ライフサイエンスコーパス: post-mortem brain

1 ent contrasts in different tissue types of a post mortem brain.

2 f-principle NODDI estimates in a whole human post-mortem brain.

3 o define the tau PTM landscape present in AD post-mortem brain.

4 in protein changes similar to schizophrenia post-mortem brain.

5 confirmed by pathological analysis of their post mortem brains.

6 ronal vulnerability previously identified in post-mortem brains.

7 s have been detected in Huntington's disease post-mortem brains.

8 could be detected in patient cell lines and post-mortem brains.

9 iplexed immunofluorescence on HD and control post-mortem brains.

10 required to form the aggregates observed in post-mortem brains.

11 mation, demyelination and remyelination from post-mortem brains.

12 d 159 clinico-pathologically diagnosed human post-mortem brains (48 controls, 47 AD, 25 DLB, 20 mixed

13 hesis has gained indirect support from human post-mortem brain analyses and genetic studies, little i

14 Post-mortem brain analyses and some genetic studies have

15 Six patients had post-mortem brain analysis available for assessment of n

16 individual tau aggregates in AD and control post-mortem brain and biofluids.

17 been informed by both direct analysis of the post-mortem brain and by study of the biological consequ

18 pes predicted levels of NPY messenger RNA in post-mortem brain and lymphoblasts, and levels of plasma

19 the cohort (21 familial, 137 sporadic) were post-mortem brain and spinal cord donors.

20 Post-mortem brain and spinal cord tissue has been examin

21 athy in two distinct ALS mouse models and in post-mortem brain and spinal cord tissues of ALS patient

22 ve MS (PPMS) using a cross-tissue (blood and post-mortem brain) and multilayered data (genetic, epige

23 ogenic human induced pluripotent stem cells, post-mortem brain, and APOE targeted replacement mice.

24 single-cell transcriptomic analyses of human post-mortem brains are important for documentation of pa

25 Post-mortem brains, as previously reported, had the grea

26 context to transcriptomic analysis of human post-mortem brain at single-cell resolution.

27 and TRIM33 in the human prefrontal cortex of post-mortem brains between subjects with and those witho

28 AD using samples from four independent human post-mortem brain cohorts.

29 se models as well as increased binding in HD post-mortem brains, compared to first generation ligands

30 tem cell, genome-wide association study, and post-mortem brain data.

31 enes in deletion astrocytes, consistent with post-mortem brain data.

32 In a series of patients with post-mortem brain examination, imaging using [(123)I]iof

33 d no reliable method of diagnosis other than post-mortem brain examination.

34 Two patients underwent post-mortem brain examination.

35 Additionally, post-mortem brain extracts from patients with Alzheimer

36 ines and demonstrate its upregulation in the post-mortem brain from 15q11-13 duplication patients for

37 NMR) spectroscopy, we biochemically profiled post-mortem brain from mice that suffered mild TBI (N =

38 mately 50% in various cortical structures of post-mortem brain from patients diagnosed with schizophr

39 d protein are reduced in multiple regions of post-mortem brain from patients diagnosed with schizophr

40 ation of GFAP and AQP4 immunoreactivities in post-mortem brains from adult baboons with cerebral hypo

41 Studies of post-mortem brains from Alzheimer disease patients sugge

42 prefrontal cortex in an extensive series of post-mortem brains from fetal development through ageing

43 motor cortex, hippocampus and cerebellum of post-mortem brains from HD individuals, particularly in

44 ide microRNA (miRNA) expression profiling in post-mortem brains from individuals with ASD and control

45 eq and meRIP-seq in middle frontal cortex of post-mortem brains from individuals with or without AD,

46 tilize non-targeted mass spectrometry on 316 post-mortem brains from participants in the Religious Or

47 P2X(7)R protein levels increase in human AD post-mortem brain, in agreement with an upregulation of

48 Post-mortem brain material from a subset of the multiple

49 scovery and proteomics approach by comparing post-mortem brain material from schizophrenia patients a

50 eocortical neuronal subtypes lost with AD in post-mortem brain middle temporal gyri from non-diseased

51 Here we present evidence from post-mortem brain (N = 21 patients, compared with 17 pre

52 Validation of methylation findings in post-mortem brains (N = 596) from independent schizophre

53 r from an independent (Oxford, UK) cohort of post-mortem brains (n = 74), we confirmed the significan

54 We analysed post-mortem brains obtained from a cohort of 85 subjects

55 genetic expression changes in the blood and post-mortem brain of autistic individuals.

56 f Long COVID patients, have been detected in post-mortem brain of COVID patients, and exhibit neuroin

57 estigated large-scale gene expression in the post-mortem brain of MDD subjects paired with matched co

58 le of the immune system in a large sample of post-mortem brain of patients with schizophrenia: RNA se

59 d altered PSAP levels in the plasma, CSF and post-mortem brain of PD patients.

60 We examined post-mortem brains of affected individuals as well as li

61 VDAC1 is overexpressed in post-mortem brains of Alzheimer disease (AD) patients.

62 cortical, limbic and subcortical areas, from post-mortem brains of familial Alzheimer's disease (n =

63 Alcohol-dependent rats as well as post-mortem brains of human alcoholics and controls were

64 d-type PSEN1 allele expression is reduced in post-mortem brains of human EOfAD mutation carriers (and

65 ruitment and activation was also observed in post-mortem brains of humans that died after myocardial

66 r cingulate cortex and amygdala samples from post-mortem brains of individuals with BD and neurotypic

67 ast growth factor (FGF) system is altered in post-mortem brains of individuals with major depressive

68 Altered DISC1 expression in the post-mortem brains of individuals with psychiatric illne

69 The study of post-mortem brains of nonhuman primates (NHPs) has been

70 occludin, in 12 brain regions dissected from post-mortem brains of normal ageing (n = 10), pathologic

71 gomers in brain lysates prepared from frozen post-mortem brains of normal, Alzheimer's disease and DL

72 L), enhanced production of which is found in post-mortem brains of Parkinson disease patients.

73 erived sarkosyl-insoluble tau fractions from post-mortem brains of patients with progressive supranuc

74 clein mRNA and soluble protein in five human post-mortem brain regions from four groups of individual

75 ) to measure metabolites and metals in seven post-mortem brain regions of nine AD patients and nine c

76 ression Consortium involving 12 human frozen post-mortem brain regions.

77 pecific genes differentially expressed in HD post-mortem brains relative to controls using snRNAseq w

78 Analysis of three independent data sets of post-mortem brains revealed signs of increased methylati

79 ay approach for gene expression profiling in post mortem brain samples from patients with cirrhosis w

80 time-dependent changes in gene expression in post mortem brain samples is critical for the interpreta

81 sequencing data from male Grade 1 HD patient post-mortem brain samples and male zQ175 and R6/2 mouse

82 ampus, and dorsolateral prefrontal cortex of post-mortem brain samples from 358 individuals.

83 We analyzed MSUT2 protein in age-matched post-mortem brain samples from AD patients and observe a

84 ripotent stem cell-derived motor neurons and post-mortem brain samples from ALS patients.

85 compared DSCR1 (Adapt78) mRNA expression in post-mortem brain samples from Alzheimer's disease patie

86 In comparison, post-mortem brain samples from Down syndrome patients (w

87 ed these to a series of fibroblast lines and post-mortem brain samples from individuals with either a

88 tant HTT and its oligomeric intermediates in post-mortem brain samples from patients with Huntington'

89 APT H1/H2 haplotypes on tau transcription in post-mortem brain samples from patients with Lewy body d

90 from the anterior cingulate cortex in human post-mortem brain samples from patients with PD and heal

91 pression of chosen nuclear import factors in post-mortem brain samples from patients with TDP-43 posi

92 We used it to examine post-mortem brain samples from seven subjects who had ha

93 hrenia and bipolar disorder by analyzing 115 post-mortem brain samples from the frontal lobe.

94 Over the past 25 years, studies analyzing post-mortem brain samples have found evidence of aberran

95 omplexes of Abeta and COX-2 were detected in post-mortem brain samples in greater amounts in AD tissu

96 Through analysis of the post-mortem brain samples in individuals with MDD that d

97 nular osmiophilic material in skin biopsy or post-mortem brain samples of affected members in the Swe

98 By analyzing gene expression data in human post-mortem brain samples, from the prenatal period to l

99 e-wide DNA methylation was quantified in 262 post-mortem brain samples, representing tissue from four

100 anoids from dup15q patient-derived iPSCs and post-mortem brain samples, we identify increased glycoly

101 ing RNA sequencing and genetic data from 792 post-mortem brain samples.

102 to examine mRNA expression of parvalbumin on post-mortem brain sections.

103 We assayed human post-mortem brain, serum and cerebrospinal fluid of pati

104 Following infusion completion (Day 9), post-mortem brain slices were studied for antibody bindi

105 In HD post-mortem brain, specific antibody reagents detect eac

106 Examination of post-mortem brain specimens revealed significant levels

107 Neuroimaging, in vitro and post-mortem brain studies were consistent with an elevat

108 We applied our approach to RNA-seq data of post-mortem brains that compared the Alcohol Use Disorde

109 In post-mortem brains, the GAA*TTC repeat was remarkably st

110 measures of correlated gene expression in a post mortem brain tissue data set.

111 iNOS) to be prevalent in the plaque areas of post mortem brain tissue from patients with MS.

112 oups, though, as with any method for imaging post mortem brain tissue, care should be taken when inte

113 Post-mortem brain tissue (12 multiple sclerosis and eigh

114 A series of post-mortem brain tissue and in vitro experiments sugges

115 ble protein aggregates in vitro and in human post-mortem brain tissue but the cellular dynamics of th

116 Neuropathological analysis of post-mortem brain tissue demonstrated that pIRE1alpha is

117 of OXD-2115 were synthesized and screened in post-mortem brain tissue for tau affinity against [(3)H]

118 expression of TSPO was further described in post-mortem brain tissue from 20 cases with secondary pr

119 mmunohistochemical analysis was performed on post-mortem brain tissue from 26 cases with primary prog

120 rs PI2620, RO948, MK6240 and JNJ067 in human post-mortem brain tissue from a cohort of 25 dementia ca

121 at function in sound source localization, in post-mortem brain tissue from autistic individuals.

122 e shown patterns of molecular convergence in post-mortem brain tissue from autistic subjects.

123 f alpha-synuclein with PSEN1 was detected in post-mortem brain tissue from cognitively normal cases a

124 vidence from cerebrospinal fluid samples and post-mortem brain tissue from individuals with multiple

125 ped with an up-regulated gene set from human post-mortem brain tissue from individuals with schizophr

126 In a blinded study with post-mortem brain tissue from patients with Parkinson's

127 istant aggregates, which are also present in post-mortem brain tissue from patients.

128 r improved MX-Raman methodology, we utilized post-mortem brain tissue from several neurodegenerative

129 We examined post-mortem brain tissue from six patients with lacunar

130 Tof-MS) and chemometrics for the analysis of post-mortem brain tissue from subjects with Alzheimer's

131 d 407 individuals with an antemortem MRI and post-mortem brain tissue from the Mayo Clinic Alzheimer'

132 In post-mortem brain tissue from the same participants, we

133 and 14 H1/H2 heterozygous control individual post-mortem brain tissue from two brain regions.

134 We have compared KLK6 expression in post-mortem brain tissue in AD, vascular dementia (VaD)

135 ningeal IgA(+), IgM(+) and IgG(+) B cells in post-mortem brain tissue of 20 MS patients and 6 control

136 ies revealed increased levels of sortilin in post-mortem brain tissue of AD patients and that overexp

137 ongitudinal retrospective study, we analysed post-mortem brain tissue of all individuals with an Alzh

138 More TGF-beta1 messenger RNA was present in post-mortem brain tissue of Alzheimer's patients than in

139 fficient purification of inclusions from the post-mortem brain tissue of FXTAS patients.

140 recognized intracellular inclusions in human post-mortem brain tissue of Lewy body disease cases, but

141 We isolated microglia from post-mortem brain tissue of patients with MDD (n = 13-19

142 ans and ruminants relies on the detection in post-mortem brain tissue of the protease-resistant form

143 CT), positron emission tomography (PET), and post-mortem brain tissue RNA analysis or pathological an

144 Moreover, post-mortem brain tissue studies showed increases in who

145 roteomics and metabolomics were performed on post-mortem brain tissue to identify potential pathways

146 We also analysed matched CSF, post-mortem brain tissue, and iPSCs from the same partic

147 ously been employed to biochemically profile post-mortem brain tissue, and the novel methods describe

148 values with normative gene expressions from post-mortem brain tissue, we constructed a grade-related

149 In both tissue culture and post-mortem brain tissue, we show that the MAPT H1 haplo

150 In post-mortem brain tissue, we show that the total level o

151 in DS, focusing primarily on data from human post-mortem brain tissue.

152 confirming the initial findings observed in post-mortem brain tissue.

153 erivascular macrophages and T lymphocytes in post-mortem brain tissue.

154 the topography of parvalbumin expression in post-mortem brain tissue.

155 mble changes observed in human schizophrenia post mortem brain tissues.

156 we conducted whole transcriptome analysis of post-mortem brain tissues (cingulate cortex) from SCZ, B

157 nd fluorescent LMTK2 immunohistochemistry on post-mortem brain tissues and compared them to age-match

158 In post-mortem brain tissues from AIDS patients with opport

159 Post-mortem brain tissues from post-stroke dementia and

160 roblasts, induced pluripotent stem cells and post-mortem brain tissues from six controls and six pati

161 ng to pathologic alpha-syn aggregates in MSA post-mortem brain tissues was significantly higher than

162 y (PSP), and corticobasal degeneration (CBD) post-mortem brain tissues.

163 d as downregulated in synapses of BD and SCZ post-mortem brain tissues.

164 parate neuronal and glial DNA fractions from post-mortem brain tissues.

165 integrate SVs with RNA-sequencing from human post-mortem brains to quantify their dosage and regulato

166 lood methylomic data and post-disease onset (post-mortem) brain transcriptional data, we have identif

167 Using post-mortem brain transcriptomic data, we confirmed alte

168 distribution of neurofibrillary pathology in post-mortem brains was used to classify SPET scans taken

169 d in vitro model of the BBB and T2DM patient post-mortem brains, we show the translatable applicabili