ライフサイエンスコーパス: pregnenolone sulfate

1 ally, testosterone antagonized the effect of pregnenolone sulfate.

2 t postulated for the inhibitory neurosteroid pregnenolone sulfate.

3 allopregnanolone and the inhibitory steroid pregnenolone sulfate.

4 fected the negative allosteric modulation by pregnenolone sulfate.

5 losteric interaction between PI(4,5)P(2) and pregnenolone sulfate.

6 ue, previously shown to ablate inhibition by pregnenolone sulfate.

7 eady-state current of the inhibitory steroid pregnenolone sulfate.

8 osteric agonists, and the inhibitory steroid pregnenolone sulfate.

9 omers of dehydroepiandrosterone sulfate (1), pregnenolone sulfate (2), and (3alpha,5beta)-3-hydroxypr

10 teric potentiation of NMDA receptor pores by pregnenolone sulfate, 24(S)-hydroxycholesterol, and doco

11 The ability of pregnenolone sulfate (a positive modulator) and epipregn

12 The steroid pregnenolone sulfate activates the transcription factor

13 resence of the steroids allopregnanolone and pregnenolone sulfate, although the steroids interact wit

14 iously shown that the sulfated neurosteroids pregnenolone sulfate and 3alpha-hydroxy-5beta-pregnan-20

15 parent lack of state dependence suggest that pregnenolone sulfate and 3alpha5betaP inhibit the GABA(A

16 ivated by heat and chemical agonists such as pregnenolone sulfate and CIM0216.

17 Sig-1R agonists such as pregnenolone sulfate and cocaine caused the dissociation

18 his study shows that the inhibitory steroids pregnenolone sulfate and dehydroepiandrosterone sulfate

19 loreclezole, had different IC(50) values for pregnenolone sulfate and lanthanum, and were insensitive

20 sure alters the actions of the neurosteroids pregnenolone sulfate and pregnenolone hemisuccinate, whi

21 oth compounds competed with progesterone and pregnenolone sulfate and significantly reduced CatSper a

22 bserve enantioselectivity for the actions of pregnenolone sulfate and steroid sulfate 3 indicates tha

23 hermore, the GluN2A/B-selective potentiator (pregnenolone sulfate) and the GluN2C/D-selective potenti

24 ymmetrical and symmetrical dimethylarginine, pregnenolone sulfate, and adenosine.

25 s steroids allopregnanolone (3alpha5alphaP), pregnenolone sulfate, and beta-estradiol in the absence

26 tsynaptic neuron depolarization, and an anti-pregnenolone sulfate antibody scavenger blocked this eff

27 The neurosteroids alphaxalone and pregnenolone sulfate appropriately modulated GABAR curre

28 lopregnanolone and/or the inhibitory steroid pregnenolone sulfate closely matched predicted open prob

29 ulfated and unsulfated neurosteroids such as pregnenolone sulfate, dehydroepiandrosterone sulfate (DH

30 Another class of neurosteroid, pregnenolone sulfate, engages a similar GluN2B pocket, b

31 l CatSper currents, whereas the neurosteroid pregnenolone sulfate exerted similar effects as progeste

32 ectrophysiological techniques, we found that pregnenolone sulfate increases the frequency of AMPA-med

33 c-Jun-specific short hairpin RNA attenuated pregnenolone sulfate-induced AP-1 activation.

34 We conclude that pregnenolone sulfate-induced TRPM3 channel activation ch

35 report here that the excitatory neurosteroid pregnenolone sulfate induces a long-lasting strengthenin

36 Pregnenolone sulfate inhibited GABA-evoked currents with

37 The mechanism of action of pregnenolone sulfate involved a short-term increase in t

38 This finding indicates that a pregnenolone sulfate-like neurosteroid is a previously u

39 Moreover, the actions of pregnenolone sulfate on type A gamma-aminobutyric acid a

40 modulation by 3alpha5alphaP but not that by pregnenolone sulfate or beta-estradiol.

41 sure to the steroids cortisol, pregnenolone, pregnenolone sulfate, or progesterone.

42 ne mediating the effects of the neurosteroid pregnenolone sulfate, or the allosteric regulatory site

43 of NMDARs include an endogenous neurosteroid pregnenolone sulfate (PES), but the binding site of PES

44 pounds, such as cholesterol and neurosteroid pregnenolone sulfate (PES).

45 vity for activation by the endogenous ligand pregnenolone sulfate, pointing to an allosteric interact

46 roid pregnenolone (PREG) and its metabolites pregnenolone sulfate (PregS) and allopregnanolone in ser

47 TRPM3 can be activated by the neurosteroid pregnenolone sulfate (PregS) and heat.

48 Pregnenolone sulfate (PREGS), one of the most abundantly

49 h models of the GABA-inhibitory neurosteroid pregnenolone sulfate (PREGS), suggesting common mechanis

50 ates serum levels of the neuroactive steroid pregnenolone sulfate (PregS).

51 nhibited by the endogenous sulfated steroids pregnenolone sulfate (PS) and dehydroepiandrosterone sul

52 o stimulation by the endogenous neurosteroid pregnenolone sulfate (PS) and heat, and altered response

53 ted by heat and chemical agonists, including pregnenolone sulfate (PS) and nifedipine (Nif).

54 Sulfated steroids like pregnenolone sulfate (PS) are found endogenously in the

55 Pregnenolone sulfate (PS) is a sulfated neurosteroid whi

56 Pregnenolone sulfate (PS) is an abundant neurosteroid th

57 Pregnenolone sulfate (PS) is an abundant neurosteroid th

58 Pregnenolone sulfate (PS) is an endogenous neurosteroid

59 The endogenous neurosteroid pregnenolone sulfate (PS) is known to enhance memory and

60 We examined the effects of the neurosteroid pregnenolone sulfate (PS) on GABA(A) receptor-mediated s

61 Here, we report that pregnenolone sulfate (PS) uses a unique mechanism for en

62 The effects of the neurosteroid pregnenolone sulfate (PS) were studied in 3- to 9-week-o

63 One of these neurosteroid, pregnenolone sulfate (PS), depends on six identified M1

64 Pregnenolone sulfate (PS), one of the most commonly occu

65 exceeds that of the canonical TRPM3 agonist, pregnenolone sulfate (PS).

66 either enhance (allopregnanolone) or reduce (pregnenolone sulfate) receptor function.

67 These results indicate that (i) pregnenolone sulfate together with progesterone are the

68 Neurosteroids, such as pregnenolone sulfate, were previously shown to modulate

69 nhanced responses to the neurosteroid ligand pregnenolone sulfate when co-expressed with wild-type TR