ライフサイエンスコーパス: post-transcriptional

1 gulatory circuits, the majority of which are post-transcriptional.

2 U6 snRNA undergoes post-transcriptional 3' end modification prior to incorp

3 he coupling is coordinating transcription or post-transcriptional activities we used stochastic switc

4 is pathway, such as alternative splicing and post transcriptional and translational modifications.

5 and differentiation at the transcriptional, post-transcriptional and epigenetic levels.

6 Long non-coding RNAs (lncRNAs) are post-transcriptional and epigenetic regulators, whose im

7 uss extracellular hyaluronan biology and the post-transcriptional and post-translational modification

8 transcriptional feedback loops subjected to post-transcriptional and post-translational regulation.

9 S also regulates splicing of other splicing, post-transcriptional and transcription regulators includ

10 l and computational framework to deconvolute post-transcriptional and transcriptional changes using a

11 infection, geminiviruses are targets of the post-transcriptional and transcriptional gene silencing

12 ding PtrHCT, PtrCAD, and Ptr4CL, involved in post-transcriptional and/or post-translational regulatio

13 n factor that is subject to transcriptional, post-transcriptional, and post-translational control.

14 itself is regulated through transcriptional, post-transcriptional, and post-translational modificatio

15 posons and their control at transcriptional, post-transcriptional, and reverse transcriptional levels

16 ture of Ot, we find evidence for wide-spread post-transcriptional antisense regulation.

17 U6 RNA processing enzyme Usb1, reconstitute post-transcriptional assembly of yeast U6 snRNP in vitro

18 pparatus fragmentation, as well as extensive post-transcriptional buffering of stress-response genes.

19 he second major mechanism-RNA editing due to post-transcriptional changes of individual nucleotides-r

20 We discuss the dynamic features of post-transcriptional control during CD8(+) T cell homeos

21 these results suggest an integrated view of post-transcriptional control in human cells where most t

22 Here, we identified a post-transcriptional control mechanism, centered around

23 human antigen R (HuR) are key regulators in post-transcriptional control of gene expression in sever

24 e activatable guide RNAs enable temporal and post-transcriptional control of in vivo gene editing.

25 A-binding proteins like RBM24 mediate in the post-transcriptional control of key transcription factor

26 rter zebrafish strain, we document that this post-transcriptional control of Nrf2 activity is conserv

27 We conclude post-transcriptional control of Xist RNA splicing is an

28 ed set of target mRNAs, where FBF-1-mediated post-transcriptional control requires the activity of CC

29 he potential for widespread dysregulation of post-transcriptional control that likely limits the effe

30 a previously unrecognized layer of bacterial post-transcriptional control whereby mRNAs influence eac

31 tory networks connecting transcriptional and post-transcriptional control.

32 n detail, much less is known about circadian post-transcriptional control.

33 ge cells are under tight transcriptional and post-transcriptional control.

34 sis of in-house ccRCC cell lines suggested a post-transcriptional control.

35 has demonstrated the importance of rhythmic post-transcriptional controls, and it remains unclear ho

36 ronal development and underscore the risk of post-transcriptional dysregulation in co-occurring neuro

37 ium channel gene KCNA1 was mutated to bypass post-transcriptional editing and was packaged in a nonin

38 especially important role because, following post-transcriptional editing at the Q607 site, it render

39 Post-transcriptional effects were scaled across the phys

40 sponding transcriptome data, suggesting that post-transcriptional events such as changes in enzyme ac

41 RNAs can drive different transcriptional and post-transcriptional events that impact cellular functio

42 n remodeling, along with transcriptional and post-transcriptional events; in this way, they affect ge

43 y is ancient and the primary function is for post transcriptional gene repression and intermediate be

44 adenosine (m(6)A) enables multiple layers of post-transcriptional gene control, often via RNA-binding

45 Ps) that regulate the essential processes of post-transcriptional gene expression and splicing throug

46 RNA-binding proteins (RBPs) regulate post-transcriptional gene expression by recognizing shor

47 e unicellular microorganisms rely largely on post-transcriptional gene expression pathways.

48 Alternative pre-mRNA-splicing-induced post-transcriptional gene expression regulation is one o

49 up of exorribonucleases which participate in post-transcriptional gene expression regulation.

50 MicroRNAs (miRNAs) are key mediators of post-transcriptional gene expression silencing.

51 By transforming the landscape of post-transcriptional gene expression, [SMAUG(+)] regulat

52 roplast proteins predicted to be involved in post-transcriptional gene expression.

53 transcripts, has well-characterized roles in post-transcriptional gene regulation and transposon repr

54 further examine roles for cotranscriptional/post-transcriptional gene regulation during development.

55 Widespread APA affects post-transcriptional gene regulation in mRNA translation

56 iterature by demonstrating when and how this post-transcriptional gene regulation is mediated in the

57 d regions (UTRs) regulate crucial aspects of post-transcriptional gene regulation that are necessary

58 NA-binding proteins (RBPs) play key roles in post-transcriptional gene regulation, and genetic varian

59 he important components of RNA silencing and post-transcriptional gene regulation, and they interact

60 anges in LIN28 expression define patterns of post-transcriptional gene regulation.

61 ed signalling in an organism that depends on post-transcriptional gene regulation.

62 ized to play an important regulatory role in post-transcriptional gene regulation.

63 ng TP53 signaling, chromatin modulation, and post-transcriptional gene regulation.

64 molecules (~22 nucleotide long) involved in post-transcriptional gene regulation.

65 s of petunia (Petunia hybrida) are caused by post-transcriptional gene silencing (PTGS) of the key en

66 ) associate with ARGONAUTE1 (AGO1) to direct post-transcriptional gene silencing and regulate numerou

67 MicroRNAs regulate post-transcriptional gene silencing through base-pair bi

68 volutionary conserved microRNA that mediates post-transcriptional gene silencing to regulate a wide r

69 load miRNAs on target mRNAs without causing post-transcriptional gene silencing, due to its inabilit

70 ripts and inhibiting their translation (i.e. post-transcriptional gene silencing, PTGS).

71 son silencing, heterochromatin formation and post-transcriptional gene silencing.

72 ss response, broadening our knowledge of the post-transcriptional genetic basis underlying the diverg

73 These results demonstrate complex, post-transcriptional genetic effects on gene expression.

74 or-like effector nucleases, and CRISPR/Cas9; post-transcriptional huntingtin-lowering approaches such

75 Depletion of VPS13A or VPS13C caused a post-transcriptional increase in cellular GLUT4 protein

76 mice was associated with transcriptional and post-transcriptional (increased plasma membrane affiliat

77 with greater affinity and confers a dominant post-transcriptional inhibition compared to miR-125b.

78 Molecular mechanisms regulating aging at the post-transcriptional level are not clear.

79 Utrophin expression is repressed at the post-transcriptional level by a set of miRNAs, among whi

80 ression of Aire-sensitive genes, revealing a post-transcriptional level of control of Aire-activated

81 Gene expression is tightly regulated at the post-transcriptional level through splicing, transport,

82 last gene expression is predominantly at the post-transcriptional level via the coordinated action of

83 lasts, much of this regulation occurs at the post-transcriptional level, but the proteins responsible

84 At the post-transcriptional level, IGF2BP1 sustains the express

85 ng RNAs which control gene expression at the post-transcriptional level, play a key role in the patho

86 ponents of gene expression regulation at the post-transcriptional level.

87 ncRNAs) that regulate gene expression at the post-transcriptional level.

88 protein levels, by acting indirectly at the post-transcriptional level.

89 VEGF-C via targeting the 3'UTR of mRNAs at a post-transcriptional level.

90 thus promoting MYC mRNA stabilization at the post-transcriptional level.

91 ts allowing negative feedback control at the post-transcriptional level.

92 f c-Fos/AP-1 activity at transcriptional and post transcriptional levels in OA chondrocytes.

93 n of key pathways at the transcriptional and post-transcriptional levels that lead to ethylene synthe

94 e expression at both the transcriptional and post-transcriptional levels.

95 etween regulation at the transcriptional and post-transcriptional levels.

96 gene regulation at both transcriptional and post-transcriptional levels.

97 ent eukaryotic N(6)-methyladensosine (m(6)A) post-transcriptional mark can be "erased" by the m(6)A d

98 In the present study, we identified a post-transcriptional mechanism mediated by miR-34c-5p th

99 (m(6)A) mRNA modification is as an important post-transcriptional mechanism of gene regulation(2-4) a

100 These findings establish a post-transcriptional mechanism that controls CPSF6 expre

101 Our data indicate that ACK1 loss may be a post-transcriptional mechanism that increases EGFR signa

102 Our data reveal a post-transcriptional mechanism that maintains actin dyna

103 In this study, we report a post-transcriptional mechanism that regulates CPSF6 via

104 native polyadenylation (APA) is a widespread post-transcriptional mechanism that regulates gene expre

105 cantly down-regulated by IGF1 signaling by a post-transcriptional mechanism through the MAPK pathway.

106 reduces ZTL and GI protein levels through a post-transcriptional mechanism.

107 ferent phases of the day and may depend on a post-transcriptional mechanism.

108 f differentiation-specific keratins involves post-transcriptional mechanisms as we show KRT2 mRNA is

109 remains unclear how the transcriptional and post-transcriptional mechanisms collectively control rhy

110 The post-transcriptional mechanisms contributing to molecula

111 Here, we discuss how post-transcriptional mechanisms enable stem cell homeost

112 SigB-dependent promoter activity as well as post-transcriptional mechanisms ensure the appropriate r

113 Post-transcriptional mechanisms have the potential to in

114 Post-transcriptional mechanisms regulate the stability a

115 Post-transcriptional mechanisms regulating cell surface

116 to inhibit tumor growth in vivo However, the post-transcriptional mechanisms that cause miR-34a loss

117 Little is known about the post-transcriptional mechanisms that modulate the geneti

118 The interplay between transcriptional and post-transcriptional mechanisms that normally control th

119 on tightly co-ordinated transcriptional and post-transcriptional mechanisms.

120 elf-renewal through both transcriptional and post-transcriptional mechanisms.

121 main unanswered regarding the involvement of post-transcriptional mechanisms.

122 pendent on germline nuclear RNAi factors and post-transcriptional mechanisms.

123 o silencing through both transcriptional and post-transcriptional mechanisms.

124 tivated siRNAs, which likely silence TEs via post-transcriptional mechanisms.

125 Here we report a post-transcriptional modality to directly regulate Nrf2-

126 des 22 tRNAs, 2 rRNAs and 11 mRNAs and their post-transcriptional modification constitutes one of the

127 -methyladenosine (m6A) is the most prevalent post-transcriptional modification in eukaryotes, and pla

128 Evidence of post-transcriptional modification in small RNAs-includin

129 f epitranscriptomics continues to reveal how post-transcriptional modification of RNA affects a wide

130 including snord115 that negatively regulates post-transcriptional modification of the serotonin 2C re

131 s for catalysis, binding proteins and drugs, post-transcriptional modification, and deleterious mutat

132 by assessing cccDNA-associated histone tails post-transcriptional modifications (PTMs) by micro-chrom

133 rom RNA sequencing is further complicated by post-transcriptional modifications and bias due to ampli

134 Post-transcriptional modifications and nuclear transloca

135 ell documented in thymocyte development, co-/post-transcriptional modifications are also important bu

136 Human mRNAs possess two post-transcriptional modifications at their 5' end: an i

137 mt-tRNAs contain post-transcriptional modifications introduced by nuclear

138 ut knowledge about these transcriptional and post-transcriptional modifications is sparse.

139 Here, we perform a comprehensive analysis of post-transcriptional modifications of all human mt-tRNAs

140 C-MS/MS) is classically used to characterize post-transcriptional modifications of ribonucleic acids

141 m(5)C axis that promotes HR, suggesting that post-transcriptional modifications of RNA can also serve

142 e genomic origin, short length, and abundant post-transcriptional modifications of sRNA species.

143 un-on assay for capturing nascent RNA before post-transcriptional modifications, a circular-sequencin

144 s found to be two-pronged: (a) RvD5 inhibits post-transcriptional modifications, by miRs and 3'exonuc

145 encing methods cannot distinguish TEELs from post-transcriptional modifications, stochastic transcrip

146 and folding independently from proteins and post-transcriptional modifications.

147 ctivation of mineralocorticoid receptors and post-transcriptional modifications.

148 n and the evolutionary conservation of miRNA post-transcriptional modifications.

149 e models that overcome this limitation using post-transcriptional modifications.

150 red small ncRNAs; high-throughput mapping of post-transcriptional modifications; and RNA structure ma

151 ppears to be the progenitor, with subsequent post-transcriptional modulation highlighting the complex

152 ctures proposed to function as regulators of post-transcriptional mRNA localisation and translation.

153 Methyladenosine (m(6)A) is the most abundant post-transcriptional mRNA modification in eukaryotes and

154 ies, the global regulator Hfq contributes to post-transcriptional networks that control expression of

155 ation of carbon-5 of cytosines (m(5) C) is a post-transcriptional nucleotide modification of RNA foun

156 e data reveal a feedforward circuit in which post-transcriptional oligoadenylation controls RNA matur

157 Post-transcriptional or posttranslational mechanisms hav

158 Here, we report a new post-transcriptional pathway regulating autophagy involv

159 RNA editing is an essential post-transcriptional process that creates functional mit

160 insights into the various chromatin factors, post-transcriptional processes and features of genomic o

161 ations in the nucleus and cytoplasm indicate post-transcriptional processes enable cells to conserve

162 ering RNA binding proteins play key roles in post-transcriptional processes in all eukaryotes.

163 D community and illustrate the importance of post-transcriptional processes in DUX4-induced pathology

164 ing the importance of cell-type specific and post-transcriptional processes in shaping mitochondrial-

165 roteins that contribute to the regulation of post-transcriptional processes in the cell, including sp

166 of diverse AR-Vs in certain CRPC tumors, but post-transcriptional processes represent a broader regul

167 e as the binding sites for RBPs that control post-transcriptional processes such as splicing, cleavag

168 portant roles in pre-mRNA splicing and other post-transcriptional processes.

169 in structure, transcriptional activation and post-transcriptional processes.

170 Mature tRNAs are generated by multiple post-transcriptional processing steps, which can include

171 , helps quantify mature miRNAs, accounts for post-transcriptional processing, such as nucleotide edit

172 biquitous on eukaryotic mRNAs, essential for post-transcriptional processing, translation initiation

173 This was associated with a specific post-transcriptional reduction in the KU70 subunit of DN

174 NA-binding proteins (RBPs) play key roles in post-transcriptional regulation and disease.

175 y managing corresponding mRNA levels through post-transcriptional regulation based on nucleotide sequ

176 identification of novel mechanisms including post-transcriptional regulation by microRNA (miRNA) cont

177 been studied at the transcriptome level, how post-transcriptional regulation contributes to their che

178 iRNA) and alternative splicing (AS)-mediated post-transcriptional regulation has been extensively stu

179 presents an important tool in investigating post-transcriptional regulation in cancer on a high-thro

180 of nuclear organization, transcriptional and post-transcriptional regulation in defining covariations

181 To study post-transcriptional regulation in G0 leukemic cells, we

182 ortance, not much is known about the role of post-transcriptional regulation in mediating responses t

183 rotein interactions for analysis of abnormal post-transcriptional regulation in patient-derived archi

184 APA) was performed to understand the role of post-transcriptional regulation in various silicon-relat

185 Abnormal post-transcriptional regulation induced by alterations o

186 The post-transcriptional regulation involved in the response

187 However, when post-transcriptional regulation is acquired and how prot

188 olume of functional genomic data focusing on post-transcriptional regulation logics continues to grow

189 l miRNAs and targets, but also a view of the post-transcriptional regulation of adaptations.

190 hasize the importance of transcriptional and post-transcriptional regulation of antioxidant response

191 ved understanding of the transcriptional and post-transcriptional regulation of chondrogenesis will e

192 d activation of DUX requires GRSF1-dependent post-transcriptional regulation of Dux mRNA.

193 ch play important roles in translational and post-transcriptional regulation of gene expression and b

194 Whether post-transcriptional regulation of gene expression contr

195 ding RNAs that function in RNA silencing and post-transcriptional regulation of gene expression in mo

196 nthesis to decay. In mammalian mitochondria, post-transcriptional regulation of gene expression is co

197 The latter properties are subject to post-transcriptional regulation of gene expression, meri

198 zyme molecular machines that act as hubs for post-transcriptional regulation of gene expression.

199 -coding RNAs that play critical roles in the post-transcriptional regulation of gene expression.

200 g cascade, including the previously reported post-transcriptional regulation of HasAp by the heme met

201 have revolutionized our understanding of the post-transcriptional regulation of inflammatory genes by

202 revealed functional iron deficiency, altered post-transcriptional regulation of iron metabolism genes

203 BH5 exerts tumor-promoting effects in AML by post-transcriptional regulation of its critical targets

204 Post-transcriptional regulation of Nrf2-mRNA by the mRNA

205 Dynamic post-transcriptional regulation of protein-coding and no

206 Post-transcriptional regulation of RNA stability is a ke

207 Post-transcriptional regulation of RNAs is critical to t

208 Post-transcriptional regulation of single-cell transcrip

209 These findings indicate that post-transcriptional regulation of tankyrase serves as a

210 The multiple layers of post-transcriptional regulation of the ECF signaling cas

211 We hypothesize that the complex post-transcriptional regulation of the Has system provid

212 Although substantial post-transcriptional regulation of this hardwired progra

213 he functions of piRNAs in the epigenetic and post-transcriptional regulation of transposons and genes

214 both DGCs are essential for the Hfq-mediated post-transcriptional regulation on RsmB.

215 Post-transcriptional regulation plays important roles to

216 ell-types, and highlight the contribution of post-transcriptional regulation to shaping tissue-type-s

217 These studies uncover post-transcriptional regulation underlying chemoresistan

218 le meiosis, is crucial for piRNA biogenesis, post-transcriptional regulation, and spermiogenesis.

219 cluding those associated with transcriptome, post-transcriptional regulation, epigenetics, proteomics

220 mapping 5'UTR sequences crucial for chinmo's post-transcriptional regulation.

221 tructed to find out the probable pathways of post-transcriptional regulation.

222 ng the functional impact of context-specific post-transcriptional regulation.

223 128 binding, imposing an additional level of post-transcriptional regulation.

224 protein interaction plays important roles in post-transcriptional regulation.

225 pressing an unmodified SP6A, could be due to post-transcriptional regulation.

226 amo is achieved via both transcriptional and post-transcriptional regulation.

227 and the coordination of different layers of post-transcriptional regulation.

228 import, and downstream pathways such as mRNA post-transcriptional regulation.

229 resource for understanding the complexity of post-transcriptional regulation.

230 ein-RNA interaction plays important roles in post-transcriptional regulation.

231 functional genetic variants (GVs) mediating post-transcriptional regulation.

232 re highly translated, indicating alternative post-transcriptional regulation.

233 SD probands harbor both transcriptional- and post-transcriptional-regulation-disrupting de novo mutat

234 These data identify m(5)C as a post-transcriptional regulator of both splicing and func

235 ectively, our data uncover Nudt21 as a novel post-transcriptional regulator of cell fate and establis

236 nitor mitosis duration and uncover a crucial post-transcriptional regulator of interneuron fate relev

237 ith the target sequence of miR-125b, another post-transcriptional regulator of Parp-1.

238 3SS by repressing the expression of a global post-transcriptional regulator- (RsmA-) associated sRNA

239 MicroRNAs are important post-transcriptional regulators during development.

240 Overall, our in silico search for post-transcriptional regulators identified miR-495 as a

241 MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression and a

242 plasticity.SIGNIFICANCE STATEMENT miRNAs are post-transcriptional regulators of gene expression with

243 MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression.

244 MicroRNAs (miRNAs) are critical post-transcriptional regulators of gene expression.

245 family proteins have recently emerged as key post-transcriptional regulators of mitochondrial gene ex

246 (ZBP1/IMP1, IMP2, IMP3) are highly conserved post-transcriptional regulators of RNA stability, locali

247 MicroRNAs (miRNAs) are important non-coding post-transcriptional regulators that are involved in man

248 They act as master post-transcriptional regulators that control most cellul

249 l non-coding RNAs that primarily function as post-transcriptional regulators that target messenger RN

250 rative networks with FMRP and possibly other post-transcriptional regulators to regulate neurogenesis

251 Complex networks of transcriptional and post-transcriptional regulators, including microRNAs (mi

252 (via SmaI and SmaR) and transcriptional and post-transcriptional regulators, including RbsR and RsmA

253 are controlled by master transcriptional and post-transcriptional regulators, including the SmaI/SmaR

254 enting an opportunity to study mechanisms of post-transcriptional regulatory control.

255 We find that the HBV post-transcriptional regulatory element (PRE), specifica

256 ise regulation of gene expression, including post-transcriptional regulatory events such as alternati

257 Here, we describe a novel role for the post-transcriptional regulatory factor Mkt1 in establish

258 nserved, endogenous small RNAs with critical post-transcriptional regulatory functions throughout euk

259 OSTAR2 will help researchers investigate the post-transcriptional regulatory logics coordinated by RN

260 Micro(mi)RNA-based post-transcriptional regulatory mechanisms have been bro

261 Little is known about co-transcriptional or post-transcriptional regulatory mechanisms linking nonco

262 tion by integrating both transcriptional and post-transcriptional regulatory mechanisms.

263 environments via complex transcriptional and post-transcriptional regulatory mechanisms.

264 trol and regulatory functions within complex post-transcriptional regulatory networks.

265 We discuss the overlapping post-transcriptional regulatory pathways that mediate mu

266 gulation of these factors, and that multiple post-transcriptional regulatory pathways work dependentl

267 findings suggest RNA editing is an important post-transcriptional regulatory program in AD pathogenes

268 lternative polyadenylation (APA) plays a key post-transcriptional regulatory role in mRNA stability a

269 Since the initial discovery of microRNAs as post-transcriptional, regulatory key players in the 1990

270 Post-transcriptional regulons coordinate the expression

271 elp organize transcriptomes into clusters of post-transcriptional regulons.

272 e identified a subset of genes with apparent post-transcriptional repression in young adult mouse HSC

273 However, post-transcriptional repression mechanisms targeting the

274 hanism by which the cell cycle is coupled to post-transcriptional repression of key stem cell identit

275 mall molecules capable of relieving utrophin post-transcriptional repression.

276 d activity of PUMILIO proteins, which act as post-transcriptional repressors of target mRNAs to which

277 Post-transcriptional ribosomal RNA (rRNA) modifications

278 l maxicircle-encoded mRNAs undergo extensive post-transcriptional RNA editing via addition and deleti

279 The theme of post-transcriptional RNA fate, and how it relates to co-

280 of preinitiation complexes and can impact on post-transcriptional RNA fates.

281 The role of post-transcriptional RNA modification is of growing inte

282 2'-O-Methyl (Nm) is a highly abundant post-transcriptional RNA modification that plays importa

283 Over one hundred different types of post-transcriptional RNA modifications have been identif

284 Post-transcriptional RNA modifications, the epitranscrip

285 Our results lend support to the concept of post-transcriptional RNA operons, but we further present

286 This work reveals an incredible post-transcriptional robustness in T3SS assembly and aid

287 Several post-transcriptional rRNA modifications and some ribosom

288 sion yeast, and unveil an important role for post-transcriptional silencing in establishment of heter

289 insight into the mechanism of RNAi-mediated post-transcriptional silencing in fission yeast, and unv

290 aled that Mkt1 is required for RNAi-mediated post-transcriptional silencing, downstream of small RNA

291 t of these was identified to be deficient in post-transcriptional steps of chloroplast gene expressio

292 esistance phenotype through reduced targeted post-transcriptional suppression of transcripts encoding

293 g non-coding RNAs (lncRNAs) that can undergo post-transcriptional surveillance whereby only a subset

294 are small non-coding molecules that regulate post-transcriptional target gene expression and are invo

295 are small non-coding molecules that regulate post-transcriptional target gene expression.

296 Systematically identifying the post-transcriptional targets of miRNAs and the mechanism

297 dance increases during ER stress, first by a post-transcriptional, then by a transcriptional mechanis

298 2A2 ion co-transporter that are required for post-transcriptional upregulation of MYC and subsequent

299 m mirror-miRNA genes and can also experience post-transcriptional variation.

300 rved, organ-specific mechanisms may regulate post-transcriptional variations in miRNA sequence.