ライフサイエンスコーパス: preassembled

1 ignaling components are compartmentalized or preassembled.

2 ether with E1b to degrade de novo-expressed, preassembled AAV5 capsid proteins and Rep52 in a proteos

3 lts show first that aneural myotubes contain preassembled AChR protein complexes that may function in

4 We show that preassembled actin filaments are cross-linked directly b

5 The persistence of preassembled and complete translocons between successive

6 ined size and having the same effect on both preassembled and growing FtsZ protofilaments.

7 Glycophosphorylation of preassembled and properly protected peptides was found t

8 d functional elongation complexes, by mixing preassembled and RNA-primed DNA "bubble" constructs with

9 Duct cell P2X7Rs are preassembled and therefore continually subject to rapid

10 Thus, the apicosome is a unique preassembled apical structure that can be rapidly used i

11 proximity measurements support formation of preassembled apo-GHSR1a:DRD1:Galphaq heteromeric complex

12 r assembly, and induced rapid disassembly of preassembled asters.

13 ng to rapid degradation, and Ste2-3p that is preassembled at the plasma membrane is also removed and

14 tional elongation activity of pol II that is preassembled at the transcription start site.

15 adapters that enable flagellar transport of preassembled axonemal substructures by IFT.

16 ed "threading," passing between parts of the preassembled beta-subunit.

17 related stopped-flow signals revealed that a preassembled beta.

18 y, simulations of these systems start from a preassembled bilayer because the timescale on which self

19 n of downstream signal transduction involves preassembled BRI1-BAK1(SERK3) heterooligomers.

20 Our results suggest that preassembled building blocks present a viable route to h

21 blunt-ended alpha-helical barrels, that is, preassembled bundles of alpha-helices with central chann

22 though purified MAC complexes generated from preassembled C5b6 perforate artificial lipid membranes a

23 One function of this cap may be to provide preassembled Ca(2+) channel components to existing and n

24 the structural effects of TRIM5 proteins on preassembled CA-NC complexes by electron microscopy.

25 odeling at cell-cell contacts and stabilizes preassembled cadherin complexes.

26 bacteriophage varphi29, DNA is packed into a preassembled capsid from which it ejects under high pres

27 molecular motors to translocate dsDNA into a preassembled capsid shell.

28 l molecular motor compacts the genome into a preassembled capsid.

29 Genomic DNA is inserted into preassembled capsids through a unique portal vertex.

30 pose that UL32 may play a role in "bringing" preassembled capsids to the sites of DNA packaging and t

31 eavage and packaging of herpesvirus DNA into preassembled capsids.

32 nome-editing tool for the direct delivery of preassembled Cas9 ribonucleoproteins into protoplasts of

33 Preassembled CB1-Galphai complexes were detected by BRET

34 The LUBAC also participates in preassembled CBM complex in cells derived from ABC DLBCL

35 ing, which explains how they can inhibit the preassembled Cdk4/6-cyclin D complexes as well.

36 polysaccharides, which bind to surfaces as a preassembled cell group.

37 ing newly synthesized CENP-A and maintaining preassembled CENP-A at centromeres.

38 e of NURF in activating transcription from a preassembled chromatin template and have found that NURF

39 that Staf activates U6 transcription from a preassembled chromatin template in vitro and associates

40 (II)s are necessary for transcription from a preassembled chromatin template.

41 AP3 binds both inositol hexakisphosphate and preassembled clathrin cages with high affinity.

42 We confirmed that TNFR1 forms preassembled clusters at the plasma membrane of adherent

43 1) and Pt@Pb(1)(2)(1)(-) were prepared from "preassembled" clusters generated from crystalline sample

44 ds the need for liquid infiltration into the preassembled colloidal crystal and minimizes the associa

45 d lithographically fabricate two-dimensional preassembled colloidal linkages of custom-shaped, discre

46 We demonstrate the approach using preassembled colloidal tetrahedra and spheres, obtaining

47 helial cells, PAR1 and beta-arrestins form a preassembled complex and cosegregate in caveolin-1-enric

48 l delta and Pol zeta catalytic subunits on a preassembled complex of accessory proteins retained on D

49 nity either to empty importin alpha5 or to a preassembled complex of importin alpha5 bound to the C-t

50 in vitro CCT-ACT1-PLP2 folding cycle of the preassembled complex takes 90 s at 30 degrees C, several

51 nactive heterotrimeric G proteins, forming a preassembled complex that is potentially braced for GPCR

52 The first of these assemblies is a preassembled complex with the receptor in its basal conf

53 ll three nonidentical CBF/NF-Y subunits in a preassembled complex.

54 OPII vesicles, implying their ER export as a preassembled complex.

55 ignals with both rapid reaction times of the preassembled complexes and efficient resupply at the mem

56 In contrast, preassembled complexes catalyzed strand transfer equally

57 ments have suggested stepwise recruitment of preassembled complexes, including chromatin remodeling,

58 ocking binding by Mnk1, which occurs only on preassembled complexes, resulting in dephosphorylation o

59 of PIP2 by PIP5K then recruited TIRAP to the preassembled complexes, which were required for TLR sign

60 are unlikely to exist in stable constitutive preassembled complexes.

61 hibited catalytic activities of IN in IN-DNA preassembled complexes.

62 we introduce a new design principle based on preassembled components of the desired superstructure an

63 -negative Orai1 monomer along with different preassembled concatenated Orai1 constructs, we recently

64 hin the triad junction but do not exist in a preassembled context.

65 It aligns paired-end (PE) reads and preassembled contigs or scaffolds to a close reference.

66 roach to viral haplotype reconstruction from preassembled contigs.

67 -based magnets by postsynthetic reduction of preassembled coordination networks that incorporate chro

68 Using microinjection of preassembled cores as a tool, a system has been establis

69 nelles, the fusiform vesicles, which deliver preassembled crystalline arrays of uroplakin proteins to

70 ng of Scm3 can replace histones H2A-H2B from preassembled Cse4-containing histone octamers.

71 Moreover, kinetic study of preassembled cube and tetrahedron demonstrated a slow li

72 microtubule assembly and cause breakdown of preassembled cytoplasmic microtubules in human polymorph

73 A preassembled DAMed complex bypasses the requirement for

74 ment and selection, we generated mice with a preassembled Dbeta1Jbeta1.1 complex on the Jbeta1(omega)

75 that a preassembled TCRbeta gene, but not a preassembled DbetaJbeta complex or the prosurvival BCL2

76 mesh-like polylithomers having controllable preassembled dimensions, topologies, configurations, int

77 A preassembled DJbeta complex that decreases the number of

78 Finally, inclusion of an endogenous preassembled DJbeta complex that enhances Vbeta recombin

79 Gold electrodes modified with preassembled DNA duplexes are used to monitor the electr

80 The PNA-peptides were found to bind to the preassembled DNA nanocage in 5-10 min at room temperatur

81 oters on which Notch:CSL complexes have been preassembled, ensuring tight transcriptional control of

82 ed number of permissive GC niches containing preassembled FDC clusters.

83 Co, Ni, Cu), have been synthesized using the preassembled [Fe3O(OOCCH3)6] building block.

84 gree in a Rho-independent fashion, gathering preassembled filaments to the equatorial zone via cortic

85 or approximately 25 s with the barbed end of preassembled filaments, inhibiting their elongation.

86 VopL/F do not associate with the ends of preassembled filaments.

87 Immunoprecipitation shows that large preassembled flagellar complexes containing all five tes

88 s subunit proteins can exist in immature and preassembled forms, but may execute cellular roles irrel

89 rete candidates, this soft strategy based on preassembled frameworks will help integrate specific com

90 volatile anesthetics were introduced into a preassembled fully hydrated 512-molecule lipid bilayer a

91 Expression of either a preassembled functional TCRbeta gene (Vbeta1(NT)) or the

92 , Ccnd3(-/-), and Lat(-/-) mice containing a preassembled functional Vbeta1DJCbeta1 (Vbeta1(NT)) gene

93 nalyzed mice with TCRbeta alleles containing preassembled functional VbetaDJbetaCbeta1 genes.

94 aryltransferase (OST), PglB, which transfers preassembled glycans to specific asparagine residues in

95 de novo from the ER or whether it requires a preassembled Golgi matrix.

96 reas PIGT is essential for attachment of the preassembled GPI anchor to proteins.

97 l sequence and replaces this sequence with a preassembled GPI anchor.

98 nsists of a transamidation reaction in which preassembled GPI donors are substituted for C-terminal s

99 complex) with the ethanolamine moiety of the preassembled GPI unit serving as a nucleophile.

100 dings are consistent with a model in which a preassembled GT1b-synaptotagmin complex constitutes the

101 ase concentrations, occurs by threading of a preassembled helicase over free 5'-ends, an event that c

102 lishment of centromeric heterochromatin, but preassembled heterochromatin can be maintained when Chp1

103 f BMPRII exhibit confined motion, reflecting preassembled heteromeric receptor complexes.

104 ic reticulum (ER), catalyzes the transfer of preassembled high mannose oligosaccharides onto certain

105 ransferase (OST), involves the transfer of a preassembled high-mannose oligosaccharide from a dolicho

106 and Artemis-deficient B cells that harbored preassembled Ig heavy chain and kappa-light chain "knock

107 sayed CSR in Lig4(R/R) B cells generated via preassembled IgH and IgK V region exons (HL).

108 91, which demonstrates late association with preassembled IMV, also did not show any quenching.

109 transcription and processing components are preassembled in Cajal bodies before transport to the chr

110 We find that IL-15 and IL-15Ralpha are preassembled in complexes within the endoplasmic reticul

111 aining syntaxin-1, SNAP-25, and Munc18-1 are preassembled in microdomains on the presynaptic plasma m

112 ) are essential for ciliary motility and are preassembled in the cytoplasm before trafficking into ci

113 yneins are multisubunit enzymes that must be preassembled in the cytoplasm, transported into cilia by

114 nein arm (ODA) motor complexes, produced and preassembled in the cytosol, are transported to the cili

115 ur data suggest that a WC-1/NGF-1 complex is preassembled in the dark on light-inducible promoters an

116 its surrounding a central channel, which are preassembled in the ER and transported in their final st

117 Eukaryotic ribosomes are preassembled in the nucleus and mature in the cytoplasm.

118 ts multimerize, and, if so, whether they are preassembled in the plasma membrane.

119 intrinsically stable prothrombinase complex preassembled in the venom gland of the Australian Easter

120 Importantly, the regulatory spine is preassembled in this gatekeeper mutant, rendering phosph

121 rangements in Vbeta14(Rep) mice containing a preassembled in-frame transgenic Vbeta8.2Dbeta1Jbeta1.1

122 we compared caspase-1 activation induced by preassembled insoluble ASC specks and soluble monomeric

123 FBG preassembled into matrix prior to scrape-wounding induce

124 Lys-174, Arg-239, Asn-280, and Tyr-289) are preassembled into the active site in the absence of DNA

125 In X. leavis M phase extracts, preassembled kinetochores disassemble after inhibiting A

126 recognition, or when added exogenously to a preassembled lipid vesicle complex, underscoring the imp

127 itution system, we show that MEX-5 dissolves preassembled liquid-like PGL-3/RNA condensates by alteri

128 The resulting colloidal clusters serve as "preassembled" mesoscale building blocks for larger-scale

129 ry systems, with approximately 25% acquiring preassembled metal cofactors.

130 ters requires its direct interactions with a preassembled MHC-II enhanceosome consisting of cyclic AM

131 ls moderate binding affinity between tau and preassembled microtubules and rapid dissociation/associa

132 , both HTI-286 and hemiasterlin depolymerize preassembled microtubules at micromolar concentrations.

133 inding occurs between tau and the surface of preassembled microtubules, whereas irreversible binding

134 he effects of HTI-286 on soluble tubulin and preassembled microtubules.

135 isoform and caused disassembly when added to preassembled microtubules.

136 lexes, and coactivators are recruited to the preassembled MMP-9 promoter in a stepwise and coordinate

137 ity, we investigated the effect of Gadd45 on preassembled mononucleosomes.

138 Preassembled MukBEF was inert in DNA binding or reshapin

139 cruitment of additional Orai1 units to these preassembled multimers in order to form functional chann

140 of these spore coat glycoproteins exist as a preassembled multiprotein complex (the PsB multiprotein

141 r circular double-stranded DNA template with preassembled mushroom-shaped nanostructures having a pos

142 ts with calcium channel beta subunits in the preassembled N-type channel, thereby forming a nonconduc

143 late physiological H/ACA RNP assembly with a preassembled NAF1/dyskerin/NOP10/NHP2 scaffold purified

144 ions within the hysteresis loop, addition of preassembled nanofiber seeds leads to seeded polymerizat

145 In this study, we test whether the preassembled nature of the SCT makes them effective for

146 ce resonance energy transfer to characterize preassembled neuronal SNARE complexes consisting of synt

147 In our implementation, preassembled NGS contigs are used to derive the compact

148 K(+)-dependent conformational change of the preassembled NLRP3-inactive inflammasome during cell swe

149 gs suppress by releasing exosomes that carry preassembled NOX2 membrane clusters and are taken up by

150 During the assembly of alphaviruses, a preassembled nucleocapsid buds through the cell plasma m

151 rotein via a cytoplasmic endodomain with the preassembled nucleocapsid.

152 ase of H4), in activating transcription from preassembled nucleosomal array templates in vitro.

153 H4 (NuA4) stimulate HIV-1 transcription from preassembled nucleosomal templates in an acetyl CoA-depe

154 mes, activators must either invade a stable, preassembled nucleosome or preempt the formation of nucl

155 ot dissociate, H1 from its binding site on a preassembled nucleosome.

156 o 6- to 8-mer oligomers; condensation of the preassembled oligomers into large clusters containing hu

157 ked protein glycosylation, the transfer of a preassembled oligosaccharide from its lipid carrier onto

158 al step in this process is the transfer of a preassembled oligosaccharide to nascent proteins in the

159 for the maturation of [Fe-S] proteins can be preassembled on a molecular scaffold designated IscU.

160 enhancer function in which a TBP complex is preassembled on a promoter via localized recruitment and

161 d by rapid transfer of [4Fe-4S](2+) clusters preassembled on either the N- or C-terminal domains to t

162 Transcription complexes preassembled on immobilized templates were depleted of p

163 Antibody pairs are preassembled on target-specific, barcoded beads, which e

164 When the helicase was not preassembled on the DNA, a >65-nt long 5'-tail was requi

165 When the helicase was preassembled on the forked DNA before the start of unwin

166 erNAc-alpha-l-Fuc-beta-D-Glc-alpha-D-GalNAc, preassembled on undecaprenyl pyrophosphate (Und-P-P).

167 y they are decorated by a 'glycan', which is preassembled onto a membrane-anchored dolichol molecule

168 nonbent flanking sequence when a nucleosome preassembled onto this template was exposed to the drug

169 Cross-seeding peptide solutions with a preassembled peptide nanotube seed leads to domains of d

170 Using stepwise preassembled PICs, we show that hTR alpha targets either

171 blocked during assembly or dissociated from preassembled PICs.

172 onitored at a typical venous shear rate over preassembled platelet-associated prothrombinase neither

173 in a cell culture model based on delivery of preassembled polyGln aggregates into the cell nucleus.

174 s the regiospecific cyclization of a linear, preassembled polyketide chain catalyzed by aromatase/cyc

175 An alternative strategy is to use a preassembled polymer backbone devoid of sequence informa

176 lity and can rely mostly on the transport of preassembled polymer.

177 that are consistent with the insertion of a preassembled pore complex into the bilayer.

178 ies have suggested that inactive R and G are preassembled (precoupled) as stable R-G complexes.

179 phage 29 packages its 19.3-kbp genome into a preassembled procapsid structure by using a transiently

180 the packaging of double-stranded DNA into a preassembled procapsid.

181 ontain molecular machines that pump DNA into preassembled procapsids, generating internal capsid pres

182 omes from concatemers and packages them into preassembled procapsids.

183 l molecular motors to translocate DNA into a preassembled prohead and compact the DNA to near crystal

184 ase (30-50%) in the elongational activity of preassembled, promoter-paused, pol II, and encompasses a

185 triggered by recruitment of SUMO ligases to preassembled protein complexes.

186 double-stranded DNA genomes package DNA into preassembled protein shells called procapsids.

187 Coscinodiscus wailesii, which suggests that preassembled protein-based templates might be general co

188 vity is usually granted by administration of preassembled protein/RNA complexes.

189 ration of proteolyzed prothrombin species by preassembled prothrombinase in phospholipid-coated glass

190 that BoNT/A simultaneously interacts with a preassembled PSG-synaptotagmin-1 (Syt1) complex and SV2

191 g nucleation of RAD51 by chaperoning a short preassembled RAD51 filament onto the ssDNA complexed wit

192 er reads for construction of highly accurate preassembled reads through a directed acyclic graph-base

193 These advances with versatile, preassembled reagents could greatly reduce the time and

194 on involves conformational rearrangements of preassembled receptor dimers.

195 ation is accompanied by a rearrangement of a preassembled receptor:G protein complex, ultimately lead

196 coating, called a nanocapsule (NC), around a preassembled ribonucleoprotein (RNP) complex between a C

197 ivery of CRISPR-Cas genome editors either as preassembled ribonucleoproteins or encoded in mRNA.

198 ow that many PRGs, in contrast to SRGs, have preassembled RNA polymerase II (Pol II) and positive his

199 functional, robust pillars on well-defined, preassembled Ru porphyrin monolayers on silver and chara

200 via templated nucleation of thin leaflets on preassembled scaffolds made of 20-nm-thick amyloid fiber

201 CRES3 beaded amyloids may function as stable preassembled seeds.

202 may involve the subcellular translocation of preassembled signaling complexes from the plasma membran

203 -specific recombination was used to uncouple preassembled silent chromatin fragments from silencers.

204 ing factors can associate with and stabilize preassembled silent chromatin in non-S-phase cells demon

205 ramework (MOF) with a pcu-a topology using a preassembled soluble molecular octahedron has been reali

206 tenance, we used microneedle manipulation of preassembled spindles in Xenopus egg extracts.

207 I initiation and thereby controls the use of preassembled stable transcription complexes.

208 l factor in end-joining, does not exist in a preassembled state and that relative accumulation of the

209 Complex I is put together from preassembled subcomplexes.

210 Coordinated transfer of a preassembled T complex is supported by these data and co

211 interacts directly and functionally with the preassembled t-SNARE complex.

212 ituted giant unilamellar vesicles containing preassembled t-SNARE proteins (syntaxin 1.SNAP-25), we d

213 he kinetic mechanism of dTTP hydrolysis by a preassembled T7 helicase hexamer in the absence of DNA.

214 used an approach involving the expression of preassembled tandem Orai1 multimers comprising different

215 netically defined a transition step in which preassembled Tat:P-TEFb complexes switch to TAR.

216 RNA polymerase II (RNAP II) recruitment to a preassembled TBP/TFIIB-containing scaffold and p53 stron

217 nhibition, we found that expression of these preassembled TCR beta-chains did not downregulate recomb

218 In this study, we demonstrate that a preassembled TCRbeta gene, but not a preassembled DbetaJ

219 However, addition of hTRas009 or hTRas010 to preassembled telomerase resulted in little or no inhibit

220 of additional allosteric dNTP ligands to the preassembled tetramer.

221 DNA as well as the recruitment of pol III to preassembled TFIIIB.DNA complexes.

222 Yet if the MuA-DNA complexes are preassembled, the first-order rate constants for both DN

223 Here, we used a library of preassembled three-finger zinc finger proteins (ZFPs) di

224 ly, talin1 was required for the formation of preassembled TLR complexes in DCs at steady state via di

225 rate that talin1 promotes the formation of a preassembled TLR-Myddosome signaling complex in steady-s

226 scription complexes, active genes migrate to preassembled transcription sites.

227 in complexes that comprise these domains are preassembled, transported, and inserted as a complex or

228 o the DJCbeta2 cluster on alleles carrying a preassembled Trbv31-DJCbeta1 gene.

229 a substrate can be achieved by transferring preassembled ubiquitin chains from Ube2g2 to a lysine re

230 Purified preassembled vacuolar SNARE complex, when reconstituted

231 Expression of these preassembled VbetaDJbeta rearrangements inhibited endoge

232 Expression of either preassembled VbetaDJbetaC beta-chain accelerated thymocy

233 Presynaptic nerve terminals are formed from preassembled vesicles that are delivered to the prospect

234 omplex (STC) intasome produced with IN and a preassembled viral/target DNA substrate at 3.36 angstrom

235 ex (NEC) that orchestrates the egress of the preassembled virus capsids from the nucleus.

236 Providing Emu-deficient mice with a preassembled VL gene led not only to a larger immature B

237 We report fabrication of a 4 mm thick, preassembled whispering gallery mode (WGM) sensor that c

238 ready-to-use microwell array device that is preassembled with custom titers of various antibiotics a