ライフサイエンスコーパス: pregnane X receptor

1 (CXD2), as well as induction by rifampicin (pregnane X receptor).

2 involve the glucocorticoid receptor and the pregnane X receptor.

3 ling modulates the phosphorylation status of pregnane x receptor.

4 tion in CD4(+) T cells(3) and agonism of the pregnane X receptor(4).

5 loss of the nuclear xenobiotic receptor PXR (pregnane X receptor), a regulator of enterohepatic drug

6 ebulette (Nebl) to be efficiently induced by pregnane X receptor activating compounds.

7 er intraperitoneal treatment with the rodent pregnane X receptor activator 5-pregnen-3beta-ol-20-one-

8 genes can be targeted for regulation by the pregnane X receptor activator pregnenolone-16alpha-carbo

9 Cotreatment with the prototypical pregnane X receptor activator, rifampicin, significantly

10 sults identify a novel mode of regulation of pregnane x receptor activity and highlight prominent fun

11 ibited progesterone, estrogen, androgen, and pregnane X receptor activity, albeit generally with redu

12 protein kinase-mediated repression of human pregnane x receptor activity.

13 y, is a potent ligand (K(i) = 27 nM) for the pregnane X receptor, an orphan nuclear receptor that reg

14 ation of the intestinal xenobiotic receptors pregnane X receptor and constitutive androstane receptor

15 ng pathway, which is a critical regulator of pregnane X receptor and hepatocyte nuclear factor 1alpha

16 ic AMP-dependent protein kinase signaling on pregnane x receptor and provide a molecular explanation

17 ctivated transcription factors including the pregnane X receptor and the aryl hydrocarbon receptor.

18 to determine whether the interaction between pregnane x receptor and these key biochemical pathways i

19 xenobiotic-activated nuclear receptors PXR (pregnane X receptor) and CAR (constitutive androstane re

20 ncoding P-glycoprotein), NR1I2 (encoding the pregnane X receptor), and PPIA (encoding cyclophilin).

21 the nuclear receptors farsenoid X receptor, pregnane X receptor, and constitutive androstane recepto

22 ative binding sites for retinoid X receptor, pregnane X receptor, and estrogen receptor.

23 receptors constitutive androstane receptor, pregnane X receptor, and peroxisome proliferator-activat

24 including constitutive androstane receptor, pregnane X receptor, and retinoid X receptor (RXR), modu

25 ers, expression of nuclear receptors CAR and pregnane X receptor, and structure of the ALDH1A7 promot

26 s: farnesoid X receptor, vitamin D receptor, pregnane X receptor, and TGR5.

27 as enhanced in mice lacking the SXR ortholog pregnane X receptor, and treatment of humans with the SX

28 ity is opposite to the sensitizing effect of pregnane X receptor, constitutive androstane receptor, a

29 ilirubinemia can be reduced by activation of pregnane X receptor, constitutive androstane receptor, o

30 h the ability of these compounds to activate pregnane X receptor-dependent pathways in vivo.

31 of the protein in vivo indicates that human pregnane x receptor exists as a phosphoprotein and that

32 Protein structure information on the pregnane X receptor helped in overcoming a persistent cy

33 The human nuclear pregnane X receptor (hPXR) activates cytochrome P450-3A

34 Activation of human pregnane X receptor (hPXR) has been associated with indu

35 ein receptors to which PFASs bind, the human pregnane X receptor (hPXR) is found to be a host for a v

36 rapeutic tool.The xenobiotic-activated human pregnane X receptor (hPXR) regulates drug metabolism.

37 The human pregnane X receptor (hPXR) regulates the expression of c

38 Many drugs bind to and activate human pregnane X receptor (hPXR) to upregulate drug-metabolizi

39 ed off-target activities, most notably human pregnane X receptor (hPXR) transactivation, and led to s

40 A potent agonist of the human pregnane X receptor (hPXR) was designed from two ligands

41 Human pregnane X receptor (hPXR), an orphan nuclear receptor k

42 bound to RNA polymerase (RNAP) and the human pregnane X receptor (hPXR), representative examples (2b-

43 atter exhibiting potent agonism on the human pregnane X receptor (hPXR).

44 itutive androstane receptor (hCAR) and human pregnane X receptor (hPXR).

45 xons with the Nebl gene is a novel target of pregnane X receptor in mouse liver.

46 role of the nuclear xenobiotic receptor PXR (pregnane X receptor) in this process.

47 Pregnane x receptor is a ligand-activated transcription

48 We also report that pregnane X receptor is essential to maintain robust in v

49 The mouse pregnane X receptor is highly similar to the human ortho

50 The nuclear receptor PXR (pregnane X receptor) is a broad-specificity sensor that

51 ty, reducing active efflux, and addressing a pregnane X-receptor liability.

52 her supports this finding but shows that the pregnane X receptor-ligand hyperforin is not the driving

53 These findings suggest that treatment with pregnane X receptor ligands may be useful clinically in

54 ein kinase signaling pathway synergizes with pregnane x receptor-mediated gene activation in mouse he

55 inase signaling has a repressive effect upon pregnane x receptor-mediated gene activation in rat and

56 Both constitutive and pregnane X receptor-mediated inducible activities were m

57 Furthermore, IL-6 attenuated pregnane X receptor-mediated transcription of the CYP3A2

58 The effect of IL-6 on pregnane X receptor-mediated transcription of the rat CY

59 n at 24 hrs, potentially via IL-6 effects on pregnane X receptor-mediated transcription.

60 tutive androstane receptor) (NR1I3) and PXR (pregnane X receptor) (NR1I2) was generated to study thei

61 by the constitutive androstane receptor and pregnane X receptor nuclear receptors.

62 f CYP3a13 by dexamethasone occurring only in pregnane X receptor null mice.

63 RDelta8 did not repress the nuclear receptor pregnane X receptor or estrogen receptor alpha but did r

64 HNSCC and focused on the role of the nuclear pregnane X receptor (or NR1I2) and epigenetic mechanisms

65 These data demonstrate an impact of pregnane X receptor polymorphisms on tacrolimus pharmaco

66 The nuclear receptor PXR (pregnane X receptor) protects the body from hepatotoxici

67 We show that the human pregnane x receptor protein can serve as an effective su

68 sistance 1 (MDR1 C3435T) P-glycoprotein, and pregnane X receptor (PXR C-25385T, C8055T, and A7635G).

69 mes and drug export pumps, but only one, the pregnane X receptor (PXR in rodents, SXR in humans), reg

70 ehyde-O-(3,4-dichlorobenz yl)oxime (CITCO)], pregnane X receptor (PXR) [rifampicin], and peroxisome p

71 Ketoconazole binds to and antagonizes pregnane X receptor (PXR) activation.

72 er intraperitoneal treatment with the rodent pregnane X receptor (PXR) activator 5-pregnen-3beta-ol-2

73 Upon treatment with the pregnane X receptor (PXR) activator rifampicin (RIF), hu

74 The pregnane X receptor (PXR) acts as a receptor to induce g

75 Pregnane X receptor (PXR) and AhR-mediated activities we

76 sm by which the nuclear xenobiotic receptors pregnane X receptor (PXR) and constitutive active/andros

77 The orphan nuclear receptors pregnane X receptor (PXR) and constitutive androstane re

78 The nuclear pregnane X receptor (PXR) and constitutive androstane re

79 the molecular basis of crosstalk between the pregnane X receptor (PXR) and constitutive androstane re

80 expression of xenobiotic nuclear receptors, pregnane X receptor (PXR) and constitutive androstane re

81 The xenobiotic receptors pregnane X receptor (PXR) and constitutive androstane re

82 dicates that xenobiotic sensors, such as the pregnane X receptor (PXR) and constitutive androstane re

83 The nuclear receptors pregnane X receptor (PXR) and constitutive androstane re

84 xenobiotic receptor [SXR; also known as the pregnane X receptor (PXR) and formally known as NR1I2] i

85 Statins utilize pregnane X receptor (PXR) and serum/glucocorticoid regul

86 , a by-product of intestinal flora, activate pregnane X receptor (PXR) and subsequent CYP3A4 and CYP2

87 anscription-factor interactions, namely, the pregnane X receptor (PXR) and the aryl hydrocarbon recep

88 The pregnane X receptor (PXR) and the constitutive androstan

89 ion, is shown here to directly bind to human pregnane X receptor (PXR) and thereby act as a partial a

90 s constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are involved in the transcript

91 Constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are xenobiotic sensors that en

92 uided optimization with respect to decreased pregnane X receptor (PXR) binding was started.

93 The steroid and xenobiotic-responsive human pregnane X receptor (PXR) binds a broad range of structu

94 The pregnane X receptor (PXR) detects the presence of a wide

95 investigated whether the xenobiotic receptor pregnane X receptor (PXR) has a role in pathogenesis of

96 Pregnane X receptor (PXR) has been reported to regulate

97 Ralpha) as well as its heterodimeric partner pregnane X receptor (PXR) in mice.

98 CYP3A4, hepatocyte nuclear factor-4alpha, or pregnane X receptor (PXR) in PHHs.

99 Here we show that the pregnane X receptor (PXR) interacts more strongly with S

100 The pregnane X receptor (PXR) is a key regulator of drug met

101 The pregnane X receptor (PXR) is a key regulator of xenobiot

102 The pregnane X receptor (PXR) is a ligand-activated regulato

103 Pregnane X receptor (PXR) is a ligand-activated transcri

104 Pregnane X receptor (PXR) is a ligand-dependent transcri

105 The pregnane X receptor (PXR) is a master regulator of xenob

106 The pregnane X receptor (PXR) is a master regulator of xenob

107 Pregnane X receptor (PXR) is a master xenobiotic-sensing

108 The pregnane X receptor (PXR) is a nuclear receptor (NR), in

109 Pregnane X receptor (PXR) is a nuclear receptor consider

110 The pregnane X receptor (PXR) is a nuclear receptor signific

111 The human pregnane X receptor (PXR) is a promiscuous nuclear recep

112 Pregnane X receptor (PXR) is a xenobiotic receptor that

113 The nuclear receptor pregnane X receptor (PXR) is activated by a range of xen

114 The pregnane X receptor (PXR) is an important regulator of h

115 The pregnane X receptor (PXR) is an important transcriptiona

116 The pregnane X receptor (PXR) is an orphan nuclear receptor

117 Pregnane X receptor (PXR) is known to function as a xeno

118 The nuclear xenobiotic receptor pregnane X receptor (PXR) is promiscuously activated by

119 The pregnane X receptor (PXR) is the molecular target for ca

120 mponent, furanodienone (FDN), is a selective pregnane X receptor (PXR) ligand with agonistic transcri

121 Pregnane X receptor (PXR) mediates xenobiotic and endobi

122 GSTA2 and expression plasmids for either GR, pregnane X receptor (PXR) or a combination of both.

123 The nuclear pregnane X receptor (PXR) plays a central role in regula

124 The pregnane X receptor (PXR) plays a fundamental role in re

125 In mammals the pregnane X receptor (PXR) plays a key role in the regula

126 form with the retinoid X receptor (RXR), the pregnane X receptor (PXR) plays an essential role in con

127 Pregnane X receptor (PXR) plays an important role in det

128 The pregnane X receptor (PXR) plays an important role in the

129 Pregnane X receptor (PXR) plays roles in detoxification

130 me) have limited selectivity, activating the pregnane X receptor (PXR) receptor, a related receptor o

131 constitutive androstane receptor (CAR), and pregnane X receptor (PXR) regulate and alter the metabol

132 The human pregnane X receptor (PXR) regulates genes involved in dr

133 Upon drug activation, the nuclear pregnane X receptor (PXR) regulates not only hepatic dru

134 The pregnane X receptor (PXR) regulates the metabolism and e

135 By employing a pregnane X receptor (PXR) reporter gene assay to priorit

136 The human nuclear receptor pregnane X receptor (PXR) responds to a wide variety of

137 man hepatocytes, but does not activate human pregnane X receptor (PXR) significantly in cell-based tr

138 iosgenin increased the expression of several pregnane X receptor (PXR) target genes and the cholereti

139 nduced by the farnesoid X receptor (FXR) and pregnane X receptor (PXR) through the same IR0.

140 The aryl hydrocarbon receptor (AhR) and pregnane X receptor (PXR) transcription factors showed t

141 The pregnane X receptor (PXR) was isolated as a xenosensor r

142 ARgamma activity, and specific activation of pregnane X receptor (PXR) was observed together with Apo

143 Pregnane X receptor (PXR) was originally characterized a

144 ells had reduced nuclear localization of the pregnane X receptor (PXR), a key transcriptional regulat

145 The pregnane X receptor (PXR), a ligand-activated nuclear re

146 Pregnane X receptor (PXR), a member of the NR1I nuclear

147 e sought to interrogate the influence of the pregnane X receptor (PXR), a modulator of xenobiotic and

148 In contrast, expression levels of the pregnane X receptor (PXR), a nuclear receptor most simil

149 cluding BPA, have been shown to activate the pregnane X receptor (PXR), a nuclear receptor that funct

150 aphy to characterize a structural feature of pregnane X receptor (PXR), a nuclear receptor that is ac

151 and the BET-inactive (-)-JQ1 are agonists of pregnane X receptor (PXR), a nuclear receptor that trans

152 (SJW), from traditional herbs, activates the pregnane X receptor (PXR), a potential drug target for t

153 Pregnane X receptor (PXR), a previously known "xenobioti

154 been reported regarding PB regulation of the pregnane X receptor (PXR), a sister receptor of CAR, and

155 fampicin and efavirenz are activators of the pregnane X receptor (PXR), a transcription factor with s

156 Recent reports suggest that pregnane X receptor (PXR), a xenobiotic nuclear receptor

157 in was transcriptionally up-regulated by the pregnane X receptor (PXR), a xenobiotic-activated nuclea

158 Pregnane X receptor (PXR), acting as a xenobiotic-activa

159 ydrocarbon receptor (AhR), activation of the pregnane X receptor (PXR), activation of the estrogen re

160 The pregnane X receptor (PXR), along with its sister recepto

161 The human pregnane X receptor (PXR), also known as steroid and xen

162 eptors including farnesoid X receptor (FXR), pregnane X receptor (PXR), and constitutive active/andro

163 tream promoter-transcription factor COUP-TF, pregnane X receptor (PXR), and hepatocyte nuclear factor

164 ar receptors, farnesoid X receptor (FXR) and pregnane X receptor (PXR), are important in maintaining

165 cells and hepatoma cells overexpressing the pregnane X receptor (PXR), but not in hepatoma cells in

166 al regulation by nuclear factors such as the pregnane X receptor (PXR), constitutive androstane recep

167 f CYP2B6 and CYP3A4, targets of hCAR and the pregnane X receptor (PXR), in HPH, HepaRG, and PXR-knock

168 e investigated the role of nuclear receptor, pregnane X receptor (PXR), in M. tuberculosis infection

169 We found that chemicals activating the pregnane X receptor (PXR), peroxisome proliferator recep

170 s constitutive androstane receptor (CAR) and pregnane X receptor (PXR), respectively.

171 -carbonitrile (PCN), a ligand for the rodent pregnane X receptor (PXR), significantly enhances the ra

172 uman (h) orphan nuclear receptor, termed the pregnane X receptor (PXR), that binds to a response elem

173 a novel orphan nuclear receptor, termed the pregnane X receptor (PXR), that is activated by naturall

174 y increased in mice lacking the SXR ortholog pregnane X receptor (PXR), thereby demonstrating a direc

175 promoter element has been shown to bind the pregnane X receptor (PXR), this receptor does not mediat

176 to the hCAR: PK1195 strongly activated human pregnane X receptor (PXR), whereas it did not alter the

177 mplicated in activating the nuclear receptor pregnane X receptor (PXR), which acts as a xenobiotic se

178 Xenosensing pregnane X receptor (PXR), which also participates in th

179 expression is transcriptionally regulated by pregnane X receptor (PXR), which is a ligand-dependent t

180 Here, using a pregnane X receptor (PXR)-humanized mouse model, we foun

181 id, antimineralocorticoid, progestogenic and pregnane X receptor (PXR)-like activities (mug standard-

182 olished in hepatocyte cultures prepared from pregnane X receptor (PXR)-null mice, and cotransfection

183 Experiments performed using pregnane X receptor (PXR)-null mouse hepatocytes reveale

184 n CYP3A4-null animals, suggesting that other pregnane X receptor (PXR)-regulated pathways may contrib

185 tagonists have been identified for the human pregnane X receptor (PXR).

186 vated the human nuclear xenobiotic receptor, pregnane X receptor (PXR).

187 ession by activation of the nuclear receptor pregnane X receptor (PXR).

188 multiple mechanisms, including activation of pregnane X receptor (PXR).

189 hift assays showed that CAR-RE binds CAR and pregnane X receptor (PXR).

190 s regulated by nuclear receptors such as the pregnane X receptor (PXR).

191 e constitutive androstane receptor (CAR) and pregnane X receptor (PXR).

192 potently activate the human nuclear receptor pregnane X receptor (PXR).

193 mouse liver in response to the activation of pregnane X receptor (PXR).

194 rier function through the xenobiotic sensor, pregnane X receptor (PXR).

195 ted during confluence in a process involving pregnane X receptor (PXR).

196 n of constitutive androstane receptor and/or pregnane X receptor (PXR).

197 nuclear receptors, including the xenobiotic pregnane X receptor (PXR); (c) the ability to induce hum

198 own that MRP2 expression is regulated by the pregnane X receptor (PXR, NR1I2) and constitutive andros

199 The pregnane X receptor (PXR, NR1I2) is a xenobiotic-sensing

200 e have previously shown that the xenosensing pregnane x receptor (pxr, nr1i2) is lost in many teleost

201 Ligand-mediated activation of the pregnane X receptor (PXR, NR1I2) is postulated to affect

202 Pregnane X receptor (PXR, NR1I2), a member of the superf

203 Recently, the pregnane X receptor (PXR, NR1I2), initially characterize

204 that the ligand-activated nuclear receptors pregnane X receptor (PXR; NR1I2) and constitutive andros

205 ers of the nuclear receptor superfamily, the pregnane X receptor (PXR; NR1I2) and constitutive andros

206 ptor (CAR; NR1I3) and to a lesser extent the pregnane X receptor (PXR; NR1I2) are responsible for med

207 itutive androstane receptor (CAR; NR1I3) and pregnane X receptor (PXR; NR1I2), respectively.

208 ted with rifampicin in order to identify new pregnane-X receptor (PXR) target genes.

209 Genes encoding CYP3A6, in addition to the pregnane-X-receptor (PXR) and P-glycoprotein (P-gp) were

210 arbonitrile to activate the nuclear receptor pregnane X receptor restores P-glycoprotein expression a

211 pathways and biological functions, including pregnane X receptor/retinoic acid receptor activation as

212 biotic receptor) and its rodent homolog PXR (pregnane X receptor) serve as functional bile acid recep

213 e acids as CYP3A4 inducers and activators of pregnane X receptor/steroid and xenobiotic receptor (PXR

214 Expression of other pregnane X receptor target enzymes and transporter genes

215 that topotecan and etoposide are ligands of pregnane X receptor that induce CYP3A4 transcription.

216 ptors, constitutive androstane receptor, and pregnane X receptor, these results suggest that decrease

217 Elevated bile acids activated pregnane X receptor, which was sufficient to recapitulat

218 signaling also modulates the interactions of pregnane x receptor with protein cofactors.