ライフサイエンスコーパス: precursor lesion

1 melanoma earlier and through the removal of precursor lesions).

2 were histologically associated with a benign precursor lesion.

3 stage in the sequence of development from a precursor lesion.

4 e absence of a well-defined, intraepithelial precursor lesion.

5 ese acinar regions represent an early cancer precursor lesion.

6 cal basaloid follicular hamartoma or similar precursor lesion.

7 revention by detection and removal of cancer precursor lesions.

8 venting the onset of cancers in mice bearing precursor lesions.

9 e-adjusted prevalence and location of cancer precursor lesions.

10 s demonstrating cells exfoliated from cancer precursor lesions.

11 ution of bladder cancer from intraurothelial precursor lesions.

12 e to the malignant transformation of gastric precursor lesions.

13 verexpressed in esophageal carcinoma and its precursor lesions.

14 ) in both human colorectal cancers and their precursor lesions.

15 or the prevention of cervical cancer and its precursor lesions.

16 adenomas and flat dysplasias are regarded as precursor lesions.

17 tumor antigens (Nd2 and sialyl Tn) in these precursor lesions.

18 een elucidated in the context of noninvasive precursor lesions.

19 r development but is also observed in benign precursor lesions.

20 is also present in early human atheroma and precursor lesions.

21 ool to examine DPC4 status in these putative precursor lesions.

22 tly decreased the incidence of chest and ear precursor lesions.

23 ing the evolution of an invasive cancer from precursor lesions.

24 bnormalities were detected in the associated precursor lesions.

25 analysis corroborates Netrin-1 expression in precursor lesions.

26 l as guidelines on the management of gastric precursor lesions.

27 pancreatic intraepithelial neoplasia (PanIN) precursor lesions.

28 gulated in pancreatic cancers and associated precursor lesions.

29 s of 37 primary melanomas and their adjacent precursor lesions.

30 traductal papillary mucinous neoplasm (IPMN) precursor lesions.

31 (ccRCCs) is believed to develop from cystic precursor lesions.

32 venile polyps in CS are bona fide neoplastic precursor lesions.

33 tiation and maintenance of pancreatic cancer precursor lesions.

34 tenance and progression of pancreatic cancer precursor lesions.

35 in detection of both early cancer and cancer precursor lesions.

36 oma, squamous-cell carcinomas can arise from precursor lesions.

37 ge of enabling both detection and removal of precursors lesions.

38 d with increased detection of skin cancer or precursor lesions (5 studies) or stage at melanoma detec

39 d carriers have normal numbers of neoplastic precursor lesions, a relatively low phenotypic penetranc

40 Beginning with precursor lesions, aberrant DNA methylation marks the en

41 s cell carcinoma (SCC) as well as dysplastic precursor lesions, actinic keratoses.

42 the treatment of SCCs and their premalignant precursor lesions, actinic keratoses.

43 is relation is less well established for the precursor lesions, adenomatous polyps.

44 describe the dynamics of immune evolution in precursor lesions all the way to overt malignancy.

45 evelop anal invasive cancer or its immediate precursor lesion, anal carcinoma in situ (CIS).

46 By focusing on a cancer precursor lesion and using a variety of methods to asses

47 riptome sequencing of 98 lung adenocarcinoma precursor lesions and 99 invasive adenocarcinomas.

48 frequent early event in a distinct subset of precursor lesions and colorectal cancer (CRC) associated

49 d in the normal pancreas but arise in cancer precursor lesions and diminish during progression to car

50 Inactivation of KrasG12D in established precursor lesions and during progression to cancer led t

51 een for colorectal cancer (CRC); they detect precursor lesions and early-stage disease.

52 difficulty of early detection, lack of known precursor lesions and high mortality rates.

53 r and it is expressed at high levels in both precursor lesions and invasive cancer.

54 ated spatial transcriptomic maps of 56 human precursor lesions and LUADs from 25 patients and of an i

55 gh-risk individuals are targeted to identify precursor lesions and PDAC at an early resectable stage.

56 biological response of cells in human cancer precursor lesions and provide strong evidence that TDIS

57 Important precursor lesions and syndromes are stressed.

58 rder to obtain the holistic view of both the precursor lesions and their microenvironment.

59 racterized by palmoplantar keratoderma, oral precursor lesions, and a high lifetime risk of esophagea

60 liary stenosis, classification of dysplastic precursor lesions, and assessment of pancreatic abnormal

61 r mortality, its ability to detect cancer or precursor lesions, and its risk of harms.

62 port their use, ability to detect cancer and precursor lesions, and risk of serious adverse events in

63 nt versions lack high sensitivity for cancer precursor lesions, and tests need to be repeated at regu

64 The concepts of malignancy, precursor lesions, and the tumour microenvironment (TME)

65 mRNA and protein were detected in the early precursor lesions, and their expression intensified with

66 of pancreatic ductal adenocarcinoma and its precursor lesions, and we highlight translational applic

67 rrated polyps, and in particular as advanced precursor lesions (APLs), which have the potential to pr

68 ficult to observe human tumor progression as precursor lesions are systematically removed.

69 risks of colorectal cancer and adenoma, the precursor lesion, are believed to be influenced by dieta

70 progression of invasive carcinomas from PIN precursor lesions, as may occur during the development o

71 Nephrogenic rests are precursor lesions associated with about 40% of Wilms' tu

72 for more definitive terminology to describe precursor lesions associated with rupture, now referred

73 mportance: Esophageal adenocarcinoma and its precursor lesion Barrett esophagus have seen a dramatic

74 mptive cancer treatment using the neoplastic precursor lesion Barrett's esophagus as an exemplar(5).

75 nterest in strategies that might prevent the precursor lesion Barrett's oesophagus.

76 ween esophageal adenocarcinoma (EAC) and its precursor lesion, Barrett's esophagus, is poorly underst

77 n world has led to continued interest in its precursor lesion, Barrett's esophagus.

78 as therefore been increasing interest in the precursor lesion, Barrett's esophagus.

79 f esophageal adenocarcinoma and its presumed precursor lesion, Barrett's esophagus; the pathogenesis

80 increase in the incidence of its recognized precursor lesion, Barrett's metaplasia.

81 lial-proinflammatory niches are prevalent in precursor lesions but become less frequent in LUADs.

82 ncogene induces apoptosis in cervical cancer precursor lesions but the mechanism is poorly understood

83 f melanomas emerge from clear skin without a precursor lesion, but it is unknown whether these melano

84 rate that multiple and distinct human cancer precursor lesions, but not corresponding malignant cance

85 nal genetic damage that creates a histologic precursor lesion called endometrial intraepithelial neop

86 ought to arise from noninvasive, intraductal precursor lesions called pancreatic intraepithelial neop

87 rather than the ovary, developing from small precursor lesions called serous tubal intraepithelial ca

88 tionary trajectory of the tumour lineage and precursor lesions can be divergent.

89 l tissues from 20 CCs and their accompanying precursor lesions (cervical intraepithelial neoplasia, C

90 ter GA enlargement rates compared with other precursor lesion classes.

91 es of prostate cancer progression, including precursor lesions, clinically localized disease, and met

92 In a search for possible precursor lesions clonal ERG rearrangements were found b

93 mors from individuals with pancreatic cancer precursor lesions confirmed known early-occurring mutati

94 udied to identify and characterize potential precursor lesions containing foci of atypical epithelial

95 otably, even PanIN-1A, the earliest putative precursor lesion, demonstrated a dramatic reduction of t

96 d data exist characterizing the incidence of precursor lesions detected by anal cytology.

97 ming of this model is that clonally expanded precursor lesions do not always belong to the tumour lin

98 heavy-chain immunoglobulin (IgH) and is the precursor lesion for 80% of cases of multiple myeloma.

99 Of the three types of coronary thrombosis, a precursor lesion for acute rupture has been postulated.

100 uamous cell carcinoma, a clinically apparent precursor lesion for BCC has not been identified.

101 Barrett's esophagus (BE) is a precursor lesion for esophageal adenocarcinoma (EAC).

102 If, as shown previously, MH is the precursor lesion for melanoma in this model, these resul

103 Similarly, Barrett's metaplasia (a precursor lesion for oesophageal adenocarcinoma) has an

104 ; the evidence that retinoma may represent a precursor lesion for retinoblastoma prior to the acquisi

105 Barrett's esophagus is the presumed precursor lesion for this cancer.

106 Recognized precursor lesions for gastric adenocarcinoma are intesti

107 ary/progenitor markers and frequently act as precursor lesions for HCC.

108 Direct precursor lesions for manifest retinal atrophy were dete

109 tiating event that leads to the formation of precursor lesions for pancreatic ductal adenocarcinoma (

110 f atypical adenomatous hyperplasia (possible precursor lesions for peripheral adenocarcinomas) were n

111 was very similar suggesting that patches are precursor lesions for SCC, (b) a small number of patches

112 ferative inflammatory atrophy or PIA) may be precursor lesions for the development of prostate cancer

113 uctal metaplasia (ADM) and pancreatic cancer precursor lesion formation by blocking acinar regenerati

114 al alveolar hyperplasia (AAH) is a potential precursor lesion from which lung adenocarcinomas arise a

115 gulated during progression of ovarian cancer precursor lesions from the p53 signature to STIC stages

116 n human MPNSTs and neurofibromas, the benign precursor lesions from which MPNSTs arise.

117 The nomenclature for these precursor lesions has been standardized as pancreatic in

118 ancers, where subsequent surgical removal of precursor lesions has resulted in a reduction in cancer

119 ers do not arise de novo, and three distinct precursor lesions have been identified.

120 Studies of pancreatic cancer precursor lesions have begun to elucidate the evolutiona

121 lasms for which morphologically recognizable precursor lesions have not been identified, so-called de

122 ompanying molecular profiles of PDAC and its precursor lesions have provided the framework for emergi

123 to rapid metastasis without an identifiable precursor lesion (high-grade pathway).

124 at both prostate carcinomas and the presumed precursor lesion (high-grade prostatic intraepithelial n

125 A total of 9 out of 13 MCRs in the putative precursor lesion, high-grade prostatic intraepithelial n

126 brogated p53 function recapitulate human PCA precursor lesions, histopathology, and clinical behavior

127 al screening involves detecting and treating precursor lesions; however, scaling screening efforts in

128 tumour, and many forms are derived from the precursor lesions, hydatidiform moles.

129 foci (ACF) are postulated to be the earliest precursor lesion in colorectal carcinogenesis, and CpG i

130 delays the progression of pancreatic cancer precursor lesions in a preclinical animal model.

131 raloxifene, efficiently clear cancer and its precursor lesions in both the cervix and the vagina.

132 foci (ACF) are postulated to be the earliest precursor lesions in colorectal carcinogenesis.

133 nt of pancreatic ductal adenocarcinoma (PDA) precursor lesions in mice expressing a constitutively ac

134 umors and is sufficient to induce neoplastic precursor lesions in mouse models.

135 arrett's esophagus and associated neoplastic precursor lesions in order to optimize decision making w

136 SSA/P were the most frequently observed CRC precursor lesions in patients aged <50.

137 Among colonoscopies yielding CRC precursor lesions in patients under 50 years, SSA/P occu

138 However, data on precursor lesions in patients who are asymptomatic, espe

139 evelopment of oesophageal adenocarcinoma and precursor lesions in people with Barrett's oesophagus--a

140 In this model, noninvasive precursor lesions in the pancreatic ductules accumulate

141 ith an increased frequency of neuroendocrine precursor lesions in young TRAMP mice, detectable at 4 w

142 that can detect both early cancer and cancer precursor lesions include sigmoidoscopy and colonoscopy.

143 Precursor lesions including ductal hyperplasia and hyper

144 CRC precursor lesions (including sessile serrated adenoma/po

145 s displayed a heterogeneous pattern of ccRCC precursor lesions, including cysts, clear cell-type cell

146 fallopian tubes contains multiple concurrent precursor lesions, including serous tubal intraepithelia

147 reported in a wide range of human and murine precursor lesions, including the pancreas, lung, colon a

148 n-4 is overexpressed in several premalignant precursor lesions, including those of cancers of the bre

149 ant hypoautofluorescence was the most common precursor lesion, increasing from 42% to 81% over 3 year

150 d with loss of expression in both tumors and precursor lesions indicating that both alleles were func

151 led to a significantly elevated incidence of precursor lesions induced by AOM.

152 kingly, the development of pancreatic cancer precursor lesions induced by either DMBA or mutant Kras

153 onal "hits" is needed to convert an indolent precursor lesion into malignant disease.

154 be used to study the transition from benign precursor lesions into invasive vaginal human papillomav

155 subtypes (55.2%) and of the usually rare BTC precursor lesion, intraductal papillary neoplasia (18.3%

156 at is aberrantly activated in gastric cancer precursor lesions is beta-catenin, and activation of bet

157 and atypical renal cysts that resemble ccRCC precursor lesions is greatly accelerated by the combined

158 reported in gastric cancer, but the role in precursor lesions is not well understood.

159 r regeneration versus the development of PDA precursor lesions is poorly understood.

160 cinoma of the lung develops from noninvasive precursor lesions known as atypical adenomatous hyperpla

161 ough a multistep model comprised of putative precursor lesions known as pancreatic intraepithelial ne

162 ic events defining a clinically undetectable precursor lesion leading to a grade II astrocytoma.

163 The natural progression in precursor lesions leading to GA formation and their asso

164 The molecular pathology of precursor lesions leading to invasive pancreatic ductal

165 gle dominant tumor surrounded by a region of precursor lesions (low- and high-grade dysplasia) and oc

166 arly phase in CLL development before the CLL precursor lesion monoclonal B cell lymphocytosis.

167 ncluding the first analysis of Wilms' tumour precursor lesions, nephrogenic rests.

168 y updated two-tier classification system for precursor lesions, new findings in premalignant cystic n

169 e to occur, it is important to recognize the precursor lesion of ACS.

170 AT) in subjects with adenomatous polyps, the precursor lesion of colorectal cancer.

171 for Barrett's esophagus (BE), the only known precursor lesion of EAC, is indicated for individuals wi

172 a further supports the concept that PIN is a precursor lesion of invasive carcinoma.

173 Ductal carcinoma in situ (DCIS) is a precursor lesion of invasive ductal carcinoma (IDC) of t

174 for urothelial carcinoma in situ (CIS), the precursor lesion of most muscle-invasive bladder cancers

175 epithelial neoplasia (HGPIN) is considered a precursor lesion of prostate cancer (PCa).

176 tic intraepithelial neoplasia, a microscopic precursor lesion of prostate cancer.

177 inomas, we conclude that high-grade PIN is a precursor lesion of prostate carcinoma in this transgeni

178 We will define the precursor lesion of type I endometrioid cancer and the r

179 frequent loss of CDKN2A/Ink4a/Arf and may be precursor lesions of aggressive malignant peripheral ner

180 r UV-induced p53 patches, known to represent precursor lesions of carcinomas, in Xpc(-/-)G1-G3Terc(-/

181 nding of the risk factors, pathogenesis, and precursor lesions of colorectal cancer has advanced, the

182 od was expertly reviewed and histopathologic precursor lesions of hepatocellular carcinoma were also

183 Molecular studies of the earliest precursor lesions of ovarian cancer reveal a role of IGF

184 y factor secreted by pancreatic cells within precursor lesions of pancreatic cancer.

185 neoplasms are increasingly diagnosed cystic precursor lesions of pancreatic cancer.

186 (ADM), as in the case of pancreatitis where precursor lesions of pancreatic ductal adenocarcinoma (P

187 lterations identified to date in noninvasive precursor lesions of the bladder, are detectable in urin

188 cid synthase (FAS) have been found in cancer precursor lesions of the colon, stomach, esophagus, oral

189 mas likely arise from local dissemination of precursor lesions of the fallopian tube.

190 lial neoplasia (PanIN) are pancreatic cancer precursor lesions of unclear origin and significance.

191 lineages precede, and are thought to be the precursor lesions of, gastric cancer.

192 tly either from the progression of low grade precursor lesions or rapidly in a de novo fashion and co

193 ciency had little effect on the incidence of precursor lesions, or apoptosis induced by AOM or DSS, o

194 Morbidity; mortality; skin cancer stage, precursor lesions, or lesion thickness at detection; har

195 flammation, and development of advanced PDAC precursor lesions (pancreatic intraepithelial neoplasia

196 Hh signaling in the formation of PDA and its precursor lesion, pancreatic intraepithelial neoplasia (

197 e and tumour nodal status, while analysis of precursor lesions, pancreatic intraepithelial neoplasias

198 pressed in pancreatic adenocarcinoma and its precursor lesions: pancreatic intraepithelial neoplasia

199 riven pancreatic cancer, loss of AGO2 allows precursor lesion (PanIN) formation yet prevents progress

200 We have analysed the precursor lesions, PanINs, from prophylactic pancreatect

201 e resistant to MEKi, as well as in the MPNST precursor lesion plexiform neurofibroma.

202 It is unclear whether CIN is stable between precursor lesions, primary tumor, and metastases or if i

203 llance aids detection of early-stage PDAC or precursor lesions (PRLs) and improves the prognosis.

204 cinogenesis is a multistage process in which precursor lesions progress into early hepatocellular car

205 Washington DC, advances in identification of precursor lesions, progress in disease biomarkers and an

206 ct on the development of the prostate cancer precursor lesions (prostate intraepithelial neoplasia) w

207 pancreatic ductal adenocarcinomas, in which precursor lesions remain unknown.

208 of EZH2 in driving GC formation and lymphoma precursor lesions require site-specific binding by the B

209 nomas (STIC) as the tissue of origin and the precursor lesion, respectively, for the majority of high

210 papillary serous cancer are that a potential precursor lesion, serous endometrial intraepithelial car

211 to improve early detection of the respective precursor lesions, squamous dysplasia, and Barrett's eso

212 erous carcinomas (HGSCs) are associated with precursor lesions (STICs) in the fallopian epithelium in

213 g testing, detection of cancer and important precursor lesions such as APLs, and costs make for a com

214 r cell, and granulosa cell carcinomas and in precursor lesions such as inclusion cysts.

215 hat were reminiscent of early gastric cancer precursor lesions such as intestinal Alcian blue-positiv

216 arly inflammation-associated prostate cancer precursor lesions, such as proliferative inflammatory at

217 eatic ductal adenocarcinoma develops through precursor lesions termed pancreatic intraepithelial neop

218 tal adenocarcinoma is believed to arise from precursor lesions termed pancreatic intraepithelial neop

219 ent of squamous anogenital cancers and their precursor lesions, termed "squamous intraepithelial neop

220 model of tumorigenesis, based on analyses of precursor lesions, termed pancreatic intraepithelial neo

221 Monoclonal B-cell lymphocytosis (MBL) is a precursor lesion that can be screened for in apparently

222 aepithelial neoplasia (PanIN), a microscopic precursor lesion that gives rise to pancreatic cancer, i

223 of this difference, we sought a surrogate or precursor lesion that leads to hemolysis, and potassium

224 is a prevalent disease with an identifiable precursor lesion that, when treated, favorably alters th

225 nzyme in the subset of human HGPINs or other precursor lesions that are COX-2 positive, as well as in

226 air mutant KRAS-expressing pancreatic cancer precursor lesions that are prevalent in the average heal

227 high- and intermediate-grade DCIS, which are precursor lesions that carry a higher risk for transitio

228 ic events in such cancers because of two-hit precursor lesions that have a low probability of maligna

229 plastic progression, resulting in dysplastic precursor lesions that may arise in multiple areas of th

230 ransgenic mice and were found to emerge from precursor lesions that were of two distinct types: dyspl

231 tly observing this risk is challenging since precursor lesions, that is, advanced adenomas (AAs), are

232 hat may arise from a hitherto underestimated precursor lesion, the proximal hyperplastic polyp-serrat

233 s the inheritance of risk, the nature of the precursor lesions, the challenges involved in the develo

234 mented in the development of intraurothelial precursor lesions, the MTS genes do not seem to represen

235 germline predisposition, the cell of origin, precursor lesions, the sequence of genetic alterations,

236 able to cure, and can also detect and remove precursor lesions, thus also preventing CRC.

237 tive inflammatory atrophy, a prostate cancer precursor lesion, ties inflammatory responses to prostat

238 e (MGUS) is a common disorder of aging and a precursor lesion to full-blown multiple myeloma (MM).

239 erous tubal intraepithelial carcinoma as the precursor lesion to high-grade serous ovarian and perito

240 al carcinoma in situ (DCIS) is a noninvasive precursor lesion to invasive breast carcinoma.

241 ndetermined significance (MGUS) represents a precursor lesion to myeloma (MM).

242 er IRMA represents a biomarker or a vascular precursor lesion to NV has not been demonstrated.

243 RA biosynthesis in Barrett's oesophagus, the precursor lesion to oesophageal adenocarcinoma.

244 intraepithelial neoplasia (PanIN), a common precursor lesion to pancreatic cancer.

245 small glandular proliferation, is a putative precursor lesion to prostate cancer, in particular to th

246 neoplasia on needle biopsy--the most common precursor lesion to prostate cancer--is the crucial issu

247 lead to acinar-to-ductal metaplasia (ADM), a precursor lesion to the development of pancreatic ductal

248 Barrett esophagus appears to be a common precursor lesion to this cancer.

249 Precursor lesions to cervical cancer may be effectively

250 endoscopy is key for detecting and removing precursor lesions to colorectal cancer (CRC).

251 As recognized precursor lesions to colorectal cancer, colorectal adeno

252 the ability of graders to reliably identify precursor lesions to geographic atrophy (GA), known as p

253 the number of microadenomas, the presumptive precursor lesions to gross intestinal polyps.

254 different cell subsets in the progression of precursor lesions to lung adenocarcinoma (LUAD) is incom

255 rom mitotic catastrophe, thus allowing early precursor lesions to overcome oncogenic stress.

256 intraepithelial neoplasias, the most common precursor lesions to pancreatic cancer, and in the maint

257 a beta-catenin and is sufficient to initiate precursor lesions to prostate cancer in vivo.

258 ancer regions in CRCs and their premalignant precursor lesions to provide mechanistic insights into t

259 endocrine cell proliferations believed to be precursor lesions to pulmonary carcinoids.

260 We found that a significant fraction of precursor lesions to some of the most common human cance

261 ethylation change was frequently detected in precursor lesions to the tumors: adenomas, and hyperplas

262 enetic heterogeneity during progression from precursor lesions toward malignancy.

263 ats 9 months after carcinogen exposure, with precursor lesions (tubular complexes) developing 1 month

264 methylation status of sigma in breast cancer precursor lesions using microdissection for selective ti

265 rified TMPRSS2:ERG genomic rearrangements in precursor lesions using tricolor fluorescence in situ hy

266 development of gastritis and gastric cancer precursor lesions, using a variety of experimental infec

267 ated from human subjects with gastric cancer precursor lesions versus persons with gastritis alone.

268 volving from minimal change autofluorescence precursor lesions was associated with faster GA enlargem

269 The type of precursor lesions was not associated with incident GA ar

270 n in the normal colonic mucosa as a possible precursor lesion, we studied 700 bp upstream of MLH1 cov

271 Precursor lesions were initiated by mutations of genes t

272 These regions, defined as precursor lesions, were classified into minimal change a

273 c intraepithelial neoplasias (PanIN) are the precursor lesions which could be an ideal target for che

274 e need consider only tests that can identify precursor lesions whose treatment might prevent cancer,

275 Precursor lesions with AGO2 ablation undergo oncogene-in

276 ation, whereas acinar cells readily form PDA precursor lesions with ductal features.

277 Our comprehensive analysis of precursor lesions without the invasive component provide