ライフサイエンスコーパス: postnatal

1 Exposures from the prenatal and early postnatal (2-month) visits were evaluated together with

2 Animal studies demonstrated that early postnatal ablation of the NMDAR in corticolimbic interne

3 Here, we demonstrate in vivo that early postnatal ablation of the NMDAR in corticolimbic interne

4 This MS-based lipidomic study quantified the postnatal adaptations to plasma PC molecular composition

5 closely with postconceptional age than with postnatal age, implicating the level of maturity more th

6 ring frequency of action potentials at early postnatal ages and were hypersusceptible to chemically i

7 iome influences fetal immune development and postnatal allergic outcomes.

8 nary dysplasia, characterized by interrupted postnatal alveolar development and increased morbidity t

9 sting pan-otic CRE drivers, particularly for postnatal analyses.

10 Using both postnatal and adult mice, as well as embryonic zebrafish

11 sion continues from embryonic stages through postnatal and adult stages exclusively in a skeletal ste

12 lular and molecular mechanisms that regulate postnatal BAT growth.

13 Knockout of the serotonin transporter or postnatal blockade with selective serotonin reuptake inh

14 atal osteoclasts that can create a space for postnatal bone marrow haematopoiesis.

15 ng osteoclast precursors that contributed to postnatal bone remodelling in both physiological and pat

16 structure and prevented RVH in antenatal and postnatal BPD models.

17 nerations to disease-relevant alterations in postnatal brain gene expression and adult behavior.

18 oline transporter in the embryonic and early postnatal brain to determine the developmental timing of

19 role for the pericentriolar material in the postnatal brain, with progressive degenerative ciliary a

20 ell RNA-sequencing of perturbed cells in the postnatal brain.

21 but little is known about their roles in the postnatal brain.

22 is highly expressed on the prenatal, but not postnatal, brain.

23 Notably, a postnatal burst of PACAP expression occurred in RTN neur

24 We identified the postnatal cardiac ECM as a nonpermissive environment for

25 es as essential to mouse development, and to postnatal cardiac function.

26 s SLIT2 and NPNT (nephronectin) in promoting postnatal cardiomyocyte cytokinesis.

27 t that Hoxb13 acts as a cofactor of Meis1 in postnatal cardiomyocytes.

28 ry continuity of antenatal, intrapartum, and postnatal care (Pilot study Of midwifery Practice in Pre

29 a significantly higher rate when cultured on postnatal cFb-derived ECM compared with embryonic cFb-de

30 Thus, postnatal CFs are heterogeneous and include a transient

31 his work is among the first to examine early postnatal changes in this initial cortical region of the

32 tructural brain injury, brain volumetry, and postnatal clinical factors.

33 .34), findings that differ from those in two postnatal clinical populations that were also evaluated

34 urthermore, we found that both embryonic and postnatal CMs binucleate at a significantly higher rate

35 NPNT (nephronectin), promote cytokinesis of postnatal CMs in vitro and in vivo.

36 yte layer features, established in the early postnatal cortex, mostly persisted in adult mouse and hu

37 glycolysis (AG), AG-related gene expression, postnatal cortical surface expansion, and adolescent shr

38 array (Quantum Devices, Barneveld, WI) from postnatal day (p) 10 to p25.

39 embrane-bound ephrin-B1 in astrocytes during postnatal day (P) 14-28 period would affect synapse form

40 NEC was induced in mouse pups between postnatal day (P) 5 and 9.

41 are prominent in the somatosensory cortex by postnatal day (P) 7.

42 ms of germ and granulosa cells from E16.5 to postnatal day (PD) 3 were reported.

43 e molar in K14-Cre;Wnt10a(flox/flox) mice at postnatal day 0 (PN0), just before the initiation of roo

44 , on cultured primary neurons harvested from postnatal day 0-1 mouse brains.

45 and anterior cingulate cortical thickness at postnatal Day 1 (P1) in HC and LC voles.

46 riostin (Postn)+ lineage CFs were found from postnatal day 1 (P1) to P11 but were not detected at P30

47 neration after myocardial infarction (MI) on postnatal day 1 (P1), but this ability is lost by postna

48 elevated hypothalamic ER stress as early as postnatal day 10, i.e., prior to the development of obes

49 selective breeding (postnatal day 7: n = 22; postnatal day 14: n = 49; postnatal day 21: n = 21; adul

50 This dWAT phenotype was established around postnatal day 18 and did not depend on the hair growth c

51 On Postnatal Day 2, polyethylenimine-(5) myristic acid/poly

52 Male offspring were weaned at postnatal Day 21 and then fed a HFD for 9 weeks.

53 ring gestation and lactation; once weaned at postnatal day 21, Gen-1 mice were then kept on the contr

54 electrophysiological effects of prepubertal (postnatal day 21-40) EE on DA neurons, pyramidal neurons

55 tal day 7: n = 22; postnatal day 14: n = 49; postnatal day 21: n = 21; adult: n = 46; all male).

56 results demonstrate that hindpaw incision at postnatal day 3 (P3) significantly decreased the strengt

57 in dynamic environments in rats as young as postnatal day 30.

58 hock/restraint stress in either adolescence (postnatal day 31-40) or adulthood (postnatal day 65-74).

59 At postnatal day 4 (P4), conventionalized mice and Bifidoba

60 We focused on postnatal day 4, shortly after a transient perinatal and

61 tal time points between embryonic day 10 and postnatal day 45.

62 rimary cultures of GCPs from Jdp2-KO mice at postnatal day 5 were more resistant to apoptosis than GC

63 etion of Fth in oligodendroglial cells after postnatal day 60 has no effect on myelin production and/

64 lescence (postnatal day 31-40) or adulthood (postnatal day 65-74).

65 t the basal arbor grew substantially between postnatal day 7 (P7) and P30, undergoing a 45% increase

66 Cs become functionally competent from around postnatal day 7 (P7), before the primary sensory inner h

67 atal day 1 (P1), but this ability is lost by postnatal day 7 (P7).

68 thy exposing C57BL/6 mice to 75% oxygen from postnatal day 7 to 12.

69 imited bedding at postnatal days 2-9, adult (postnatal day 70) cerebellar and hippocampal endocannabi

70 anning 43 generations of selective breeding (postnatal day 7: n = 22; postnatal day 14: n = 49; postn

71 birth, but they rapidly worsened and died by postnatal day 9.

72 ketamine (20 mg/kg) for 15 consecutive days (Postnatal Day [PD] 35-49).

73 owever, these responses are diminished after postnatal day-6 (P6), representing a barrier to building

74 ere exposed to limited nesting material from postnatal days (P) 2-9.

75 Female mice were exposed to GEN on postnatal days (PND)1-5 and uterine tissues collected on

76 ere exposed to normoxia or hyperoxia through postnatal days (PNDs) 1 to 14, and the hyperoxia-exposed

77 S, the limited bedding paradigm (LB) between postnatal days 1-10, we previously documented that LB ma

78 At postnatal days 12 and 18, mild lung disease was evident

79 Following limited bedding at postnatal days 2-9, adult (postnatal day 70) cerebellar

80 s in vitro in the left and right amygdala of postnatal days 22-28 male and female offspring from norm

81 HC during an early-middle adolescent window (postnatal days 27-45) in which the brain may be particul

82 are transiently recruited to the lung during postnatal days 3-14, which specifically corresponds to t

83 mas containing GDNF or saline (control) from postnatal days 4 through 8.

84 Both male and female (postnatal days 60-90) mice, including 140 D(2)R, 24 D(1)

85 ous injections of 30 mg/kg ketamine (KET) on postnatal days 7, 9, and 11] results in long-lasting alt

86 iod for thalamocortical connectivity between postnatal days P12 and P15, during which tone exposure a

87 posed to either (1) adolescent-stress (33-35 postnatal days) then SPS (58-60 postnatal days; n = 14),

88 entials (APs), but only during the first few postnatal days.

89 tress (33-35 postnatal days) then SPS (58-60 postnatal days; n = 14), or (2) no adolescent-stress and

90 , or (2) no adolescent-stress and SPS (58-60 postnatal days; n = 14), or (3) unstressed conditions (n

91 ted to stress urinary incontinence (SUI) and postnatal depression (PD) after birth, and (2) investiga

92 problems, even when accounting for maternal postnatal depression and prenatal stress.

93 for mood symptomatology using the Edinburgh Postnatal Depression Scale (EPDS).

94 %), pregnant and postpartum women (Edinburgh Postnatal Depression Scale: sensitivity, 74%; specificit

95 d cohort EDEN (a study on the pre- and early postnatal determinants of child health and development).

96 eneity during aging (20 + years) compared to postnatal development (0 to 20 years).

97 oss of corticospinal regrowth ability during postnatal development and after SCI.

98 DNF-induced beta-actin mRNA transport during postnatal development and reveal a new molecular mechani

99 euron polarization and their coupling during postnatal development are unclear.

100 ith the vasculature during the first week of postnatal development compared with older ages and that

101 eation of the mechanisms involved in cardiac postnatal development could provide new insight into the

102 ormalities in interneurons can interact with postnatal development during adolescence, triggering pat

103 of pyramidal neurons collected across early postnatal development in visual cortex of mice of either

104 t function, only a little is known about the postnatal development of dendritic arbors of cortical py

105 ng among ependymal cells is downregulated as postnatal development proceeds but increases after injur

106 fiber synaptic refinement during cerebellar postnatal development using the Npc1(nmf164) mouse.

107 the neonatal mouse heart but is lost during postnatal development when cardiomyocytes undergo cell-c

108 etic cannabinoid during the first 10 days of postnatal development, and experiments were then conduct

109 During the critical period of postnatal development, neuronal properties are tuned to

110 During embryonic and postnatal development, organs and tissues grow steadily

111 oteome during peak eosinophil recruitment in postnatal development, we identified markers that functi

112 nd calcium-dependent refinements during late postnatal development, we quantified EPSCs and calcium e

113 , parasite expulsion) but also during normal postnatal development.

114 and optogenetic stimulations in mice across postnatal development.

115 alance in the mouse hippocampus during early postnatal development.

116 ng that NM hTau pathogenicity is specific to postnatal development.

117 murine lung immune compartment during early postnatal development.

118 ntiation of microglia precursor cells during postnatal development.

119 connectivity of mouse retinal AII ACs across postnatal development.

120 f structural and molecular maturation during postnatal development.

121 zed function through refinements during late postnatal development.

122 ortex (Eo, Er, Elr, Ei, Elc, Ec, Ecl) during postnatal development.

123 The spatial distribution and postnatal developmental dynamic of neurons expressing no

124 f genes involved in virtually all aspects of postnatal developmental maturation, including mitochondr

125 ogical cell shedding outcomes throughout the postnatal developmental period, and which host and micro

126 es of AIF1L deficient mice showed no obvious postnatal developmental phenotype.

127 has been primarily studied in the context of postnatal, differentiated neurons that fire action poten

128 The principal finding is that postnatal EC-specific loss of Kif11 leads to severely st

129 included in clinical COVID-19 studies, early postnatal ECGs should be considered.

130 ore this relationship, we created a model of postnatal elimination of insulin signaling in osteoproge

131 In this review, we critically evaluate how postnatal ELS relates to abnormalities in miRNA expressi

132 implicating the level of maturity more than postnatal environmental influences in governing the timi

133 GI colonization following both perinatal and postnatal exposure to GBS, with 21% and 27%, respectivel

134 of congeners, growth dilution, and pre- and postnatal exposures by children.

135 s, we identified an altered perinatal and/or postnatal expression of genes involved in lung developme

136 alysis was performed with prenatal and early postnatal farm-exposure variables to assign farm childre

137 ensable for differentiation but required for postnatal function and survival.

138 ces in skull organization, such as extensive postnatal fusion of cranial bones in crown birds, can ex

139 Using murine models of both perinatal and postnatal GBS acquisition, we assessed the kinetics of G

140 on and progression to invasive disease after postnatal GBS exposure in offspring.

141 dary analysis of data from the retrospective Postnatal Growth and Retinopathy of Prematurity Study (G

142 rst stage of ROP (p < 0.0001) and to develop postnatal growth failure (p = 0.01) than non-IUGR infant

143 n the 129 Sv/Ev x C57BL/6 F2 background, but postnatal growth failure occurred.

144 Independent of postnatal growth failure status, IUGR infants had a 4-5

145 nopathy outcomes, age at worst ROP stage, or postnatal growth failure.

146 The correlates of prenatal and postnatal growth on Intelligence Quotient (IQ) in childh

147 stage of and need for treatment for ROP, and postnatal growth was obtained.

148 anges in the in utero environment normalized postnatal growth, decreased white adipose tissue (WAT) a

149 LF morphology with anterior open bite during postnatal growth, resembling clinical features of the se

150 Juvenile dogs exhibited stunted postnatal growth, steatorrhea, abdominal distension and

151 own about the cellular dynamics that mediate postnatal growth.

152 Cardiac maturation lays the foundation for postnatal heart development and disease, yet little is k

153 lling transcription in cardiomyocytes of the postnatal heart.

154 tantially delays cardiomyocyte maturation in postnatal hearts, and markedly enhances cardiomyocyte pr

155 Whether antenatal or postnatal HIF (hypoxia-inducible factor) augmentation ca

156 is that BCG vaccination is a risk factor for postnatal HIV transmission or increased pathogenesis in

157 erved lung structure and prevented RVH after postnatal hyperoxia.

158 e and investigated the consequences of early postnatal inactivation of Kif11 in vascular endothelial

159 Homozygous mutant mice develop lethal postnatal inflammation of the salivary glands and medias

160 such as chorioamnionitis, preeclampsia, and postnatal injury, are associated with an increased risk

161 Plp1-targeting antisense oligonucleotides in postnatal jimpy mice fully restored oligodendrocyte numb

162 ed atRA concentrations in the skin while the postnatal knockout of both Cyp26a1 and Cyp26b1 resulted

163 Postnatal knockout of Cyp26b1 resulted in increased atRA

164 Notably, maternal nutrition and postnatal leptin surge have a profound impact on cilioge

165 lls, failure of alveolar inflation and early postnatal lethality in mouse.

166 srupt its H3K27me3 engagement causes partial postnatal lethality, supporting a role in development.

167 ation of forebrain excitatory neurons during postnatal life (P2-14), but not in juvenile or adult win

168 of stem cell-driven neurogenesis persists in postnatal life and is reduced in large-brained species.

169 aling in forebrain excitatory neurons during postnatal life can evoke persistent mood-related behavio

170 onal status during intrauterine and/or early postnatal life has substantial influence on adult offspr

171 f glucose (fetal life) to the use of lipids (postnatal life).

172 During postnatal life, thymopoiesis depends on the continuous c

173 ernal separation during the first 2 weeks of postnatal life.

174 man disease, either during development or in postnatal life.

175 verall numbers of precursor cells throughout postnatal life.

176 lity of lung clocks in priming the fetus for postnatal life.

177 yp26b1 in regulating retinoid homeostasis in postnatal life.

178 esses that take place during fetal and early postnatal life.

179 r, Dcc-deficient retinas displayed a massive postnatal loss of retinal ganglion cells and a large fra

180 ible, endothelial-specific deletion impaired postnatal lymphatic valve maturation in mice.

181 hat Cyp26b1 is the main atRA clearing Cyp in postnatal mammals.

182 In rodents, postnatal maturation of movement occurs from rostral to

183 subpopulations and the heterochrony of their postnatal maturation.

184 rease in proliferation of mural cells during postnatal maturation.

185 d their shift in compartmentalization during postnatal maturation.

186 genetic protein (BMP) signal transduction in postnatal mice, with BMP signaling being restricted to b

187 In blood, postnatal miR-218 expression parallels changes occurring

188 d gamma, known transcriptional regulators of postnatal mitochondrial biogenesis and function, serve a

189 oluble fms-like tyrosine kinase 1), and in a postnatal model due to prolonged hyperoxia.Methods: ETX

190 sely with maternal fructose consumption at 1 postnatal month (B = -0.08; 95% CI = -0.13, -0.03; P < 0

191 via whisker trimming for the animals' first postnatal month.

192 rted 6.9 +/- 2.1 breastfeedings per day at 1 postnatal month.

193 at infant cognitive development scores at 24 postnatal months correlated inversely with maternal fruc

194 ompleted two 24-h dietary recalls at 1 and 6 postnatal months, and reported breastfeedings per day.

195 ternal fructose and SSB + J consumption at 6 postnatal months.

196 s in community assembly during the first six postnatal months.

197 lates neuronal apoptosis, and leads to early postnatal mortality.

198 ented Pou3f4 protein expression in the early postnatal mouse cochlea and compared SGNs in Pou3f4 knoc

199 primordial follicle formation during early, postnatal mouse oogenesis.

200 ile actively transcribed genes in developing postnatal mouse PCs and used metagene projection to iden

201 nd the likely involvement of neuronal NAA in postnatal myelination in these mice.

202 Regarding postnatal myelination, myelin basic protein (MBP) and my

203 the role of NAA as a lipid precursor during postnatal myelination.

204 pring during this critical period and alters postnatal neurodevelopment.

205 ced at PND21, suggesting a potential role of postnatal nutrition in facilitating the sex-specific adi

206 owever, no differences were observed between postnatal-OIRKO and control mice in: body composition (l

207 ) genotypic male and female mice (designated postnatal-OIRKO).

208 search provides a comprehensive resource for postnatal OTR expression in the mouse brain.

209 tially heterogeneous patterns with transient postnatal OTR expression without cell death.

210 During the early postnatal period in developing mice, GABAergic neurons a

211 During the postnatal period in mammals, the cardiac muscle transiti

212 ch from excitatory to inhibitory at an early postnatal period in rodents.

213 The postnatal period is also a time of rapid brain growth, a

214 from elevated apoptosis during the critical postnatal period of programmed cell death (PCD).

215 Thus, innervation of ipRGCs in the early postnatal period tunes the IGL(NPY)-SCN circuit to allow

216 logical functions and transitions during the postnatal period were examined in sorted cells using RNA

217 maintaining SGN populations during the early postnatal period.

218 ly and highly expressed in both prenatal and postnatal periods and demostrate enriched expression in

219 Exercise studies targeting postnatal periods of hippocampal maturation (specificall

220 ppocampal excitability when occurring during postnatal periods of hippocampal maturation.

221 freely accessed a running wheel during three postnatal periods: the 4(th) postnatal week (juvenile EL

222 rom E16 to weaning, significantly suppressed postnatal peripheral proinflammatory insult-induced syst

223 th inhibition of angiogenic signaling, and a postnatal phase with proteolytic activity and reduced el

224 In the postnatal phase, lung capillaries (< 20 um) were signifi

225 We speculate that antenatal or postnatal PHi therapy may provide novel strategies to pr

226 rcate the genes and transcripts that produce postnatal piRNAs in human juvenile and adult testes.

227 ic origins and transcriptional regulation of postnatal piRNAs remain undefined.

228 n, migration, and axonal guidance as well as postnatal plasticity.

229 ogy end points of the uteri were analyzed at postnatal (PND) day 21, 90, and 365.

230 te bursts increased progressively during the postnatal prehearing period yet remained dependent on P2

231 roblems, hyperactive startle reflex), severe postnatal progressive neurological abnormalities (includ

232 bjectives: To determine whether antenatal or postnatal prolyl-hydroxylase inhibitor (PHi) therapy inc

233 Maternal pre-postnatal psychosocial distress increases the risk for c

234 -endorphin peptides in the hypothalamus in a postnatal rat model of fetal alcohol spectrum disorders.

235 red from hypothalamic tissues collected from postnatal rats (both males and females) fed daily with 2

236 m hypothalamic microglia cells obtained from postnatal rats, grown in cultures for several days, and

237 ival from fetal diagnosis to age 6 years and postnatal restricted mean transplant-free survival time.

238 Interestingly, signals secreted by the early postnatal retina suppressed acquisition of mature GABA r

239 Deletion of GLUT1 from the developing postnatal retinal endothelium reduces retinal EC prolife

240 eolar type 2 cell proliferation.Conclusions: Postnatal rhIGF-1/BP3 treatment preserved lung structure

241 muscle function, consistent with a prolonged postnatal role for EphA4 in adolescent muscle growth.

242 estimated associations of repeated pre- and postnatal serum PFAS concentrations with adolescent adip

243 Families were approached via antenatal or postnatal services for recruitment of term infants (at l

244 ed the cellular dynamics taking place during postnatal skin epidermis expansion.

245 se findings point to the significant role of postnatal social experience in specialised face percepti

246 elty-induced exploration in adulthood due to postnatal SSRI exposure.

247 as the appendages, or during homeostasis in postnatal stages and adulthood.

248 docrine progenitors were normal during early postnatal stages but gradually developed diabetes before

249 Innervation of ipRGCs at early postnatal stages influences IGL neurons that express neu

250 ions of somatostatin interneurons from early postnatal stages of cortical development.

251 At early postnatal stages with low GZ vascularization, Hif1alpha

252 f VGluT2 in DA neurons can be reactivated at postnatal stages, contributing to postlesional plasticit

253 -sequencing data of mouse hearts at multiple postnatal stages, we construct cellular interactomes and

254 rowth greatly outpaces that of the RV during postnatal stages.

255 al muscle tissues from embryonic, fetal, and postnatal stages.

256 fibroblasts, adult tail-tip fibroblasts and postnatal supporting cells into induced hair cell-like c

257 xone treatment exhibited comparable rates of postnatal survival and growth to carrier-treated control

258 absorption, diminishes diarrhea and rescues postnatal survival.

259 oss brain development in mice, we identify a postnatal switch in the transcriptional regulatory circu

260 a delayed effect of season of conception on postnatal telomere maintenance.

261 dependent effects of prenatal THs related to postnatal temperature on growth, survival and potential

262 atogonial stem/progenitor cell population in postnatal testis.

263 quencing (scRNA-seq) to examine the immature postnatal thymocyte population in humans.

264 tal balance of neural connections during the postnatal time period.

265 or organogenesis and plays critical roles in postnatal tissue maintenance and renewal.

266 p mouse dentoalveolar defects at 42 and 90 d postnatal to comparatively define effects of XLH on dent

267 ialized craniofacial morphology preceded the postnatal transformation of the skull anatomy in adults

268 ory events (CRE), in preterm neonates during postnatal transition.

269 To better understand the mechanics of postnatal transmission, we performed a comprehensive stu

270 H is unknown.Objectives: To evaluate whether postnatal treatment with rhIGF-1 (recombinant human IGF-

271 and vascular homeostasis by participating in postnatal vasculogenesis.

272 ancer cluster was essential for prenatal and postnatal ventricular expression of Nppa and Nppb but no

273 esis and neural differentiation in the young postnatal ventricular-subventricular zone (V-SVZ), in wh

274 More than 75% of antenatal and postnatal visits were provided by a named/partner midwif

275 Postnatal visits with 155 mother-infant dyads occurred w

276 postnatal week (juvenile ELE, P21-27), 6(th) postnatal week (adolescent ELE, P35-41), or 4(th)-6(th)

277 el during three postnatal periods: the 4(th) postnatal week (juvenile ELE, P21-27), 6(th) postnatal w

278 collected from embryonic day 12.5 (E12.5) to postnatal week 8 (W8), encompassing major developmental

279 ha10-mediated transmission beyond the second postnatal week associated with abnormally persistent cho

280 unctional histamine receptors from the first postnatal week onwards, with histamine having diverse ef

281 stamine receptors in striatum from the first postnatal week onwards, with pronounced developmental in

282 triatal synaptic transmission from the first postnatal week onwards.

283 igodendrocytes during the first or the third postnatal week significantly reduces oligodendrocyte iro

284 atal histaminergic innervation by the second postnatal week, and qRT-PCR shows transcripts for H(1),

285 ent LTP via H(3) receptors during the second postnatal week, but inhibits synaptic plasticity at late

286 life exercise, specifically during the 4(th) postnatal week, can enable hippocampal memory, synaptic

287 l cortex becomes prominent during the second postnatal week.

288 g and excitability decreasing into the third postnatal week.

289 of the deep cortical layers until the first postnatal week.

290 eek (adolescent ELE, P35-41), or 4(th)-6(th) postnatal weeks (juvenile-adolescent ELE, P21-41).

291 ring the establishment of emmetropia between postnatal weeks 4-6.

292 mPFC neuron excitability during the first 2 postnatal weeks caused a premature differentiation of ol

293 d at higher levels in the embryo and earlier postnatal weeks, it is also expressed in the adult rat b

294 Starting from about 4 postnatal weeks, SOD1-G93A and wild-type (WT) mice were

295 th acutely and longer-term, during the first postnatal weeks, using patch-clamp and field recordings

296 each their ventral destinations during first postnatal weeks.

297 Low birthweight and decreased postnatal weight gain are known predictors of worse reti

298 brain excitatory neurons during the critical postnatal window is sufficient to program altered mood-r

299 Here we show that postnatal ZIKV infection in a rhesus macaque model resul

300 Overall, this study demonstrates that postnatal ZIKV infection in this model may have long-las