control, n = 6) for 12 days by oral gava

59 ct of Gattefosse s.a, St Priest, France) and polysorbate 80; these are known to improve solubility of

60 ified by ABPP and confirmed to contribute to polysorbate-80 degradation for the first time.

61 al consumption of carboxymethylcellulose and polysorbate-80 resulted in transient alterations in offs

62 using media supplemented with a surfactant (polysorbate-80, 0.002%).

63 etary emulsifiers, carboxymethylcellulose or polysorbate-80, exacerbated tumor development.

64 ulsifiers, namely carboxymethylcellulose and polysorbate-80, induced low-grade inflammation and obesi

65 r supplementation with human serum, albumin, polysorbate-80, or pulmonary surfactant) or assay parame

66 % w/v hydroxypropyl-methylcellulose 0.1% w/v polysorbate-80; n = 9), 88 mg( )kg(-1) day(-1) simvastat

67 rsion prepared with the non-ionic surfactant polysorbate 85 and the hydroalcoholic extract standardiz

68 2 vaccines because of cross-reactive PEG and polysorbate allergy.

69 hapter <797> calls for tryptic soy agar with polysorbate and lecithin (TSApl) for bacteria and malt e

70 e REGN probe), which mimics the structure of polysorbate and targets lipases catalyzing polysorbate d

71 The molecular heterogeneity of polysorbate and the interference from proteins and the e

72 ential allergens, polyethylene glycol (PEG), polysorbate and tromethamine are excipients.

73 In reality, polysorbates are complex mixtures of multiple components

74 Polysorbates are nonionic surfactants often used at vari

75 Polysorbates are nonionic surfactants that have been wid

76 The polysorbates are often pictured as polyoxyethylated sorb

77 However, polysorbates are subject to degradation after prolonged

78 ity of polysorbate 20 in mAb formulations as polysorbate can gradually degrade in aqueous solution ov

79 Degradation of polysorbate can lead to particle formation in drug produ

80 Complex synthetic formulations based on polysorbates can be challenging to characterize.

81 Because the degradation of polysorbates compromises the shelf life of biotherapeuti

82 ic probe 5-dodecanoylaminofluorescein (DAF), polysorbate concentrations above the critical micelle co

83 and comparison of the enzymatic activity of polysorbate degradation from endogenous proteins.

84 and activity, which enables more meaningful polysorbate degradation investigations for biotherapeuti

85 lipases and esterases plays a major role for polysorbate degradation.

86 f polysorbate and targets lipases catalyzing polysorbate degradation.

87 h to identify active enzymes responsible for polysorbate degradation.

88 o further resolve as well as to identify the polysorbate ester subspecies.

89 We found different polysorbate esters degrade at different rates, and impor

90 is presented for the profiling of the PS-80 polysorbate form using high resolution mass spectrometry

91 omponents of identical molecular mass in the polysorbate formulations have been separated by ion mobi

92 Cross-reactivity between PEG and polysorbate has been suggested, based on their compositi

93 ulation excipients, such as sodium chloride, polysorbate, histidine, arginine, and sucrose.

94 to identify the active enzymes that catalyze polysorbate hydrolysis.

95 y has been developed for the quantitation of polysorbate in bioprocess samples.

96 mulation matrix make it a challenge to study polysorbate in protein formulations.

97 the first dimension to separate protein and polysorbate in the formulation sample, while polysorbate

98 ven at concentrations lower than 0.1%, these polysorbates induced a proinflammatory response suggesti

99 Polysorbate is widely used to maintain stability of biot

100 Following lung injury induced by polysorbate lavage, a higher PEEP (20-24 cm H2O) with LT

101 Following lung injury induced by polysorbate lavage, the APRV group was ventilated with a

102 Following lung injury induced by polysorbate lavage, the LTVV group was ventilated with a

103 Lung injury was induced by polysorbate lavage.

104 oups with surfactant deactivation induced by polysorbate lavage: the LTVV group (n = 5) and the APRV

105 Polysorbate (PS) is a widely used polymeric excipient in

106 Polysorbates (PS) are widely used as oil-in-water emulsi

107 vidence and propose a novel mechanism of how polysorbate stabilizes protein in pharmaceutical formula

108 Rats received polysorbate TW80 (vehicle) or MRE (10, 30, and 90 mg/kg)