ライフサイエンスコーパス: post-translational

1 Post-translational access to such reactions and chemical

2 Low abundant glycans as well as additional post-translational and chemical modifications could also

3 (MAM), i.e., the quantification of multiple post-translational and chemical modifications in a singl

4 ilt from the same polypeptide blocks with no post-translational and other modifications, showed predi

5 Importantly, we found that both their post-translational and transcriptional regulators are in

6 heir autophagy-related interactors and their post-translational and transcriptional regulators.

7 Both NLRP1 and CARD8 undergo post-translational autoproteolysis to generate two non-c

8 gand-independent developmental mechanism for post-translational beta-catenin activation and is requir

9 owever, their often-small size and intricate post-translational biogenesis preclude the use of simple

10 Our findings highlight the power of "post-translational chemical modification" as a tool to s

11 arginine deiminase 4 (PAD4) facilitates the post-translational citrullination of the core histones H

12 Herein, we describe allomorphy, a post-translational control mechanism of enzyme activity.

13 ovide a roadmap for future research into the post-translational control of cholesterol synthesis, and

14 we discuss applications of Acr proteins for post-translational control of CRISPR-Cas systems in prok

15 have previously identified specific modes of post-translational control of DHCR7, but it is unknown w

16 ur findings unveil the previously unreported post-translational control of LGR receptors via NEDD4/NE

17 Post-translational control of PERIOD stability by Casein

18 phosphorylation is an important mechanism of post-translational control of protein kinases.

19 Post-translational control of these enzymes provides a r

20 Lysine acetylation is a key mechanism of post-translational control of various transcription fact

21 niversal immune receptor that allows for the post-translational covalent attachment of targeting liga

22 ategy which can lead to time and cost saving post-translational, covalent conjugation of recombinant

23 ontogeny and integrates transcriptional and post-translational determinants of progression through t

24 PKG activation provides post-translational enhancement of protein quality contro

25 composition, ubiquitous isomers, lability of post-translational glycan modifications, and complexity

26 The importance of post-translational glycosylation in protein structure an

27 The importance of germline-inherited post-translational histone modifications on priming earl

28 (2OG)-dependent oxygenase that catalyzes the post-translational hydroxylation of Asp and Asn residues

29 Prolyl 4-hydroxylases (P4Hs) catalyze post-translational hydroxylation of peptidyl proline res

30 le of modulating protein concentrations at a post-translational level by co-opting the ubiquitin-prot

31 n at the transcriptional, translational, and post-translational level using custom engineered circuit

32 ted, implying that most changes occur at the post-translational level.

33 S-Acylation, a reversible post-translational lipid modification of proteins, contr

34 S-Acylation, the reversible post-translational lipid modification of proteins, is an

35 S-Palmitoylation is a reversible post-translational lipid modification that dynamically r

36 Here, we report that post-translational lipidation of newly synthesized prote

37 ibited variable deficiencies in biosynthetic post-translational maturation, membrane sorting, pH home

38 plast of host cells via a previously unknown post-translational mechanism of endoplasmic reticulum (E

39 Previously, multiple transcriptional and post-translational mechanisms are reported to control Si

40 f enzyme activity is often delivered through post-translational mechanisms, such as allostery or allo

41 tion and does not involve transcriptional or post-translational mechanisms.

42 processes, static RNA buffering, and dynamic post-translational mechanisms.

43 Blockade of Ras activity by inhibiting its post-translational methylation catalyzed by isoprenylcys

44 Syn's aggregation propensity is sequence and post translational modification dependent.

45 The close proximity of this post translational modification to both the alphabeta su

46 Lysine acetylation (Kac), an abundant post-translational modification (PTM) in prokaryotes, re

47 o comprehensively analyze cell-type-specific post-translational modification (PTM) signaling networks

48 viding a deep-learning framework for protein post-translational modification (PTM) site prediction an

49 essiveness of the clinical disease, and some post-translational modification (PTM) sites appear to be

50 g of O-linked N-acetylglucosamine (O-GlcNAc) post-translational modification (PTM) sites in proteins

51 To elucidate the role of Tau isoforms and post-translational modification (PTM) stoichiometry in A

52 his "parameter geography" for bistability in post-translational modification (PTM) systems.

53 These Abs carry a unique but crucial post-translational modification (PTM), namely O-sulfated

54 Ubiquitylation is a form of Post-Translational Modification (PTM): addition of a ubi

55 n of the small subunit 6 (eS6), a ubiquitous post-translational modification across kingdoms, is infl

56 ycosylphosphatidylinositol (GPI) anchor is a post-translational modification added to approximately 1

57 In addition to histone post-translational modification and chromatin remodellin

58 The balance between FGF23 production, post-translational modification and cleavage is maintain

59 of FGF23 regulation in bone: transcription, post-translational modification and peptide cleavage.

60 ta subunit, establishing precedence for this post-translational modification as a regulatory mechanis

61 Here, we show that a ubiquitous post-translational modification called O-GlcNAc, which i

62 iption and translation, signal transduction, post-translational modification cascades, and metabolic

63 llular signalling networks including various post-translational modification cascades, phosphotransfe

64 This post-translational modification disrupts the normal func

65 Succinylation is a novel post-translational modification identified on many prote

66 recognized as a critically important protein post-translational modification in mammalian cells.

67 O-GlcNAcylation is an abundant post-translational modification in neurons.

68 ted that actinonin inhibited prokaryote-like post-translational modification in the apicoplast; mimic

69 , we show that O-GlcNAcylation, an essential post-translational modification in various types of cell

70 no-ubiquitinated in S phase and loss of this post-translational modification increases S phase progre

71 This post-translational modification initiates a transduction

72 O-GlcNAcylation, a post-translational modification involving O-linkage of b

73 This post-translational modification is prevalent for the phy

74 functions, but the enzyme(s) catalyzing this post-translational modification is unknown.

75 Protein ubiquitination is a very diverse post-translational modification leading to protein degra

76 In the DNA damage responses, this post-translational modification occurs predominantly on

77 provides improved localization of a possible post-translational modification of aquaporin Z (AqpZ), a

78 e behavior regulation occurs in part through post-translational modification of both the alpha- and b

79 ally regulated by promoter hypermethylation, post-translational modification of histone marks, and tr

80 y to regulate gene expression and direct the post-translational modification of histone proteins.

81 t epigenetic processes - DNA methylation and post-translational modification of histones - in tumour

82 High-throughput quantification of the post-translational modification of many individual prote

83 It is hypothesized that post-translational modification of NAT1 by acetylation a

84 cation, suggesting that FAM19As regulate the post-translational modification of neurexins.

85 Disulfide bond formation is a critical post-translational modification of newly synthesized pol

86 ork demonstrates how other processes-such as post-translational modification of one such regulator-af

87 How specificity is programmed into post-translational modification of proteins by glycosyla

88 it is not entirely clear how nutrient-driven post-translational modification of proteins impacts the

89 Glycosylation is a major post-translational modification of proteins that regulat

90 O-glycosidase treatment, thus revealing this post-translational modification of red and green cone op

91 Here, we show that post-translational modification of regulatory proteins p

92 We aimed to test the hypothesis that post-translational modification of SK channels under con

93 O-GlcNAcylation is a post-translational modification of tau understood to low

94 Although post-translational modification of the C-terminus of RAS

95 Glycosylation is a common post-translational modification of therapeutic monoclona

96 Despite nitroTyr being an abundant post-translational modification on calmodulin, the mecha

97 quitinated, but the possible effects of this post-translational modification on its function are unkn

98 The impact of this post-translational modification on viral entry is yet un

99 nscriptional changes correlates with histone post-translational modification patterns.

100 ndrogen exposure suppresses the inactivating post-translational modification phospho-Ser-127 in YAP1,

101 Protein phosphorylation is a key post-translational modification regulating protein funct

102 ible protein phosphorylation is an essential post-translational modification regulating protein funct

103 Mucin-type O-glycosylation is an essential post-translational modification required for protein sec

104 ue possibilities for the characterization of post-translational modification sites.

105 Poly(ADP-ribosyl)ation is a reversible post-translational modification synthetized by ADP-ribos

106 ependent enzymes, catalyze citrullination, a post-translational modification that alters protein func

107 1 undergoes lysine acetylation, an important post-translational modification that can regulate protei

108 tion by focal adhesion kinase (FAK), a HDAC5 post-translational modification that controls its subcel

109 eine oxidation represents a new type of TFEB post-translational modification that functions as a mole

110 Ubiquitination is a reversible post-translational modification that has emerged as a cr

111 lyases, or phospholyases, catalyze a unique post-translational modification that introduces dehydrob

112 Lysine crotonylation (Kcr) is a histone post-translational modification that is implicated in nu

113 toylation (S-palmitoylation) is a reversible post-translational modification that is installed by the

114 -acetylation of the Thr-2 residue on EsxA, a post-translational modification that is present in mycob

115 , proline hydroxylation of ChREBP is a novel post-translational modification that may allow for thera

116 Acetylation is a reversible post-translational modification that neutralizes lysine'

117 Glycosylation is a major protein post-translational modification whose dysregulation has

118 Protein glycosylation is a complex post-translational modification with crucial cellular fu

119 Post-translational modification with one of the isoforms

120 rginine methylation has been recognized as a post-translational modification with pleiotropic effects

121 ls of cells that encompass processes such as post-translational modification, and help bioengineers d

122 ehaviors, with changes to Vang localization, post-translational modification, and mechanistic functio

123 Protein tyrosine O-sulfation is an important post-translational modification, as it has been correlat

124 These results indicate that the nitroTyr post-translational modification, like tyrosine phosphory

125 A recently-discovered protein post-translational modification, lysine polyphosphorylat

126 ered and soluble forms, and a high degree of post-translational modification, notably asparagine-link

127 They can be created by defects in post-translational modification, suggesting that these m

128 yphosphorylation (K-PPn) is a relatively new post-translational modification, the full targets and fu

129 , polyubiquitination of Rheb is an important post-translational modification, which facilitates the b

130 Thousands of proteins are targets of this post-translational modification, which is catalyzed by a

131 atus, and HDAC6 is capable of reversing this post-translational modification.

132 legans orthologous proteins involved in this post-translational modification.

133 g regulatory significance to this widespread post-translational modification.

134 een shown to impart selectivity for specific post-translational modification.

135 e LA noncoding genome by profiling 7 histone post-translational modifications (active: H3K4me3, H3K4m

136 Specific histone post-translational modifications (hPTMs) have been shown

137 he physiological binding partners of histone post-translational modifications (hPTMs) is key to under

138 substrate function and circuits/networks of post-translational modifications (PTM) are ubiquitous in

139 Post-translational modifications (PTMs) afford both the

140 tigates the applicability of Raman to detect Post-Translational Modifications (PTMs) and degradation

141 on of primary sequence and identification of post-translational modifications (PTMs) are key elements

142 Post-translational modifications (PTMs) are key events i

143 Post-translational modifications (PTMs) are one of the m

144 Peptidyl post-translational modifications (PTMs) could influence

145 However, it is not known how these post-translational modifications (PTMs) disrupt the olig

146 ubulin tyrosination and Delta2 cleavage, two post-translational modifications (PTMs) essential for RG

147 Post-translational modifications (PTMs) greatly expand t

148 Many examples of histone post-translational modifications (PTMs) have been associ

149 Histone post-translational modifications (PTMs) have emerged as

150 Monitoring of post-translational modifications (PTMs) in therapeutic m

151 However, protein regulation by post-translational modifications (PTMs) is not binary, m

152 d that Hb-dependent oxidative stress induced post-translational modifications (PTMs) of Hb and red bl

153 These nitroalkylated proteins mimic key post-translational modifications (PTMs) of proteins and

154 andard off-line processes for characterizing post-translational modifications (PTMs) of therapeutic m

155 ern proteomics has uncovered a vast array of post-translational modifications (PTMs) on Hsp70 family

156 Post-translational modifications (PTMs) play very import

157 We propose a model where two sequential post-translational modifications (PTMs) regulate SPRTN c

158 Because the state of protein post-translational modifications (PTMs) such as phosphor

159 olding conformations and express the correct post-translational modifications (PTMs) to exhibit appro

160 e many peptide hormones, OCN is subjected to post-translational modifications (PTMs) which control it

161 HSF1 is known to be regulated by multiple post-translational modifications (PTMs), and we observe

162 including changes in MT network density and post-translational modifications (PTMs), elevated NOX2 e

163 tion is regulated in several ways, including post-translational modifications (PTMs), protein-protein

164 s of protein complexes such as the impact of post-translational modifications (PTMs), stoichiometry,

165 explore how metabolic transitions influence post-translational modifications (PTMs), which play cent

166 ddition, removal, and recognition of histone post-translational modifications (PTMs).

167 regulated both by co-chaperone proteins and post-translational modifications (PTMs).

168 l functions of many proteins are governed by post-translational modifications (PTMs).

169 gs, drug candidates, metabolites, or protein post-translational modifications (PTMs).

170 chiometry in each pMMO subunit and to detect post-translational modifications (PTMs).

171 racterization of global proteome and protein post-translational modifications (PTMs).

172 ics: tubulin isoform composition [9, 10] and post-translational modifications [11].

173 ue to quantify the quality attributes (e.g., post-translational modifications [PTMs]) of monoclonal a

174 PCVR) as indicated by the crystal structure, post-translational modifications and activity of the pro

175 vels of pre-mRNA splicing regulation such as post-translational modifications and changes in the expr

176 gles of CTE contain both 3R and 4R tau, with post-translational modifications and conformations consi

177 Besides post-translational modifications and diverse intermolecu

178 regulate epigenetic inheritance via histone post-translational modifications and DNA methylation.

179 Protein alterations include post-translational modifications and elimination of indi

180 hanisms, including RLR-interacting proteins, post-translational modifications and non-coding RNAs.

181 lypeptide features, suggesting no additional post-translational modifications apart from the CS glyco

182 These post-translational modifications are predominantly serin

183 ol for characterizing genetic variations and post-translational modifications at intact protein level

184 Post-translational modifications can result in subtle ch

185 Histone post-translational modifications contribute to chromatin

186 Several studies have shown that post-translational modifications control the activity or

187 Post-translational modifications create a diverse mixtur

188 ed by residual solvation, ionic adducts, and post-translational modifications creates a high degree o

189 We found that post-translational modifications do affect microtubule s

190 re, we take advantage of naturally occurring post-translational modifications for stabilization of pu

191 n map, a peptide coverage map, and a list of post-translational modifications identified, are generat

192 Glycosylation is one of the most important post-translational modifications in biological systems.

193 y antibodies to measure proteins and protein post-translational modifications in cells and tissues.

194 er, the specific tau isoform composition and post-translational modifications in CTE remain largely u

195 We also found S. Typhi-induced post-translational modifications in histone methylation

196 mechanisms of ACLP secretion or the role of post-translational modifications in these processes.

197 A variety of post-translational modifications including acetylation,

198 tivity regulates a growing number of diverse post-translational modifications including SUMOylation,

199 gh the secretory pathway, and for subsequent post-translational modifications including tyrosine sulf

200 endent upon changes in the status of tubulin post-translational modifications indicative of highly dy

201 ges in activity that match those elicited by post-translational modifications inside the cell, and pe

202 ow the stability of ROS1 may be regulated by post-translational modifications is unknown.

203 In humans, several post-translational modifications occur on CENP-A, but th

204 However, the effect of post-translational modifications of ACTN4 on podocyte in

205 t sirtuin activity is regulated by oxidative post-translational modifications of cysteines during inf

206 (from 1DLC-MS/MS) and 229 (from 2DLC-MS/MS) post-translational modifications of ECM proteins, includ

207 Post-translational modifications of proteins are widespr

208 Post-translational modifications of proteins at DNA dama

209 l pathogens, we globally assessed changes in post-translational modifications of proteins during infe

210 Post-translational modifications of proteins involved in

211 ored the structure-function relationship and post-translational modifications of sKlotho variants to

212 tory signals result in expression changes of post-translational modifications of splicing or polyaden

213 glycinergic dis-inhibition and suggest that post-translational modifications of the ICD, such as pho

214 Post-translational modifications of the RNA polymerase I

215 ions, protein-protein interaction sites, and post-translational modifications of the two PA2G4 isofor

216 tails and this recognition was sensitive to post-translational modifications of these sequences.

217 It remains elusive whether post-translational modifications of transcription factor

218 initiation, by increased gene expression and post-translational modifications of transcription factor

219 Post-translational modifications of tubulin also alter m

220 ndscape through remodeling and regulation of post-translational modifications on chromatin-are very f

221 exhibit preferences for specific patterns of post-translational modifications on core and variant his

222 r ability to recognize N-acetyl lysine (KAc) post-translational modifications on histone tails.

223 lex samples and the accurate localization of post-translational modifications on proteoforms.

224 of the ubiquitin code is further enhanced by post-translational modifications on ubiquitin itself, th

225 Cytoskeletal proteins and post-translational modifications play a role in mood dis

226 re not well understood, particularly whether post-translational modifications play a role in regulati

227 Post-translational modifications play essential roles in

228 of drug conjugation as well as the numerous post-translational modifications possible in the monoclo

229 The method was also extended to common post-translational modifications potentially interesting

230 y is often regulated by ligand binding or by post-translational modifications such as phosphorylation

231 cs on the chromatin fiber, primarily through post-translational modifications that occur on the histo

232 nan biology and the post-transcriptional and post-translational modifications that regulate its main

233 ity that actin acetylation, along with other post-translational modifications to actin, might constit

234 Regulating the activity of a coregulator via post-translational modifications would thus affect only

235 d by a cell's choice of tubulin isoforms and post-translational modifications, a "tubulin code," whic

236 chanisms, including DNA methylation, histone post-translational modifications, and chromatin structur

237 hat are sensitive to the cellular context or post-translational modifications, and may serve as regul

238 ulatory mechanisms including autoregulation, post-translational modifications, and protein compartmen

239 protein complexes with different cofactors, post-translational modifications, and protein membership

240 via intramolecular repressive interactions, post-translational modifications, and protein-protein in

241 identify ECM proteins and characterize their post-translational modifications, but ECM proteomics rem

242 ubiquitination is one of the most prevalent post-translational modifications, controlling virtually

243 ntral role in redox signalling via different post-translational modifications, denoted as 'oxidative

244 , trafficking, and function are regulated by post-translational modifications, including N-glycosylat

245 ny other cellular proteins, IQGAP1 undergoes post-translational modifications, including phosphorylat

246 henotypes remain poorly understood, although post-translational modifications, including phosphorylat

247 e primary breast cancers accrued to preserve post-translational modifications, including protein phos

248 REBP is activated by glucose metabolites and post-translational modifications, inducing nuclear accum

249 unctions of deubiquitinases are regulated by post-translational modifications, mainly phosphorylation

250 es that regulate DNA methylation and histone post-translational modifications, mutations in histone g

251 or obtaining insight into subunit diversity, post-translational modifications, stoichiometry, structu

252 stone variants can be enriched with specific post-translational modifications, which in turn can prov

253 f DNA replication and repair proteins and by post-translational modifications.

254 ' chains ratio; the N-glycosylation; and the post-translational modifications.

255 cture and locations of N-linked carbohydrate post-translational modifications.

256 oteins by catalyzing the addition of unusual post-translational modifications.

257 and exhibits intricate splicing patterns and post-translational modifications.

258 e moiety for O-linked beta-GlcNAc (O-GlcNAc) post-translational modifications.

259 e to the pathology of SCL deficiency through post-translational modifications.

260 wn about how PARN's function is regulated by post-translational modifications.

261 he p53 gene and maintain naturally occurring post-translational modifications.

262 nd phosphorylation are two important protein post-translational modifications.

263 regulated by ATP binding, co-chaperones, and post-translational modifications.

264 genomic, transcriptional, translational, and post-translational molecular features.

265 Thus, our study reveals an intricate post-translational network that negatively regulates the

266 Post-translational oxidative modifications of hemoglobin

267 Barttin undergoes post-translational palmitoylation that is essential for

268 12/13) family (Galpha(12)) in the absence of post-translational phosphorylation.

269 Our work highlights the complexity of post-translational precursor maturation allowing for str

270 ng virulence factor, and PrgA is involved in post-translational processing of PrgB.

271 PI omega-site (aa 4-7) resulted in extensive post-translational processing of the GPI anchor to a for

272 a 3C-like cysteine protease (3CL(pro)) in a post-translational processing step that is critical for

273 ons present in individuals with CADASIL to a post-translational protein alteration in degenerating br

274 criptional repression as a backup system for post-translational protein degradation which ensures rob

275 O-ARABINOSYLTRANSFERASEs (HPATs) initiate a post-translational protein modification (Hyp-Ara) found

276 Neddylation is the post-translational protein modification most closely rel

277 sms involving tRNA sequence optimisation and post-translational protein modification that determine t

278 on of histidine to hydroxyaspartate is a new post-translational protein modification, and it is found

279 n, platelet activation and degranulation, or post-translational protein phosphorylation.

280 Therefore post-translational proteolytic processing of polyprotein

281 uman urinary ELVs and that all three undergo post-translational proteolytic processing.

282 e, using Xenopus as a model, we analyzed the post-translational regulation and functional consequence

283 How this post-translational regulation coordinates VRN2 activity

284 the ~20 enzymes in cholesterol biosynthesis, post-translational regulation has only been examined for

285 osite is evolutionarily conserved suggesting post-translational regulation of auxin biosynthesis may

286 Here, we elucidate the mechanism of post-translational regulation of cellular HO2 levels by

287 hat cellular labile heme is critical for the post-translational regulation of HAP complex activity, m

288 n ccRCC (R = 0.02), reflecting the primarily post-translational regulation of HIF1alpha.

289 ration and cancer, little is known about the post-translational regulation of LGR5.

290 However, the post-translational regulation of SNAI2 is less well stud

291 pe-tagged DHCR14 or LBR, we investigated the post-translational regulation of these enzymes.

292 lizable methods for assessing the effects of post-translational regulation on enzymatic activity.

293 complex, essential networks of small RNA and post-translational regulation to these developmental sta

294 Due to tight post-translational regulation, determination of the expr

295 und that DHCR14 and LBR undergo differential post-translational regulation, with DHCR14 being rapidly

296 4CL, involved in post-transcriptional and/or post-translational regulation.

297 iosynthesis, yet little is known about their post-translational regulation.

298 itin-proteasome system (UPS) is an important post-translational regulatory mechanism that controls ma

299 emarkably, two mutations that mildly perturb post-translational translocation and reduce the extent o

300 ugh no growth defects were observed, co- and post-translational translocation of alpha-helical protei