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1 STDP rule in which pairs of single pre- and postsynaptic action potentials induce synaptic modificat
3 al mitochondrial bioenergetics that the fuel postsynaptic activities of the respiratory motor drive.
5 transient ACh signaling with more sustained postsynaptic activity patterns to support relatively per
6 , whereby similarity between presynaptic and postsynaptic activity selectively strengthens some synap
8 teract trans-synaptically with multitudinous postsynaptic adhesion molecules, including SliTrks, SALM
9 n the AWC sensory neurons, which inhibit the postsynaptic AIA interneurons to override and disrupt AF
10 f synaptic plasticity involve the control of postsynaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolep
11 air cells from TMIE mutant mice show altered postsynaptic alpha9alpha10 function and retain alpha9alp
12 can interact with presynaptic neurexins and postsynaptic AMPA-type ionotropic glutamate receptors an
13 ergic currents by promoting the insertion of postsynaptic AMPARs that contain fast desensitizing flop
14 owever, the effects of mTORC1 on eEPSCs were postsynaptic and the effects of mTORC2 were presynaptic.
15 complex biochemical networks at presynaptic, postsynaptic, and astrocytic sites to the time window of
16 ental disorders, with the majority affecting postsynaptic apparatuses and much fewer in presynaptic p
17 s(2-4), and silences these neurons and their postsynaptic ascending neurons in the abdominal ganglion
20 of presynaptic partners and communicate with postsynaptic brain regions to convey features of the vis
21 s of Ca(2+) dynamics indicated that rises in postsynaptic Ca(2+) are necessary and sufficient for Z-L
22 electrical stimulation, and is sensitive to postsynaptic Ca(2+) chelation and blockers of nicotinic
23 induce LTP, which was prevented by chelating postsynaptic Ca(2+) or blocking nicotinic receptors.
27 connections of dopaminergic cells and their postsynaptic cells, AII amacrine and melanopsin-containi
28 idelity was affected by both presynaptic and postsynaptic changes after ear occlusion and was only af
30 echanisms, such as retrograde signaling from postsynaptic cholinergic and GABAergic systems, among ot
31 with NS9283 restores the rapid onset of the postsynaptic cholinergic response without triggering des
33 This impairment correlates with disrupted postsynaptic clustering of Homer1b, Shank, and AMPAR sub
34 vity-dependent accumulation of Msp300 in the postsynaptic compartment of the Drosophila larval neurom
37 , which determines the shape of the pre- and postsynaptic compartments, organizes the neurotransmitte
40 n in complex with PSD-95 or PSD-95-assembled postsynaptic complexes form highly concentrated and dyna
43 d the relative importance of presynaptic and postsynaptic contributions to the faithful transfer of i
45 g Na(+)/H(+) exchange activity decreased the postsynaptic current and caused failures in postsynaptic
46 h ASD exhibited reduced miniature excitatory postsynaptic current frequency and N-methyl-D-aspartate
47 ecapitulated diminished miniature excitatory postsynaptic current frequency, supporting a role for th
49 uction of synchronous spontaneous inhibitory-postsynaptic-current events in mutants, which was revers
50 /kainate receptor-mediated evoked excitatory postsynaptic currents (eEPSCs), by 94% and 72%, respecti
51 ls (BCs), we found that classical excitatory postsynaptic currents (EPSCs) are followed by GABA(A) re
53 led higher frequency of miniature excitatory postsynaptic currents (mEPSCs) immediately after 2-h imm
54 potentials (fEPSPs) and miniature excitatory postsynaptic currents (mEPSCs) in rat hippocampal slices
55 s and decreased frequency of mini inhibitory postsynaptic currents (mIPSC) in the NAc of susceptible
56 The observation of spontaneous excitatory postsynaptic currents (sEPSCs), spontaneous inhibitory p
57 ssion (versus N40) of spontaneous inhibitory postsynaptic currents (sIPSCs) across multiple subjects.
58 sant-induced burst of spontaneous inhibitory postsynaptic currents (sIPSCs) on CA1 pyramidal neurons
59 ic currents (sEPSCs), spontaneous inhibitory postsynaptic currents (sIPSCs), and bidirectional electr
60 the amplitude of the spontaneous excitatory postsynaptic currents and decreased the frequency of spo
61 nd modeled using intracellular recordings of postsynaptic currents and potentials, inferring synaptic
63 ity of only one motoneuron and recordings of postsynaptic currents from inputs formed by the differen
64 ity by inferring the magnitude of excitatory postsynaptic currents from the N20 component of the soma
67 uced the frequency of spontaneous excitatory postsynaptic currents in the direct pathway MSNs, wherea
69 viously shown that the physiological size of postsynaptic currents maximises energy efficiency rather
70 neurons in heterozygous mice evoked biphasic postsynaptic currents not significantly different from t
72 me of NMDAR-dependent spontaneous excitatory postsynaptic currents suggesting a prolonged open time o
78 igured as presynaptic axon terminations onto postsynaptic dendrites or somata, giving rise to axo-den
79 sed PSD95-eGFP mice, to visualise excitatory postsynaptic densities (PSDs) using high-resolution and
80 nt mono-ubiquitination, compartmentalized at postsynaptic densities, gates retrograde signaling and p
83 ence point to glutamatergic signaling in the postsynaptic density (PSD) as a pathophysiologic mechani
85 ASD risk genes and genes encoding inhibitory postsynaptic density (PSD) proteins, but not for genes i
87 f neuronal nitric oxide synthase (nNOS) from postsynaptic density 95 (PSD95) and a reduced production
91 tron microscope imaging demonstrated reduced postsynaptic density formation and fewer dendritic polyr
95 m the smooth endoplasmic reticulum) near the postsynaptic density to promote the persistent firing ne
96 to cell bodies and dendrites, including the postsynaptic density, and within the last 5 years severa
97 guingly suggests that SR may be found at the postsynaptic density, yet the functional implications of
98 thyl-d-aspartate receptor subunit 2B (NR2B), postsynaptic density-95 (PSD-95) and microtubule-associa
99 ely 65%) of LDLR and LRP1 is associated with postsynaptic density-95 (PSD-95)-positive synaptosomes,
102 s implicated in learning and memory in which postsynaptic depolarization strengthens synapses, promot
103 ASP1 and LASP2 play an important role in the postsynaptic development of rat hippocampal neurons from
104 ecific exon are necessary and sufficient for postsynaptic differentiation and scaling growth, and the
105 by neuronal activity and requires increased postsynaptic differentiation induced by insulin receptor
106 ns of antipsychotic drugs on presynaptic and postsynaptic dopamine dysregulation, this study evaluate
107 ribbons are normally apposed to two distinct postsynaptic "dyad" partners, but in the absence of LRRT
109 e conditions allows the determination of the postsynaptic E/I ratio for at least 120 h after death, e
111 synaptic plasticity involves presynaptic and postsynaptic elements as well as adjacent astroglial pro
112 There was also a decrease in phagocytosis of postsynaptic elements by microglia expressing TREM2R47H
115 Electrophysiological measurements assessing postsynaptic expression mechanisms, and imaging studies
116 neuronal release of transmitter up-regulates postsynaptic expression of appropriate transmitter recep
123 s, but the effect is mediated by the loss of postsynaptic GABA(A) receptors, gephyrin, and neuroligin
125 ransmitter release in response to diminished postsynaptic GluR functionality, a process referred to a
126 necessary for the homeostatic modulation of postsynaptic GluRs in mammals, our data demonstrate that
127 about the auxiliary subunits associated with postsynaptic GluRs, far less is understood about presyna
128 factor BIN1, and that Amph itself modulated postsynaptic glutamate receptor (GluRII) localization.
132 letion in granule cells of the OB of Bai3, a postsynaptic GPCR that binds C1ql3, similarly suppressed
133 scillations in a cell-intrinsic manner, with postsynaptic Group 1 metabotropic glutamate receptor act
134 thalamoreticular inputs but did not require postsynaptic Group 1 metabotropic glutamate receptor act
135 are presynaptic homomeric GlyRs, rather than postsynaptic heteromeric GlyRs (which mediate glycinergi
136 of presynaptic homomeric GlyRs (rather than postsynaptic heteromeric GlyRs), because homomeric GlyRs
137 show that selective block of Panx1 in single postsynaptic hippocampal CA1 neurons from male rat or mo
138 napses undergo bidirectional presynaptic and postsynaptic homeostatic changes with increased and decr
142 neurotransmission.SIGNIFICANCE STATEMENT The postsynaptic ion and metabolite channel, pannexin-1, is
144 n pre- and post-synaptic cells, we find that postsynaptic Kenyon cells set convergence ratio: Kenyon
145 c voltage-gated calcium channels (VGCCs) and postsynaptic ligand-gated ion channels such as AMPA rece
147 ere unitary release of glutamate can trigger postsynaptic local activation of voltage-gated Na(+)-cha
148 inotopic alignment, (2) the amplitude of the postsynaptic local field potential elicited near the int
149 Here, we show an age-dependent dendritic and postsynaptic localization of SR and d-serine by immunohi
151 Certain transcriptional programs (e.g., postsynaptic machinery) are segregated to specialized do
152 by the increase of anatomic presynaptic and postsynaptic markers in the peri-infarct zone and corres
153 tic morphogenesis, increased accumulation of postsynaptic markers, early expression of synapse activi
154 reased frequency of sIPSCs without affecting postsynaptic measures, suggesting increased CeA GABA rel
155 cells in rodent hippocampus likely through a postsynaptic mechanism, and has a variable effect on the
160 smission from the presynaptic calyces to the postsynaptic medial nucleus of the trapezoid body (MNTB)
161 e that the focal insertion of AChRs into the postsynaptic membrane is regulated by stable MTs and hig
162 were dependent on Ca(2+) movement across the postsynaptic membrane, rather than neurotransmitter rele
166 to influence active zone formation, whereas, postsynaptic miR-34 inhibits Hts to regulate the initiat
168 Here, we analyze the response of a single postsynaptic model neuron receiving tuned excitatory con
169 provide functional evidence of Amh-mediated postsynaptic modulation of synaptic transmission and Amh
172 s glutamatergic motoneurons that coinnervate postsynaptic muscles of male or female Drosophila melano
173 creasing release of ACh onto presynaptic and postsynaptic nAChRs in primary auditory cortex (A1).
175 napses with highly organized presynaptic and postsynaptic nanomachines that are aligned by synaptic a
176 inding to presynaptic neurexin-1alpha and to postsynaptic neuroligin-1B, thereby catalyzing formation
178 in layer 2/3 and favoured locations near the postsynaptic neuron and ahead of its preferred direction
180 retina via coordinate regulation of pre and postsynaptic neuron structure and the localization of sy
182 d, synapses, the overall excitability of the postsynaptic neuron, and how recently the postsynaptic n
183 coaxial to the preferred orientation of the postsynaptic neuron, favouring the region opposite to it
184 sensory cortex, we show that a signal from a postsynaptic neuron, orchestrated by endocannabinoids, a
185 findings support a cell-autonomous role for postsynaptic neuronal SR in regulating synaptic NMDAR fu
186 e transfer anterogradely from presynaptic to postsynaptic neurons in the adult Drosophila olfactory s
192 tical structures to bi-directionally control postsynaptic neurons, thus helping to orchestrate severa
193 e optogenetic manipulations of input-defined postsynaptic neurons, we show that dCA1 PYRs drive NAc m
195 NARE fusion machinery play critical roles in postsynaptic neurotransmitter receptor trafficking, whic
196 ll understood, the basis of specification of postsynaptic neurotransmitter receptors matching the new
197 but control synapse properties by regulating postsynaptic NMDA-receptors via a trans-synaptic mechani
198 -induced tonic activation of presynaptic and postsynaptic NMDARs at the spinal cord level and that pr
200 ory synapses whereby Ca(2+)-entering through postsynaptic NMDARs promotes the recruitment and strengt
202 unexpected role for metabotropic NMDARs and postsynaptic Panx1 in suppression of facilitated glutama
207 signaling between potential presynaptic and postsynaptic partners, the extracellular factors and the
208 ntials propagate through long axons to their postsynaptic partners, which requires axons not only to
212 glutamate transporter inhibition reduced the postsynaptic population response to TBS, calcium respons
214 ration time window of concomitant excitatory postsynaptic potentials (EPSPs) and dampens their tempor
215 were examined by recording field excitatory postsynaptic potentials (fEPSPs) and miniature excitator
217 itic propagation attenuates the amplitude of postsynaptic potentials and widens their temporal spread
218 e and sharpens the time course of excitatory postsynaptic potentials by reducing current sinks and mo
220 ion and even decrease the temporal spread of postsynaptic potentials, if active subthreshold potassiu
224 ns were regulated, including pre- as well as postsynaptic proteins with diverse molecular functions.
225 disease caused by autoantibodies that target postsynaptic proteins, primarily the acetylcholine recep
226 us fluorescent labeled presynaptic VAMP2 and postsynaptic PSD95 in long-term cultured live primary ne
227 INs) and decreased intrinsic excitability of postsynaptic Purkinje neurons (PNs) resulted in low PN f
229 btypes, including in presynaptic plasticity, postsynaptic receptor function, and synaptic connectivit
230 presynaptic ligand cerebellin-1 (Cbln1) and postsynaptic receptor GluD2 mediate synaptogenesis betwe
234 concentrations of GABA can both activate the postsynaptic receptors generating sustained low-amplitud
235 cation requires the expression of functional postsynaptic receptors that match the presynaptically re
236 n-3 (Lphn3) are adhesion GPCRs that serve as postsynaptic recognition molecules in CA1 pyramidal neur
237 ressed in larval muscles and enriched in the postsynaptic regions of the glutamatergic neuromuscular
238 resulted in sustained synaptic inhibition in postsynaptic relay neurons of the ventrobasal thalamus (
239 underlying estradiol-induced alterations in postsynaptic response to GABA, and also AMPA, receptor a
241 mulation of the claustrum induced excitatory postsynaptic responses in most neocortical neurons, but
242 lances excitation, resulting in uncorrelated postsynaptic responses regardless of the inhibitory tuni
245 at mTORC1 and mTORC2 differentially modulate postsynaptic responsiveness and presynaptic release to o
246 Although previous studies have delineated postsynaptic roles for mTOR, whether it regulates presyn
249 at complexes containing CaMKII and Shank3, a postsynaptic scaffolding protein known to interact with
250 ssemblies likely form via interactions among postsynaptic scaffolding proteins and receptors and alig
251 n brain circuits, uniform downscaling on the postsynaptic side is implicated in sleep- and memory-rel
254 erefore operates on both the presynaptic and postsynaptic sides to maintain target cell activity.
255 nstrated how these drugs modulate inhibitory postsynaptic signaling by direct binding to the postsyna
256 istinct vHC-PrL projection neurons modulates postsynaptic signaling in both inhibitory and excitatory
257 structure and morphology, neurotransmission, postsynaptic signaling pathways, and neural circuitry to
262 f synaptic activity in ovBNST, which acts at postsynaptic sites to dampen excitability at short and l
263 onstrate that SULT4A1 is highly expressed at postsynaptic sites where it sequesters Pin1, preventing
264 NAcylation are found at both presynaptic and postsynaptic sites, and O-GlcNAcylated proteins localize
265 er of efferent synapses per OHCs, defined as postsynaptic SK2 puncta, was reduced in aged OHCs of all
267 t-mediated changes in the number of pre- and postsynaptic spike pairing events and by firing rate cha
268 sticity can only be recovered when bursts of postsynaptic spikes are used, or when neurons fire at su
269 well as effects due to the recent history of postsynaptic spiking and slow changes in postsynaptic ex
270 eters estimated from ongoing presynaptic and postsynaptic spiking are highly uncertain, our results a
271 her or not a synaptic current contributes to postsynaptic spiking depends not only on the amplitude o
273 , using only observations of presynaptic and postsynaptic spiking, aims to describe the dynamics of i
277 density, yet the functional implications of postsynaptic SR on synaptic transmission are not yet kno
280 educed active zone (AZ) number and decreased postsynaptic subsynaptic reticulum volume, with the emer
282 ecific neuronal classes innervating the same postsynaptic target display distinct types of plasticity
284 al transmission of ACh and GABA based on the postsynaptic target neuron is reflected in VIP(+)/ChAT(+
286 le of GluA3 may be important to allowing the postsynaptic targets of spherical bushy cells in mice us
287 ctivity that occur at the synapse in vivo to postsynaptic targets that use rate information for sound
288 initial over-innervation by multiple pre- or postsynaptic targets, followed by a process of refinemen
296 insights into the mesoscale architecture of postsynaptic trafficking compartments and their regulati
298 how interplay between adhesion molecules and postsynaptic transmitter receptors orchestrates function