ライフサイエンスコーパス: preinvasive

1 ed as a continuum from lung preneoplasia, to preinvasive ADC, minimally-invasive ADC and frankly inva

2 lung, 29 normal bronchial epithelium, and 20 preinvasive and 36 invasive lung tumor tissue samples fr

3 accumulate, the clinical characteristics of preinvasive and early invasive glandular cervical neopla

4 is a marker of aggressiveness in subsets of preinvasive and invasive breast cancer.

5 athway as a potential therapeutic target for preinvasive and invasive breast carcinoma treatment.

6 ia, NKX3.1 expression levels were similar in preinvasive and invasive cancer cells and significantly

7 st of genes differentially expressed between preinvasive and invasive cells.

8 Further studies of gene expression in preinvasive and invasive cervical cancers should assist

9 entive and therapeutic roles of retinoids in preinvasive and invasive cervical neoplasia.

10 luding human papillomavirus (HPV)-associated preinvasive and invasive genital squamous lesions.

11 ogression genes using gene array analysis of preinvasive and invasive tumors from mice, which were th

12 and their accompanying normal epithelium and preinvasive and metastatic lesions.

13 Abnormal mucosal cells surrounding preinvasive and microinvasive lesions shared common gene

14 sion in invasive human cancers compared with preinvasive and normal samples.

15 stemTOC compares favorably, specially in the preinvasive and normal-tissue contexts.

16 alization as cancers progress from normal to preinvasive and ultimately to invasive tumors, discoveri

17 pattern of TN isoform expression in benign, preinvasive, and invasive breast lesions using reverse t

18 e (iKnife), to discriminate between healthy, preinvasive, and invasive cervical tissue.

19 l predictive accuracy of over 90% of normal, preinvasive, and invasive lung tissues.

20 to classify this independent set of normal, preinvasive, and invasive lung tissues.

21 ene expression profiles of the premalignant, preinvasive, and invasive stages of human breast cancer.

22 Preinvasive breast cancer accounts for approximately one

23 tromal and myoepithelial microenvironment of preinvasive breast cancer actively participates in the t

24 ma in situ (DCIS) is the most common form of preinvasive breast cancer and, despite treatment, a smal

25 reast tissue, and they strongly suggest that preinvasive breast cancer develops and evolves along two

26 tal carcinoma in situ (DCIS) is a nonlethal, preinvasive breast cancer for which breast MRI is best s

27 Preinvasive breast cancer, or ductal carcinoma in situ (

28 ma, 1 astrocytoma, 1 low-grade glioma, and 2 preinvasive breast cancers [ductal carcinoma in situ]);

29 ents with high-risk breast lesions (HRLs) or preinvasive breast cancers face an elevated risk of futu

30 w tool for dissection of mechanisms by which preinvasive breast cells could acquire invasiveness in a

31 ether expression differed between benign and preinvasive breast epithelial tissue.

32 d alveolar tissue with normal histology from preinvasive bronchial lesions and from invasive lung can

33 There was a lower detection rate of preinvasive cancer in the 65-year-old and older patients

34 Genes that distinguish invasive from preinvasive cells were then hierarchically clustered wit

35 diagnosis and treatment of more problematic preinvasive cervical lesions.

36 severity of histopathological preneoplastic/preinvasive changes.

37 have recently exposed the high prevalence of preinvasive colorectal neoplasia in the adult U.S. popul

38 Early detection of preinvasive (curative cancers) is significantly less tha

39 HGF/c-Met signaling between fibroblasts and preinvasive DCIS cells enhances the transition to invasi

40 rop6(DN) plants exhibited enhanced preinvasive defense responses to a host-adapted virulent

41 t powdery mildew fungus but were impaired in preinvasive defenses upon inoculation with a nonadapted

42 matopoietic compartment occurred as early as preinvasive disease stages.

43 ductal adenocarcinoma from the inception of preinvasive disease to invasive cancer.

44 The ability to screen and treat women for preinvasive disease, cervical dysplasia, is the key fact

45 5.0% [95% CI, 14.4%-35.6%]) for treatment of preinvasive disease.

46 continue screening efforts and treatment of preinvasive disease.

47 The transition from preinvasive ductal carcinoma in situ (DCIS) to invasive

48 hown that myoepithelial cells in a subset of preinvasive ductal carcinoma in situ (DCIS) upregulate e

49 breast cancers and at higher frequencies in preinvasive ductal carcinoma in situ (DCIS).

50 the uterine cervix are thought to arise from preinvasive dysplastic lesions, termed cervical intraepi

51 However, LC risk in patients with preinvasive endobronchial lesions is unclear.

52 microdissected SV40 TAg-expressing cells in preinvasive foci and invasive tumors.

53 ental allele lost comparing 42 preneoplastic/preinvasive foci with those lost in the lung cancer in t

54 invasive PDAs and accelerates progression of preinvasive foci.

55 infection after local surgical treatment of preinvasive genital disease in individuals who were vacc

56 Human papillomavirus can cause preinvasive, high-grade squamous intraepithelial lesions

57 e SYP12 clade to provide a broad and durable preinvasive immunity to facilitate their life on land an

58 r, loss-of-function mutants were hampered in preinvasive immunity toward a range of phylogenetically

59 Plant preinvasive immunity toward nonadapted filamentous patho

60 ation at the site of attack is essential for preinvasive immunity; in postinvasive immunity, the enca

61 We found PLK1 to be also highly expressed in preinvasive in situ carcinomas of the breast.

62 ek2 protein is significantly up-regulated in preinvasive in situ ductal carcinomas of the breast as w

63 ied six susceptibility loci that affect mean preinvasive lesion multiplicity.

64 LCs occur both at preinvasive lesion sites and elsewhere in the bronchial

65 allow the progression from a precancerous or preinvasive lesion to a malignant tumor.

66 The progression from preinvasive lesion to invasive carcinoma is a critical s

67 of 30 mo, range 4-152) of 164 subjects with preinvasive lesions (80 high grade and 84 low grade at i

68 s confirmed the presence of clonally related preinvasive lesions across distinct airway regions.

69 HERVH-CALB1 expression was initiated in preinvasive lesions and associated with their progressio

70 even lesions of the head and neck, including preinvasive lesions and benign lesions associated with c

71 Furthermore, preinvasive lesions arising in basal cells displayed upr

72 lung cancers, 70% of normal or preneoplastic/preinvasive lesions associated with lung cancer, and 49%

73 0% of all EL-Kras/Tgfbr1(+/-) mice developed preinvasive lesions compared with 100% of EL-Kras (wild-

74 Ultimately, preinvasive lesions developed from a few highly mutated

75 mors because the molecular phenotypes of the preinvasive lesions differed at various sites.

76 47 normal, mildly abnormal, or preneoplastic/preinvasive lesions found in smokers without lung cancer

77 We found a significant increase in CN in preinvasive lesions graded severe dysplasia or higher.

78 1%) of the adenocarcinomas and preneoplastic/preinvasive lesions had smaller chromosome areas of 3p a

79 mas and the frequency of PIK3CA mutations in preinvasive lesions has not been explored.

80 n individual tumors; occurs in preneoplastic/preinvasive lesions in smokers with and without lung can

81 We asked whether we could classify preinvasive lesions of airway epithelium according to th

82 (c) address the interpretation of benign and preinvasive lesions of the mouse lung.

83 lleles of Nkx3.1 leads to the development of preinvasive lesions that resemble PIN.

84 rs can become lethal when they progress from preinvasive lesions to invasive carcinomas.

85 ell populations from prostate cancer and its preinvasive lesions using laser capture microdissection,

86 xpression levels in invasive lesions than in preinvasive lesions using samples obtained by laser capt

87 iary care referral center, 164 subjects with preinvasive lesions were monitored up to 12.5 years by r

88 In preinvasive lesions, amplification of the PIK3CA and ove

89 ic infiltration even around the lowest grade preinvasive lesions, but immunosuppressive cells, includ

90 creasing molecular characterisation of these preinvasive lesions, data will be available for how fact

91 Presence of preinvasive lesions, especially high-grade lesions, may

92 Effector T cells, however, were scarce in preinvasive lesions, found in only a subset of advanced

93 94% of human breast carcinomas and in 95% of preinvasive lesions, such as ductal and lobular carcinom

94 wth appear to occur after the development of preinvasive lesions, suggesting that these agents inhibi

95 lung cancers and in 78% of the preneoplastic/preinvasive lesions.

96 g cancer types (30 of 40; 75%) but not in 10 preinvasive lesions.

97 mutagenesis in both prostate cancer and its preinvasive lesions.

98 immunohistochemistry in 242 invasive and 43 preinvasive lung cancers and correlated our findings wit

99 hosphorylated Akt expression in invasive and preinvasive lung cancers.

100 rms that SOX2-overexpression initiates early preinvasive LUSC stages, and co-operation with the oxida

101 ctal carcinoma in situ is considered to be a preinvasive malignant lesion.

102 No significant differences in the numbers of preinvasive mammary intraepithelial neoplasia lesions (h

103 t ERK1/2 can promote noninvasive motility in preinvasive mammary tumors.

104 cervical cancer education and prevention and preinvasive management procedures compared among prior E

105 llular localization changes from nuclear, in preinvasive melanomas (melanomas in situ), to nuclear an

106 d pressure transducer provides a convenient, preinvasive method to measure and study IOP in unrestrai

107 In this study a preinvasive method was developed for determining the cam

108 udies on 97 lung cancer and 54 preneoplastic/preinvasive microdissected respiratory epithelial sample

109 Among the neoplastic disorders, preinvasive, microinvasive, and poorly differentiated ne

110 ryngeal carcinoma (NPC) and all EBV-infected preinvasive nasopharyngeal lesions.

111 Preinvasive neoplasias of the mouse prostate were recogn

112 DNA methylation studies profiling epithelial preinvasive neoplasias.

113 a2 dysregulation and identify new markers of preinvasive neoplastic change during progression to SCC.

114 ressor genes (TSGs) in sporadic invasive and preinvasive non-small-cell lung cancer (NSCLC) genomes,

115 one of the screen-detected malignancies were preinvasive or subcentimeter node-negative breast cancer

116 n instead develops in the earliest stages of preinvasive pancreatic intraepithelial neoplasia (PanIN)

117 eficiency in eNOS limited the development of preinvasive pancreatic lesions and trended toward an ext

118 c cancer cell lines, we investigated whether preinvasive pancreatic neoplasia contains a subpopulatio

119 t promotes the initiation and progression of preinvasive pancreatic neoplasia.

120 ult mice in two surviving lineages displayed preinvasive pancreatic neoplastic lesions with ductal mo

121 rophages from radiation treated invasive and preinvasive pancreatic tumors had an immune-suppressive,

122 DNA damage repair signaling upregulation in preinvasive PanIN lesions and is a promising new tool to

123 ylation defects were present in superficial, preinvasive, papillary tumors.

124 losses of the p53 gene were mapped to early preinvasive phases of urothelial neoplasia.

125 allelic losses of chromosome 17 in the early preinvasive phases of urothelial neoplasia.

126 raepithelial neoplasia (HGPIN) is a putative preinvasive precursor of prostatic adenocarcinoma, the m

127 ade the surprising finding that PDAC and its preinvasive precursors, pancreatic intraepithelial neopl

128 diagnosis and enhance the early detection of preinvasive precursors.

129 ed in regions of inflammatory atrophy and in preinvasive prostate cancer.

130 l as detection of molecular abnormalities in preinvasive respiratory lesions, have recently come into

131 analyzed p63 CN and protein expression in 41 preinvasive squamous lesions.

132 Preinvasive squamous lung lesions are precursors of lung

133 Such a high frequency of LOH at a preinvasive stage of breast cancer suggests that a candi

134 ndostatin (Ad-mEndo) administered during the preinvasive stage of mammary tumor development in C3(1)/

135 HG-DCIS lesions, in spite of representing a preinvasive stage of tumor progression, displayed molecu

136 he invasive progression of DCIS occur at the preinvasive stage, and these events include changes in t

137 asia at a surgically curative and preferably preinvasive stage, i.e., dysplasia.

138 ny breast cancers to be detected at an early preinvasive stage.

139 iated disease rapidly progresses through the preinvasive stages of neoplasia.

140 terized by a sequence of low- and high-grade preinvasive stages with increasing probability of malign

141 istant tissue transformation at premalignant/preinvasive stages, suggesting that circulating messenge

142 r invasive growth are already present in the preinvasive stages.

143 mproved understanding of the transition from preinvasive to invasive breast cancer will pave the way

144 elial compartment during the transition from preinvasive to invasive disease, distinct molecular alte

145 actively participates in the transition from preinvasive to invasive disease.

146 tatively correlated with the transition from preinvasive to invasive growth.

147 culture models to study the transition from preinvasive to invasive phenotype as it may occur "spont

148 nally significant changes in transition from preinvasive to invasive phenotype, we performed attribut

149 hysterectomy as an exposure, and evidence of preinvasive vaginal disease or vaginal carcinoma outcome

150 we found that S100A7 is highly expressed in preinvasive, well-differentiated and early staged human