ライフサイエンスコーパス: post-translational modification

1 atus, and HDAC6 is capable of reversing this post-translational modification.

2 legans orthologous proteins involved in this post-translational modification.

3 g regulatory significance to this widespread post-translational modification.

4 een shown to impart selectivity for specific post-translational modification.

5 ' chains ratio; the N-glycosylation; and the post-translational modifications.

6 cture and locations of N-linked carbohydrate post-translational modifications.

7 oteins by catalyzing the addition of unusual post-translational modifications.

8 and exhibits intricate splicing patterns and post-translational modifications.

9 e moiety for O-linked beta-GlcNAc (O-GlcNAc) post-translational modifications.

10 e to the pathology of SCL deficiency through post-translational modifications.

11 wn about how PARN's function is regulated by post-translational modifications.

12 been suggested that proANP also may undergo post-translational modifications.

13 tion of specific protein levels and specific post-translational modifications.

14 ajor pilin subunit of the T4P bears multiple post-translational modifications.

15 sing events such as alternative splicing and post-translational modifications.

16 yptic digest-like features and peptides with post-translational modifications.

17 ted by hormone or nutrient signaling-induced post-translational modifications.

18 le protein isoform expression and associated post-translational modifications.

19 he p53 gene and maintain naturally occurring post-translational modifications.

20 nd phosphorylation are two important protein post-translational modifications.

21 regulated by ATP binding, co-chaperones, and post-translational modifications.

22 f DNA replication and repair proteins and by post-translational modifications.

23 ics: tubulin isoform composition [9, 10] and post-translational modifications [11].

24 d by a cell's choice of tubulin isoforms and post-translational modifications, a "tubulin code," whic

25 n of the small subunit 6 (eS6), a ubiquitous post-translational modification across kingdoms, is infl

26 e LA noncoding genome by profiling 7 histone post-translational modifications (active: H3K4me3, H3K4m

27 ycosylphosphatidylinositol (GPI) anchor is a post-translational modification added to approximately 1

28 NO results in S-nitrosylation, a ubiquitous post-translational modification and a primary mediator o

29 In addition to histone post-translational modification and chromatin remodellin

30 The balance between FGF23 production, post-translational modification and cleavage is maintain

31 of FGF23 regulation in bone: transcription, post-translational modification and peptide cleavage.

32 PCVR) as indicated by the crystal structure, post-translational modifications and activity of the pro

33 vels of pre-mRNA splicing regulation such as post-translational modifications and changes in the expr

34 gles of CTE contain both 3R and 4R tau, with post-translational modifications and conformations consi

35 adds insight into the regulation of PANX1 by post-translational modifications and connects a signific

36 Besides post-translational modifications and diverse intermolecu

37 regulate epigenetic inheritance via histone post-translational modifications and DNA methylation.

38 Protein alterations include post-translational modifications and elimination of indi

39 prising residues 1-16 of Abeta(1-40), due to post-translational modifications and mutations in the be

40 hanisms, including RLR-interacting proteins, post-translational modifications and non-coding RNAs.

41 transcription factor binding sites, histone post-translational modifications and regions of chromati

42 ls of cells that encompass processes such as post-translational modification, and help bioengineers d

43 ehaviors, with changes to Vang localization, post-translational modification, and mechanistic functio

44 lecular phase separation: membrane surfaces, post-translational modifications, and active processes.

45 chanisms, including DNA methylation, histone post-translational modifications, and chromatin structur

46 hat are sensitive to the cellular context or post-translational modifications, and may serve as regul

47 ormation on the primary amino acid sequence, post-translational modifications, and other structure ch

48 ulatory mechanisms including autoregulation, post-translational modifications, and protein compartmen

49 protein complexes with different cofactors, post-translational modifications, and protein membership

50 via intramolecular repressive interactions, post-translational modifications, and protein-protein in

51 lypeptide features, suggesting no additional post-translational modifications apart from the CS glyco

52 Histone post-translational modifications are key gene expression

53 These post-translational modifications are predominantly serin

54 ta subunit, establishing precedence for this post-translational modification as a regulatory mechanis

55 Protein tyrosine O-sulfation is an important post-translational modification, as it has been correlat

56 ol for characterizing genetic variations and post-translational modifications at intact protein level

57 identify ECM proteins and characterize their post-translational modifications, but ECM proteomics rem

58 One such pathway is post-translational modification by the addition of poly(

59 Here, we show that a ubiquitous post-translational modification called O-GlcNAc, which i

60 ormation and/or presence of cysteine-related post-translational modifications can cause a loss of bio

61 Post-translational modifications can result in subtle ch

62 iption and translation, signal transduction, post-translational modification cascades, and metabolic

63 llular signalling networks including various post-translational modification cascades, phosphotransfe

64 Deimination, a post-translational modification catalyzed by a family of

65 Histone post-translational modifications contribute to chromatin

66 Several studies have shown that post-translational modifications control the activity or

67 ubiquitination is one of the most prevalent post-translational modifications, controlling virtually

68 Post-translational modifications create a diverse mixtur

69 ed by residual solvation, ionic adducts, and post-translational modifications creates a high degree o

70 ntral role in redox signalling via different post-translational modifications, denoted as 'oxidative

71 Syn's aggregation propensity is sequence and post translational modification dependent.

72 This post-translational modification disrupts the normal func

73 We found that post-translational modifications do affect microtubule s

74 re, we take advantage of naturally occurring post-translational modifications for stabilization of pu

75 O-GlcNAc is an abundant post-translational modification found on nuclear and cyt

76 eral different factors, such as mutations or post translational modifications, have been shown to inf

77 Specific histone post-translational modifications (hPTMs) have been shown

78 he physiological binding partners of histone post-translational modifications (hPTMs) is key to under

79 Succinylation is a novel post-translational modification identified on many prote

80 n map, a peptide coverage map, and a list of post-translational modifications identified, are generat

81 recognized as a critically important protein post-translational modification in mammalian cells.

82 O-GlcNAcylation is an abundant post-translational modification in neurons.

83 ted that actinonin inhibited prokaryote-like post-translational modification in the apicoplast; mimic

84 , we show that O-GlcNAcylation, an essential post-translational modification in various types of cell

85 Glycosylation is one of the most important post-translational modifications in biological systems.

86 y antibodies to measure proteins and protein post-translational modifications in cells and tissues.

87 er, the specific tau isoform composition and post-translational modifications in CTE remain largely u

88 We also found S. Typhi-induced post-translational modifications in histone methylation

89 MCR contains a number of unique post-translational modifications in its alpha subunit, i

90 mechanisms of ACLP secretion or the role of post-translational modifications in these processes.

91 A variety of post-translational modifications including acetylation,

92 tivity regulates a growing number of diverse post-translational modifications including SUMOylation,

93 gh the secretory pathway, and for subsequent post-translational modifications including tyrosine sulf

94 , trafficking, and function are regulated by post-translational modifications, including N-glycosylat

95 ny other cellular proteins, IQGAP1 undergoes post-translational modifications, including phosphorylat

96 henotypes remain poorly understood, although post-translational modifications, including phosphorylat

97 e primary breast cancers accrued to preserve post-translational modifications, including protein phos

98 MUPs exhibit added complexity in the form of post-translational modifications, including the phosphor

99 no-ubiquitinated in S phase and loss of this post-translational modification increases S phase progre

100 endent upon changes in the status of tubulin post-translational modifications indicative of highly dy

101 REBP is activated by glucose metabolites and post-translational modifications, inducing nuclear accum

102 This post-translational modification initiates a transduction

103 ges in activity that match those elicited by post-translational modifications inside the cell, and pe

104 O-GlcNAcylation, a post-translational modification involving O-linkage of b

105 This post-translational modification is critical for synaptic

106 This post-translational modification is prevalent for the phy

107 functions, but the enzyme(s) catalyzing this post-translational modification is unknown.

108 Stoichiometric analysis of post-translational modifications is an emerging strategy

109 ow the stability of ROS1 may be regulated by post-translational modifications is unknown.

110 Protein ubiquitination is a very diverse post-translational modification leading to protein degra

111 These results indicate that the nitroTyr post-translational modification, like tyrosine phosphory

112 A recently-discovered protein post-translational modification, lysine polyphosphorylat

113 unctions of deubiquitinases are regulated by post-translational modifications, mainly phosphorylation

114 We conclude that different pilin post-translational modifications moderately affect the a

115 This post-translational modification mostly occurs extracellu

116 es that regulate DNA methylation and histone post-translational modifications, mutations in histone g

117 ered and soluble forms, and a high degree of post-translational modification, notably asparagine-link

118 minolysis, suggests a potential role for the post-translational modification O-GlcNAc as a critical n

119 In humans, several post-translational modifications occur on CENP-A, but th

120 Glycosylation is a fundamental post-translational modification, occurring on half of al

121 In the DNA damage responses, this post-translational modification occurs predominantly on

122 provides improved localization of a possible post-translational modification of aquaporin Z (AqpZ), a

123 e behavior regulation occurs in part through post-translational modification of both the alpha- and b

124 ally regulated by promoter hypermethylation, post-translational modification of histone marks, and tr

125 y to regulate gene expression and direct the post-translational modification of histone proteins.

126 t epigenetic processes - DNA methylation and post-translational modification of histones - in tumour

127 Post-translational modification of intracellular protein

128 of EphB4 expression is linked to a competing post-translational modification of its carboxy-terminal

129 High-throughput quantification of the post-translational modification of many individual prote

130 S-acylation is a common post-translational modification of membrane protein cyst

131 It is hypothesized that post-translational modification of NAT1 by acetylation a

132 cation, suggesting that FAM19As regulate the post-translational modification of neurexins.

133 Disulfide bond formation is a critical post-translational modification of newly synthesized pol

134 ork demonstrates how other processes-such as post-translational modification of one such regulator-af

135 /reactive nitrogen species scavenging, or 3) post-translational modification of proteins by addition

136 How specificity is programmed into post-translational modification of proteins by glycosyla

137 Increased O-GlcNAcylation, a well-known post-translational modification of proteins causally lin

138 it is not entirely clear how nutrient-driven post-translational modification of proteins impacts the

139 Glycosylation is a major post-translational modification of proteins that regulat

140 Glycosylation is an important post-translational modification of proteins.

141 O-glycosidase treatment, thus revealing this post-translational modification of red and green cone op

142 Here, we show that post-translational modification of regulatory proteins p

143 We aimed to test the hypothesis that post-translational modification of SK channels under con

144 O-GlcNAcylation is a post-translational modification of tau understood to low

145 Although post-translational modification of the C-terminus of RAS

146 Glycosylation is a common post-translational modification of therapeutic monoclona

147 However, the effect of post-translational modifications of ACTN4 on podocyte in

148 ights into growth, stability and the role of post-translational modifications of axonemal microtubule

149 t sirtuin activity is regulated by oxidative post-translational modifications of cysteines during inf

150 (from 1DLC-MS/MS) and 229 (from 2DLC-MS/MS) post-translational modifications of ECM proteins, includ

151 Post-translational modifications of proteins are widespr

152 Post-translational modifications of proteins at DNA dama

153 l pathogens, we globally assessed changes in post-translational modifications of proteins during infe

154 Post-translational modifications of proteins involved in

155 ve against the other enzymes involved in the post-translational modifications of Ras.

156 Post-translational modifications of RBPs also strongly c

157 ored the structure-function relationship and post-translational modifications of sKlotho variants to

158 tory signals result in expression changes of post-translational modifications of splicing or polyaden

159 glycinergic dis-inhibition and suggest that post-translational modifications of the ICD, such as pho

160 Post-translational modifications of the RNA polymerase I

161 ions, protein-protein interaction sites, and post-translational modifications of the two PA2G4 isofor

162 tails and this recognition was sensitive to post-translational modifications of these sequences.

163 It remains elusive whether post-translational modifications of transcription factor

164 initiation, by increased gene expression and post-translational modifications of transcription factor

165 Post-translational modifications of tubulin also alter m

166 Microtubules are regulated by post-translational modifications of tubulin.

167 Despite nitroTyr being an abundant post-translational modification on calmodulin, the mecha

168 quitinated, but the possible effects of this post-translational modification on its function are unkn

169 The impact of this post-translational modification on viral entry is yet un

170 ndscape through remodeling and regulation of post-translational modifications on chromatin-are very f

171 exhibit preferences for specific patterns of post-translational modifications on core and variant his

172 r ability to recognize N-acetyl lysine (KAc) post-translational modifications on histone tails.

173 lex samples and the accurate localization of post-translational modifications on proteoforms.

174 of the ubiquitin code is further enhanced by post-translational modifications on ubiquitin itself, th

175 can reflect protein conformational changes, post-translational modifications, or protein interaction

176 nscriptional changes correlates with histone post-translational modification patterns.

177 ndrogen exposure suppresses the inactivating post-translational modification phospho-Ser-127 in YAP1,

178 Post-translational modifications play a fundamental role

179 Cytoskeletal proteins and post-translational modifications play a role in mood dis

180 re not well understood, particularly whether post-translational modifications play a role in regulati

181 Post-translational modifications play essential roles in

182 of drug conjugation as well as the numerous post-translational modifications possible in the monoclo

183 The method was also extended to common post-translational modifications potentially interesting

184 ranscriptional and translational regulation, post-translational modifications, protein degradation, b

185 To date, trimethyllysine (Kme3) is the only post translational modification (PTM) of the eight possi

186 peptide-centric quantification dealing with post-translational modification (PTM) analysis like reve

187 tion of binding sites, few examined how CTCF post-translational modification (PTM) could contribute t

188 Lysine acetylation (Kac), an abundant post-translational modification (PTM) in prokaryotes, re

189 o comprehensively analyze cell-type-specific post-translational modification (PTM) signaling networks

190 viding a deep-learning framework for protein post-translational modification (PTM) site prediction an

191 Computational methods for protein post-translational modification (PTM) site prediction pr

192 essiveness of the clinical disease, and some post-translational modification (PTM) sites appear to be

193 g of O-linked N-acetylglucosamine (O-GlcNAc) post-translational modification (PTM) sites in proteins

194 To elucidate the role of Tau isoforms and post-translational modification (PTM) stoichiometry in A

195 Post-translational modification (PTM) such as phosphoryl

196 his "parameter geography" for bistability in post-translational modification (PTM) systems.

197 Acetylation is a reversible post-translational modification (PTM) which regulates th

198 ine residues in proteins, an enzyme-mediated post-translational modification (PTM), is important for

199 As a newly discovered post-translational modification (PTM), lysine malonylati

200 These Abs carry a unique but crucial post-translational modification (PTM), namely O-sulfated

201 ent with changes to protein conformation and post-translational modification (PTM).

202 Protein phosphorylation is a critical post-translational modification (PTM).

203 Ubiquitylation is a form of Post-Translational Modification (PTM): addition of a ubi

204 substrate function and circuits/networks of post-translational modifications (PTM) are ubiquitous in

205 Glycation is a one of the post-translational modifications (PTM) where sugar molec

206 Post-translational modifications (PTMs) afford both the

207 do not quantify the impact of cell-specific post-translational modifications (PTMs) and cooperative

208 tigates the applicability of Raman to detect Post-Translational Modifications (PTMs) and degradation

209 Characterization and monitoring of post-translational modifications (PTMs) are key analytic

210 on of primary sequence and identification of post-translational modifications (PTMs) are key elements

211 Post-translational modifications (PTMs) are key events i

212 Post-translational modifications (PTMs) are one of the m

213 Histone post-translational modifications (PTMs) contribute to ch

214 Peptidyl post-translational modifications (PTMs) could influence

215 However, it is not known how these post-translational modifications (PTMs) disrupt the olig

216 ubulin tyrosination and Delta2 cleavage, two post-translational modifications (PTMs) essential for RG

217 dure enables accurate measurement of histone post-translational modifications (PTMs) genome-wide in m

218 Post-translational modifications (PTMs) greatly expand t

219 Many examples of histone post-translational modifications (PTMs) have been associ

220 Histone post-translational modifications (PTMs) have emerged as

221 Monitoring of post-translational modifications (PTMs) in therapeutic m

222 However, protein regulation by post-translational modifications (PTMs) is not binary, m

223 With the developed procedure, the main post-translational modifications (PTMs) of etanercept we

224 d that Hb-dependent oxidative stress induced post-translational modifications (PTMs) of Hb and red bl

225 These nitroalkylated proteins mimic key post-translational modifications (PTMs) of proteins and

226 andard off-line processes for characterizing post-translational modifications (PTMs) of therapeutic m

227 ern proteomics has uncovered a vast array of post-translational modifications (PTMs) on Hsp70 family

228 Lysine post-translational modifications (PTMs) play a crucial r

229 Post-translational modifications (PTMs) play very import

230 We propose a model where two sequential post-translational modifications (PTMs) regulate SPRTN c

231 neered to contain non-coded elements such as post-translational modifications (PTMs) represent a powe

232 Because the state of protein post-translational modifications (PTMs) such as phosphor

233 atasets as well as the increasing numbers of post-translational modifications (PTMs) that are being i

234 Pathological tau can undergo a range of post-translational modifications (PTMs) that are implica

235 Biological systems use post-translational modifications (PTMs) to control the s

236 olding conformations and express the correct post-translational modifications (PTMs) to exhibit appro

237 e many peptide hormones, OCN is subjected to post-translational modifications (PTMs) which control it

238 HSF1 is known to be regulated by multiple post-translational modifications (PTMs), and we observe

239 including changes in MT network density and post-translational modifications (PTMs), elevated NOX2 e

240 o identifying thousands of potential protein post-translational modifications (PTMs), it has historic

241 tion is regulated in several ways, including post-translational modifications (PTMs), protein-protein

242 s of protein complexes such as the impact of post-translational modifications (PTMs), stoichiometry,

243 ally, we discuss the hypothesis that protein post-translational modifications (PTMs), which can alter

244 explore how metabolic transitions influence post-translational modifications (PTMs), which play cent

245 ddition, removal, and recognition of histone post-translational modifications (PTMs).

246 regulated both by co-chaperone proteins and post-translational modifications (PTMs).

247 l functions of many proteins are governed by post-translational modifications (PTMs).

248 gs, drug candidates, metabolites, or protein post-translational modifications (PTMs).

249 chiometry in each pMMO subunit and to detect post-translational modifications (PTMs).

250 ic mechanisms, tissue-specific isoforms, and post-translational modifications (PTMs).

251 rizing recombinant monoclonal antibody (mAb) post-translational modifications (PTMs).

252 racterization of global proteome and protein post-translational modifications (PTMs).

253 ue to quantify the quality attributes (e.g., post-translational modifications [PTMs]) of monoclonal a

254 Protein phosphorylation is a key post-translational modification regulating protein funct

255 ible protein phosphorylation is an essential post-translational modification regulating protein funct

256 Mucin-type O-glycosylation is an essential post-translational modification required for protein sec

257 e 637 on the dynamin-related protein DRP1, a post-translational modification responsible for unoppose

258 As a post-translational modification, S6 kinase undergoes ace

259 n sites, suggesting that protein domains and post-translational modification sites have distinct sens

260 ue possibilities for the characterization of post-translational modification sites.

261 s carefully regulated through integration of post-translational modifications, spatial regulation at

262 egulated the biology of SENP2 by a different post-translational modification, specifically ubiquitina

263 or obtaining insight into subunit diversity, post-translational modifications, stoichiometry, structu

264 ible with multimeric proteins and those with post-translational modifications such as glycosylation.

265 y is often regulated by ligand binding or by post-translational modifications such as phosphorylation

266 They can be created by defects in post-translational modification, suggesting that these m

267 ch as insulin secretion are regulated by the post-translational modification, SUMOylation, and indeed

268 everal lines of evidence have implicated the post-translational modification, SUMOylation, in insulin

269 Poly(ADP-ribosyl)ation is a reversible post-translational modification synthetized by ADP-ribos

270 Protein ubiquitination is a multi-functional post-translational modification that affects all cellula

271 ependent enzymes, catalyze citrullination, a post-translational modification that alters protein func

272 1 undergoes lysine acetylation, an important post-translational modification that can regulate protei

273 tion by focal adhesion kinase (FAK), a HDAC5 post-translational modification that controls its subcel

274 eine oxidation represents a new type of TFEB post-translational modification that functions as a mole

275 Ubiquitination is a reversible post-translational modification that has emerged as a cr

276 It contains an unprecedented post-translational modification that intramolecularly li

277 lyases, or phospholyases, catalyze a unique post-translational modification that introduces dehydrob

278 Lysine crotonylation (Kcr) is a histone post-translational modification that is implicated in nu

279 toylation (S-palmitoylation) is a reversible post-translational modification that is installed by the

280 -acetylation of the Thr-2 residue on EsxA, a post-translational modification that is present in mycob

281 , proline hydroxylation of ChREBP is a novel post-translational modification that may allow for thera

282 Acetylation is a reversible post-translational modification that neutralizes lysine'

283 in phosphorylation is the best characterized post-translational modification that regulates almost al

284 cs on the chromatin fiber, primarily through post-translational modifications that occur on the histo

285 in glycosylation is one of the most abundant post-translational modifications that plays an important

286 nan biology and the post-transcriptional and post-translational modifications that regulate its main

287 yphosphorylation (K-PPn) is a relatively new post-translational modification, the full targets and fu

288 The close proximity of this post translational modification to both the alphabeta su

289 ity that actin acetylation, along with other post-translational modifications to actin, might constit

290 , polyubiquitination of Rheb is an important post-translational modification, which facilitates the b

291 Thousands of proteins are targets of this post-translational modification, which is catalyzed by a

292 stone variants can be enriched with specific post-translational modifications, which in turn can prov

293 ion (also called palmitoylation) is a common post-translational modification whose deregulation plays

294 Glycosylation is a major protein post-translational modification whose dysregulation has

295 Protein glycosylation is a complex post-translational modification with crucial cellular fu

296 Post-translational modification with one of the isoforms

297 rginine methylation has been recognized as a post-translational modification with pleiotropic effects

298 actome and to identify residues subjected to post-translational modifications, with a special focus o

299 l and symmetrical dimethylation as novel Myc post-translational modifications, with different functio

300 Regulating the activity of a coregulator via post-translational modifications would thus affect only