ライフサイエンスコーパス: precocious

1 oval or antagonism of endogenous PU.1 allows precocious access to T-cell differentiation.

2 Here, we identify a precocious accumulation of Sox9-expressing glial cells i

3 Enforcing precocious acquisition of constitutive heterochromatin r

4 n an 'alerted' state of MuSCs, which display precocious activation and faster cell cycle entry ex viv

5 scence into a solitary flower as a result of precocious activation of a conserved floral specificatio

6 rgilli, as deleting nsdD causes enhanced and precocious activation of conidiation in Aspergillus fumi

7 1-silencing transcription factor) results in precocious activation of QNPs and reduced neurogenesis o

8 We demonstrate that precocious activation of Shh signaling during this early

9 educed levels of the Dpp transducer pMad and precocious activation of the master differentiation fact

10 is an enhancer-binding protein that prevents precocious activation of the neural gene expression prog

11 es Fgf4-Fgfr-ERK signalling, thus preventing precocious activation of the PrE specification programme

12 The precocious adherence to these principles suggests that a

13 expression and activation of Stat5 leads to precocious alveolar development in the absence of pregna

14 on, whereas overexpression of SIM2s promotes precocious alveolar differentiation in nulliparous mouse

15 l macrophage AEBP1 overexpression results in precocious alveologenesis in the virgin AEBP1 transgenic

16 its Cdc20, an activator of APC/C, to prevent precocious anaphase onset.

17 Altogether, our results demonstrate a precocious and efficient sorting of homologous versus ho

18 active asexual development (conidiation) and precocious and elevated accumulation of AfubrlA during d

19 ing regulatory genes, mibR or mibX, leads to precocious and enhanced microbisporicin production.

20 estricting SM differentiation and preventing precocious and excessive SM differentiation when airways

21 n both female and male mice characterized by precocious and highly increased ductal growth and branch

22 d-forward Hox-miRNA loops accounting for the precocious and noisy Hoxa5 expression, as well as an ill

23 uronal progenitors, which is followed by the precocious and transient acceleration of neuronal differ

24 Loss of Shisa2 led to precocious anterior turning of commissural axons before

25 g Met RNAi in lamina neurons led only to the precocious appearance of EcR-B1 in the lamina.

26 enchymal cells which are responsible for the precocious astrogenesis.

27 her sex exhibit a grossly enlarged IG due to precocious astroglial translocation and conditional Hs2s

28 on of Pax5 emerges as a mechanism to prevent precocious B-lymphoid differentiation, while Hox-mediate

29 Increases in Bcd binding caused the precocious Bcd-dependent activation of genes that are no

30 N-methyl-D-aspartate receptors, represents a precocious biological marker of the disease.

31 Increased Cdc42 activation promotes precocious bipolar growth activation, bypassing the norm

32 Therefore, precocious BLA-mPFC connectivity alterations may represe

33 reover, dpp hypomorphic mutants also induced precocious br expression.

34 efects, and time lapse analysis reveals that precocious branch formation in turnout and plexin A3 mut

35 BO1 signaling in this layer alone results in precocious branching due to a surplus of basal cells.

36 ial cells showed increased proliferation and precocious branching morphogenesis.

37 In backcross hybrids, we show that precocious burrowing and adult tunnel length are genetic

38 gions from the nuclear periphery, leading to precocious cardiac gene expression and differentiation i

39 (Hdac3) in cardiac progenitor cells exhibit precocious cardiomyocyte differentiation, severe cardiac

40 ted with appearance of dystrophic microglia, precocious caspase-3 activation, and cell death in corti

41 n activity or actin polymerisation exhibited precocious cell contraction through changes in the subce

42 activity and hindbrain growth downstream of precocious cell cycle exit, premature neuronal different

43 specific promoters, a function that prevents precocious cell differentiation in the skeletal muscle l

44 Because precocious cell division before establishing cell polari

45 er cell line and it correctly identifies two precocious cells in a study of paracrine signalling in m

46 ron-mediated paracrine signalling from these precocious cells.

47 iral genes is expressed very early by a few 'precocious' cells in response to uniform stimulation wit

48 g OsFIE1 had reduced seed size and exhibited precocious cellularization.

49 Centrosome fragmentation and precocious centriole disengagement depend on separase an

50 a subunit of the cohesin complex, prevented precocious chromatid segregation induced by MYPT1 deplet

51 ound that depletion of MYPT1 by siRNA led to precocious chromatid segregation when HeLa cells were ar

52 counteracting PP2A phosphatase, resulting in precocious chromatid segregation.

53 nction cancer-associated mutations conferred precocious chromatin accessibility.

54 e checkpoint proteins MAD2 and BUBR1 prevent precocious chromosome segregation and suppress aneuploid

55 ad21 proteins failed to significantly rescue precocious chromosome separation caused by depletion of

56 ypes, including decreased basal cell number, precocious club cell differentiation, and increased secr

57 These precocious collateral branches emerge along the proximal

58 nin in mouse corneal keratocytes resulted in precocious corneal epithelial stratification.

59 is permanently disrupted in mice that have a precocious critical period due to genetically enhanced i

60 ion or signaling is precocious, it induces a precocious critical period.

61 JNK-JUN pathway safeguards pluripotency from precocious DE differentiation.

62 microRNAs (miRNAs) cooperate to prevent the precocious death of mothers of cells programmed to die b

63 we show that UbcH10 overexpression leads to precocious degradation of cyclin B by the APC/C, supernu

64 at prophase appears to protect cyclins from precocious degradation.

65 suppression of CARM1 expression resulted in precocious dendritic maturation, with increased spine wi

66 yocytes, a phenotype that is consistent with precocious depletion of the progenitor pool.

67 PKA activity that have been associated with precocious development and find that this loss in respon

68 Knockdown of Kr-h1 in N4 resulted in a precocious development of adult structures.

69 dysfunctional telomeres (G3 Terc(-/-)) show precocious development of anaphase-bridge formation, p21

70 Cartilage fatigue may be a factor in the precocious development of degenerative changes in the te

71 and reduced motor thresholds, suggestive of precocious development.

72 essing Ovol2 in their skin epithelia exhibit precocious differentiation accompanied by smaller progen

73 proliferation, extensive side branching, and precocious differentiation in PELP1-overexpressing mamma

74 ctivity of NSCs is required to prevent their precocious differentiation in vivo Thus, blood vessel fu

75 SIGNIFICANCE: Understanding how precocious differentiation is prevented is critical for

76 of Ezh2 from mammary stem cells resulted in precocious differentiation of alveolar epithelium during

77 Notch inhibition also led to precocious differentiation of epithelial progenitors int

78 y, a reduction in GSK3 activity promotes the precocious differentiation of later stage cortical proge

79 ss of Fezf2(+)/Ctip2(+) layer V neurons, and precocious differentiation of normally late-born, Satb2(

80 NTDs) coupled with reduced proliferation and precocious differentiation of NPCs.

81 ligodendrocyte precursor cells (OPCs) causes precocious differentiation of oligodendrocytes, conditio

82 mechanism for the premature delamination and precocious differentiation of progenitors.

83 is essential to prevent oxidative stress and precocious differentiation of satellite cells.

84 We identified six hits that can induce precocious differentiation of secondary islets in larval

85 the lymph gland structure but that included precocious differentiation of the prohemocytes located w

86 , placodal activation of beta-catenin drives precocious differentiation of Type I glial-like taste ce

87 ence indicating that SOBIR1/EVR prevents the precocious differentiation of xylem fiber, a key cell ty

88 Cranial NC defects were associated with precocious differentiation towards osteoblast and chondr

89 liferation, but biases granule cells towards precocious differentiation, alters their migration path

90 mpromised myoblast proliferation and induced precocious differentiation, phenotypes that were rescued

91 n, depletes meristematic activity and causes precocious differentiation, which is attenuated by EBP1.

92 ll proliferation and its inactivation causes precocious differentiation.

93 137 recognition site rescued miR-137-induced precocious differentiation.

94 of adult urothelial progenitors and prevents precocious differentiation.

95 The precocious discovery of word meanings suggests a perspec

96 another Scc1-interacting cohesin regulator, precocious dissociation of sisters 5 (Pds5), Scc2 consis

97 ions between Sororin and the cohesin subunit precocious dissociation of sisters protein 5 (Pds5) by p

98 egulator of cohesin and forms a complex with precocious dissociation of sisters protein 5 (Pds5) to p

99 By dissociating precocious DNA displacement loops (D-loops) between sist

100 mutant shows severely delayed flowering and precocious doming of the vegetative SAM LTM encodes a ke

101 SP-overexpressing wild-type plants exhibited precocious doming of vegetative SAMs combined with late

102 g of Fanconi anemia helicase FANCM, prevents precocious DSB strand exchange between sister chromatids

103 Recapitulation of ovarian abnormalities by precocious E2 revealed a relatively simple mechanism und

104 occur later in development, indicating that precocious E93 accelerates the wild-type developmental p

105 Genomic profiling reveals that precocious E93 expression is sufficient to regulate chro

106 that target enhancers that do not respond to precocious E93 in early wings become responsive after a

107 reas maternal-excess crosses (4 x 2) promote precocious EC and produce smaller seeds.

108 However, we observed precocious ectopic expression of Sox2 prior to the 16-ce

109 stage also led to variable enamel defect and precocious/ectopic formation of fragmented root epitheli

110 The precocious emigration of the early arriving neurons in t

111 progenitor differentiation protocols promote precocious endocrine commitment, ultimately resulting in

112 gical inhibition of Notch signaling leads to precocious endocrine differentiation and the early appea

113 ors during pancreatic specification prevents precocious endocrine formation while treatment with reti

114 level, the moderate heat stress resulted in precocious endosperm cellularization, whereas severe hea

115 Cas9-mediated single knockout mutants showed precocious endosperm cellularization.

116 at EcR acts as both a temporal gate to block precocious entry to the next developmental stage as well

117 site; b) test the ability of developmentally precocious estrogen exposure to recapitulate site-associ

118 tration that synaptotoxicity and gliosis are precocious events in MJD and that caffeine and A2A R ina

119 trol levels of beta-catenin and thus prevent precocious/excessive myoblast fusion.

120 1 by PP2A(Cdc55) is essential for preventing precocious exit from meiosis I.

121 MicroRNA biogenesis impairment leads to precocious expression and propagates the noise of Hoxa5

122 We propose that, by preventing precocious expression of differentiation-promoting trans

123 Precocious expression of E93 early in wing development r

124 Precocious expression of ETV1 in mouse CGNs accelerated

125 are transcribed before the MBT, but whether precocious expression of specific mRNAs is important for

126 d chromatin cohorts at ZGA, preventing their precocious expression.

127 Myopic vitreopathy features precocious fibrous vitreous liquefaction and early poste

128 ld protect axillary meristems in phyB-1 from precocious floral induction and decrease bud sensitivity

129 of Arath;WEE1 in tobacco plants resulted in precocious flowering and increased shoot morphogenesis o

130 riod reaches a certain length and preventing precocious flowering in Arabidopsis.

131 expression of FT (FLOWERING LOCUS T) caused precocious flowering in short-day-grown Col-0 but this w

132 d of floral competence acquisition, prevents precocious flowering when there is insufficient biomass,

133 Plants overexpressing SPL10 showed precocious flowering, whereas the triple loss-of-functio

134 tely formed at low temperatures and prevents precocious flowering.

135 l phloem-translocated protein that regulates precocious flowering.

136 VE PHASE (SVP) function, perhaps to suppress precocious flowering.

137 r, only AtSUC2-CcFT3 was capable of inducing precocious flowers.

138 Precocious foragers completed far fewer foraging trips i

139 nae were nearly twice as likely to engage in precocious foraging and lived 9 days less, on average, c

140 ed to impaired learning, which together with precocious foraging can lead to increased occurrence of

141 tag tracking to examine the consequences of precocious foraging for their performance.

142 emography of experimental colonies to induce precocious foraging in bees and used radio tag tracking

143 commonplace and has been causally linked to precocious foraging, which itself has been linked to col

144 vitro and in PV cell networks in vivo causes precocious formation of PV cell perisomatic innervation

145 a premature increase in CDK1 activity led to precocious formation of stable attachments and eventuall

146 nd ERECTA act together in the control of the precocious formation of xylem fiber development.

147 loidy, vacuolization, protruding spikes, and precocious fusion of membranous organelles.

148 at may confer a protective mechanism against precocious gene expression that is the product of a rela

149 reover, Sonic Hedgehog was able to stimulate precocious generation of NSCs by inducing Sox9 expressio

150 phylogenetically ancient and developmentally precocious geometric representations that guide their na

151 during seed development suppressed vivipary, precocious germination of developing seeds.

152 Precocious germination of spd1 embryos showed that the a

153 ting two-stage DNA demethylation in PGCs was precocious germline differentiation leading to hypogonad

154 condensed shoots, rapid flowering (SP5G) and precocious growth termination (SP).

155 in geographically dispersed, technologically precocious hominin populations with a shared technologic

156 e expression of whiB is sufficient to induce precocious hypersporulation.

157 newly differentiated chondrocytes underwent precocious hypertrophic enlargement accompanied by early

158 Precocious hypsodonty in middle Eocene ( approximately 3

159 of the claustrum and Layer 6b are similarly precocious in mice.

160 strate that HCN channels are developmentally precocious in OSNs and therefore are plausible candidate

161 GPseudoRank also correctly identifies cells precocious in their antiviral response and links uncerta

162 In addition, Fzd8CRD caused precocious induction of IGFBP5 in normal mammary glands

163 duction in prespore cell differentiation and precocious induction of prestalk cells, which were remin

164 tion in cAS cells was closely related to the precocious inhibition of mitosis due to a delay in cell

165 the floral transition, ER and ERL1 prevented precocious initiation of the GA-mediated fiber formation

166 Increasingly precocious initiation of UDCA treatment did not change t

167 of reduced tillering mutant associated with precocious internode elongation that diverts sucrose (Su

168 ted with histologic and biochemical signs of precocious involution.

169 ithelial dysfunction postpartum resulting in precocious involution.

170 e, conversely, overexpression of NFIX led to precocious IPC generation.

171 When inhibitory maturation or signaling is precocious, it induces a precocious critical period.

172 yndrome, which is characterized primarily by precocious joint failure.

173 , a reduced tumor burden was observed due to precocious keratinocyte differentiation by Fra-2 express

174 om wild-type mice but displayed hallmarks of precocious lactogenic differentiation.

175 to ABA treatment, more rapid water loss, and precocious leaf senescence.

176 ulting in increased epithelial curvature and precocious lens vesicle closure.

177 sensitivity to experience, highlights how a precocious link between language and cognition advances

178 e cells by genetic manipulations that favor 'precocious' lncRNA 3'-processing/termination upstream of

179 how that Agr2 constitutive expression drives precocious lobuloalveolar development and increased milk

180 of sister centromere separation, as well as precocious loss of cohesion along the arms of achiasmate

181 uce U3 fates and PRC gain of function causes precocious loss of competence to make motoneurons.

182 Precocious loss of lamin B1 in ANSPCs transiently promot

183 eiosis I leads to premature Sgo1 removal and precocious loss of pericentromeric cohesion.

184 ted expression of p53 downstream targets and precocious loss of pluripotent gene expression compared

185 tudy, we show that depletion of H2A.Z causes precocious loss of sister chromatid cohesion in yeast wi

186 Transgenics overexpressing PtabZIP1L showed precocious LRP and LR development, while PtabZIP1L suppr

187 ically, we show that Ackr2(-/-) mice display precocious mammary gland development.

188 of REST in neural progenitors in mice led to precocious maturation into neurons at the expense of mus

189 oliferation of granule neuron precursors and precocious maturation of Bergmann glia and Purkinje neur

190 We found that IUHCTx leads to precocious maturation of neonatal host dendritic cells (

191 premature cranial suture closure because of precocious maturation of osteoblasts.

192 Tiggrin mutants exhibit precocious maturation of plasmatocytes, whereas Tiggrin

193 patterning defects, aberrant innervation and precocious maturation of the NMJ.

194 recocious spermatogonial differentiation and precocious meiotic initiation; thus, RA acts instructive

195 tase that activates CDK1, is responsible for precocious meiotic resumption and also contributes to su

196 nists and/or KIT blocking antibodies prevent precocious melanocyte stem cell differentiation in the N

197 h the nutritional checkpoints, which inhibit precocious metamorphosis during nutrient restriction in

198 roposterior extension of the hard palate and precocious mid-line fusion.

199 at the expense of later-born fates, whereas precocious misexpression of Casz1 has the opposite effec

200 However, precocious mitotic exit by mitotic slippage limits the c

201 We conclude that whatever cognitive capacity precocious MSA artifacts imply, it was not associated wi

202 ed in cultures in which H19 depletion causes precocious muscle differentiation, a phenotype recapitul

203 e and clobetasol, are effective in promoting precocious myelination in organotypic cerebellar slice c

204 tem cells from Deltex2 knockout mice exhibit precocious myogenic differentiation and accelerated rege

205 pplied a mathematical model that reveals how precocious neurogenesis affected cortical surface and th

206 reas mHtt enhances this process and promotes precocious neurogenesis and oligodendrocyte progenitor c

207 tential of Q111 dNSCs was also enhanced with precocious neurogenesis and oligodendrocyte progenitor e

208 Unexpectedly, we show that BPA-mediated precocious neurogenesis and the concomitant behavioral p

209 The precocious neurogenesis causes premature progenitor pool

210 Moreover, transient Hes1 expression rescues precocious neurogenesis in Dmrta2 knockout NPCs.

211 tion of pro-neuronal target genes to prevent precocious neuronal differentiation in cultured adult NS

212 nged neural crest emigration, and subsequent precocious neuronal differentiation of the trigeminal ga

213 hibited enhanced proliferative potential and precocious neuronal differentiation.

214 ity owing to reduced cell cycle kinetics and precocious neuronal differentiation.

215 al knockdown of SC1 in primary NSCs triggers precocious neuronal differentiation.

216 we identified cellular defects that lead to precocious neuronal specification within SLOS derived ne

217 ng genetically engineered mice, we show that precocious Norrin production leads to premature retinal

218 mally effect maternal piRNAs, which prevents precocious nuclear translocation of NRDE-3 in the early

219 ess was associated with an ability to induce precocious nucleotide incorporation within the somatic p

220 odon degus (degu), a biparental species with precocious offspring is a potential model for the study

221 Overexpression of lncOL1 promotes precocious oligodendrocyte differentiation in the develo

222 kers and birthdating experiments indicated a precocious oligodendrocyte differentiation in the mPFC a

223 Conversely, miR-219 overexpression promotes precocious oligodendrocyte maturation and regeneration p

224 o midbrain neurons as well as for preventing precocious oligodendrogliogenesis.

225 These changes correlated with a precocious onset and closure of critical period and defi

226 re not attached to microtubules and prevents precocious onset of anaphase, which can lead to aneuploi

227 variation in adults is also associated with precocious onset of burrowing in juveniles, suggesting t

228 Reduction of GAD67 expression rescued the precocious opening of the critical period, suggesting it

229 e different epigenetic effects could lead to precocious or delayed cellularization during endosperm d

230 Precocious overexpression of miR-195 in the embryonic he

231 phorylation sites in the Smad5 linker causes precocious patterning of DV tissues along the AP axis du

232 Notably, the precocious patterns of enhancer activity resemble the wi

233 There has been "precocious" penetration of rural towns by rural supermar

234 e used remote sensing data to show that this precocious phenology is ubiquitous across the woodlands

235 separation may explain the ubiquity of this precocious phenology.

236 step, and its continuous expression caused a precocious phenotype unlike in other experimental system

237 lin-42 mutants have a precocious phenotype, in which later-stage programs are

238 We found that the precocious phenotypes of meristem-deficient mutants are

239 ote perikaryal NF phosphorylation and foster precocious phospho-dependent NF-NF associations.

240 ng the matching process to coincide with the precocious plasticity.

241 d Ras homolog family member A (RhoA) induces precocious polarization as well as subsequent cell fate

242 n extracellular signaling molecule to elicit precocious production of the lantibiotic, presumably ens

243 ders were growth hormone deficiency (12.5%), precocious puberty (12.2%), thyroid-stimulating hormone

244 ilization in boys with familial male-limited precocious puberty (FMPP).

245 exoloops, and TMDs such as those involved in precocious puberty and thyroid toxic adenomas.

246 e or developmental impairment and those with precocious puberty had significantly larger lesions invo

247 re molecular defects associated with central precocious puberty have been identified.

248 mutations in MKRN3 in patients with central precocious puberty in association with the decrease in M

249 Deficiency of MKRN3 causes central precocious puberty in humans.

250 ture reactivation of GnRH neurons results in precocious puberty in mice and humans, but the mechanism

251 yndrome, characterized by fibrous dysplasia, precocious puberty, and cafe au lait spots.

252 f the lesions correlate with the presence of precocious puberty, and does the type of lesion influenc

253 9-year-old boy, with a diagnosis of CAH and precocious puberty, who was referred to our department f

254 ng in 40 members of 15 families with central precocious puberty.

255 ic-pituitary-gonadal axis results in central precocious puberty.

256 decline, neuropsychiatric comorbidities and precocious puberty.

257 boys and girls with gonadotropin-independent precocious puberty.

258 dvanced prostatic cancer, endometriosis, and precocious puberty.

259 s of Lhx2 in cortical progenitors results in precocious radial glia differentiation and a temporal sh

260 of function and Siah loss of function induce precocious radial migration.

261 displays synaptic terminal overgrowth and a precocious regenerative response to nerve injury.

262 modeling is delayed in hbl-1 mutants whereas precocious remodeling is observed in mutants lacking the

263 l (Gwl) mediates a pathway that prevents the precocious removal of phosphorylations added to target p

264 tion of blood progenitors in trol mutants is precocious, resulting in the break-down of the usual zon

265 letion of Lsd1 in growing oocytes results in precocious resumption of meiosis and spindle and chromos

266 th Onecut1 transcriptional activity leads to precocious rod development, suggesting that Onecut1 is c

267 Cdh1 ablation promotes precocious S-phase entry, but it was unclear how this af

268 Precocious SC protein expression is observed even when m

269 duced levels of transcytosis have delayed or precocious sealing of the BRB, respectively.

270 mutant plants also had few lateral roots and precocious secondary growth in primary roots.

271 Precocious segregation induced by MYPT1 depletion requir

272 y because a PLK1 inhibitor, BI-2536, blocked precocious segregation.

273 tresses, whereas in jub1-1 knockdown plants, precocious senescence and lowered abiotic stress toleran

274 f SA and its sugar conjugates, and exhibit a precocious senescence phenotype.

275 However, precocious senescence results in loss of biomass and see

276 e tissues transitioning from rapid growth to precocious senescence.

277 s accidents) and antisocial behaviors (e.g., precocious sexual activity, bullying, illicit substance

278 Precocious Shtn1 isoform switch contributes to disorgani

279 ttached to spindle microtubules and prevents precocious sister-chromatid separation and aneuploidy.

280 ild-type adult males induced, independently, precocious spermatogonial differentiation and precocious

281 Disruption of rsbN causes precocious sporulation and biochemical experiments demon

282 s of Foxp1 in skin epithelial cells leads to precocious stem cell activation, resulting in drastic sh

283 /6(cKO)) in corneal stromal cells results in precocious stratification of the corneal epithelium.

284 milarly, genetic loss of JNK function led to precocious stream departure ex vivo, and stream disrupti

285 slowing spinogenesis, loss of Icam5 induced precocious stubby spine maturation on pyramidal cell den

286 ture, as persistent oblique divisions induce precocious, sustained differentiation.

287 Precocious swarming is due to an increase in the number

288 s can accumulate to toxic levels that elicit precocious termination by CPF/Rhn1.

289 n) de-represses the PHO regulon and leads to precocious termination of prt lncRNA synthesis.

290 hemum (Chrysanthemum morifolium), results in precocious transition from juvenile to adult, as well as

291 l fertility and mutations in alg-5 lead to a precocious transition from spermatogenesis to oogenesis.

292 n is a functional mechanism for forestalling precocious translation of transcripts in the male gameto

293 ic survival, as Elf5 overexpression triggers precocious trophoblast differentiation.

294 Conversely, precocious upregulation of Syp reduces the number of cel

295 ey2 but differentiate prematurely because of precocious upregulation of the pro-HC factor Atoh1.

296 This precocious VMC differentiation resulted in nonproductive

297 ring rvr1 phenotype is dependent on VRN1 The precocious VRN1 expression in rvr1 is associated with re

298 ort that Peromyscus polionotus is strikingly precocious with regard to burrowing behavior, but not ot

299 NAC domain transcription factor XVP leads to precocious Xylem differentiation, disruption of Vascular

300 This Essay follows Richards from his precocious youth to becoming a celebrated chemist and em