ライフサイエンスコーパス: postinfection

1 virus that subsequently coalesced from 10 h postinfection.

2 soft-tissue infection at both 24 h and 48 h postinfection.

3 pread systemically in the period immediately postinfection.

4 d alveolar epithelial cells at 1, 3, and 6 h postinfection.

5 nother for S. aureus tissue burden at 3 days postinfection.

6 ed postvaccination and returned to prelevels postinfection.

7 nomes in a quiescent state for at least 5 wk postinfection.

8 he DP148R gene is transcribed at early times postinfection.

9 ment of the lymph nodes and peaked on day 10 postinfection.

10 A was substantially diminished at late times postinfection.

11 changes that occur at early and later times postinfection.

12 as dramatically reduced in Il-17ra(-/-) mice postinfection.

13 ance antiviral responses postvaccination and postinfection.

14 ic acid, was administered at different times postinfection.

15 the role of these cells in viral suppression postinfection.

16 t retained the viral genome for at least 4 h postinfection.

17 Ccl4, when compared with adult mice, at 72 h postinfection.

18 aneous neutralization observed up to 3 years postinfection.

19 of mucosal-associated invariant T cells 6 mo postinfection.

20 d for Abeta and p-tau expression over 7 days postinfection.

21 n of inclusion bodies (IBs) from early times postinfection.

22 ed pigs cleared fecal viral shedding at 8 wk postinfection.

23 increased necrosis in infected cells at 10 h postinfection.

24 1 polypeptides, was observed at days 7 to 10 postinfection.

25 and computed tomography at early time points postinfection.

26 ICOS in TFH differentiation only after day 6 postinfection.

27 fection, and virus had not cleared by day 13 postinfection.

28 sing infected mice to succumb at 4 to 6 days postinfection.

29 ormal IFN-alpha levels during the first days postinfection.

30 d bacterial burden in lung and liver at 24 h postinfection.

31 positively with chronic viremia at 3 months postinfection.

32 three or more inhibitory receptors on day 14 postinfection.

33 izing activity (bNA) close to the first year postinfection.

34 brain, respectively, was measured at 5 weeks postinfection.

35 cumulate significant amounts of genomic mRNA postinfection.

36 alveolar lavage, and spleens of mice at 24 h postinfection.

37 d airway responsiveness were assessed 1-12 d postinfection.

38 mory population during the maintenance phase postinfection.

39 nary cytokines were measured at 6 h and 24 h postinfection.

40 ), and fetal lung fibroblasts (HFLs) at 72 h postinfection.

41 gp130, and this was sustained for up to 2 mo postinfection.

42 hen given once at the peak of viremia 3 days postinfection.

43 to almost 50% of the vacuoles within 20 min postinfection.

44 tners were followed for a median of 847 days postinfection.

45 ted AIEC intramacrophage survival up to 24 h postinfection.

46 und in the spleens of Irgm3-/- mice at day 4 postinfection.

47 y continued to increase for at least 3 years postinfection.

48 hen administered at 50 mg/kg on days 4 and 6 postinfection.

49 All animals were asymptomatic postinfection.

50 e PCR detection of the bacteria up to day 15 postinfection.

51 ses, and histological features up to 12 days postinfection.

52 t to restrict RSV infection at an early time postinfection.

53 es but was cleared from all sites by 14 days postinfection.

54 ion were measured by flow cytometry at day 3 postinfection.

55 hibited normal intestinal pathology at day 2 postinfection.

56 ted with HSV-CD80 or parental virus on day 4 postinfection.

57 died increased or decreased more than 2-fold postinfection.

58 neutrophil infiltration to the spleen 5 days postinfection.

59 ract of infected mice, with a peak at 4 days postinfection.

60 All infected mice seroconverted by 14 days postinfection.

61 eningitis, and 100% mortality within 2 weeks postinfection.

62 tions was observed in all animals at 14 days postinfection.

63 ation and mucus production for at least 7 wk postinfection.

64 rting an efficient cell cycle entry on day 3 postinfection.

65 cell responses that were sustained for weeks postinfection.

66 ounts of IFN-gamma in their spleens on day 1 postinfection.

67 and more complex at 28 days than at 10 days postinfection.

68 heters compared to sterile controls at day 1 postinfection.

69 gnosis and 64.7% (95% CI 55.4-72.9%) 4 weeks postinfection.

70 related significantly with decreased viremia postinfection.

71 ected in virus-infected organoids at 52 days postinfection.

72 cause an acute pneumonia and death by 4 days postinfection (100%), strain Lp01 does not cause mortali

73 located near the cell nucleus at early times postinfection (2 h) but were redistributed during infect

74 at 6-7 days of life were analyzed at 8 days postinfection, 5 weeks postinfection, or after a chronic

75 d the virus titer by about 100-fold on day 8 postinfection, according to the findings of a virus yiel

76 We simulated the implementation of a postinfection adult vaccine with 60% efficacy and a mean

77 Interaction of Rubicon and Beclin-1 at 1 h postinfection affirmed the prevalence of noncanonical au

78 At 2 d postinfection, aged mice suffered 1000-fold higher pulmo

79 semination to all organs in the first 4 days postinfection, albeit with a lower burden, followed by c

80 At 3 months postinfection, all H. saguini-monoassociated gnotobiotic

81 all of which were readily detectable by 24 h postinfection and accumulated to high levels by 72 h.

82 antly greater than those in WT mice by day 3 postinfection and at all time points thereafter.

83 antly lower in coinfected infants 2.5 months postinfection and at the time of coinfection.

84 specifically with cART started within 1 year postinfection and continued for at least 9 months.

85 ificantly increased bacterial burden 10 days postinfection and delayed pathogen clearance.

86 rather than effector memory T cell phenotype postinfection and expressed high levels of PD-1, Lag-3,

87 Next, we evaluated IFN-I treatment postinfection and found that SARS-CoV-2 was sensitive ev

88 system drives the myocardial immune response postinfection and harbors a promising potential as a the

89 ntained high mucosal plasma cell frequencies postinfection and if this translated to reduced viremia.

90 ns of CO92 Deltapgm-infected animals by 24 h postinfection and in the livers by 4 days.

91 Immune parameters were analyzed at 30 days postinfection and included cellular profiles in bronchoa

92 ficiently in lymphoid tissues at early times postinfection and induced higher levels of IFN productio

93 ficiently in lymphoid tissues at early times postinfection and induced higher levels of interferon pr

94 It can be administered up to 8 h postinfection and is effective against multiple human as

95 ucleoprotein) reduced viral load immediately postinfection and partially attenuated interferon respon

96 inflammation is detectable as early as 1 day postinfection and peaks 1 to 2 weeks later, after which

97 f B. burgdorferi-infected mice around day 21 postinfection and peaks around day 28.

98 Brain atrophy was observed at 1 mo postinfection and persisted through the 4-mo observation

99 to profile protective immune responses, both postinfection and postvaccination, although no vaccine-d

100 durability of IL-10-producing CD4(+) T cells postinfection and provide information on how IL-10 may c

101 on, samples were collected at 4, 8, and 16 h postinfection and RNA-Seq data were acquired using an Io

102 the cytoplasm of infected cells within 12 h postinfection and subsequent accumulation of puncta in t

103 y clearance from the blood and organs 7 days postinfection and survival of all animals.

104 ounts are significantly reduced at 1 and 2 d postinfection and that KC-mediated mature neutrophil rec

105 Trif, Tbk1, and Irf7/Irf3 in the liver 42 h postinfection and the initiation of an early burst of pr

106 an inflammatory arthritis that peaks 3-4 wk postinfection and then spontaneously resolves.

107 By 20 days postinfection and through the 80-day observation period,

108 as those from animals started on cART 1 year postinfection and treated for 1 year contained intact ge

109 RNA was isolated at several times postinfection and treated with various RNA-modifying enz

110 reduction neutralization test (6 to 21 days postinfection) and with 97% and 100% specificity in shee

111 with ehrlichial morulae on days 1, 2, and 3 postinfection, and increased LC3II levels were detected

112 pecific IgM and IgG were detected at 15 days postinfection, and isotyping of the Ig subclass showed t

113 ing in the ipsilateral ankle at days 3 and 7 postinfection, and this correlated with higher levels of

114 aked at approximately 1 x 10(6) PFU on day 5 postinfection, and virus had not cleared by day 13 posti

115 main are protective in both prophylactic and postinfection animal models.

116 r differentiation into B cells in the spleen postinfection are not defined.

117 y, apolipoprotein B levels in the lung early postinfection are significantly reduced with lipoprotein

118 genes which increase in abundance at day 21 postinfection are still increased at 6 months postinfect

119 colonization of the stomach (1 day or 1 week postinfection) as measured by total CFU.

120 ing the innate immune response (prior to 7 d postinfection) as well as decreased survival in response

121 live A549 cells was recorded within 3 to 4 h postinfection at 100 frames/s by fluorescence video micr

122 pression of several miRNAs was modulated 3 h postinfection (at a multiplicity of infection of 25).

123 Here, we show that at 1 month postinfection, B cell deficiency alone enhanced resistan

124 inducible NO synthase in the TME merely 4 d postinfection, before significant virus spread or the ap

125 By day 6 postinfection, both virus variants were mostly cleared f

126 SGs or eIF2alpha phosphorylation at any time postinfection but is unable to fully inhibit SG formatio

127 s throughout each mouse within the first day postinfection, but by 48 h the viral populations were do

128 sections at time points from day 3 to day 10 postinfection, but nearly all appeared degraded with inf

129 The factors and steps controlling postinfection CD8(+) T cell terminal effector versus mem

130 sed [(18)F]-FDG uptake in bone marrow 4 days postinfection compared to surviving NHPs.

131 duced neutrophils in TLR9(-/-) mice on day 1 postinfection compared to the levels in WT mice.

132 bclinical visually were detected within 2 wk postinfection compared with 1 to 32 mo for qPCR.

133 n the spleens and livers on both day 1 and 3 postinfection compared with C5aR2(+/+) mice.

134 P-1 in the serum, spleen, and liver on day 1 postinfection compared with C5aR2(+/+) mice.

135 +) and CD8(+) T cells in the spleen on day 3 postinfection compared with C5aR2(+/+) mice.

136 des from IL-10-neutralized animals at 3-4 wk postinfection compared with control animals.

137 s), defined as PTCs, who started ART 8 weeks postinfection, continued ART for >7 months, and controll

138 in viral titer in liver and spleen at day 5 postinfection (d p.i.), although both wild-type and DUBm

139 synovium became immunopositive beginning on postinfection day 6.

140 Both untreated control animals died on postinfection day 9.

141 of APOBEC3G with a half-life of roughly 6 h postinfection, demonstrating that Vif can concurrently m

142 ort-term (3-d) local CD4(+) T cell depletion postinfection did not influence chemokine levels in corn

143 so mounting evidence that they are linked to postinfection disorders.

144 g both viral and host transcriptomes on days postinfection (dpi) 3, 7, 10, 14, and 100.

145 nsiently activated intestinal STAT1 at 1 day postinfection (dpi) but not subsequently at 2 to 3 dpi.

146 assical (CD14(+) CD16(+)) subsets at 12 days postinfection (dpi) during lethal infection but not duri

147 leared the infection had occurred by 10 days postinfection (dpi) in vaccinated cattle and by 21 dpi i

148 lated at the transcriptional level at 7 days postinfection (dpi), most of which fall into the categor

149 ree animals were euthanized at 10 or 11 days postinfection (dpi).

150 type 2 infection at 0, 3, 7, 14, and 28 days postinfection (dpi).

151 with either ET-1 or saline from 2 to 8 days postinfection (dpi).

152 or recovering infectious FMDV up to 400 days postinfection (dpi).

153 pigs were challenged at either 21 or 28 days postinfection (dpi).

154 n within the virus gene at both 1 and 3 days postinfection (dpi).

155 different proportions, depending on the day postinfection (dpi).

156 through acute and chronic infection (90 days postinfection [dpi]) and quantified viral (SIV gag RNA),

157 in transcriptional activity occurred 20-56 d postinfection, during which fluctuation of innate and ad

158 sids that assist in expressing their genomes postinfection, e.g., retroviruses.

159 yrin (CoPP, a potent HO-1 inducer), pre- and postinfection, effectively inhibited BVDV replication.

160 allenge with P. murina at 2, 7, 14, and 28 d postinfection even after CD4(+) T cell depletion.

161 th seasonal influenza A(H3N2) (sH3N2), using postinfection ferret antisera.

162 ses from the 1970s-1990s were observed using postinfection ferret antisera.

163 iral isolates tested against strain-specific postinfection ferret antisera.

164 25 mg/kg of body weight/dose) was given 4 h postinfection, followed by twice-daily treatment for 5 d

165 ostinfection are still increased at 6 months postinfection for both male and female mice.

166 E, and gI, was significantly reduced at 36 h postinfection for the hyperfusogenic mutants.

167 ntrol and infected birds at 2, 3, and 4 days postinfection from two lines that differ in their resist

168 emales and males, carrying the potential for postinfection genital tract sequelae.

169 nce-daily 10 mg/kg iv treatment on days 3-14 postinfection had a significant effect on viremia and mo

170 d with ASA, or animals receiving ASA 3 hours postinfection, had significantly reduced platelet aggreg

171 etween males and females, including immunity postinfection, have been well documented, as have steroi

172 remia was generally cleared by 2 to 3 months postinfection, hepatitis and liver fibrosis persisted af

173 acrophages and neutrophils for at least 17 h postinfection; however, MNGC formation is not induced in

174 mean of 60 to 5 per cell between 10 and 24 h postinfection (hpi) (P < 0.0001), while the average area

175 pression of surface and total HLA-DR at 72 h postinfection (hpi) and 120 hpi in infected cells.

176 competent state began at approximately 20 h postinfection (hpi) and facilitated systemic invasion an

177 gnificantly less extracellular HSV-1 by 24 h postinfection (hpi), suggesting a unique neuronal respon

178 Pol II relocated to viral genomes within 3 h postinfection (hpi), when it occupied genes of all tempo

179 COX-2 mRNA and protein levels at 24 and 36 h postinfection (hpi), with only a transient increase in C

180 rasite growth kinetics during the first 24 h postinfection (hpi).

181 o in equine endothelial cells (EECs) at 12 h postinfection (hpi).

182 However, by day 21 postinfection, Icos(-/-) mice accumulated fewer splenic

183 ocular herpesvirus infection (i.e., on day 2 postinfection), IFN-gamma-producing PLZF(lo)RORgammat(lo

184 However, after day 21 postinfection, IL-10-expressing T cells were also highly

185 Four weeks postinfection, IL-12, type 1 IFN, and IL-27 were all req

186 assay detected F. tularensis on days 1 to 4 postinfection in 21%, 17%, 60%, and 83% of macaques, res

187 ody responses to ZIKV ~2 weeks and ~8 months postinfection in 31 pediatric subjects with 0, 1 or >1 p

188 of C3, macrophage death was observed at 24 h postinfection in a quarter of the macrophages that conta

189 rrelated positively with viremia at 3 months postinfection in all three infection models.

190 of MCP-1 correlated with viremia at 3 months postinfection in both nonprogressive infections.

191 regions under selection at 1, 3, and 9 days postinfection in chicks.

192 infection in monocytes, compared with 30 min postinfection in fibroblasts and endothelial cells, sugg

193 etected in the nucleus beginning only at 3 d postinfection in monocytes, compared with 30 min postinf

194 th a pulse of serum IFN-gamma at 3 to 4 days postinfection in the absence of detectable IL-12.

195 ngal growth within the kidney occurs by 24 h postinfection in the mutant mice.

196 ral cell syncytia formation and viral titers postinfection in vitro Transcranial inoculation of C57Bl

197 e cytokines upon TLR stimulation in vitro or postinfection in vivo.

198 ngly wild-type-like immune cell organization postinfection, including extensive iNOS(+) granuloma for

199 ly, ototopical administration of vinpocetine postinfection inhibited MUC5AC expression and middle ear

200 The existence of postinfection irritable bowel syndrome (PI-IBS) has been

201 ncreased proliferation between days 8 and 14 postinfection is associated with subsequent decreased CD

202 proximately 2 d, whereas treatment given 2 d postinfection is mostly ineffective in accelerating plas

203 elonging to CD8(+) T cells as early as day 2 postinfection is responsible for protection.

204 infection, and depletion beginning at 3 days postinfection led to more pronounced sensitivity than de

205 d that bafilomycin treatment from 48 to 72 h postinfection lowered VZV titers substantially (P <= 0.0

206 culum (1 x 10(6) to 1 x 10(8) CFU/mouse) and postinfection lung bacterial burden did not appreciably

207 ive tissue, and vascular abnormalities, poor postinfection lung healing, and subsequent pulmonary fai

208 At 8 wk postinfection, lung granulomas from IL-10-neutralized an

209 d expiratory volume in 1 second decline >=5% postinfection may be markers for increased mortality.

210 ion selectively influenced immune memory, as postinfection memory CD4(+) populations contained signif

211 H3 and H4 present in the chromatin from 48-h-postinfection minichromosomes and disrupted virions.

212 t, phagocytosis of C. albicans by PMN 60 min postinfection occurred almost independently of C5a and m

213 egulated TGF-beta expression as early as 6 h postinfection of epithelial cells and stimulated both th

214 At 14 and 15 weeks postinfection, one group was given praziquantel to treat

215 ific depletion of dendritic cells from day 2 postinfection or by sterile induction of type I IFN.

216 red serum samples collected preinfection and postinfection or vaccination to assess durability of hum

217 re analyzed at 8 days postinfection, 5 weeks postinfection, or after a chronic cockroach allergen ast

218 pathways were also activated on days 1 and 3 postinfection, ostensibly due to epithelial cell distres

219 an their uninfected counterparts at 16 weeks postinfection (P < 0.0001).

220 breadth was positively associated with time postinfection (P = 0.0001), but contrary to what has bee

221 ale macaques postvaccination (p = 0.018) and postinfection (p = 0.0048) exhibited higher Breg frequen

222 fold lower virus titer in the lung at 5 days postinfection (p.i.) and had markedly reduced weight los

223 icantly decreased the lesion size at 14 days postinfection (p.i.) compared to results for nontreated,

224 orsal root ganglionic (DRG) neurons at day 4 postinfection (p.i.) for both viruses.

225 nd virus shedding were detected up to day 60 postinfection (p.i.) in all treatment groups following s

226 STAT3 were increased between 94 and 131 days postinfection (p.i.) in brains of mice infected with str

227 ially detected in neurons as early as 3 days postinfection (p.i.) in the brains of RABV-infected mice

228 dentified 5 macaques (38%) from 1 to 2 years postinfection (p.i.) with broadly neutralizing antibodie

229 er were harvested at 0, 2, 5, 8, and 14 days postinfection (p.i.), and the frequency and function of

230 ction, level of viral gB DNA in TG on day 28 postinfection (p.i.), and virus reactivation on day 28 p

231 gous B. burgdorferi at different time points postinfection (p.i.).

232 s Il6, Tnf, and Il1beta between days 4 and 6 postinfection (p.i.).

233 ium isolates obtained at various time points postinfection (p.i.).

234 as cage mates for contact exposure at 1 day postinfection (p.i.).

235 t in CD4(+/+) mice at days 5, 10, 15, and 30 postinfection (p.i.).

236 intrinsic pathway later in infection (>10 h postinfection [p.i.]) after maximal virus titers (150 to

237 on in most cells early after infection (<6 h postinfection [p.i.]), while transcription inhibition oc

238 r up to 11 weeks to capture steady-state and postinfection phases.

239 By 7 days postinfection (PI), mice infected with FMLV-IL-1beta exh

240 ganglia infected with DeltaCTRL2 by 31 days postinfection relative to the level with 17syn+ infectio

241 and that total reactivity to influenza virus postinfection represented approximately 0.1% of the circ

242 achment; in contrast, addition of galectin-1 postinfection results in reduced production of progeny v

243 Postinfection, RTE numbers contracted less dramatically

244 of infection was not maintained, and by 8 wk postinfection sanroque mice demonstrated an increased ba

245 s of cell-cultured virus isolates and ferret postinfection sera displayed a directional evolution of

246 Pre- and postinfection sera were assayed by enzyme-linked immunos

247 of infection (two as early as 77 and 96 days postinfection) showed substantial cross-neutralization.

248 ion of recombinant IL-22 (rIL-22), given 2 h postinfection, significantly reduced the bacterial burde

249 ce with recombinant IL-17A, as late as day 6 postinfection, significantly reduces the viral burden an

250 timately cleared the bacteria within 3 weeks postinfection, similar to the findings for wild-type mic

251 AV-1a destroys most fat body cells by 7 days postinfection, so innate immunity gene transcripts appar

252 We determined the early postinfection TCF7(high) population is marked by low TIM

253 Day 5 postinfection, TCF7(high) cells express higher memory-as

254 pressed transcripts between preinfection and postinfection, the greatest change in transcriptional ac

255 By 6 days postinfection, there is a loss of lytic gene transcripti

256 By 17 weeks postinfection, there was a significant increase in pulmo

257 infected animals at day 1; however, by day 5 postinfection, there was an increase in the number of di

258 ranscriptional analysis on 38 macaques at 11 postinfection time points during the first 6 mo of M. tu

259 nd CD8 (CD8(lo) CD11a(hi)) T cells at day 10 postinfection to determine the impact of pregnancy-assoc

260 During chronic infection (1 or 3 months postinfection), total CFU were highly variable but simil

261 ly, despite this approach being an effective postinfection treatment option, research on novel approa

262 Furthermore, postinfection treatment with RvD1 and RvD5 led to protec

263 Strikingly, postinfection treatment with RvD1 and RvD5 reduced bacte

264 ere analyzed at various times from 0 to 72 h postinfection, using transcriptome sequencing analysis a

265 ed long term with RhCMV to determine whether postinfection vaccination against vIL-10 could change th

266 ing but unfulfilled goal has been to develop postinfection vaccine strategies that could "reboot" the

267 ed to a 26-fold reduction in lung CFU by 6 d postinfection versus nondepleted mice.

268 The expansion of the proteome at day 5 postinfection was interesting, as bacterial burdens bega

269 treatment with MEDI8852 24, 48, or 72 hours postinfection was superior to oseltamivir for H5N1.

270 f-1") expression is FOXO1 independent, early postinfection we report bimodal, FOXO1-dependent express

271 By supplying dissolved N as (15)N postinfection, we found that proteins in progeny phage p

272 se (PO) response and bacterial load at 24-hr postinfection were ascertained.

273 ction, are uniquely expressed in the EP 60 d postinfection when animals are no longer suffering from

274 nd lower parasite burdens at different times postinfection when compared with their infected wild-typ

275 After 2 to 4 days postinfection, when map is suppressed, EPEC colonization

276 On day 3 or 4 postinfection, when parasitemia levels typically exceede

277 ased toward undergoing glycolytic metabolism postinfection, which compromises their ability to develo

278 the autophagy marker LC3 (42% +/- 7%) at 2 h postinfection, which constituted a 5-fold increase over

279 lycolytic activity than adult CD8(+) T cells postinfection, which may be due to age-related differenc

280 increased in the lungs at early time points postinfection, which was correlated with increased innat

281 xtensively colonized antral glands at 1 week postinfection, while csd6 mutants showed variable coloni

282 d with [(18)F]-FDG uptake and peaked 10 days postinfection, while minimal lymphadenopathy and higher

283 At day 4 postinfection, while the DeltafakA mutant maintains larg

284 arly 80% of spores were inside cells at 24 h postinfection with 10(4) spores.

285 prone, low-affinity T cells and SIRPa(+) DCs postinfection with bacteria expressing the peptide of in

286 Supernatant from plasmacytoid DCs harvested postinfection with BVDV or recombinant bovine IFN-alpha

287 ent animals showed no impairment in survival postinfection with either HSV type 1 or encephalomyocard

288 6(1-20)-specific TCR transgenic mice at 2 wk postinfection with M. tuberculosis and progressively dec

289 showed increased [(18)F]-FDG uptake by day 4 postinfection with minimal lymph node enlargement, indic

290 nflammasome activation was not evident early postinfection with N. brasiliensis, and in contrast to N

291 l role in protection against disease in vivo postinfection with RSV.

292 increased dramatically between days 1 and 4 postinfection with VACV.

293 Postinfection with West Nile virus (WNV), BAFF increased

294 ponectin-deficient mice at early time points postinfection, with a specific increase in intracellular

295 oduce effector cytokines or degranulate late postinfection, with minimally increased function even in

296 leukocyte composition was altered at 10 days postinfection, with notable gains in the frequency of T

297 A rapid host response was observed 24 h postinfection, with over 2,500 significantly differentia

298 (RM) cell surface phenotype develops by 2 wk postinfection, with the majority of the population expre

299 Viral persistence for weeks postinfection (wpi) has also been documented by the demo

300 suppressed in challenged animals by 5 weeks postinfection (wpi).