ライフサイエンスコーパス: precapillary

1 h normal hemodynamics (30.8%, both P<0.001), precapillary (28.2%, both P<0.001), and exercise PH (26.

2 /-17.3 mm Hg; P=0.015) but not in those with precapillary (49.0+/-12.6 versus 51.6+/-14.3; P=0.36).

3 but lower than those with HFpEF and combined precapillary and postcapillary PH.

4 s; this phenotype is referred to as combined precapillary and postcapillary pulmonary hypertension (C

5 61) but less severe than those with combined precapillary and postcapillary pulmonary hypertension HF

6 molecular studies in patients with combined precapillary and postcapillary pulmonary hypertension.

7 evere pulmonary hypertension associated with precapillary arterial occlusion by proliferating endothe

8 vascular smooth muscle cell proliferation in precapillary arteries, perivascular inflammation, and as

9 egenerative function associated with loss of precapillary arteries.

10 ypertension (PH) is characterized by complex precapillary arteriolar lesions, which contain phenotypi

11 In the precapillary arteriole, 1 myocyte covers a approximately

12 In the precapillary arteriole, Ca signals arise solely from Ca

13 dothelial cell-proliferative lesions of lung precapillary arterioles composed of clusters of phenotyp

14 signaling and coordination of contraction in precapillary arterioles in ureter and vas deferens.

15 ut 50% of total oxygen uptake takes place in precapillary arterioles of less than 30 mum in diameter

16 In pulmonary hypertension the loss of precapillary arterioles results from vascular injury cau

17 patients with PH, the abundance of PAECs in precapillary arterioles was increased, and that of MVECs

18 anthosis and a preferential occlusion of the precapillary arterioles with infiltration of neutrophils

19 Blood flow is assumed to be regulated by precapillary arterioles, because capillaries lack smooth

20 m vessels near metabolically active cells to precapillary arterioles, suggesting that blood flow cont

21 mulation of mural cells on upstream pial and precapillary arterioles.

22 d ECs from contracting and reorganizing into precapillary cords within collagen gels.

23 rtension (IpcPH), combined postcapillary and precapillary (CpcPH), or exercise PH.

24 , we set aside considerations of established precapillary disease, focusing specifically on the proce

25 Fractional precapillary gas exchange (F) was quantified for each ga

26 Precapillary gas exchange contributes importantly to blo

27 Precapillary gas exchange for oxygen has been documented

28 (D) and a systemic artery (A), we evaluated precapillary gas exchange in 27 paired samples from seve

29 We evaluated fractional precapillary gas exchange in canines for O(2) and two in

30 It has been suggested that, if precapillary gas exchange occurs to a greater extent for

31 ditions, this suggests only minor effects of precapillary gas exchange on the magnitude of calculated

32 Fractional precapillary gas exchange was similar for SF(6) , ethane

33 nd-diastolic pressure, >15 mm Hg; n=269) and precapillary groups (left ventricular end-diastolic pres

34 r 1-year mortality rate was observed in both precapillary (hazard ratio, 2.30; 95% confidence interva

35 Pulmonary hypertension (PH) is classified as precapillary, isolated postcapillary pulmonary hypertens

36 intraarterially delivered MSCs entrap at the precapillary level because of their large size, with a s

37 and interrupt flow during first pass at the precapillary level, resulting in decreased flow in the f

38 Abundance of PAECs versus MVECs in precapillary microvessels was assessed in lung tissue fr

39 in TRPC1(-/-) animals as well as in isolated precapillary murine PASMC after TRPC1 knockdown by TRPC1

40 nsisted of N=209 patients (n=55 normal, n=72 precapillary, n=27 CpcPH, n=15 IpcPH, n=34 exercise, and

41 functional features that do not overlap with precapillary or arteriolar smooth muscle actin-expressin

42 In chronic hypoxic mice, precapillary oxygenation was significantly attenuated as

43 scular resistance defines combined post- and precapillary PH (Cpc-PH).

44 We prospectively included 17 patients with precapillary PH and 7 control subjects without PH who pe

45 haracteristics and outcomes of patients with precapillary PH and COVID-19.

46 e association was strongest in patients with precapillary PH at the time of catheterization, in whom

47 Dasatinib may induce severe precapillary PH fulfilling the criteria of pulmonary art

48 Isolated cases of precapillary PH have been reported in patients who have

49 agement, and outcomes of adult patients with precapillary PH in the French PH network who had COVID-1

50 Conversely, precapillary PH may be diagnosed in the presence of card

51 Conclusions: COVID-19 in patients with precapillary PH was associated with a high in-hospital m

52 Right heart catheterization showed severe precapillary PH with a mean pulmonary artery pressure of

53 t diagnosis, patients had moderate to severe precapillary PH with functional and hemodynamic impairme

54 (42 PV, 35 ET, 13 primary MF) presented with precapillary PH with severe hemodynamic impairment, with

55 acoronary aortic banding+MetS rats developed precapillary PH, as measured by both echocardiography an

56 roportional to the physiological severity of precapillary PH, demonstrating its prognostic and clinic

57 PC1 and TRPC6 are predominantly expressed in precapillary pulmonary arterial smooth muscle cells (PAS

58 Precapillary pulmonary arteries are affected by medial h

59 k exposure) results in obliteration of small precapillary pulmonary arteries by proliferating endothe

60 in human severe pulmonary hypertension, the precapillary pulmonary arteries show occlusion by prolif

61 nsion (PAH) is an obstructive disease of the precapillary pulmonary arteries.

62 cular smooth muscle hypertrophy of the small precapillary pulmonary arteries.

63 progressive replacement of MVECs by PAECs in precapillary pulmonary arterioles, thus providing a macr

64 characterized by vascular remodeling in the precapillary pulmonary arterioles.

65 patients (11%) met hemodynamic criteria for precapillary pulmonary hypertension (mean pulmonary arte

66 Rationale: Precapillary pulmonary hypertension (PH) is a rare and l

67 Precapillary pulmonary hypertension (PH) is an important

68 Precapillary pulmonary hypertension (precPH) patients ha

69 major predictor of outcomes in patients with precapillary pulmonary hypertension because of pulmonary

70 measures in a large cohort of patients with precapillary pulmonary hypertension before and after ini

71 sion and present in all 14 of the identified precapillary pulmonary hypertension cases among the comb

72 of 150-450 m, WHO functional classes II-IV, precapillary pulmonary hypertension confirmed by right h

73 trait locus, rs10857560, was associated with precapillary pulmonary hypertension defined as mean pulm

74 ely in a cohort of consecutive patients with precapillary pulmonary hypertension referred between 200

75 Patients with sarcoidosis and precapillary pulmonary hypertension should be treated wi

76 tion fraction and combined postcapillary and precapillary pulmonary hypertension were randomized 1:1

77 related pulmonary hypertension patients have precapillary pulmonary hypertension with potential etiol

78 with advanced pulmonary sarcoidosis develop precapillary pulmonary hypertension, which is associated

79 tion fraction and combined postcapillary and precapillary pulmonary hypertension, with potential safe

80 ower pulmonary pressure in SCD patients with precapillary pulmonary hypertension.

81 hort comprised 777 patients (514 women) with precapillary pulmonary hypertension.

82 ion quantitative trait locus associated with precapillary pulmonary hypertension.

83 tion fraction and combined postcapillary and precapillary pulmonary hypertension.

84 These data support the notion that precapillary resistance is influenced by signals generat

85 g that both mean arterial blood pressure and precapillary resistance remained constant.

86 , ANP causes greater increases in post- than precapillary resistance, thus increasing intrasplenic ca

87 sure steps is associated with a reduction in precapillary resistance.

88 Pulmonary arteriolar (precapillary) resistance is elevated.

89 acuity due to microvascular occlusion of the precapillary retinal arterioles.

90 ally and functionally distinct from adjacent precapillary smooth muscle cells (SMCs).

91 mechanism for cerebral blood flow control, a precapillary sphincter at the transition between the pen

92 othelin-1 exert far greater effects on brain precapillary sphincters and first-order capillaries than

93 The high level of responsiveness at precapillary sphincters and first-order capillaries was

94 Our results confirm a key role for precapillary sphincters and pericytes on first-order cap

95 Thus, precapillary sphincters are bottlenecks for brain capill

96 The hemodynamic consequence is that precapillary sphincters can generate the largest changes

97 on 3D vasculature reconstruction showed that precapillary sphincters predominantly regulate capillary

98 elial cells to form solid cords that imitate precapillary structures found during angiogenesis.

99 ling from postcapillary (wedged balloon) and precapillary (unwedged) position to obtain transpulmonar

100 efenses against heat are sweating and active precapillary vasodilation; the primary autonomic defense

101 hypertension have a PGIS deficiency of their precapillary vessels, but the importance of this deficie