ライフサイエンスコーパス: premature

1 f PPD has more widespread effects, including premature accumulation of late transcripts.

2 expression of its genes by preventing their premature accumulation.IMPORTANCE Kaposi's sarcoma-assoc

3 at systemic autophagy inhibition induces the premature acquisition of age-associated phenotypes and p

4 hese indicate that SARM1 homo-octamer avoids premature activation by assuming a packed conformation,

5 eregulated version of Yen1, showing that its premature activation interferes with the response to per

6 Premature activation of Akt in G(1) phase causes an earl

7 er of interaction that prevents deleterious, premature activation of crossovers.

8 Moreover whether CFRI dysfunction or premature activation underlie certain Na(V) channelopath

9 of an autoinhibitory mechanism that prevents premature activation.

10 oxidative stress, mitochondrial dysfunction, premature ageing and epigenetic changes are common featu

11 mark features of HR insufficiency, including premature aging and hypersensitivity to PARPi.

12 nA homolog, OOC-5, rescues the sterility and premature aging caused by a null mutation in the single

13 Here we evaluated whether premature aging caused by accumulation of mitochondrial

14 A cause degenerative disorders including the premature aging disorder Hutchinson-Gilford progeria, bu

15 The premature aging is not associated with increased cellula

16 resilience against neurological diseases or premature aging of the brain.

17 ocused on lowering cancer risk by preventing premature aging or promoting healthy aging.

18 helicase, deficient in the cancer-prone and premature aging Rothmund-Thomson syndrome, physically an

19 opoietic system from changes associated with premature aging.

20 hritis features was not found accelerated in premature aging.

21 ut mice are prone to genomic instability and premature aging.

22 mutator mouse is a well-established model of premature aging.

23 Both the premature and delayed weaning groups had poorer clinical

24 s occur with opportune weaning compared with premature and delayed weaning.

25 73 premature- and 89 mature-born adults aged 25-27 years un

26 in cholesterol (LDL-C) and increased risk of premature atherosclerotic cardiovascular disease (ASCVD)

27 can serve as paradigms for the prevention of premature atherosclerotic cardiovascular disease in all

28 ple rounds of local translation and prevents premature ATI protein aggregation and trapping of virion

29 ity, enhanced late I(Na) and correlated with premature atrial contraction severity.

30 een 1990 and 2017 had achieved low levels of premature avertable mortality from NCDs by 2017.

31 Globally, premature avertable mortality from NCDs for both sexes c

32 tality while avoiding arbitrary age cutoffs, premature avertable mortality from NCDs is a robust, com

33 In 2017, high premature avertable mortality from NCDs was clustered in

34 e, there has been a substantial reduction in premature avertable mortality from NCDs, but progress ha

35 vers of the global and regional reduction in premature avertable mortality from NCDs, whereas prematu

36 This study focuses on premature avertable mortality from NCDs-premature deaths

37 s been a global slowdown in the reduction of premature avertable mortality from NCDs.

38 By accounting for premature avertable mortality while avoiding arbitrary a

39 in perinatal care have improved survival for premature babies, so many now present as adolescents and

40 atients) with anomalous bundles, ventricular premature beats, atrial flutter, atrioventricular nodal

41 61; 95% confidence interval [CI], 8.5-18.5), premature birth (46.0%, RR = 11.32; 95% CI, 8.1-15.7) an

42 Survivors following very premature birth (i.e., <= 32 weeks gestational age) rema

43 t lower FD partly underpins FA reductions of premature birth but that other processes such as hypomye

44 Results provide evidence that premature birth leads to lower FD in adulthood which lin

45 Premature birth occurs during a period of rapid brain gr

46 Premature birth was identified in 15.0% of EXPECT infant

47 yopia, autosomal recessive bestrophinopathy, premature birth) having a similar FAZ phenotype.

48 /ethnicity, glomerular status, birth weight, premature birth, angiotensin-converting enzyme inhibitor

49 drome (RDS) is the commonest diagnosis after premature birth.

50 I, we tested the hypothesis of reduced FD in premature-born adults and investigated its link with the

51 Premature-born adults exhibit lasting white matter alter

52 hereas Hoxb1-deficient mouse embryos display premature cardiac differentiation.

53 ial hypercholesterolemia is characterized by premature cardiovascular disease caused by markedly elev

54 hypertension, smoking, and family history of premature cardiovascular disease contributed to progress

55 s a critical role in inducing telomere loss, premature cell aging, and CD4 T-cell apoptosis or deplet

56 SV) and human metapneumovirus (hMPV) LRTI in premature children and determine risk factors for RF and

57 lower respiratory tract infection (LRTI) in premature children in developing countries are necessary

58 A total of 664 premature children participated.

59 d nucleus first enters a mitotic-like state (premature chromatin condensation).

60 e spindle assembly checkpoint (SAC) prevents premature chromosome segregation by inactivating the ana

61 regenerative process is highly complex, and premature claims of successful heart regeneration have b

62 to albumin prior to administration minimized premature cleavage and instability of the drug in plasma

63 rmation in Grhl3 mutant mice associated with premature closure of the canal.

64 eatures in South Asian populations including premature coronary heart disease, early type 2 diabetes

65 lthood was associated with very low rates of premature CVD and mortality over 32 years, indicating th

66 ociations of CVH at ages 18 to 30 years with premature CVD and mortality.

67 childhood approximately doubled the rate of premature death (ie, before age 70 years).

68 d's adult population and is a major cause of premature death despite considerable advances in pharmac

69 e hypertension is the leading risk factor of premature death globally.

70 R2 editing leads to early-onset epilepsy and premature death in a mouse model.

71 hence, these cells are highly susceptible to premature death in retinal degenerative disorders.

72 AV-Slc25a46 treatment was able to rescue the premature death in the mutant mice (Slc25a46-/-).

73 causes, the years of life lost (YLLs) due to premature death were calculated.

74 Fatty liver causes premature death worldwide and requires long-term health

75 rder marked by growth retardation, diabetes, premature death, and severe lymphoid and myeloid hypopla

76 ent to induce progressive motor symptoms and premature death, but genetically lacks corticospinal neu

77 d Health Organization 25x25 risk factors for premature death, smoking and body mass index (BMI) were

78 often results in advanced heart failure and premature death.

79 quently culminate in right heart failure and premature death.

80 e motor neuron loss leading to paralysis and premature death.

81 ve stress, symptoms of hemolytic anemia, and premature death.

82 hich can progress to heart failure and cause premature death.

83 emodelling, progression to heart failure and premature death.

84 idney failure, cardiovascular morbidity, and premature death.

85 heart failure, reduced quality of life, and premature death.

86 eta and hs-CRP concentrations on the risk of premature death.

87 , motor and cognitive decline, seizures, and premature death.

88 antibiotic exposure may be a risk factor of premature death.

89 rated macrocephaly, spontaneous seizures and premature death.

90 a wheelchair, respiratory insufficiency and premature death.

91 malities, compromised motor performance, and premature death.

92 s that contribute to increased morbidity and premature death.

93 PUFA intake in lowering the risk of CVD and premature death.

94 nal shortening, hypertrophy, dilatation, and premature death.

95 For premature deaths (age 30-69 years), the WHO triple-inter

96 o an estimated 16,889 (3,839-30,663, 95% CI) premature deaths annually combining the effects of NMVOC

97 ely equating to 3.9 million (95% CI 2.5-5.6) premature deaths averted annually.

98 aged 40-74 years, we estimated the number of premature deaths averted for all adults and by gender.

99 s on premature avertable mortality from NCDs-premature deaths caused by NCDs that could be prevented

100 primary PM(2.5) emissions led to cross-state premature deaths equal to three times those associated w

101 % in India and Nepal, and result in ~300 000 premature deaths from chronic obstructive pulmonary dise

102 ioxide emissions caused the most cross-state premature deaths in 2005, but by 2018 primary PM(2.5) em

103 the atmosphere and contribute to millions of premature deaths in humans each year.

104 Smoking accounted for a quarter of all premature deaths in this population, but quitting before

105 o migration drove 137.1 (95%CI: 93.2, 179.4) premature deaths related to air pollution, with rural-ur

106 e change in the number and economic value of premature deaths using modeled changes in ozone levels r

107 It leads to millions of premature deaths.

108 cerbated organ damage, ultimately leading to premature deaths.

109 xes outside the capsid lattice, which led to premature degradation of the viral genome and IN in targ

110 anical properties and improved resistance to premature degradation.

111 ants, hyperoxia is simultaneously harmful to premature developing tissues such as in the retina.

112 Grade III Dindo-Clavien in 22%, and required premature device explantation in 16%.

113 l adhesion protein E-CADHERIN, which lead to premature differentiation and cell cycle arrest.

114 8(+) T cells, acting as a barrier to prevent premature differentiation and controlling epigenetic int

115 vels of lamin B1 in ANSPCs safeguard against premature differentiation and regulate the maintenance o

116 show here that the Cohesin complex prevents premature differentiation of Drosophila ISCs into entero

117 t various times and durations did not induce premature differentiation of odontoblasts.

118 during the first 2 postnatal weeks caused a premature differentiation of oligodendrocytes similar to

119 resulted in loss of naive CD8(+) T cells and premature differentiation toward a memory-like state, in

120 Undifferentiated uveitis may be prone to premature discontinuation of ADA due to adverse events.

121 ated interim analysis was done, resulting in premature discontinuation of the study for futility.

122 tabolic disorders are intimately linked with premature disease onset but the underlying mechanisms re

123 t destabilization of the CA lattice leads to premature dissociation of CA from viral cores, which exp

124 ly, destabilization of the CA lattice led to premature dissociation of CA from vRNPs in target cells,

125 with ATG5 on isolation membranes, precluding premature dynein recruitment and autophagosome transport

126 veloping pancreas, and loss of Dll1 leads to premature endocrine differentiation.

127 during red wine aging can contribute to the premature evolution of aroma, characterized by the loss

128 in self-renewal, loss of cell identity, and premature exhaustion of the quiescent satellite cell poo

129 ntal exposure, reducing strength and causing premature failure.

130 causes ectopic clustering of nodal proteins, premature formation of heminodes around early ensheathin

131 he phytohormone abscisic acid (ABA) prevents premature germination and seedling growth under unfavora

132 and induces Olig2 expression, indicative of premature gliogenesis.

133 Delay in such treatment is a major cause of premature graft loss in these patients.

134 anisms that may explain an increased risk of premature HF in South Asians compared with other groups,

135 We hypothesized that a premature His complex (PHC) will always perturb AVRT bec

136 ild-type mice, and loss of miR-146a promoted premature HSC aging and inflammation in young miR-146a-n

137 ful, the intein fusion approach suffers from premature hydrolysis and low compatibility with denature

138 ent stress-induced expression and to prevent premature hypertrophy.

139 zed our sample into three weaning groups: 1) premature: if the weaning trial took place before fulfil

140 7% [1:15]) among 31,316 unique subjects with premature IHD (1,471 patients with FH) on the basis of 3

141 subjects with ischemic heart disease (IHD), premature IHD, and severe hypercholesterolemia (low-dens

142 mates of FH prevalence in subjects with IHD, premature IHD, and severe hypercholesterolemia compared

143 atory CD151+ T cells could contribute to the premature immunological aging phenotype observed in thes

144 ted in an independent longitudinal cohort of premature infants (<=36 weeks PMA, n = 130; Bogota).

145 nce interval [CI], 41.7-118.2) for 213 early premature infants (P < .001), 18.2 hospitalizations/100

146 ient-years (95% CI, 29.1-39.2) for 4446 late premature infants (P < .001), and 16.1 hospitalizations/

147 /100 patient-years (95% CI, .8-35.7) for 397 premature infants (P = .04), 34.2 hospitalizations/100 p

148 s (NEC) is an inflammatory bowel necrosis of premature infants and an orphan disease with no specific

149 1,259 premature infants at risk for ROP were evaluated.

150 utic target for prevention of diffuse WMI in premature infants experiencing chronic IH stress.

151 ective for prevention of allergic disease in premature infants remains lacking; adequately powered ra

152 In total, 296 premature infants were enrolled and compared with a cont

153 Serial fecal samples were collected from premature infants with birth weight (BW) <= 1800 g, esti

154 Premature infants with bronchopulmonary dysplasia, chara

155 ctor for bronchopulmonary dysplasia (BPD) in premature infants, a disease characterized by dysregulat

156 is required to promote survival of severely premature infants, hyperoxia is simultaneously harmful t

157 acia, a major form of brain injury affecting premature infants.

158 tood pathophysiology predominantly affecting premature infants.

159 f visual impairment in diabetic patients and premature infants.

160 ly 2 months premature to affecting extremely premature infants.

161 on standards and the Fenton growth chart for premature infants.

162 D risk assessment, particularly in extremely premature infants.

163 n by negative regulation mechanisms to avoid premature inflammasome assembly.

164 MKRN3) as an inhibitory signal that prevents premature initiation of puberty.

165 These findings led to premature interruption of the trial and suggest the unli

166 ed LXRalphabeta protects against homeostatic premature involution and orchestrates thymic regeneratio

167 tion effect, but disadvantages including the premature leakage and non-selective release of photosens

168 gh molecular weight ubiquitin conjugates and premature lipofuscin accumulation in brains of young TAX

169 aceholders Rlp24, Arx1 and Mrt4 that prevent premature loading of the ribosomal protein eL24, the pro

170 esis that constitutive levels of Nrf2 in the premature lung are insufficient to mitigate hyperoxia-in

171 In zebrafish, this mechanism controls premature melanoblast expansion and differentiation from

172 Associations were larger for natural premature menopause (all CHIP: odds ratio, 1.73 [95% CI,

173 Just under 10,000 (9.4%) women experienced premature menopause and 22,240 (22%) experienced early m

174 606 women, including 418 (2.1%) with natural premature menopause and 887 (4.5%) with surgical prematu

175 examined sex-specific risk factors, such as premature menopause and early menarche, with risk of AAA

176 analyses considered natural versus surgical premature menopause and gene-specific CHIP subtypes.

177 Whether premature menopause is associated with CHIP is unknown.

178 Natural premature menopause may serve as a risk signal for predi

179 Premature menopause was associated with increased risk o

180 After multivariable adjustment, premature menopause was independently associated with CH

181 Women with premature menopause were more likely to be overweight, B

182 ogistic regression tested the association of premature menopause with CHIP, adjusted for age, race, t

183 oking history (n = 19,286), 2148 (11.1%) had premature menopause, which was associated with greater r

184 but smaller and nonsignificant for surgical premature menopause.

185 ature menopause and 887 (4.5%) with surgical premature menopause.

186 NMT3A CHIP was significantly associated with premature menopause.

187 While premature mitotic entry inhibits mesoderm invagination,

188 ivity prevalence has contributed to averting premature mortality across all countries.

189 ht the associations of young-onset T2DM with premature mortality and morbidity.

190 ria(10,11) protects C9orf72-mutant mice from premature mortality and significantly ameliorates their

191 es in the development of chronic illness and premature mortality at older ages.

192 years, a one-third reduction in the rate of premature mortality from cervical cancer in LMICs is pos

193 ature avertable mortality from NCDs, whereas premature mortality from substance use disorders, chroni

194 age when smokers started) and cause-specific premature mortality in a cohort of adults in Cuba.

195 tors and emission species that contribute to premature mortality may help to guide improvements to ai

196 hat 41 to 53 per cent of air-quality-related premature mortality resulting from a state's emissions o

197 uous United States, and assess its impact on premature mortality that is linked to increased human ex

198 ent emission sectors and chemical species to premature mortality, and changes in these variations ove

199 type 2 diabetes, cardiovascular disease, and premature mortality, whereas evidence for artificially s

200 us organ systems, and decreases the risk for premature mortality.

201 terns within Peru and quantify its effect on premature mortality.

202 s can decrease the behaviors associated with premature mortality.

203 veloping interventions to reduce the risk of premature mortality.

204 increased risk of many chronic diseases and premature mortality.

205 , 1.61-2.00) had a moderately higher risk of premature mortality.

206 for preventive therapy in young adults with premature myocardial infarction (MI).

207 Early premature (n = 213), premature (n = 397), late premature

208 Early premature (n = 213), premature (n = 397), late premature (n = 4446), and full

209 emature (n = 213), premature (n = 397), late premature (n = 4446), and full-term (n = 33 417) RSV-inf

210 on and World Bank geographic region, risk of premature NCD mortality, percentage of all deaths caused

211 of the cilium base, promoting ciliopathy and premature neurogenesis.

212 using an atypical non-genetic ciliopathy and premature neuron delamination.

213 phorylated/pathologically conformed Tau, and premature neuronal loss.

214 The reduction by a third of premature non-communicable disease (NCD) mortality by 20

215 and Fgf20, rescuing bilateral renal agenesis premature NPC differentiation, NPC proliferation, and ce

216 CU-free days, and hospital-free days between premature, opportune, and delayed weaning groups.

217 were retrospectively determined to have been premature, opportune, or delayed based on when they met

218 red urinary Pi excretion, low autophagy, and premature organ dysfunction.

219 d increased risk for cardiomyopathy, stroke, premature ovarian failure, chronic liver disease, and re

220 link between anti-KHDC3L autoantibodies and premature ovarian insufficiency, and between anti-RFX6 a

221 ta were requested from multiple providers on premature patients with a history of ROP and no treatmen

222 ive treatment for LGEA in both full-term and premature patients, suggesting delayed or diminished CC

223 of their high drug loading capacity and low premature release profile.

224 of membranes (aOR, 1.96; 95% CI, 1.11-3.45), premature rupture of membranes (aOR, 1.42; 95% CI, 1.08-

225 onfidence interval [CI], 1.19-1.88), preterm premature rupture of membranes (aOR, 1.96; 95% CI, 1.11-

226 ioamniotic membranes from women with preterm premature rupture of membranes (pPROM) and normal term p

227 After preterm premature rupture of membranes (PPROM), antibiotics and

228 7 weeks due to spontaneous preterm labour or premature rupture of membranes (sPTB).

229 on between HPV and preterm birth and preterm premature rupture of membranes.

230 mortality and morbidity and leads to preterm premature rupture of placental chorioamniotic membranes.

231 ed to the equivalent stage in dunnarts, with premature SATB2 overexpression in mice to match that of

232 epair factors by phosphorylation, preventing premature segregation of entangled chromosomes formed du

233 ferentiation into adipocyte precursors (AP), premature senescence emerged, impairing later stages of

234 n fragments in the cytosol, which leads to a premature senescence phenotype.

235 ction (NDJ) in meiosis I and meiosis II, and premature separation of sister chromatids (PSSC) and rev

236 e transcriptase (tert) mutant zebrafish have premature short telomeres and anticipate cancer incidenc

237 The competing phosphorylation routes prevent premature Sic1 degradation and demonstrate how integrati

238 ic entry directs the RZZ complex to minimize premature stabilization of erroneous attachments, wherea

239 NA, shifts the reading frame, and produces a premature stop codon downstream.

240 that shifts the reading frame, and creates a premature stop codon downstream.

241 single nucleotide polymorphism introducing a premature stop codon in the lysosomal trafficking regula

242 in the open reading frame of Ma1 leads to a premature stop codon that truncates the protein by 84 am

243 uplication causes a frame shift leading to a premature stop codon.

244 Premature stop codons introduced by mis-splicing of PgAB

245 C-RPE models to gene editing, which produced premature stop codons specifically within the mutant BES

246 ubstitutions to frameshift mutations causing premature stop codons, and led to specific differences i

247 y of which introduced frameshifts or encoded premature stop codons.

248 ipping resulting in frameshifts that lead to premature stop codons.

249 es also occurred, leading to frameshifts and premature stop codons.

250 ad to markedly altered protein sequences and premature stop codons.

251 ying a homozygous mutation that introduces a premature stop in exon 2 of the appb gene.

252 le-nucleotide polymorphism that results in a premature stop in translation, yielding a truncated, non

253 or 3 (TLR3) gene resulting in formation of a premature stop-codon.

254 wever, enrollment was suboptimal, triggering premature study discontinuation.

255 unction during mtLSU assembly that minimizes premature subunit joining to ensure the assembly of the

256 lso abnormal: the epithelial cells underwent premature swelling, and host robustness was reduced.

257 os have fewer motor neurons resulting from a premature switch from motor neuron to OPC production.

258 D) in tapetal cells, resulting in delayed or premature tapetal degeneration, respectively.

259 ents can be therapeutically desirable when a premature termination codon (PTC) is found in a critical

260 ecies encodes a frame-shifted protein with a premature termination codon (PTC) predicted to elicit de

261 ng non-sense progranulin mutations contain a premature termination codon (PTC), thus progranulin hapl

262 ) mouse model from Igh (Ter5H) mice having a premature termination codon at position +5 in leader exo

263 sulting in splicing to a cryptic exon with a premature termination codon.

264 hway degrades some but not all mRNAs bearing premature termination codons (PTCs).

265 nd cancers are caused by the introduction of premature termination codons (PTCs).

266 In addition to premature termination codons, plant microRNAs can also d

267 Promoter-proximal and premature termination is common and might in turn regula

268 for the first time, we demonstrate that the premature termination of host gene transcripts upstream

269 yonic stem cell (ESC) identity by preventing premature termination of numerous transcripts at cryptic

270 sTer10) in F3, the gene encoding TF, causing premature termination of TF (TFshort) in a woman with un

271 e interpreted in the context of wide CIs and premature termination of the trial.

272 ownregulate protein production by inducing a premature termination of translation, which triggers mes

273 Premature termination requires RNA cleavage by the endon

274 rom affecting infants approximately 2 months premature to affecting extremely premature infants.

275 of a delay on vaccine coverage suggest it is premature to change current vaccine recommendations, alt

276 ligonucleotides (U1 AMO) triggers widespread premature transcription termination and mRNA shortening.

277 Integrator is further employed to trigger premature transcription termination at many protein-codi

278 RNA, an interaction important for preventing premature transcription termination by Rho factor.

279 sting the existence of mechanisms to prevent premature transcription termination by Rho, a conserved

280 ascent transcripts and, consequently, induce premature transcription termination downstream of the cl

281 IS)-dependent RNA cleavage, or as drastic as premature transcription termination or degradation of po

282 complex can bind paused RNA Pol II and drive premature transcription termination, potently attenuatin

283 tion and rapid degradation of mRNA harboring premature translation termination codons (PTCs) serves t

284 ally protect against inactivation of EBOV by premature triggering of GP2.

285 of Elp1, Shp1 was hyperactivated, leading to premature TrkA receptor dephosphorylation, which resulte

286 ied by mutations resulting in frame shift or premature truncation.

287 l predictors, only 4 (younger age, male sex, premature ventricular complex count, and number of leads

288 Premature ventricular complexes (PVCs) are extremely com

289 There was a trend for decreased spontaneous premature ventricular complexes and pacing-induced ventr

290 chycardia; or aborted SCD), syncope, 24-hour premature ventricular complexes count, the number of ant

291 lar tachycardia (NSVT), and Lown's grade >=2 premature ventricular complexes, were enrolled.

292 phic VA (NSVT and VT: 19% vs. 2%; p = 0.002; premature ventricular complexes: 63% vs. 16%; p < 0.001)

293 nce and significance of neural remodeling in premature ventricular contraction-induced cardiomyopathy

294 in 13 patients (62%), whereas 6 patients had premature ventricular contraction-induced ventricular fi

295 e-like interface with residual traction, and premature vitreous syneresis.

296 icipants (60.8%) were classified as having a premature weaning trial, 196 underwent opportune weaning

297 s in early school-age children who were born premature were different from those of full-term childre

298 pathway to mitigate disturbed myelination in premature white matter injury.

299 ce of clinical and histologic relapse and no premature withdrawal for any reason.

300 ar calcium causes mitochondrial dysfunction, premature zymogen activation, and necrosis, ultimately l