ライフサイエンスコーパス: polytopic

1 The polytopic 5-domain multidrug resistance protein 1 (MRP1/

2 SRP pathway also affected the insertion of a polytopic AcrB-AP fusion.

3 -linking the functionalized polyolefins with polytopic amines provided dynamically cross-linked polyo

4 e two distinct superfamilies of PGT enzymes (polytopic and monotopic) show striking differences in th

5 h promotes membrane insertion of a subset of polytopic and tail-anchored membrane proteins.

6 l proteins; polymeric IgA receptor (pIgA-R), polytopic apical, and basolateral resident distributions

7 ontain the active site of gamma-secretase, a polytopic aspartyl protease involved in the transmembran

8 eavage is effected by Presenilin, an unusual polytopic aspartyl protease that apparently cleaves Notc

9 protease complex and its similarity to other polytopic aspartyl proteases.

10 e electron transport by distinct families of polytopic b cytochromes.

11 The MOFs reported herein are of polytopic carboxylates and contain one of Zn, Pb, Co, Cd

12 ed by mutations in SLC4A1, which encodes the polytopic chloride-bicarbonate exchanger AE1 that is nor

13 form of F protein inserted in membranes in a polytopic conformation with both the amino-terminal end

14 itine palmitoyltransferase (CPT) 1A adopts a polytopic conformation within the mitochondrial outer me

15 previously that the membrane integration of polytopic connexin polypeptides can be accompanied by an

16 cation-binding abilities of these mono- and polytopic crown ethers have been probed through picrate

17 e distribution of encoded known and putative polytopic cytoplasmic membrane transport proteins within

18 d, suggesting that pCytf, in contrast to the polytopic D1 protein, does not require cpSRP for targeti

19 ur membrane-embedded interactors of RNF26, a polytopic E3 whose abundance is auto-regulated by ubiqui

20 Tsc13p is a polytopic endoplasmic reticulum (ER) membrane protein th

21 olesterol homeostasis is mediated by Scap, a polytopic endoplasmic reticulum (ER) protein that transp

22 The polytopic endoplasmic reticulum (ER)-localized enzyme 3-

23 SREBP cleavage-activating protein (SCAP), a polytopic endoplasmic reticulum membrane protein.

24 sses depend on interactions of TLR9 with the polytopic endoplasmic reticulum-resident protein UNC93B1

25 The polytopic, endoplasmic reticulum (ER) membrane protein 3

26 sociated ring-CH-type finger 6 (MARCH6) is a polytopic enzyme bound to the membranes of the endoplasm

27 are comparable with those measured for other polytopic ER integral membrane proteins.

28 Data curation prioritized six polytopic ER membrane proteins as scramblase candidates,

29 terol-dependent binding to the following two polytopic ER membrane proteins: sterol regulatory elemen

30 ER hemoproteins, CYP2C11 and CYP3A4, and the polytopic ER protein HMGR attest to the remarkable mecha

31 One polytopic ER protein subjected to ER-associated degradat

32 ata suggest that p97 recruits proteasomes to polytopic ER proteins even before they are extracted fro

33 We show that two polytopic ERAD substrates, mutated transporter of the ma

34 al type 1 glycoprotein, while the other is a polytopic form in which approximately 200 amino acids of

35 milar predictions do not appear to apply for polytopic G protein-coupled receptors.

36 -Pick C1 (NPC1) protein is predicted to be a polytopic glycoprotein, and it contains a region with ex

37 syltransferase (Und-P GT), a flippase, and a polytopic glycosyltransferase (PolM GT) dedicated to att

38 We have previously identified the ER-polytopic gp78/AMFR (autocrine motility factor receptor)

39 We describe the NMR structure of DsbB, a polytopic helical membrane protein.

40 ve monotopic P450 enzyme, in common with the polytopic HMGR, required the function of certain HRD (HM

41 Most ion transport proteins are polytopic, however, and little is known of the signals r

42 The OxlT amino acid sequence specifies a polytopic hydrophobic protein of 418 residues with a mas

43 single open reading frame (ORF), encoding a polytopic hydrophobic protein, LjN70, with a predicted m

44 to address the sequence requirements of the polytopic hydrophobic transmembrane domain for LMP-1's s

45 practical foundations required for examining polytopic IMP function using single-molecule FRET (smFRE

46 y intermediate between exported proteins and polytopic IMPs.

47 he presence of a truncated derivative of the polytopic inner membrane protein, TetA.

48 bution of Agrobacterium tumefaciens VirB6, a polytopic inner membrane protein, to the formation of ou

49 required for the efficient insertion of many polytopic inner membrane proteins (IMPs) into the Escher

50 ly blocked the membrane insertion of several polytopic inner membrane proteins (IMPs) that were predi

51 The two open reading frames encode predicted polytopic inner membrane proteins with 61% amino acid id

52 Thus, polytopic inner membrane proteins, which lack an NH2-ter

53 bed for a series of purified variants of the polytopic integral membrane protein diacylglycerol kinas

54 Recently, mutations in the novel polytopic integral membrane protein PfCRT were shown to

55 Ghrelin O-acyltransferase (GOAT) is a polytopic integral membrane protein required for activat

56 rly-onset familial Alzheimer's disease, is a polytopic integral membrane protein that is endoproteoly

57 nt anion channel (VDAC-1) as an example of a polytopic integral membrane protein.

58 ty of NMR for functional characterization of polytopic integral membrane proteins and provide insight

59 ins associated with HycC and HycD, which are polytopic integral membrane proteins believed to anchor

60 rticular, the subunit stoichiometry of these polytopic integral membrane proteins has not been unequi

61 O-acyltransferase (MBOAT) family, a group of polytopic integral membrane proteins involved in lipid-b

62 They encode the polytopic integral membrane proteins polycystin-1 (PC1)

63 The presenilin (PS) proteins are polytopic integral membrane proteins that are critically

64 librative nucleoside transporters (ENTs) are polytopic integral membrane proteins that transport nucl

65 Rhomboids form a family of polytopic intramembrane serine proteases.

66 membrane proteins with multiple TM segments (polytopic) is still incomplete.

67 ns bridged by oxygen atoms pertaining to the polytopic ligand 3,3',4,4',5,5'-hexahydroxybiphenyl, whi

68 on, we show that the proper insertion of the polytopic MalF protein (synthesized without a signal seq

69 -phosphate, which is in turn utilized by the polytopic membrane acyltransferase PlsY on the pathway o

70 sterol-sensing domain, which is part of the polytopic membrane attachment region of SCAP.

71 y sterols, which appear to interact with the polytopic membrane domain of SCAP.

72 Gaa1 is a polytopic membrane glycoprotein with a cytoplasmic N ter

73 -dependent bile acid transporter (Asbt) is a polytopic membrane glycoprotein, which is specifically e

74 hese results pinpoint RhCG and Rhcg as novel polytopic membrane glycoproteins that may function as ep

75 protein (NGEP-S) and a long form encoding a polytopic membrane protein (NGEP-L).

76 al integration of a eukaryotic multispanning polytopic membrane protein (PMP), its hydrophilic loops

77 g green fluorescent protein (GFP) fused to a polytopic membrane protein (SpoIVFB) that is involved in

78 e human MDR3 P-glycoprotein (Pgp) as a model polytopic membrane protein and expressed it in a coupled

79 P-glycoprotein (Pgp)1 is a polytopic membrane protein and functions as an energy-de

80 esents the first reported semisynthesis of a polytopic membrane protein and highlights the potential

81 s covalent linkage between a G protein and a polytopic membrane protein appears, to our knowledge, to

82 The pathway by which segments of a polytopic membrane protein are inserted into the membran

83 The polytopic membrane protein BfpE appears to be a central

84 nchored protein levels and a broader role in polytopic membrane protein biogenesis.

85 vivo and in vitro demonstrate that Akr1p, a polytopic membrane protein containing a DHHC cysteine-ri

86 The data demonstrate that mPRA1 is a polytopic membrane protein containing four TM segments.

87 1 cleavage, apparently by interacting with a polytopic membrane protein designated SREBP cleavage-act

88 each latent transmembrane segment (TMS) in a polytopic membrane protein emerges from the ribosome, it

89 PC1 is a complex polytopic membrane protein expressed in cilia that under

90 Here we show that the polytopic membrane protein FeoB, which is essential for

91 ed in prostate (NGEP) is a prostate-specific polytopic membrane protein found at high concentrations

92 he SLC26A family of anion transporters, is a polytopic membrane protein found in outer hair cells (OH

93 rod Na(+)/Ca(2+),K(+) exchanger (RodX) is a polytopic membrane protein found in photoreceptor outer

94 gamma-Glutamyl carboxylase (GC), a polytopic membrane protein found in the endoplasmic reti

95 The 1278-amino acid, polytopic membrane protein has not been purified, and it

96 g the intracellular trafficking of a complex polytopic membrane protein in yeast.

97 e, to determine whether YidC plays a role in polytopic membrane protein insertion and/or folding.

98 equential, cotranslational model of archaeal polytopic membrane protein insertion in vivo.

99 use of the assay to monitor the kinetics of polytopic membrane protein insertion in vivo.

100 The prevailing model of polytopic membrane protein insertion is based largely on

101 The final destination of this polytopic membrane protein is the Golgi apparatus, where

102 li, the major cytoplasmic domain (C6) of the polytopic membrane protein lactose permease (LacY) is ex

103 a molecular chaperone in the folding of the polytopic membrane protein lactose permease (LacY) of Es

104 However, the topology and function of the polytopic membrane protein lactose permease of Escherich

105 apical targeting information and can direct polytopic membrane protein localization.

106 hinese hamster ovary cells and shown to be a polytopic membrane protein localized in the endoplasmic

107 We report that Niemann-Pick C1 (NPC1), a polytopic membrane protein mediating lysosomal cholester

108 understand cellular response to a misfolded polytopic membrane protein of the secretory pathway, we

109 Presenilin-1 (PS1), a polytopic membrane protein primarily localized to the en

110 These data suggest that this large polytopic membrane protein requires multiple signals for

111 Lamin B receptor (LBR) is a polytopic membrane protein residing in the inner nuclear

112 These studies directly demonstrate polytopic membrane protein retrotranslocation during ERA

113 The polytopic membrane protein SCAP transports sterol regula

114 Here, we identified SpbR (SAOUHSC_00965), a polytopic membrane protein similar to a eukaryotic CAAX

115 al that SpoIIQ resides in a complex with the polytopic membrane protein SpoIIE.

116 e for studying static and dynamic aspects of polytopic membrane protein structure and function.

117 hesis is regulated by the actions of Scap, a polytopic membrane protein that binds cholesterol in mem

118 P-Glycoprotein (Pgp) is a polytopic membrane protein that consists of a tandem rep

119 the G-protein-coupled receptor family, is a polytopic membrane protein that does not encode a cleave

120 nsmembrane conductance regulator (CFTR) is a polytopic membrane protein that functions as a Cl(-) cha

121 Scap is a polytopic membrane protein that functions as a molecular

122 TM4SF20 (transmembrane 4 L6 family 20) is a polytopic membrane protein that inhibits proteolytic pro

123 osphate includes the HK protein UhpB and the polytopic membrane protein UhpC, a UhpT homolog which is

124 Here we show that the function of the polytopic membrane protein UNC93B1 is to deliver the nuc

125 ility studies support a model for VirB6 as a polytopic membrane protein with a periplasmic N terminus

126 er, these data support a model of FATP1 as a polytopic membrane protein with at least one transmembra

127 SLY41 encodes a polytopic membrane protein with homology to a class of s

128 sa aurealis insertion in SAV2335, encoding a polytopic membrane protein with predicted protease domai

129 f the nir operon, which is predicted to be a polytopic membrane protein with six membrane-spanning he

130 r such studies because it is a very abundant polytopic membrane protein, and its localization and act

131 of Escherichia coli (LacY), a highly dynamic polytopic membrane protein, catalyzes stoichiometric gal

132 In contrast, TM3 and TM4 of another polytopic membrane protein, cystic fibrosis transmembran

133 SdpI, a polytopic membrane protein, is encoded by a two-gene ope

134 protein, which was previously found to be a polytopic membrane protein, is secreted by the Dot/Icm t

135 us mutations affect membrane assembly of the polytopic membrane protein, MalF.

136 ntroduced at 55 independent sites in a model polytopic membrane protein, TM0026.

137 The polytopic membrane protein, which is similar to a eukary

138 entified ttsA, a chromosomal gene encoding a polytopic membrane protein.

139 s, we identified TMEM129, an uncharacterized polytopic membrane protein.

140 amino acids in the helix interfaces of four polytopic membrane proteins (cytochrome c oxidase, bacte

141 Transmembrane topology of polytopic membrane proteins (PMPs) is established in the

142 subunit complexes, often composed of several polytopic membrane proteins and cytosolic proteins.

143 should be useful for studying biogenesis of polytopic membrane proteins and GPCR signaling mechanism

144 Unlike most other proteases, they are polytopic membrane proteins and specialize in cleaving t

145 Most polytopic membrane proteins are believed to integrate in

146 Eukaryotic polytopic membrane proteins are cotranslationally insert

147 Polytopic membrane proteins are essential for cellular u

148 Once inserted, transmembrane segments of polytopic membrane proteins are generally considered sta

149 Polytopic membrane proteins are inserted cotranslational

150 Structural studies of polytopic membrane proteins are often hampered by the va

151 ppears in both antiparallel helical pairs of polytopic membrane proteins as well as the parallel heli

152 s to the quality control of non-glycosylated polytopic membrane proteins by binding to misfolded or u

153 e energetics and structural specificities of polytopic membrane proteins by using a battery of in sil

154 These data indicate that polytopic membrane proteins can be extracted from the ER

155 of amino acids into transmembrane helices of polytopic membrane proteins disrupt helix-helix interact

156 omain (DHHC-CRD), is a diverse collection of polytopic membrane proteins extending through all eukary

157 nobutyric acid (GABA) transporter family are polytopic membrane proteins found endogenously in both e

158 ss the yeast membrane proteome revealed that polytopic membrane proteins have relatively low ribosome

159 s that predict the transmembrane topology of polytopic membrane proteins identify 10-12 putative memb

160 Dysregulation of these polytopic membrane proteins impacts the redox signaling

161 e high-resolution structure determination of polytopic membrane proteins in a detergent-free, near-na

162 residues mediate helix-helix interactions in polytopic membrane proteins in a fashion similar to that

163 feasibility of determining the structures of polytopic membrane proteins in their native phospholipid

164 hem, the TIM22 complex mediates insertion of polytopic membrane proteins into the inner membrane, and

165 The import of polytopic membrane proteins into the mitochondrial inner

166 The membrane assembly of polytopic membrane proteins is a complicated process.

167 Insertion and folding of polytopic membrane proteins is an important unsolved bio

168 The topology of polytopic membrane proteins is determined by topogenic s

169 The topology of most eukaryotic polytopic membrane proteins is established cotranslation

170 tein (Pgp) suggested that the topogenesis of polytopic membrane proteins is likely more complicated t

171 The encoded enzymes are polytopic membrane proteins of 298 and 272 amino acids,

172 xamined 199 transmembrane alpha-helices from polytopic membrane proteins of known structure.

173 mily of DHHC cysteine-rich domain (DHHC-CRD) polytopic membrane proteins shown recently in yeast to r

174 Polytopic membrane proteins subjected to endoplasmic ret

175 TbSLSs are polytopic membrane proteins that are essential for viabi

176 resenilin 1 (PS1) and presenilin 2 (PS2) are polytopic membrane proteins that are mutated in the majo

177 PS1 and PS2 are homologous polytopic membrane proteins that are processed endoprote

178 multiple hydrophobic segments, suggestive of polytopic membrane proteins that are targeted to the sec

179 S2P defines a new family of polytopic membrane proteins that contain an HEXXH sequen

180 P(1B)-type ATPases are polytopic membrane proteins that couple the hydrolysis o

181 ette (ABC) multidrug transporters are large, polytopic membrane proteins that exhibit astonishing pro

182 Presenilins (PSs) are polytopic membrane proteins that have been implicated as

183 PS1 and PS2 are polytopic membrane proteins that undergo endoproteolytic

184 ABC transporters are polytopic membrane proteins that utilize ATP binding and

185 D family members, represent rare examples of polytopic membrane proteins with an intrinsic additional

186 The GXGD proteases are polytopic membrane proteins with catalytic activities ag

187 the orientation of transmembrane domains of polytopic membrane proteins with respect to the plane of

188 e" may be an important folding mechanism for polytopic membrane proteins, and it is regulated by the

189 mpt to investigate further the biogenesis of polytopic membrane proteins, I used the human MDR3 P-gly

190 ins are evolutionarily conserved, ubiquitous polytopic membrane proteins, including the canonical rho

191 Two polytopic membrane proteins, NarK and NarU, are assumed

192 Functional overexpression of polytopic membrane proteins, particularly when in a fore

193 aspartyl proteases are a homologous group of polytopic membrane proteins, some of which function in i

194 pholipids in the topological organization of polytopic membrane proteins, the function and assembly o

195 For polytopic membrane proteins, those with multiple transme

196 Presenilin 1 and presenilin 2 are polytopic membrane proteins, whose genes are mutated in

197 ntermembrane space, involved in transport of polytopic membrane proteins.

198 ures of transmembrane helical interfaces and polytopic membrane proteins.

199 emented to predict membrane dipping loops in polytopic membrane proteins.

200 cal sterol-sensing domain found in six other polytopic membrane proteins.

201 hould be applicable to a number of different polytopic membrane proteins.

202 nces must be considered when epitope tagging polytopic membrane proteins.

203 nd the molecular mechanism of topogenesis of polytopic membrane proteins.

204 e because of the complexity and diversity of polytopic membrane proteins.

205 ich may aid in the folding of YidC-dependent polytopic membrane proteins.

206 ly to multiple signals to drive packaging of polytopic membrane proteins.

207 e earliest steps of tertiary folding of five polytopic membrane proteins.

208 ties to study the cotranslational folding of polytopic membrane proteins.

209 tides (including dimers), and TM segments of polytopic membrane proteins.

210 ally expressed proteins were two ER-resident polytopic membrane proteins: the E3 ubiquitin ligase RNF

211 ns express markedly different pheromones and polytopic membrane receptor proteins.

212 Rhomboid, a polytopic membrane serine protease, represents a unique

213 Lactose permease of Escherichia coli is a polytopic membrane transport protein containing 12 membr

214 of a defined apical localization signal in a polytopic membrane transport protein, and suggest that t

215 g that reentrance loops are unlikely in this polytopic membrane transport protein.

216 a membrane protein does not resemble that of polytopic membrane transporters for other substrates.

217 Yeast Doa10 is a polytopic membrane ubiquitin ligase (E3) that along with

218 different sub-branches of a larger family of polytopic membrane-associated aspartyl proteases.

219 y effect on the cell surface distribution of polytopic membrane-associated proteins, suggesting that

220 identify GOAT (Ghrelin O-Acyltransferase), a polytopic membrane-bound enzyme that attaches octanoate

221 m lysosomes requires two lysosomal proteins, polytopic membrane-bound Niemann-Pick C1 (NPC1) and solu

222 T) for investigating the interactions of the polytopic membrane-bound oligosaccharyl transferases (OT

223 f the dopamine transporter, as well as other polytopic membrane-bound proteins, including G protein-c

224 Doa10 (MARCHF6 in metazoans) is a large polytopic membrane-embedded E3 ubiquitin ligase in the e

225 ptable central lipid-filled chamber, wherein polytopic membrane-proteins could fold, sheltered from a

226 There is evidence that the polytopic membrane-spanning proteins, presenilin 1 and 2

227 oundaries of MP insertion and the folding of polytopic MPs in vivo.

228 on of p97 in degrading immature forms of the polytopic, multi-domain protein CFTR (cystic fibrosis tr

229 Folding of these polytopic multidomain proteins to their functional state

230 association require the function of LMP-1's polytopic multispanning transmembrane domain, a domain t

231 Polytopic Niemann-Pick C1-like 1 (NPC1L1) plays a major

232 hosphonate were evaluated as inhibitors of a polytopic PGT (WecA from Thermotoga maritima) and a mono

233 d fusions of the monoPGT with members of the polytopic PGT superfamily were discovered, implying a po

234 The polytopic PGT superfamily, represented by MraY and WecA,

235 ternary complex mechanisms of representative polytopic PGTs.

236 Interestingly a polytopic plasma membrane protein, Fig1p, was required f

237 rates two separate Ig domain proteins from a polytopic precursor.

238 nd S2P appear to be members of a new type of polytopic protease with an intramembranous active site.

239 ssay to examine the insertion pathway of the polytopic protein bacterioopsin, the apoprotein of Halob

240 A defining feature of eukaryotic polytopic protein biogenesis involves integration, foldi

241 During polytopic protein biogenesis, multiple transmembrane seg

242 hey are presented in rapid succession during polytopic protein biogenesis.

243 to conventional cotranslational pathways of polytopic protein biogenesis.

244 ht be oriented and integrated during nascent polytopic protein biogenesis.

245 Presenilin-1 (PS-1) is a polytopic protein comprised of six to eight transmembran

246 uration factor 1 (LMF1) is predicted to be a polytopic protein localized to the endoplasmic reticulum

247 Scap is a polytopic protein of endoplasmic reticulum (ER) membrane

248 Scap is a polytopic protein of the endoplasmic reticulum (ER) that

249 Lamin B receptor (LBR) is a polytopic protein of the nuclear envelope thought to con

250 F2 (transmembrane 6 superfamily member 2), a polytopic protein of unknown function, is associated wit

251 uman RHAG locus encodes Rh50 glycoprotein, a polytopic protein that modulates expression of Rh antige

252 Polytopic protein topology is established in the endopla

253 ransmembrane conductance regulator (CFTR), a polytopic protein with 12 predicted transmembrane segmen

254 s of LmPOT1 predicted an unusual 803-residue polytopic protein with 9-12 transmembrane domains.

255 ne protein with the C terminus outside, or a polytopic protein with both termini inside.

256 e recently analyzed the GPIT subunit Gaa1, a polytopic protein with seven transmembrane (TM) spans, t

257 TolQ is a polytopic protein with three membrane-spanning regions.

258 membrane protein, in actinobacteria, it is a polytopic protein with three transmembrane domains.

259 s, we established that Arabidopsis CCDA is a polytopic protein with within-membrane strictly conserve

260 b(0,+) amino acid transporter (b(0,+)AT), a polytopic protein, and the helper, related to b(0,+) ami

261 complex structure-function relationships of polytopic proteins and for drug discovery.

262 These polytopic proteins are confined to the erythroid lineage

263 Polytopic proteins are synthesized in the endoplasmic re

264 atterns of specific transporters and unknown polytopic proteins during microgametogenesis provides ne

265 tingly, TbPT family permeases are related to polytopic proteins from plants but not to characterized

266 , the principles governing folding of native polytopic proteins have not yet been elucidated.

267 , required for the insertion of at least two polytopic proteins into the inner membrane, but not for

268 tero-oligomeric complex (TIM10) that escorts polytopic proteins into the mitochondrial inner membrane

269 plex, required for the insertion of imported polytopic proteins into the mitochondrial inner membrane

270 m22p machinery that facilitates insertion of polytopic proteins into the mitochondrial inner membrane

271 Tim17p complex) and one for the insertion of polytopic proteins into the mitochondrial inner membrane

272 ted to sterol-sensing domains found in other polytopic proteins involved in sterol interactions or st

273 Transmembrane topology of most eukaryotic polytopic proteins is established cotranslationally at t

274 egation of nascent transmembrane segments of polytopic proteins is prevented by chaperones present in

275 Thus, the early folding landscape of polytopic proteins is shaped by a spatially restricted e

276 suggest a model in which the degradation of polytopic proteins such as CFTR is coupled to retrograde

277 able to mutations in one of two presenilins, polytopic proteins that contain the catalytic site of th

278 variations in cotranslational folding enable polytopic proteins to acquire and/or maintain primary se

279 Tested on 60 non-redundant polytopic proteins using a strict leave-one-out cross-va

280 of cotranslational helix assembly of several polytopic proteins were consistent with experimental stu

281 orters, when fused to periplasmic domains of polytopic proteins, produces fusions with high AP activi

282 C is required for the efficient targeting of polytopic proteins, whereas signal-anchored proteins req

283 from the transmembrane-spanning segments of polytopic proteins.

284 cess is regulated, especially in the case of polytopic proteins.

285 ABC transporters are polytopic proteins.

286 agr (accessory gene regulator) operon uses a polytopic receptor, AgrC, activated by an autoinducing p

287 s a conformational change in the intervening polytopic sequence separating loops 1 and 7.

288 phenotype of the diseases and the predicted polytopic structure of the protein, it has been suggeste

289 translocon, we devised a self-ubiquitinating polytopic substrate (Hmg1-Hrd1p) that undergoes ERAD in

290 ual membrane-spanning domains within LMP-1's polytopic transmembrane domain.

291 n, albeit less potently than does the entire polytopic transmembrane domain.

292 distinct and separable activities of LMP-1's polytopic transmembrane domain.

293 By using a classification of polytopic transmembrane domains into families, we examin

294 hus, distinct S-acylated domains in the same polytopic transmembrane protein can be regulated by diff

295 Niemann-Pick C1-like 1 (NPC1L1) is a polytopic transmembrane protein containing a sterol-sens

296 Niemann-Pick C1-Like 1 (NPC1L1) is a polytopic transmembrane protein localized at the apical

297 ght catabolic end-products is facilitated by polytopic transmembrane proteins mediating secondary act

298 onal systems, such as the excluded volume of polytopic transmembrane proteins, proximity FRET, and ro

299 rties and function of ion channels and other polytopic transmembrane proteins.

300 ty of diverse clients, from tail-anchored to polytopic transmembrane proteins.