ライフサイエンスコーパス: pore

1 ted by exogenous drugs that bind outside the pore.

2 MDIMP binds to the extracellular side of the pore.

3 ments enable H(+) movement outside the Cl(-) pore.

4 xposure induces formation of a transmembrane pore.

5 te molecules translocate through a nanoscale pore.

6 ex results in an open, or near-open, channel pore.

7 rms a five-helix bundle surrounding a narrow pore.

8 ombines diffusion with flux through a static pore.

9 cellular vestibule of the tetrameric central pore.

10 indicates the presence of a stable postspike pore.

11 ration shell of Cl(-) while it permeates the pore.

12 e positions the substrate for entry into the pore.

13 d/or ion selectivity than those in the upper pore.

14 and hindrance of mRNPs from engaging nuclear pores.

15 c (ELYS) is a constituent protein of nuclear pores.

16 des, as do the configurations of respiratory pores.

17 tebrates, including papillae on lamprey gill pores.

18 to networks with thinner fibers and smaller pores.

19 ggered AB stacking structure with elliptical pores.

20 ity of conjugated pai-systems throughout MOF pores.

21 ture efficiency during flow through membrane pores.

22 environment and ion fluxes in these confined pores.

23 ndence on the abundance of microscopic polar pores.

24 filling must be invoked to fill interstitial pores.

25 his protective barrier by formation of leaky pores.

26 e exchange of macromolecules through nuclear pores(2).

27 particles (meso-MPN particles) with a large-pore (~40 nm) single cubic network (Pm3m).

28 king decreases NP diffusion coefficients and pore accessibility in an NP size-dependent manner and th

29 Confinement of water in hydrophobic pores alters its hydrogen bonding structure and related

30 in the transition of prepore to beta-barrel pore, although we also observe a single bound CDTa in th

31 led that it forms a ring with a wide central pore and radially arrayed helix-turn-helix domains.

32 se to an unequal distance between the fusion pore and the electrode as well as fusion pore size, whic

33 network modeling (PNM) of OCT images, larger pores and connections were found in the silicate biofilm

34 mechanism and energetics of small metastable pores and illustrates a systematic approach to uncover t

35 tein Gasdermin D, which formed mitochondrial pores and induced mitochondrial DNA (mtDNA) release into

36 eprotonation and isotopic preferences in AMT pores and that decreased deprotonation capacity is assoc

37 croporous coatings possessing interconnected pores and tunnels that were observed using electron micr

38 ne known as the PTP (permeability transition pore) and that opening of this pore leads to necroptosis

39 inding loop, residues in the hexamer central pore, and the NTD-CTD linker region, are well defined.

40 nopores, aquaporins and related polar solute pores, and a number of different classes of ion channels

41 anisotropic structure, shape of water-filled pores, and nanoscale dimensions of membranes with differ

42 located around the oral disk, nostril, gill pores, and on the dorsal fins and that SCCs are particul

43 the expansion and closing time of the fusion pore are longer, suggesting chaotropes can extend the du

44 loadings (up to 86 wt %), ensuring the foam pores are highly accessible for excellent adsorption and

45 Methods of generating lower symmetry pores are thus required to maximise the binding affinity

46 g emerging from the unmelanized, thin-walled pore at the appressorial base(1-4), forcing it through t

47 nt on the periodicity and reproducibility of pores at the atomic level.

48 - and voltage-dependent manner, indicating a pore block mechanism.

49 mble into a bilayer within the larger CALHM2 pore, but not within CALHM1, demonstrating the potential

50 lix-loop-helix (H-L-H) was suggested to form pores by virtue of its similarity to bacterial pore-form

51 ew precedent whereby features of the channel pore can be modulated by exogenous drugs that bind outsi

52 romotes the opening of Ca(2+) -permeable two-pore channels (TPCs).

53 copy structure of the 16-helix transmembrane pore closely matches the design model.

54 ne interdigitation, these cause a dehydrated pore compared with the viroporins of influenza viruses a

55 hat SARS-CoV-2 Orf6 localizes at the nuclear pore complex (NPC) and directly interacts with Nup98-Rae

56 mechanism of membrane fusion during nuclear pore complex (NPC) biogenesis.

57 The Nuclear Pore Complex (NPC) has emerged as an important hub for p

58 We propose that NUP153 links the nuclear pore complex (NPC) to chromatin architecture allowing ge

59 transcriptionally active loci to the nuclear pore complex (NPC), and it also promotes large-scale gen

60 ut of the nucleus occurs through the nuclear pore complex (NPC).

61 are insensitive to a Nup62-mediated nuclear pore complex blockade in cells that potently block infec

62 Here, we use an inducible nuclear pore complex blockade to monitor the kinetics of HIV-1 n

63 ity is also important for interphase nuclear pore complex insertion into growing germline nuclei.

64 f 8, including key components of the nuclear pore complex scaffold and the transmembrane nucleoporin

65 the phenylalanine-glycine (FG)-rich nuclear pore complex.

66 ncluding several constituents of the nuclear pore complex.

67 nsport and accumulations of specific nuclear-pore-complex-associated proteins have been reported in m

68 Nuclear pore complexes (NPCs) are important for cellular functio

69 Nuclear pore complexes (NPCs) regulate all cargo traffic across

70 Nuclear pore complexes are multiprotein channels that span the n

71 to receptor clustering in platelets, nuclear pore components, endocytic proteins and microtubule netw

72 that during gating relocates relative to the pore concomitant with bending of a GGxGG motif in the po

73 ike semi-IPNs with disordered interconnected pores, conferring different gel (and solvent) dynamics.

74 ng in considerable interest in the design of pore-containing proteins.

75 findings led us to discuss whether modifying pores could be used as a pharmacological target in HF.

76 periplasm, and upon recruitment to the curli pore, CsgG, and the secretion chaperone, CsgE.

77 PORE-cupine also captures global structural features, su

78 tructure analysis using nanopore sequencing (PORE-cupine), which combines structure probing using che

79 endence of K(v)7.2 channels and L268F at the pore decreases their current densities.

80 Utilizing their extremely high pore density of 1 sub-nm channel nm(-2) , TPT CNMs let w

81 orted by numerical simulation of theoretical pore density which are in good agreement with numerical

82 recruitment across pulmonary epithelium in a pore-dependent fashion.

83 H2A enhances AMP-induced pores, depolarizes the bacterial membrane potential, and

84 Membrane tension pores determine organelle dynamics and functions, giving

85 (2) /C(2) H(4) binary selectivity, bnn-1-Ca (pore diameter 0.31 nm) offers ideal selectivity for H(2)

86 Whereas bnn-1-Ca-H(2) O (pore diameter 0.34 nm) exhibits ultra-high CO(2) /N(2) ,

87 when imbibed within a porous medium of mean pore diameter 28.6 nm.

88 neral approach to exert precise control over pore diameter in physisorbents.

89 ristic comprising large surface area, narrow pore distribution, tunable pore size and excellent charg

90 oltage sensor, which interacts with a closed pore domain directly via two interfaces and indirectly v

91 potassium (TASK) channels-members of the two pore domain potassium (K(2P)) channel family-are found i

92 Inwardly rectifying, voltage-gated, two-pore domain, and related K(+) channels are located in eu

93 critical amino acid residues located in the pore domain.

94 Two-pore-domain potassium channels (K(2P)) are the major det

95 TMD variants differentially regulate fusion pore dynamics in mouse chromaffin cells, indicating TMD

96 To explore the possible role of fusion pore dynamics, a transformation of amperometry current w

97 that networks with thicker fibers and larger pores exhibited increased strain-stiffening relative to

98 -shaped water sorption isotherm with a steep pore-filling step at low relative humidity and without h

99 ises the reservoir storage integrity through pore fluid pressure build-up.

100 While most earthquake models assume a fixed pore fluid pressure distribution, geologists have docume

101 Pore fluids from serpentinite seamounts sampled in the M

102 ach amino acid spends sufficient time in the pore for sensitive measurement of the excluded volume of

103 importance of 3D networks of interconnected pores for efficient ion conduction in MOF/IL blends, whe

104 eating alcohol addiction, as an inhibitor of pore formation by GSDMD but not other members of the GSD

105 Pore formation by membrane-active peptides, naturally en

106 a reliable protocol to assess transmembrane pore formation driven by osmotic pressure increments thr

107 that question by trapping an early state of pore formation for the CDC intermedilysin, bound to the

108 t-A and Tat-B caused membrane disruption and pore formation in HeLa and BE(2)-C cells and inhibition

109 ver, the underlying mechanism of BAX and BAK pore formation remains incompletely understood.

110 Resistance to CDC-induced pore formation requires the production of the oxysterol

111 Importantly, time-dependent membrane pore formation was analyzed with an ensemble of single v

112 e cleavage to disrupting oligomerization and pore formation.

113 ondrial outer membrane during MOMP, inducing pore formation.

114 rafficking and biophysical properties of the pore-forming alpha1 subunit and trigger excitatory synap

115 its N-terminal region, scaffolds the L-type pore-forming alpha1 subunit and, through its C-terminal

116 More generally, treatment with H2A and the pore-forming antibiotic polymyxin B completely eradicate

117 res by virtue of its similarity to bacterial pore-forming colicins.

118 Whereas bacteria recover from the pore-forming effects of LL-37, the concomitant effects o

119 acter pylori (Hp) secrete VacA, a diffusible pore-forming exotoxin that is epidemiologically linked t

120 (uniplex) contains four core components: the pore-forming MCU protein, the gatekeepers MICU1 and MICU

121 s an enzymatic component, termed CDTa, and a pore-forming or delivery subunit termed CDTb.

122 We find that the most potent pore-forming peptides exhibit strong interpeptide intera

123 toxin lipopolysaccharide (LPS) activated the pore-forming protein Gasdermin D, which formed mitochond

124 study, we show that the membrane-associated pore-forming protein Perforin-2 (P2) is critical for LPS

125 apoptosis at mitochondria by activating the pore-forming proteins Bax and Bak and by inhibiting the

126 also exhibits behavior typically observed in pore-forming proteins, such as porins and ionic transpor

127 L46 is a pore-forming residue of the EAAT2 anion channels at the

128 otide-binding domain (CNBD) connected to the pore-forming S6 transmembrane segment via the C-linker.

129 ther-a-go-go-related gene (hERG) encodes the pore-forming subunit of the rapidly activating delayed r

130 has surrounded the molecular identity of the pore-forming subunits.

131 s modulate the biophysical properties of the pore-forming subunits.

132 y of GABA(A)Rs are determined by the channel pore-forming subunits.

133 ainst MRSA strains encoding alpha-toxin(4)-a pore-forming toxin that binds the metalloprotease ADAM10

134 Pore-forming toxins associated with S. aureus EVs were c

135 innate immune mechanisms that can neutralize pore-forming toxins during infection.

136 nflammatory form of cell death instigated by pore-forming toxins such as S. pneumoniae pneumolysin.

137 The production of pore-forming toxins that disrupt the plasma membrane of

138 S. aureus produces an array of bicomponent pore-forming toxins that target and kill leukocytes, kno

139 Voltage-gated sodium (Na(V)) channels are pore-forming transmembrane proteins that play essential

140 ane network, while breaks appear in ER-like, pore-free regions.

141 f the interaction of PAX with the BK channel pore gate domain guided by recently available liganded (

142 of a voltage sensor domain (VSD), a central pore-gate domain, and a large cytoplasmic domain (CTD) t

143 ment is explained by the initially reparable pores generated by LEEFT that cannot recover in the subs

144 ogen storage capacity of MOFs with different pore geometries.

145 ckets, to afford large changes in the global pore geometry that can, for example, segment the pore in

146 he chemical design space is a combination of pore geometry, metal nodes, organic linkers, and functio

147 s to the tunable pore size, pore volume, and pore geometry.

148 These pores have a size limit of 39 nanometres(4-7), which rai

149 Transmembrane channels and pores have key roles in fundamental biological processes

150 omitant with bending of a GGxGG motif in the pore helices.

151 eractions between the voltage sensor and the pore in the different channels.

152 , exposing different residues to the channel pore in the open and closed states.

153 rties with their ability to selectively form pores in bacterial membranes remains elusive.

154 ed permeability is the temporary creation of pores in cell membranes through a phenomenon called sono

155 nnel yields an ~10(8) higher resistance than pores in lipid membrane channels and carbon nanotubes.

156 res, from mitochondrial networks and nuclear pores in mammalian cells to amyloid-beta plaques and den

157 geometry that can, for example, segment the pore into four isolated components.

158 conserved Trp/Glu residue pair in the lower pore is detrimental to gating and selectivity, although

159 dynamics simulations, we show how the barrel pore is primed for CdiA toxin secretion.

160 Access to the pore is through a vestibule on the cytosolic side that i

161 e actin filaments surrounding the diapedesis pore, keeping this opening tightly closed around the tra

162 ty transition pore) and that opening of this pore leads to necroptosis, a regulated form of necrotic

163 h is located at the extracellular end of the pore lining M2 transmembrane segment (18').

164 involves a secondary structure change of the pore-lining helix, which contains a pai-helical segment

165 by an alpha-to-pai helical transition in the pore-lining transmembrane helix S6.

166 nts that include the CbbQ alpha4-beta4 loop, pore loop 1, and the presensor 1-beta hairpin (PS1-betaH

167 y rectifying K(+) channels in fungi with two pore-loops and eight transmembrane spans.

168 ween a small-pore (sp) structure and a large-pore (lp) structure.

169 operties, including large and interconnected pores, mechanical robustness, and shape-memory.

170 e additional yet vital driving force for the pores near the keyhole tip to move away from the keyhole

171 in the rock, and the connection between the pore network and the naturally present or mechanically i

172 tial are largely determined by the connected pore network in the rock, and the connection between the

173 Based on the pore network modeling (PNM) of OCT images, larger pores

174 y threading macromolecules through a central pore of a disc-shaped hexamer.

175 trate specific binding of the peptide to the pore of pentameric VP1.

176 e selectivity of the binding sites along the pore of potassium channels.

177 Using a simplified model of the pore of the 5-HT(3) receptor (5HT3R) which restrains the

178 siology, we show that TETS is binding in the pore of the alpha(2)beta(3)gamma(2) GABA receptor type A

179 TMC2 (TMC1/2) have been proposed to form the pore of the mechanotransduction channel of cochlear hair

180 noncompetitive antagonist (NCA) site in the pore of the receptor channel.

181 ion affected the gating of the non-canonical pore of TRPM3, resulting in large inward cation currents

182 , the excess amount of methane stored in the pores of Cr-soc-MOF-1 in the form of MH was found to be

183 nal visualization of fluid occupancy maps in pores of different sizes.

184 ed; however, solid CH(4) storage in confined pores of MOFs in the form of hydrates is yet to be disco

185 s, within the one-dimensional (1D) nanoscale pores of surfactant-templated mesoporous silica films.

186 e, we show that CLas movement through phloem pores of sweet orange (Citrus sinensis) and grapefruit (

187 the aqueous racemic mixture into the chiral pores of the AAO membrane leaving the filtrate enriched

188 ing order takes place during assembly of pre-pore oligomers.

189 bles tethered to cell membranes, a transient pore on the cell membrane (sonoporation) is generated wh

190 el to study the characteristics of transient pores on a patch of the lipid bilayer that is strengthen

191 FN) signals convey resistance to CDC-induced pores on macrophages and neutrophils.

192 on land, including the evolution of stomata-pores on the surface of plants that regulate gas exchang

193 al Ca(2+) influx and permeability transition pore opening after ischemic injury to reduce ongoing pat

194 st, the hypothesis that STIM1-mediated Orai1 pore opening is accompanied by a global conformational c

195 ducing mitochondrial permeability transition pore opening.

196 ducing mitochondrial permeability transition pore opening.

197 minal ligand binding site and culminating in pore opening.

198 The static dimensions of the pore openings of both materials are too small to admit e

199 ate its escape, but instead occupies smaller pores or is present in layers in the corners of the pore

200 We also studied the effect of possible pore overlapping on the cell membrane, introducing a dim

201 Nerve fibers extended into the gill pore papillae, as far as the SCCs and serotonergic fiber

202 Introduction of pore partition agents into hexagonal channels of MIL-88

203 ry current was introduced that yields fusion pore permeability divided by vesicle volume (g/V).

204 The postspike pore persists and is stable for tens of milliseconds, as

205 scovered that TRESK, a calcium regulated two-pore potassium channel, plays a crucial role in this sys

206 into Kilauea Volcano's subsurface increased pore pressure at depths of 1 to 3 kilometres by 0.1 to 1

207 Pore pressure modeling reveals that pore pressure changes initiate seismicity on critically

208 ing causal mechanism for induced seismicity: pore pressure increase and earthquake interactions lead

209 Pore pressure modeling reveals that pore pressure change

210 hat a slow voltage sweep charges ultranarrow pores quicker than an abrupt voltage step.

211 Moreover, the pore recovery process under negative strain rates (compr

212 that combinations of agents targeted to the pore-region binding site of lidocaine and the external b

213 at the mitochondrial permeability transition pore regulator cyclophilin D (CypD) promotes NGSIS, but

214 h as incomplete cytokinesis or muscle fusion pore regulators.

215 es remaining within dewetted sections of the pore resemble gas phase water.

216 (+) and for Cl(-) ions within the open state pore revealed more rugged energy landscapes using polari

217 ed to nanoscale interactions via mechanistic pore-scale colloid trajectory simulations that predicted

218 ce time (inactivation/death) versus removal (pore-scale delivery to surfaces) on pathogen prevalence

219 This study investigates the pore-scale displacement mechanisms of crude oil in aged

220 Pore-scale displacement mechanisms were investigated usi

221 nly by in situ degradation, but also through pore-scale remobilization (induced by the evolved gas ph

222 strongly enhances concentration gradients at pore-scale.

223 Chemical signature of femoral pore secretions is important for intra- and inter-specif

224 face area, narrow pore distribution, tunable pore size and excellent charge transport provides great

225 d cells, which ultimately determine stomatal pore size and porosity to water and CO(2) exchange (New

226 rtunities to tune these properties since the pore size and shape can be controlled by the application

227 H(4)), via precise mechanical control of the pore size aperture in a flexible metal-organic framework

228 tion of xylene isomers via refinement of the pore size in a series of porous metal-organic frameworks

229 542 +/- 0.035 mm thick (z-axis), with a mean pore size of 0.420 +/- 0.028 x 0.328 +/- 0.005 mm(2) .

230 ing and sacrificial material leaching with a pore size of 10 um.

231 ulate leaching, the m-chit-GO showed average pore size of 1mumwith slow (2 h) curing process.

232 ency by increased voltage, pressure, and the pore size of filters.

233 The results show that the pore size of the prepared porous materials could be cont

234 on the 3D nanofiber assemblies with smaller pore size show significantly higher expression of hypoxi

235 However, titanium mesh pore size specifications may influence bone quality.

236 multilayer of 48 nm has a sufficiently small pore size to sieve out surfactant molecules from the fee

237 gen gels with controlled fiber thickness and pore size were microfabricated by adjusting the gelation

238 twork structure with tunable surface charge, pore size, and interlayer spacing.

239 onstrating the potential correlation between pore size, lipid accommodation and channel activity.

240 board hydrogen storage thanks to the tunable pore size, pore volume, and pore geometry.

241 ion pore and the electrode as well as fusion pore size, which leads to different average spike shapes

242 rated a relatively smooth surface with small pore size.

243 BMSCs cultured on the assemblies with larger pore size.

244 with 0.04-mm thickness and 0.15-mm pore size; n = 7).

245 Combined with their Steiner-tree-structured pores (size 200-300 nm) consisting of nanowires (diamete

246 zes the microporous framework membranes with pore sizes lower than 2 nm based on their chemistry: ino

247 ent densities of vacancy sites and different pore sizes.

248 dynamic behavior, switching between a small-pore (sp) structure and a large-pore (lp) structure.

249 The concept allows partitioning of soil pore space according to the relative contribution of cer

250 ractions of particles to the change in total pore space.

251 r is present in layers in the corners of the pore space.

252 transformations and moving through the soil pore space.

253 tained in pacs MOFs; two thirds are used for pore-space partition.

254 the fluids are configured in the microscopic pore spaces of the reservoir rock.

255 ws a substantial prismatic layer and complex pore structure(4).

256 ical studies to better understand the carbon pore structure, electrolyte ion environment and ion flux

257 ntrusive and had a milder effect on membrane pore structure.

258 out any changes to the membrane's underlying pore structure.

259 Zeolites have unique pore structures of molecular dimensions and tunable comp

260 In consideration of pore structures, the correlation between the pore volume

261 ed, due to their limited accessibility of in-pore surface and long mass-diffusion length.

262 e silanol groups are located on the internal pore surface of calcined zeolite SSZ-70.

263 hemically modified micromodels such that the pore surfaces are representative of carbonate reservoir

264 , rich structural tunability, and functional pore surfaces, which can accommodate a variety of guest

265 ent ion conduction in MOF/IL blends, whereas pore symmetry is a less stringent condition.

266 en characterized and its connected/effective pore system has been extracted and nano-3D-printed.

267 Moreover, thanks to their hierarchical pore system, the MOFtors retain sufficient free space fo

268 diverse framework topologies and accessible pore systems.

269 ocations of the domains creates two distinct pores that can each accommodate the 12-mer of chondroiti

270 omerizes in the plasma membrane (PM) to form pores that increase membrane permeability, leading to py

271 which reveal how they form lipid-stabilized pores that might disrupt neuronal membranes and ion home

272 size and connectivity of their sub-nanometer pores, the Si/Al ratio of the anionic framework, and the

273 host membrane, and the formation of a fusion pore through which the viral genome is transferred into

274 s guard cell expansion, which opens stomatal pores to facilitate leaf cooling.

275 OH we conclude that confinement within these pores, together with the anisotropic growth of HAp, dict

276 The abundance of trichome-associated pores, together with their self-sealing capacity, presen

277 r RNA (tRNA) species based on the associated pore translocation times, ion-current noise, and blockag

278 pore structures, the correlation between the pore volume and hydrogen storage capacity is examined an

279 ted carbon possessed a high surface area and pore volume of 0.92 cm(3).g(-1) after two activation ste

280 ng two key descriptors (BET surface area and pore volume) for the adsorbents.

281 gen storage thanks to the tunable pore size, pore volume, and pore geometry.

282 groups and deprotonated silanol sites on the pore walls.

283 e of crop type, reduced iron was detected in pore water and postexperiment rhizosphere soil confirmin

284 ulting electric forces cause the movement of pore water ions in opposite directions, leading to charg

285 ons that either remained in the near-surface pore water or re-entrained to bulk pore water.

286 By combining small-volume pore water sampling, targeted analysis, and suspect scre

287 pitation in the presence of a (34)S-depleted pore water sulfide reservoir, via closed system (Raleigh

288 r-surface pore water or re-entrained to bulk pore water.

289 utations to residues in the middle and lower pore were more likely to affect gating and/or ion select

290 Water fluxes through separate intrasubunit pores were unaltered by the furan compounds (at concentr

291 asses over the uridine-binding proximal-face pore, whereas the remaining DNA duplexes interact with t

292 ce difficulties in entering and leaving such pores, which slows down charging and discharging process

293 anding, CO(2) does not reside in the largest pores, which would facilitate its escape, but instead oc

294 partner CsgF to produce a dual-constriction pore with improved signal and base-calling accuracy for

295 quencing using a prototype CsgG-CsgF protein pore with two constrictions improved single-read accurac

296 logical proton channels are sub-1-nm protein pores with ultrahigh proton (H(+)) selectivity over othe

297 e was associated with a closed transmembrane pore, with resolved monovalent cations intracellular to

298 heterogeneous structure and connectivity of pores within a model EPS polymer.

299 channel proteins form water-filled nanoscale pores within lipid bilayers, and their properties are de

300 previously shielded glycine residues to the pore without significant rotational movement of the asso