ライフサイエンスコーパス: pore-forming

1 s of CsgF bind inside the beta-barrel of the pore, forming a defined second constriction.

2 at large hydrophobic side chains occlude the pore, forming a physical gate, and that channel opening

3 barrel arrangement that we named beta-barrel pore-forming Abeta42 oligomers (betaPFOsAbeta42).

4 bacterial membranes are consistent with the pore-forming activities of AMPs previously observed in l

5 ggest the relative independence between StII pore-forming activity and its immunomodulatory propertie

6 umolysin-induced MIF production required its pore-forming activity and phosphorylation of p38-MAPK in

7 These data suggest that the pore-forming activity and the ISVP*-promoting activity o

8 sdermin D (GSDMD) induces pyroptosis via the pore-forming activity of its N-terminal domain, cleaved

9 Both activities are attributed to the pore-forming activity of the ESX-1-secreted substrate ES

10 their mechanism of action-plasmatic membrane pore-forming activity selective for bacteria.

11 ylatable Thr6 residue of GSDME, inhibits its pore-forming activity, thus uncovering a potential mecha

12 ns of the Cry protein, and in particular its pore-forming activity.

13 directed exposure of individual cells to the pore-forming agent alpha-hemolysin, we have controlled t

14 Ammonium carbonate was used as a pore-forming agent since it decomposed with volatile dur

15 recursor and introducing phenanthroline as a pore-forming agent.

16 geting nucleic acids, proteins or membranes (pore-forming agents).

17 ic alternative splice variants of the single pore-forming alpha subunit ( KCa1.1, Kcnma1, Slo1) gene,

18 d consists of a protein complex comprising a pore-forming alpha subunit and two associated beta subun

19 Interestingly, the pore-forming alpha subunit of KCa1.1 coimmunoprecipitate

20 excitable cell types and with or without the pore-forming alpha subunit present.

21 e-activated K(+)(BK) channel consists of the pore-forming alpha subunits (BKalpha) and auxiliary subu

22 ltage-gated potassium (Kv) channels comprise pore-forming alpha subunits and a multiplicity of regula

23 nd Ca(v)2 Ca(2+) channels are comprised of a pore-forming alpha(1) subunit (Ca(v)1.1-1.4, Ca(v)2.1-2.

24 e intracellular S0-S1 loop of the BK channel pore-forming alpha-subunit controls functional coupling

25 ewise, OHCs of BKalpha(-/-) mice lacking the pore-forming alpha-subunit of BK channels have longer IP

26 CaM that lack Ca(2+)-binding capacity to the pore-forming alpha-subunit of Ca(V)1.2, Ca(V)1.3, and Ca

27 Ca2+ channel beta-subunit interactions with pore-forming alpha-subunits are long-thought to be oblig

28 The properties and physiological function of pore-forming alpha-subunits of large conductance calcium

29 hannels are formed by the co-assembly of the pore-forming alpha-subunits, Kv4.2 and Kv4.3, together w

30 n of PMN number and function and the role of pore-forming alpha-toxin (AT), a virulence factor that c

31 multisubunit protein complexes composed of a pore-forming alpha1 and auxiliary beta and alpha2delta s

32 rafficking and biophysical properties of the pore-forming alpha1 subunit and trigger excitatory synap

33 its N-terminal region, scaffolds the L-type pore-forming alpha1 subunit and, through its C-terminal

34 caused by a gain-of-function mutation in the pore-forming alpha1 subunit of CaV 2.1 (P/Q-type) calciu

35 alleled by changes in phosphorylation of the pore-forming alpha1 subunit of the cardiac voltage-gated

36 divisions of calcium channel, defined by the pore-forming alpha1 subunit, the CaV 1, CaV 2 and CaV 3

37 age-gated Ca(2+) (CaV) channels consist of a pore-forming alpha1 subunit, which determines the main f

38 The pore-forming alpha1-subunit comprises four repeated doma

39 Voltage-gated CaV2.1 channels comprise a pore-forming alpha1A subunit with auxiliary alpha2delta

40 leavage of the gasdermin proteins to produce pore-forming amino-terminal fragments causes inflammator

41 Both pore forming and nitrogen doping simultaneously proceed

42 Mitochondrial calcium uniporter (MCU) is the pore-forming and Ca(2+)-conducting subunit of the unipor

43 YenTcA is the pore-forming and membrane binding A subunit of the ABC t

44 n be utilized for design and modification of pore-forming antibacterial peptides or toxins.

45 Perforin-2 (MPEG1) is a pore-forming, antibacterial protein with broad-spectrum

46 More generally, treatment with H2A and the pore-forming antibiotic polymyxin B completely eradicate

47 ocessing repeats-in-toxin (MARTX) toxins are pore-forming bacterial toxins that translocate multiple

48 Microcin E492 (Mcc) is a pore-forming bacteriotoxin.

49 This pore-forming behavior is strong evidence that Aibm (m >/

50 five proteins arranged in two-fold symmetry: pore-forming beta-barrel protein Tom40 and four auxiliar

51 ment of C9 molecules that yield an 88-strand pore-forming beta-barrel.

52 ng such tissues, we developed a new class of pore-forming bioink to spatially and temporally control

53 ssible to direct either rapid and transient (pore-forming bioinks), or slower and more sustained (sol

54 ated potassium channels (BK) are composed of pore-forming BKalpha and auxiliary beta1 subunits in art

55 K(+) (BK) currents and the expression of the pore-forming BKalpha protein were normal.

56 e attributed to the specific geometry of the pores, forming cages built with phenyl rings and enriche

57 Most gasdermin proteins are believed to have pore-forming capabilities.

58 ocessability, thermal stability, and uniform pore-forming capability, which endow the resultant frame

59 Gasdermin D (GSDMD), the pore-forming caspase-1 substrate required for efficient

60 nels, Cav1.4 channels are composed of a main pore-forming Cav1.4 alpha1 subunit and auxiliary beta an

61 nnels are oligomeric complexes formed by the pore-forming CaValpha1 with the auxiliary CaVbeta and Ca

62 ytes exist as heteromeric complexes with the pore-forming CaValpha1, CaVbeta, and CaValpha2delta1 sub

63 elation between the total amount of the LTCC pore-forming Cavalpha1.2 and the Akt-dependent phosphory

64 of a multiprotein complex consisting of the pore-forming channel subunits, the constitutively bound

65 Pannexins are large-pore forming channels responsible for ATP release under

66 etry upon the conformational behavior of the pore-forming, cholesterol-dependent cytolysin perfringol

67 oL1 has been hypothesized to function like a pore-forming colicin and has been reported to have perme

68 res by virtue of its similarity to bacterial pore-forming colicins.

69 h the threshold for oligomerization into the pore-forming complex.

70 ible mechanisms, including the production of pore-forming complexes that permeabilize membranes.

71 which the receptor complex combines with the pore-forming component to assemble a new translocase for

72 ative intracellular pathogen that secretes a pore-forming cytolysin called listeriolysin O (LLO), whi

73 the transcription factor PrfA, including the pore-forming cytolysin listeriolysin O (LLO), two phosph

74 Pneumolysin, a pore-forming cytotoxin and major virulence determinant,

75 we report the structures of a staphylococcal pore-forming cytotoxin, leukocidin GH (LukGH), in comple

76 The staphylococcal pore-forming cytotoxins hijack important immune molecule

77 echanotransduction complex that contains the pore-forming degenerin/epithelial sodium channel (DEG/EN

78 o the surface of podocytes, with most of the pore-forming domain (PFD) and C terminus of the Serum Re

79 mic N-terminal domain and smaller C-terminal pore-forming domain comprising six transmembrane helices

80 GC-35 evolved from GABA-A receptors, but the pore-forming domain contains novel molecular determinant

81 RCD-1 is a remote homolog of the N-terminal pore-forming domain of gasdermin, the executioner protei

82 Lo-like domain of HELLP is homologous to the pore-forming domain of MLKL, the cell death-execution pr

83 uman ether-a-go-go-related gene (hERG1), the pore-forming domain of the delayed rectifier K(+) channe

84 e based on expression of a chimera between a pore-forming domain of the mechanically insensitive ASIC

85 carry heterozygous missense variants in the pore-forming domain of TMEM63A.

86 Retigabine binds to the pore-forming domain, causing a hyperpolarizing shift in

87 ell death-inducing protein containing a HeLo pore-forming domain, is activated through amyloid templa

88 involves global changes in structure of the pore-forming domains transduced by interactions of the p

89 ng domains transduced by interactions of the pore-forming domains with either the NT, CT, or both, wi

90 acNavs contain conserved voltage-sensing and pore-forming domains, but they are homotetramers of four

91 osis requires cleavage and activation of the pore-forming effector protein gasdermin D by inflammator

92 During pyroptosis, GSDMD (gasdermin D), the pore-forming effector protein, is cleaved, forms oligome

93 Whereas bacteria recover from the pore-forming effects of LL-37, the concomitant effects o

94 acter pylori (Hp) secrete VacA, a diffusible pore-forming exotoxin that is epidemiologically linked t

95 Burst drug release occurred followed by pore forming from the exterior to the core of both micro

96 ne model to evaluate the contribution of the pore-forming GBS beta-hemolysin/cytolysin (betaH/C) to v

97 Recent studies have suggested that the pore-forming group A colicin N (ColN) instead uses lipop

98 odel invokes STIM1 binding directly to Orai1 pore-forming helix.

99 necessity for direct STIM1 contact with the pore-forming helix.

100 It encodes the pore-forming human CaV3.3 alpha1 subunit, a subtype of v

101 Co-expression of Neto1 and 2 with pore-forming kainate receptor subunits also increases th

102 ve potassium (K(ATP)) channels composed of a pore-forming Kir6.2 potassium channel and a regulatory A

103 tive potassium (KATP) channels comprise four pore-forming Kir6.2 subunits and four modulatory sulfony

104 f-function (GOF) mutations in genes encoding pore-forming (Kir6.1, KCNJ8) and accessory (SUR2, ABCC9)

105 Kv4 channels are ternary complexes including pore-forming Kv4 subunits and two types of auxiliary sub

106 Kv4 channels are ternary complexes including pore-forming Kv4 subunits, K(+) channel-interacting prot

107 In addition to pore-forming Kv4 subunits, modulatory auxiliary subunits

108 Using the bicomponent pore-forming leukocidin (Luk) exotoxins of the major pat

109 at are cross-reactive between members of the pore-forming leukocidin family.

110 Bicomponent pore-forming leukocidins are a family of potent toxins s

111 us is thought to depend on the production of pore-forming leukocidins that kill leukocytes and lyse e

112 of virulence factors including bi-component pore-forming leukotoxins.

113 Displacements of the pore-forming M3 segments define the energy of fast openi

114 (MABP) domain binds membranes such that the pore-forming machinery of MPEG1 is oriented away from th

115 ents (the lipid binding PlyA protein and the pore-forming MACPF component PlyB).

116 -expressed gene 1, Mpeg1), which possesses a pore-forming MACPF domain, reduces the viability of bact

117 beta), each of which comprises an N-terminal pore-forming MACPF/CDC domain, a central focal adhesion-

118 (uniplex) contains four core components: the pore-forming MCU protein, the gatekeepers MICU1 and MICU

119 The uniporter is composed of the pore-forming MCU protein, the gatekeeping MICU1 and MICU

120 It contains the pore-forming MCU protein, which possesses a DIME sequenc

121 ly, there are tantalizing hints that the CDC pore-forming mechanism is more sophisticated than previo

122 al tools to dissect different aspects of the pore-forming mechanism of StII(1-30), a peptide derived

123 order is altered in different stages of the pore-forming mechanism.

124 e make the unexpected finding that SNTX is a pore-forming member of an ancient branch of the Membrane

125 nce of a lipid-dependent bulge region in the pore-forming module of lysenin, which may explain the ga

126 s an enzymatic component, termed CDTa, and a pore-forming or delivery subunit termed CDTb.

127 rned through direct interactions between the pore-forming Orai proteins and the endoplasmic reticulum

128 K(+) channel sequence signature-containing, pore-forming P loop.

129 ances the membrane selectivity of a prolific pore-forming peptide, melittin, based on experimental ob

130 We find that the most potent pore-forming peptides exhibit strong interpeptide intera

131 of combinatorial libraries from which potent pore-forming peptides have been derived, optimized to wo

132 w that conformational fine-tuning of helical pore-forming peptides is a powerful way to modulate thei

133 e contents--granzyme (Gzm) proteases and the pore-forming perforin (PFN)--into the infected cell.

134 Their direct interaction with the pore-forming plasma membrane ORAI proteins (ORAI1, ORAI2

135 PLY non-pore-forming point mutants that are trapped at various s

136 Ls kill by secreting toxic proteases and the pore forming protein perforin into the synapse.

137 l synapse with their targets and secreting a pore-forming protein (perforin) and pro-apoptotic serine

138 in has recently been solved, showing it is a pore-forming protein (viroporin).

139 The tight junctional pore-forming protein claudin-2 (CLDN-2) mediates paracel

140 rst evidence, to our knowledge, that StII, a pore-forming protein from a marine eukaryotic organism,

141 to avoid this hurdle, sticholysin (St) II, a pore-forming protein from the Caribbean Sea anemone Stic

142 toxin lipopolysaccharide (LPS) activated the pore-forming protein Gasdermin D, which formed mitochond

143 The pyroptosis is executed by the pore-forming protein GSDMD, which is activated by cleava

144 teraction molecule 1 (STIM1) and the channel pore-forming protein Orai1.

145 ic T lymphocytes enhance the function of the pore-forming protein perforin, thereby leading to more e

146 study, we show that the membrane-associated pore-forming protein Perforin-2 (P2) is critical for LPS

147 ed endosome-disrupting agent composed of the pore-forming protein Perfringolysin O (PFO), potent sile

148 bolished the correct localisation of EXP2, a pore-forming protein required for the nutrient-permeable

149 Equinatoxin II (EqtII) is a soluble, 20 kDa pore-forming protein toxin isolated from the sea anemone

150 erall scheme of the archetypical beta barrel pore-forming protein toxin mode of action, in which the

151 specialized lysosomes containing perforin, a pore-forming protein, and granzymes, which are proteases

152 y cytokines such as IL-1beta and IL-18 and a pore-forming protein, gasdermin D, which triggers pyropt

153 ediated cytotoxicity in conjunction with the pore-forming protein, perforin.

154 ated DNA to encode either a fluorescent or a pore-forming protein.

155 elices similar in arrangement to other large-pore forming proteins but assemble as a heptameric chann

156 e similar membrane topology with other large-pore forming proteins such as connexins, innexins, and L

157 Pore-forming proteins are weapons often used by bacteria

158 apoptosis at mitochondria by activating the pore-forming proteins Bax and Bak and by inhibiting the

159 anisms from all kingdoms of life, only a few pore-forming proteins have been successfully reconstitut

160 irectly by the recently identified family of pore-forming proteins known as gasdermins, the best char

161 The gasdermins are a family of pore-forming proteins recently implicated in the immune

162 sins (CDCs) represent a family of homologous pore-forming proteins secreted by many Gram-positive bac

163 ct effector proteins termed Yops, as well as pore-forming proteins that comprise the translocon itsel

164 Cholesterol-dependent cytolysins (CDCs) are pore-forming proteins that serve as major virulence fact

165 The ability of pore-forming proteins to interact with various analytes

166 Pore-forming proteins, deployed by both hosts and pathog

167 te this inflammasome activation to different pore-forming proteins, GSDMD and pannexin-1, respectivel

168 proteins comprise the largest superfamily of pore-forming proteins, playing crucial roles in immunity

169 also exhibits behavior typically observed in pore-forming proteins, such as porins and ionic transpor

170 e engineering the target-cell specificity of pore-forming proteins.

171 nserved residue leucine 29 to alanine in the pore-forming region increased its single-channel conduct

172 gonist-binding region and the transmembrane, pore-forming region.

173 a peptide corresponding to the hERG-channel pore-forming region.

174 embers have a unique topology comprising two pore-forming regions per subunit.

175 ichia coli belong to the family of cytolytic pore-forming Repeats in ToXin (RTX) cytotoxins.

176 L46 is a pore-forming residue of the EAAT2 anion channels at the

177 to this pathway, and mutations of homologous pore-forming residues had analogous effects on GltPh sim

178 nal adenylyl cyclase (AC) domain linked to a pore-forming RTX cytolysin (Hly) moiety, binds the compl

179 otide-binding domain (CNBD) connected to the pore-forming S6 transmembrane segment via the C-linker.

180 amino acid residues in or near the S5 and S6 pore-forming segments of NALCN, highlighting the functio

181 ate new polymers with flexible backbones and pore-forming side chains that have unexplored promise fo

182 Three pore-forming sodium channel isoforms are primarily expre

183 pulations of AC5 and the L-type Ca2+ channel pore-forming subunit CaV1.2.

184 form a channel complex with the K(+) channel pore-forming subunit Kv4.3 in a subset of nociceptors to

185 The K(+) channel pore-forming subunit Kv4.3 is expressed in a subset of n

186 l the contribution of MCUB, a paralog of the pore-forming subunit MCU, in mtCU regulation and functio

187 otein 16A (TMEM16A), also known as ANO1, the pore-forming subunit of a Ca(2+) -dependent Cl(-) channe

188 neuron-specific misexpression of TRP-4, the pore-forming subunit of a mechanotransduction channel, s

189 KCNQ1 is the pore-forming subunit of cardiac slow-delayed rectifier p

190 CaVbeta binds to the alpha1 pore-forming subunit of L-type channels and augments cal

191 , a gene required for hearing that encodes a pore-forming subunit of mechanosensory transduction chan

192 Orai1 comprises the pore-forming subunit of the Ca(2+) release-activated Ca(

193 culum (ER) Ca(2+) sensor STIM1 to Orai1, the pore-forming subunit of the Ca(2+) release-activated Ca(

194 n is required for mammalian hearing and is a pore-forming subunit of the hair cell mechanotransductio

195 tations of the CACNA1A gene that encodes the pore-forming subunit of the human Cav2.1 (P/Q-type) volt

196 d by mutations in CACNA1A, which encodes the pore-forming subunit of the neuronal voltage-gated calci

197 CACNA1B encodes the pore-forming subunit of the pre-synaptic neuronal voltag

198 ther-a-go-go-related gene (hERG) encodes the pore-forming subunit of the rapidly activating delayed r

199 ther-a-go-go-related gene (hERG) encodes the pore-forming subunit of the rapidly activating delayed r

200 ther-a-go-go-related gene (hERG) encodes the pore-forming subunit of the rapidly activating delayed r

201 ther-a-go-go-related gene (hERG) encodes the pore-forming subunit of the rapidly activating delayed r

202 protein Sec61 subunit alpha isoform 1), the pore-forming subunit of the Sec61 protein translocon, as

203 nnel like protein 1 (TMC1) is likely to be a pore-forming subunit of the transduction channel of coch

204 Manipulation of the pore-forming subunit, MCU, in PASMCs was achieved throug

205 These channels consist of a primary alpha(1) pore-forming subunit, which is associated with an extrac

206 ter have been identified, including MCU, the pore-forming subunit.

207 Kv4 pore-forming subunits co-assemble with beta-subunits inc

208 of AMPA receptors (AMPARs) is observed when pore-forming subunits coassemble with or without auxilia

209 Two mammalian genes, Kcnt1 and Kcnt2, encode pore-forming subunits of Na(+)-dependent K(+) (KNa) chan

210 ne (polyQ) within the C terminus (CT) of the pore-forming subunits of P/Q-type Ca(2+) channels (Cav2.

211 f membrane proteins associated with the core pore-forming subunits of the AMPARs.

212 of evidence is consistent with these TMCs as pore-forming subunits of the long-sought hair-cell trans

213 The principal pore-forming subunits of voltage-gated sodium and calciu

214 However, the identity of the pore-forming subunits of VRAC and how the channel is gat

215 tion channels with two non-equivalent tandem pore-forming subunits that dimerize to form quasi-tetram

216 IKs channels are comprised of four KCNQ1 pore-forming subunits, two KCNE1 accessory subunits, and

217 ding domain (LBD) is essential for gating by pore-forming subunits, whereas a conserved motif on the

218 been thought to be determined by the channel pore-forming subunits.

219 has surrounded the molecular identity of the pore-forming subunits.

220 s modulate the biophysical properties of the pore-forming subunits.

221 y of GABA(A)Rs are determined by the channel pore-forming subunits.

222 crease in the level of the cation-selective, pore-forming TJ protein claudin-2 was observed after cel

223 Epsilon toxin (Etx), a potent pore forming toxin (PFT) produced by Clostridium perfrin

224 colonizes the gastric mucosa and secretes a pore-forming toxin (VacA).

225 inetics for the well-characterized bacterial pore-forming toxin aerolysin in single cells in real tim

226 ent toxins: the anthrax lethal toxin and the pore-forming toxin aerolysin.

227 H. pylori secretes a pore-forming toxin called vacuolating cytotoxin A (VacA)

228 B. thuringiensis or treatment with its major pore-forming toxin crystal protein Cry5B.

229 The alpha-pore-forming toxin Cytolysin A (ClyA) is responsible for

230 Lysenin, a pore-forming toxin extracted from the earthworm E. fetid

231 Lysenin is a pore-forming toxin from the earthworm Eisenida foetida,

232 e-threatening wound infections, secretes the pore-forming toxin hemolysin II (HlyII).

233 aining 3 (NLRP3) and ASC due to the secreted pore-forming toxin hemolysin.

234 rs ranging from 20 to 200 nm, containing the pore-forming toxin listeriolysin O (LLO) and phosphatidy

235 The secreted pore-forming toxin listeriolysin O (LLO) of the intracel

236 We studied L. monocytogenes and its secreted pore-forming toxin listeriolysin O (LLO) to identify key

237 some of the host cells via the action of the pore-forming toxin listeriolysin O (LLO).

238 ment to Lm vacuoles requires the presence of pore-forming toxin listeriolysin O.

239 cardiac damage was entirely dependent on the pore-forming toxin pneumolysin only for D39.

240 e cytosolic compartment via the pneumococcal pore-forming toxin pneumolysin.

241 Leukocidin ED (LukED) is a pore-forming toxin produced by Staphylococcus aureus, wh

242 alpha-Hemolysin (Hla), a pore-forming toxin secreted by S. aureus and a major con

243 ccus aureus Panton-Valentine leukocidin is a pore-forming toxin targeting the human C5a receptor (hC5

244 ainst MRSA strains encoding alpha-toxin(4)-a pore-forming toxin that binds the metalloprotease ADAM10

245 ostridium perfringens enterotoxin (CPE) is a pore-forming toxin that causes the symptoms of common ba

246 Helicobacter pylori VacA is a secreted pore-forming toxin that induces cell vacuolation in vitr

247 Intermedilysin (ILY), a cytolytic pore-forming toxin that is secreted by Streptococcus int

248 s white button mushrooms by secretion of the pore-forming toxin tolaasin, the main virulence factor o

249 membrane, we engineered a natural SM-binding pore-forming toxin, equinatoxin II (Eqt), into a nontoxi

250 One such example is the highly potent pore-forming toxin, hemolysin BL (HBL), produced by the

251 to activate proHlyA into a fully functional pore-forming toxin, HlyA.

252 Lysenin is a pore-forming toxin, which self-inserts open channels int

253 nd transgenic overexpression, we show that a pore-forming toxin-like (PFT) gene at Fhb1 confers FHB r

254 to be widespread and also used by other CDC pore-forming toxin-producing bacteria.

255 ional changes occurring in a large cytolytic pore-forming toxin.

256 The alpha helical CytolysinA family of pore forming toxins (alpha-PFT) contains single, two, an

257 alpha-Pore-forming toxins (alpha-PFTs) are ubiquitous defense

258 beta-Barrel pore-forming toxins (beta-PFT), a large family of bacter

259 elongs to the aerolysin family of small beta-pore-forming toxins (beta-PFTs), some members of which a

260 beta-Barrel pore-forming toxins (betaPFTs) form an obligatory oligom

261 Pore-forming toxins (PFTs) are a class of pathogen-secre

262 Pore-forming toxins (PFTs) are a class of proteins impli

263 Bacterial pore-forming toxins (PFTs) are structurally diverse path

264 the mechanisms of other important classes of pore-forming toxins and proteins across the kingdoms of

265 Pore-forming toxins associated with S. aureus EVs were c

266 innate immune mechanisms that can neutralize pore-forming toxins during infection.

267 Pore-forming toxins form a family of proteins that act a

268 pid and evolutionarily conserved response to pore-forming toxins in the gut, involving cytoplasm ejec

269 Sticholysins are pore-forming toxins of biomedical interest and represent

270 Secreted pore-forming toxins of pathogenic Gram-negative bacteria

271 The staphylococcal bicomponent pore-forming toxins Panton-Valentine leukocidin LukSF-PV

272 Cholesterol-dependent cytolysins (CDCs) are pore-forming toxins secreted by bacteria that target mem

273 n important class of such protein complexes, pore-forming toxins start their journey as soluble monom

274 nflammatory form of cell death instigated by pore-forming toxins such as S. pneumoniae pneumolysin.

275 nism that is relevant to understanding other pore-forming toxins that also require CD59.

276 The production of pore-forming toxins that disrupt the plasma membrane of

277 rol-dependent cytolysins (CDCs), a family of pore-forming toxins that form gigantic pores in cell mem

278 senin is a member of the aerolysin family of pore-forming toxins that includes many representatives f

279 S. aureus produces an array of bicomponent pore-forming toxins that target and kill leukocytes, kno

280 peratures as measured by hypersensitivity to pore-forming toxins that target PS (papuamide A) or PE (

281 Many pathogenic bacteria produce pore-forming toxins to attack and kill human cells.

282 venom of sea anemones, actinoporins are the pore-forming toxins whose toxic activity relies on the f

283 ongated shape, which resembles those of beta-pore-forming toxins, such as Aerolysin, but is devoid of

284 e bacterial pathogens that secrete cytotoxic pore-forming toxins, such as Staphylococcus aureus and S

285 ng of pore formation by other aerolysin-like pore-forming toxins, which often represent crucial virul

286 of toxins may represent a common feature of pore-forming toxins.

287 gnificant structural similarity to bacterial pore-forming toxins.

288 ne, unlike structurally homologous bacterial pore-forming toxins.

289 egulatory and agonist-binding domains to the pore-forming trans-membrane domain (TMD), and validated

290 First, the pore-forming translocators are released.

291 ed tip complex responsible for assembly of a pore-forming translocon in the host cell membrane.

292 f antagonism, and complete structures of the pore-forming transmembrane domains of these receptors re

293 Voltage-gated sodium (Na(V)) channels are pore-forming transmembrane proteins that play essential

294 l critically evaluate the candidates for the pore-forming unit of the PTP and discuss recent data sug

295 contains two constrictions, one each in the pore-forming upper and lower gates.

296 Helicobacter pylori secretes a pore-forming VacA toxin that has structural features and

297 y measurements in order to investigate how a pore-forming, virucidal peptide destabilizes lipid vesic

298 ub-strains of Escherichia coli secreting the pore-forming virulence factor alpha-hemolysin (HlyA).

299 ABC toxins are pore-forming virulence factors produced by pathogenic ba

300 determined not only by the properties of the pore-forming voltage-gated Na(+) channel (VGSC) alpha su