ライフサイエンスコーパス: post mortem

1 tantia nigra (SN) from PD patients, analyzed post mortem.

2 of sudden death medication-free individuals post mortem.

3 ivo normothermic conditions up to four hours post-mortem.

4 One case was diagnosed post-mortem.

5 s from the pig bones and surrounding tissue, post-mortem.

6 lmost half go completely unexplained despite post-mortem.

7 as performed in vivo by SPECT-CT imaging and post-mortem.

8 gh-resolution mapping of expression patterns post-mortem.

9 ed at population level from extracted skulls post-mortem.

10 amples of longissimus thoracis muscle at 2 h post-mortem.

11 lmost half go completely unexplained despite post-mortem.

12 h in vivo (1050 um isotropic resolution) and post mortem (200 um isotropic resolution).

13 Tissues were collected post mortem (2012-2016), and histopathological images we

14 significantly increased in synaptosomes from post-mortem AD brains compared to age-matched controls.

15 RNA-sequencing from post-mortem AD human brains shows downregulation in the

16 CD33 is upregulated on microglial cells from post-mortem AD patient brains, and high levels of CD33 i

17 has the potential to be applied to identify post-mortem aging of chicken meat samples.

18 We report the presence of NK cells in post-mortem ALS motor cortex and spinal cord tissues, an

19 utase 1-overexpressing mice as well as human post-mortem ALS spinal cord-derived astrocytes induce mo

20 ing assay and in vitro autoradiography using post-mortem Alzheimer's disease brain tissue.

21 Gold standard post-mortem amyloid immunostaining was used for the dete

22 hazard scores were associated with regional post-mortem amyloid load and neuronal neurofibrillary ta

23 n humans, in part because of the reliance on post mortem analyses, which cannot be directly related t

24 bout DCX-associated lissencephaly comes from post-mortem analyses of patient's brains, mainly since a

25 roscale impact have hitherto been limited to post-mortem analysis of impacted specimens, which does n

26 observed and confirmed by more conventional post-mortem analysis; X-ray tomography and scanning elec

27 We outline the next steps for in vivo, post-mortem and clinical studies that can lay the ground

28 cted from tiles removed from the tokamak for post-mortem and controlled studies.

29 ein, are significantly increased in HD human post-mortem and HD mouse striata, correlating with neuro

30 Post-mortem and identical location TEM analyses reveal t

31 Post-mortem and in vivo studies implicate HSV-1 infectio

32 s different psychiatric disorders, including post-mortem and in-vivo studies in humans and experiment

33 Both post-mortem and neuroimaging studies have identified abn

34 Taken together, these post-mortem and preclinical findings identify TG2 as a c

35 foundation for understanding RNA regulation post-mortem and provide novel insights into RNA metaboli

36 present both at Day 14 in vivo and at Day 28 post-mortem) and marked and long-lasting sensorimotor de

37 Taphonomic processes affecting bone post mortem are important in forensic, archaeological an

38 ular tissues studies, where tissues obtained post-mortem are frequently used for research or therapeu

39 Experimentally produced faults, observed post-mortem, are sealed by fluid-bearing micro-pseudotac

40 Some formed post-mortem around tusk-shells (Fissidentalium spp.), wh

41 enting a validated consensus approach to the post-mortem assessment and scoring of cerebrovascular di

42 g and validation of the criteria, by blinded post-mortem assessment of brain tissue from 113 individu

43 The post-mortem autoradiographic data showed that 18F-AV-145

44 However, post-mortem blood has not been subjected to genetic anal

45 In conclusion, post-mortem blood, which is usually disposed of during c

46 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Post-mortem Braak staging of neurofibrillary tau tangle

47 ent contrasts in different tissue types of a post mortem brain.

48 context to transcriptomic analysis of human post-mortem brain at single-cell resolution.

49 Post-mortem brain material from a subset of the multiple

50 scovery and proteomics approach by comparing post-mortem brain material from schizophrenia patients a

51 le of the immune system in a large sample of post-mortem brain of patients with schizophrenia: RNA se

52 ed these to a series of fibroblast lines and post-mortem brain samples from individuals with either a

53 Over the past 25 years, studies analyzing post-mortem brain samples have found evidence of aberran

54 Through analysis of the post-mortem brain samples in individuals with MDD that d

55 e-wide DNA methylation was quantified in 262 post-mortem brain samples, representing tissue from four

56 A series of post-mortem brain tissue and in vitro experiments sugges

57 Neuropathological analysis of post-mortem brain tissue demonstrated that pIRE1alpha is

58 e shown patterns of molecular convergence in post-mortem brain tissue from autistic subjects.

59 istant aggregates, which are also present in post-mortem brain tissue from patients.

60 d 407 individuals with an antemortem MRI and post-mortem brain tissue from the Mayo Clinic Alzheimer'

61 ongitudinal retrospective study, we analysed post-mortem brain tissue of all individuals with an Alzh

62 recognized intracellular inclusions in human post-mortem brain tissue of Lewy body disease cases, but

63 We isolated microglia from post-mortem brain tissue of patients with MDD (n = 13-19

64 We also analysed matched CSF, post-mortem brain tissue, and iPSCs from the same partic

65 the topography of parvalbumin expression in post-mortem brain tissue.

66 nd fluorescent LMTK2 immunohistochemistry on post-mortem brain tissues and compared them to age-match

67 parate neuronal and glial DNA fractions from post-mortem brain tissues.

68 Using post-mortem brain transcriptomic data, we confirmed alte

69 o define the tau PTM landscape present in AD post-mortem brain.

70 confirmed by pathological analysis of their post mortem brains.

71 single-cell transcriptomic analyses of human post-mortem brains are important for documentation of pa

72 motor cortex, hippocampus and cerebellum of post-mortem brains from HD individuals, particularly in

73 ide microRNA (miRNA) expression profiling in post-mortem brains from individuals with ASD and control

74 Alcohol-dependent rats as well as post-mortem brains of human alcoholics and controls were

75 d-type PSEN1 allele expression is reduced in post-mortem brains of human EOfAD mutation carriers (and

76 The study of post-mortem brains of nonhuman primates (NHPs) has been

77 occludin, in 12 brain regions dissected from post-mortem brains of normal ageing (n = 10), pathologic

78 integrate SVs with RNA-sequencing from human post-mortem brains to quantify their dosage and regulato

79 required to form the aggregates observed in post-mortem brains.

80 e the stability of the sequestered molecules post-mortem but there is also potential for (palaeo)diet

81 Both PD and FTD/ALS are defined at post mortem by the presence of protein aggregates and th

82 r 24 weeks of age, inflammation was assessed post-mortem by determining colon length and histological

83 deer that were analyzed for prion infection post-mortem by immunohistochemistry (IHC).

84 using a luciferase-expressing UP strain, and post-mortem by qPCR and bacterial titration.

85 ing life and had a diagnosis of AD confirmed post-mortem by standardized criteria.

86 -wide profile of cocaine dependence in human post-mortem caudate tissue.

87 Distinguishing ante-mortem pathology from post-mortem change has been a major constraint in diagno

88 olecules are short and frequently mutated by post-mortem chemical modifications.

89 PSE was induced by incubation of post-mortem chicken carcasses at 37 degrees C for 200min

90 death, but data on the role of nonselective post-mortem CIED (pacemaker or defibrillator) analysis i

91 port were all cataloged in the Johns Hopkins Post-mortem CIED Registry.

92 Post mortem, cochlear gain disappeared.

93 ress these questions, a study using a unique post-mortem cohort wherein whole body autopsy reports an

94 ection of new Mycobacterium bovis infection (post-mortem confirmed) in at least one animal in a herd.

95 or low grade inflammation and non-arthritic post-mortem controls were analysed for the polyadenylati

96 nriched for genes dysregulated in the autism post-mortem cortex (Odd Ratio (OR) = 1.11, P(corrected)

97 iptomic, histologic and cellular profiles of post mortem COVID-19 (n = 34 tissues from 16 patients) a

98 Implementation of post-mortem CT (PMCT), enhanced with targeted coronary a

99 imited coverage achieved and the presence of post-mortem damage inflating sequencing errors.

100 f cytosine to thymine mismatches, typical of post-mortem damage.

101 bly similar to profiles obtained from mature post-mortem DaNs.

102 Extrapolation of post-mortem data predicts that a approximately 30% decli

103 SZ signal and increased the concordance with post-mortem data sets.

104 ntally differ across hemispheres and support post-mortem data showing asynchrony in the loss of neuro

105 However, most analyses of post-mortem datasets are achieved by building new comput

106 gle crystals and provides the foundation for post-mortem deduction of the shape of the solid/liquid i

107 However, the irreversible post-mortem degradation(2) of ancient DNA has so far lim

108 caveats, and results of the TMA analysis of post mortem diagenesis in bone are discussed, and implic

109 tissue extracts from healthy individuals and post mortem diagnosed AD patients, using a simple and fa

110 ational sites, during which surveillance and post-mortem diagnostics, including minimally invasive ti

111 inal significance (P<0.05) in an independent post-mortem DLPFC data set (182 schizophrenia and 212 co

112 -sequencing on neuronal nuclei isolated from post-mortem dlPFC of cocaine addicts and healthy control

113 ned with DNA metabarcoding and assessment of post-mortem DNA damage allowed us to authenticate ancien

114 stid DNA metabarcoding and the assessment of post-mortem DNA damage.

115 simulates the entire molecular process from post-mortem DNA fragmentation and DNA damage to experime

116 data in a wide variety of tissue types from post-mortem donors.

117 Adipocere is a waxy substance formed post-mortem during incomplete anaerobic decomposition of

118 compounds suggests that ambrein was produced post-mortem during the microbial decomposition of faecal

119 e rise occurs with the Janus separator where post mortem electron microscopy shows the PEC layer succ

120 d by comparison with a grain map obtained by post-mortem electron backscatter diffraction (EBSD).

121 All subjects underwent detailed post-mortem evaluation, including histological analysis

122 Post-mortem evaluations of healthy grafted tissue in suc

123 veral neuropsychiatric diseases and there is post-mortem evidence of their deficit in FTLD.

124 Post mortem examination of Parkinson's disease brains su

125 hs occurred in casualty, by medico-legal and post mortem examination, with no metabolic disorders.

126 Post-mortem examination and ultrasonographic studies (3

127 All 20 turtles assessed by ultrasound and/or post-mortem examination developed GE, independent of sea

128 Post-mortem examination of an individual with a homozygo

129 Post-mortem examination of slaughtered reactors confirme

130 tive reactors to the skin test with positive post-mortem examination results (phenotype 1); ii) posit

131 tive reactors to the skin test regardless of post-mortem examination results (phenotype 2) and iii) a

132 ive reactors to the skin tests with positive post-mortem examination results (phenotype 3).

133 e mycobacterial infection, and opportunistic post-mortem examination was performed on comparative int

134 In foxes with no evidence of ICH on post-mortem examination, 29 of 154 (18.8%) red foxes had

135 ppearances and neurodegenerative features on post-mortem examination.

136 lled, consent was requested from parents for post-mortem examinations (both complete diagnostic autop

137 Post-mortem examinations in three patients confirmed neu

138 Post-mortem examinations were done on 14 people who died

139 At 48h post-mortem, export quality loins were aged at -1.7 degr

140 ization, but contrast with known patterns of post-mortem Fe mineralization.

141 s study, we demonstrate that myelin obtained post mortem from 8 out of 11 MS brain donors is bound by

142 euse of implantable cardiac devices obtained post mortem from patients in wealthier nations have been

143 Endometrial samples and ULF were collected post-mortem from sham-inseminated cows and from cows ins

144 tered expression of small GTPase proteins in post-mortem frontal cortex tissues from AD patients with

145 foraging trails, before being killed for the post mortem fungal growth.

146 By analyzing post-mortem gene expression data from the Allen Brain At

147 Leveraging a human brain atlas of post-mortem gene expression, we found that gliomas were

148 d the clinical utility and combined yield of post-mortem genetic testing (molecular autopsy) in cases

149 Evidence from post-mortem, genetic, neuroimaging, and non-human animal

150 Here, through post-mortem genome-wide transcriptome analysis of the la

151 with ER stress markers was observed in human post-mortem glaucomatous TM tissues.

152 ressed HTT protein in peripheral tissues and post-mortem HD brain tissue, as well as in tissues from

153 vation of increased type I IFN signalling in post-mortem hippocampal brain sections from patients wit

154 tlas constructed from ultra-high resolution, post-mortem hippocampal tissue was used to label seven h

155 id burden in small animals require laborious post-mortem histological analysis or resource-intensive,

156 The imaging analysis was corroborated by post-mortem histological analysis, which showed reversal

157 ich was in line with previous findings using post-mortem histology of the human substantia nigra and

158 ying an unsupervised clustering algorithm to post-mortem histopathological data from 895 patients wit

159 gions predicted by the model closely tracked post-mortem histopathological findings.

160 conserved across mammals and was detected in post mortem human amygdala, as well as human serum sampl

161 melanopsin-expressing ganglion cells in four post mortem human donor retinas.

162 d levels of active p38 MAPK were detected in post-mortem human ALS-FUS brain tissues.

163 us RNA sequencing from white matter areas of post-mortem human brain from patients with MS and from u

164 previous studies have been carried out using post-mortem human brain or non-human cells.

165 ore examined expression of synaptic genes in post-mortem human brain samples of these regions from ei

166 of CTE including AD and CTE with AD (CTE/AD) post-mortem human brain samples.

167 NT2 specifically labeled pathological tau in post-mortem human brain tissue from Pick disease, progre

168 l and temporal association of a dataset with post-mortem human brain.

169 riant affecting gene regulation in cells and post-mortem human brain.

170 then assessed for their association with the post-mortem human brain.

171 frontal, parietal, and cerebellar regions of post-mortem human brains (n = 74) from non-cognitively i

172 haracterized animal model of depression, and post-mortem human brains.

173 functional borders across species, including post-mortem human brains.

174 One post-mortem human brainstem was scanned at 11.7T to obta

175 sh single mouse cortical cells and to frozen post-mortem human cortical nuclei, matching the performa

176 aging-associated microgliosis in vivo and in post-mortem human samples.

177 arget Tau are increased by heroin use in the post-mortem human striatum, as well as in rats trained t

178 Anatomical investigations in animals and post-mortem humans have established that cerebro-cerebel

179 putamen, but not cerebral cortex samples, of post-mortem Huntington's disease patients when compared

180 Post-mortem imaging and histology revealed traumatic mic

181 ticography to identify epileptic animals and post-mortem immunohistochemistry to confirm blood-brain

182 ve cytoplasmic accumulations have been shown post-mortem in patients with Parkinson's disease and the

183 ocessing and reward function and are reduced post-mortem in schizophrenia.

184 A holistic approach involving complementary post-mortem, in situ, and operando analyses to elucidate

185 We then identified GbbLCV-1 in post-mortem infant lung tissues demonstrating histopatho

186 ed the poorest health (highest mortality and post-mortem inspection rejections, poorest walking abili

187 ere found to be diagnostic in predicting the post mortem interval (PMI).

188 ime since oviposition (i.e., egg laying) for post mortem interval determination, or for estimation of

189 ted Abeta proteoforms did not correlate with post-mortem interval, suggesting they are not artefacts.

190 ular and cellular activity after a prolonged post-mortem interval.

191 (RPE) from mouse and baboon over a series of post-mortem intervals.

192 Post-mortem interventions that restore brain perfusion s

193 The gold standard of post-mortem investigations should include both PMCT and

194 curacy of PMCTA as a first-line technique in post-mortem investigations.

195 We investigated the association between post-mortem iron levels with the clinical and pathologic

196 A new study examined post-mortem kidney tissue from 63 patients with COVID-19

197 es using a combination of histological data, post mortem magnetic resonance imaging (MRI), and in viv

198 y of diet, pre-slaughter stress i) increased post-mortem malondialdehyde (MDA) formation except in va

199 D1-type receptors has been conducted only on post-mortem material, with no differences in methampheta

200 e, quantifying neurogenesis in the caudal HF post-mortem may provide an objective, integrative measur

201 hallenging interface reaction mechanisms via post mortem measurements.

202 = 0.035), but no other associations between post-mortem measures of tauopathy and intrinsic connecti

203 A research autopsy is a post-mortem medical procedure performed on a deceased in

204 areas and 83 areas previously reported using post-mortem microscopy or other specialized study-specif

205 d IL-1beta production was investigated using post-mortem midbrain tissues of humans at young (25-38 y

206 Monte Carlo simulations estimated post-mortem migration of Anisakis from viscera to flesh

207 Post-mortem MRI was performed on non-fixed coronal hemis

208 ssue- and species-specific factors influence post-mortem mRNA stability are poorly understood.

209 e connections between the redox imbalance in post-mortem muscle, early protein oxidation and the onse

210 expressed in Hfe(-/-) x Tfr2(mut) brain and post-mortem NBIA basal ganglia.

211 also found a significant association between post-mortem neurodegeneration and in vivo volume loss in

212 functional differences have been observed in post-mortem, neuroimaging and electrophysiological studi

213 Comprehensive post-mortem neuropathological assessments were performed

214 We performed a 15-year post-mortem neuropathological follow-up of patients in t

215 ted the primary motor cortices isolated from post-mortem normal control subjects, patients with famil

216 e, we examined genome-wide RNA expression in post-mortem nucleus accumbens from donors (N=26) with kn

217 is difficult, as traditional methods rely on post-mortem or live-capture techniques.

218 erm: (schizophrenia OR schizoaffective) AND (post-mortem OR postmortem) AND hippocampus.

219 Clinical blood and plasma samples and post mortem oral swabs submitted to the Liberian Institu

220 cells in experimental mice and also in human post-mortem pancreatic samples.

221 We found that USP13 is overexpressed in post-mortem Parkinson's disease (PD) brains.

222 ss-sectional distribution of tau reported in post-mortem pathology studies, in that the most commonly

223 ship between in vivo18F-flortaucipir PET and post-mortem pathology.

224 ted in the substantia nigra pars compacta of post-mortem PD brains as compared with age-matched contr

225 Based on the analysis of post-mortem PD patients, Braak and colleagues suggested

226 o found that TG2 levels are increased in the post-mortem PFC of depressed suicide subjects relative t

227 o this, we conducted a systematic search for post-mortem, pharmacological, functional magnetic resona

228 pheral blood anti-AN1792 antibody titres and post-mortem plaque scores (rho = - 0.664, P = 0.005).

229 Furthermore, post-mortem plasma cell-free DNA sequencing (liquid auto

230 The post-mortem plasma cell-free DNA was successfully sequen

231 ntities of cell-free DNA were present in the post-mortem plasma of 12 autopsy cases.

232 Whole-exome sequencing of post-mortem plasma-derived cell-free DNA and eight froze

233 We confirmed this association with post-mortem quantification in 12 brains, demonstrating s

234 al volume loss using longitudinal MRI; (iii) post-mortem regional amyloid-beta protein and tau associ

235 nd single-subject level associations between post-mortem regional measures of neurodegeneration and t

236 mouse model of HIV-1 infection and in human post-mortem samples of HIV-1-infected brains.

237 analyses revealed that liver, lung and heart post-mortem samples were marked by tissue abnormalities,

238 ns routinely observed during the analysis of post-mortem samples, allows time-course monitoring of th

239 ries, patients with a positive antemortem or post-mortem SARS-CoV-2 result were considered eligible f

240 We review post-mortem, serum-biomarker, CSF-biomarker, and neuroim

241 to demonstrate S-acylation of SOD1 in human post-mortem spinal cord homogenates from ALS and non-ALS

242 hat individual transcripts show differential post-mortem stability, few studies have directly and com

243 from bulk electrochemical analyses, or other post-mortem strategies.

244 gamma oscillations, are reduced in number in post mortem studies of bipolar disorder and schizophreni

245 re significantly up-regulated in three prior post mortem studies of schizophrenia.

246 dict a growing convergence between hiPSC and post-mortem studies as both approaches expand to larger

247 Despite ample evidence from post-mortem studies demonstrating exposure to both mild-

248 Post-mortem studies have determined that chronic active

249 Post-mortem studies have not identified an association b

250 Post-mortem studies indicate that in ageing and Alzheime

251 Evidence from murine models and human post-mortem studies indicates that monoaminergic nuclei

252 is disorder and new in vivo neuroimaging and post-mortem studies makes it timely to review this theor

253 With respect to neurodegeneration after TBI, post-mortem studies on the long-term neuropathology afte

254 We performed post-mortem studies on two patients with advanced Parkin

255 Recent post-mortem studies reported 22-37% of patients with mul

256 Previous post-mortem studies reported conflicting findings regard

257 Recent genetic, molecular and post-mortem studies suggest impaired dopamine (DA)-D2 re

258 recent advances in psychiatric genomics and post-mortem studies that provide critical insights conce

259 ions, in accordance with previous animal and post-mortem studies, and consider the clinically asymmet

260 ed notion by bringing together findings from post-mortem studies, non-invasive imaging (including stu

261 A post mortem study confirmed that HDAC1 and HDAC2 paralog

262 s Evaluation of Advanced Cancer Environment) post-mortem study.

263 d blowhole-to-dorsal fin (BH-DF) length from post-mortem subjects (R(2) = 0.99, n = 12).

264 r disorders did not reliably correspond with post-mortem tau pathology.

265 Through a combination of in vivo and post-mortem techniques, we aimed to characterize vascula

266 Post-mortem temporal cortex samples from Alzheimer's dis

267 address the underlying etiology, we examined post mortem thoracic lymph nodes and spleens in acute SA

268 rvation method, with donor age </= 88 years, post-mortem time </= 63 h, overall preservation time </=

269 critical issue since it has been shown that post-mortem time delay and the method of fixation (i.e.,

270 by perfusion or immersion and with different post-mortem time delays (up to 5 hr) to mimic the way th

271 rs were mean aged 67.4 +/- 12.5 years with a post-mortem time of 20.7 +/- 14.7 h and ECD of 2641.0 +/

272 Main donor tissue parameters included age), post-mortem time, overall preservation time, preservatio

273 ed the loss of MALAT1 expression with longer post-mortem time, which potentially suggested a novel ro

274 major source of variation in mRNA quality is post-mortem time.

275 or neurons to serially passaged sporadic ALS post-mortem tissue (spALS) extracts.

276 Post-mortem tissue analyses showed autolysis and retenti

277 In human post-mortem tissue and mouse models humanized for apolip

278 First, in post-mortem tissue CYFIP2 expression was reduced by appr

279 lly, we examined mouse transgenic models and post-mortem tissue from human sporadic ALS cases.

280 the 18F-AV-1451 autoradiographic binding in post-mortem tissue from patients with Alzheimer's diseas

281 m induced pluripotent stem cells, as well as post-mortem tissue from patients with FTLD-PGRN, we show

282 receptor subunits have been observed in the post-mortem tissue of autistic individuals [8, 9], and G

283 cent findings from in vivo-imaging and human post-mortem tissue studies in schizophrenic psychosis (S

284 e explored the composition of Lewy bodies in post-mortem tissue using electron microscopy and immunog

285 The PET images matched ligand binding in post-mortem tissue, and histological markers of dopamine

286 defined using cytochrome-oxidase staining of post-mortem tissue.

287 WSB1 is in Lewy bodies in human PD post-mortem tissue.

288 lar respiration, undergo profound changes in post mortem tissues.

289 evidence-based discussion of the quality of post-mortem tissues compared with other types of biospec

290 detected in the prefrontal cortex region of post-mortem tissues from human patients with Alzheimer's

291 s in brain slices and structural analysis of post-mortem tissues obtained from animals exposed to end

292 rmalities reported in RPE cells studied from post-mortem tissues of affected m.3243A > G mutation car

293 We also discuss the advantages of using post-mortem tissues over other types of biospecimens, in

294 nome-wide patterns of DNA methylation in 223 post-mortem tissues samples isolated from three brain re

295 d glaucoma, primary human TM cells and human post-mortem TM tissues, we show that increased ECM accum

296 eurturin (CERE120) gene therapy, the longest post-mortem trophic factor gene therapy cases reported t

297 cfmtDNA seen in lumbar CSF translated to the post-mortem ventricular CSF.

298 in-5 in the brains of schizophrenic patients post mortem was observed compared to age-matched control

299 fibular junction of 15 week-old C57BL/6 mice post mortem, we show the bone cortical porosity simultan

300 emical differentiation of protein aggregates post-mortem would be advantageous for the insight into t