ライフサイエンスコーパス: prematurely

1 troke and ischemic retinopathy, and 48% died prematurely.

2 pport, 2 women died, and 6 infants were born prematurely.

3 to follow-up; 19% discontinued their regimen prematurely.

4 vation after Gram-negative infection and die prematurely.

5 s can dissociate replisomes from chromosomes prematurely.

6 pended dual antiplatelet therapy, in 6 cases prematurely.

7 n of patients who experience relapse and die prematurely.

8 152 singleton infants, 22 (14.5%) were born prematurely.

9 tients never started IFN-alpha-2b or stopped prematurely.

10 rogressive neuromuscular dysfunction and die prematurely.

11 17 who received 2400 mg/d of CoQ10) withdrew prematurely.

12 treatment and those who did not or recurred prematurely.

13 evious Swedish cohorts of children born less prematurely.

14 bilizing the 40S-IRES complex does not occur prematurely.

15 ive in the placebo group withdrew from study prematurely.

16 he molar tooth bud, both processes terminate prematurely.

17 is not sustained, and HF downgrowth arrests prematurely.

18 bitor 5-azacytidine and find that they ripen prematurely.

19 small peptides, some substrates are released prematurely.

20 were not blinded, and the trial was stopped prematurely.

21 c follow-up of children and adults born very prematurely.

22 conditions may doom promising new approaches prematurely.

23 terminate the breastfeeding of their infants prematurely.

24 immune disease where platelets are destroyed prematurely.

25 ed conformational changes required for entry prematurely.

26 isting interventions end their interventions prematurely.

27 ally be induced by month 2 and differentiate prematurely.

28 +) that prevents the nucleotide from leaving prematurely.

29 males, whereas older hermaphrodites succumb prematurely.

30 roteins and disassemble apical actin bundles prematurely.

31 d be exercised to avoid suspending treatment prematurely.

32 ents photocaged DHEA from activating neurons prematurely.

33 d, cell size increased, and nephrocytes died prematurely.

34 on in which one or more cranial sutures fuse prematurely.

35 white men enrolled in the study; 2 withdrew prematurely, 1 because of a non-drug-related serious adv

36 Four subjects died and 2 discontinued prematurely; 117 of 123 (95%) completed 104 weeks.

37 months of treatment, 3 patients discontinued prematurely, 2 patients died, 7 patients were hospitaliz

38 Six patients (8%) stopped HCV therapy prematurely: 2 due to HCV breakthrough, 4 to adverse eve

39 patients on veverimer discontinued treatment prematurely (3% vs 10%, respectively), and no patients o

40 la pt4 mutant in which arbuscules degenerate prematurely [4], we identified arbuscule degeneration-as

41 The trial was stopped prematurely (445 randomized patients) because of a low g

42 erotic coronary artery disease (CAD) and die prematurely (50% mortality at 42 d of age).

43 055 otherwise healthy children who were born prematurely, 583 received a diagnosis of strabismus late

44 articipants withdrew consent or discontinued prematurely, 6 owing to adverse events attributed to X-8

45 The study was discontinued prematurely (645 patients; 299 SREs) after the corporate

46 We investigated prediction in infants born prematurely, a leading cause of neuro-cognitive impairme

47 " reactions that recognize the structures of prematurely abandoned replication forks and mediate repl

48 roteins, 12S globulin and 2S albumin, became prematurely accumulated at the proliferating phase of se

49 Those that do grow prematurely acquire lipid synthesis enzymes and undergo

50 uRD-deficient lymphoid progenitors therefore prematurely activate a B cell transcriptional program an

51 e, the enhancer regulators P300 and Brd4 can prematurely activate transcription and restore transcrip

52 acinar damage caused by the accumulation of prematurely activated trypsin.

53 We hypothesize that prematurely activated virions are less fit for receptor

54 not in close proximity, and these genes were prematurely activated.

55 se sperm will go astray, invading the ovary, prematurely activating oocytes, and sometimes crossing b

56 ic progenitors do not die, but differentiate prematurely adjacent to the somite.

57 st transform new inputs into outputs without prematurely affecting downstream circuits while still ma

58 Study was terminated prematurely after interim analysis, which showed no diff

59 irological breakthrough and one discontinued prematurely after the first day of treatment.

60 is a distinctive disorder characterized by a prematurely aged appearance with lipoatrophy, epidermal

61 thymectomy and may also explain in part the prematurely aged phenotype of the naive T cell pool in i

62 ounds associated with the flavor of aged and prematurely aged red wines.

63 ains homeostasis in otherwise arrhythmic and prematurely aging animals.

64 yte cause aggravation of aging phenotypes in prematurely aging mtDNA mutator (PolgA(mut/mut)) mice.

65 atg mutants, ATG11-deficient plants senesce prematurely and are hypersensitive to nitrogen and fixed

66 raise concern that this cohort may be aging prematurely and at risk for substantial medical and cogn

67 and did not proliferate but rearranged Tcra prematurely and differentiated rapidly.

68 ications, are at a higher risk of delivering prematurely and giving birth to SGA newborns.

69 The Class I mutant secretes translocators prematurely and is specifically defective in IpaD secret

70 ased cardiovascular risk in individuals born prematurely and open perspectives for therapeutic strate

71 DeltaE26)) exhibit spontaneous seizures, die prematurely and present a respiratory phenotype includin

72 The study was terminated prematurely and the decision to discontinue the study wa

73 three patients had to discontinue treatment prematurely and the third required dose reduction.

74 aused perinatal hepatocytes to differentiate prematurely and to express genes at postnatal day 14 tha

75 eloped cervical shortening and who delivered prematurely and were predictive of sPTB < 37 weeks, with

76 cluded children aged 6-8 years who were born prematurely and who did not receive retinopathy treatmen

77 ic or substance abuse comorbidity (3.8% died prematurely) and those with solely substance abuse (6.2%

78 EFs) proliferated poorly, entered senescence prematurely, and expressed a proinflammatory gene signat

79 velopment of the immune system in those born prematurely, and of how this development is influenced b

80 gland cells overproliferated, differentiated prematurely, and often adopted a mixed lineage fate.

81 hus protecting unprimed vesicles from fusing prematurely, and redirecting them to refill the readily

82 This arm was terminated prematurely, and subsequent patients received vinblastin

83 ic Pi transport fails, arbuscules degenerate prematurely, and the symbiosis is not maintained.

84 ll, exposed colonies were more likely to die prematurely, and those that survived reached a lower fin

85 ogical deficits observed in individuals born prematurely are not completely understood.

86 essful because metal precursors precipitated prematurely at the pH and temperatures required for MFI

87 Further, ubp3 sir2 mutants age prematurely at the same rate as sir2 mutants.

88 ed the ledipasvir and sofosbuvir combination prematurely because of adverse events; 10 patients died,

89 ur patients discontinued the trial treatment prematurely because of adverse events; three of these pa

90 The study was halted prematurely because of difficulty with patient recruitme

91 The 1600-IU/d dosage was discontinued prematurely because of elevated plasma 25(OH)D concentra

92 he full study, and six (17%) discontinued it prematurely because of loss to follow-up, withdrawal of

93 Cohort A was closed prematurely because of poor accrual and is not reported.

94 e absence of Hey1 and Hey2 but differentiate prematurely because of precocious upregulation of the pr

95 Recruitment was stopped prematurely because of recruitment and retention difficu

96 Hydration treatment was terminated prematurely because of shortness of breath in three pati

97 The trial was terminated prematurely because of slower-than-expected recruitment

98 The study was terminated prematurely because of unacceptable rates of AR (4 of 14

99 Enrollment was closed prematurely because preliminary results indicated failur

100 t least 2.284 million people might have died prematurely because RRT could not be accessed.

101 The study was terminated prematurely before enrolling the target number of patien

102 uted to HIV/AIDS, and 94% of deaths occurred prematurely (before age 65).

103 d this question in 40 infants born extremely prematurely (between 25- and 32-wk gestation) in the fir

104 00 of 165 low-birth-weight survivors (60.6%) prematurely born between January 1, 1977, and December 3

105 One-third of the extremely prematurely born children in this study had some kind of

106 pothesized that cBF integrity is impaired in prematurely born individuals and mediates adult cognitiv

107 Prematurely born individuals have an increased risk for

108 velopment, and disrupted lung development in prematurely born infants may have enduring effects on ho

109 Three hundred thirty-five fundus images of prematurely born infants were obtained by neonatal inten

110 in living and nonliving human fetuses and in prematurely born neonates have provided insight into the

111 Most of the neonates were prematurely born: 19 (70.4%) were born at gestational ag

112 hout functional FAK initiate differentiation prematurely, both in vivo and in vitro.

113 s BubR1X753/L1002P and BubR1H/X753 mice died prematurely, BubR1H/L1002P mice were viable and exhibite

114 eumatoid arthritis (RA), T cell aging occurs prematurely, but the mechanisms involved and their contr

115 or recovery from hearing loss is also closed prematurely by early eyelid opening and extended by dela

116 uire the Cdk1 mitotic kinase and be promoted prematurely by ectopic expression of the NIMA kinase.

117 The current study was closed prematurely by recommendation of the Data and Safety Mon

118 The trial was terminated prematurely by the data and safety monitoring board beca

119 The trial was interrupted prematurely by the Data Safety and Monitoring Board beca

120 ailed to gain weight, were smaller, and died prematurely (by approximately 6-8 weeks of age).

121 immature physiologic functions, infants born prematurely cannot be expected to readily feed by mouth

122 tex can thereby prepare the movement without prematurely causing it.

123 ition, ICP27 induced expression of pre-mRNAs prematurely cleaved and polyadenylated from cryptic poly

124 These previously undescribed prematurely cleaved and polyadenylated pre-mRNAs, some o

125 )I-BZA2 sensitivity, this clinical trial was prematurely closed after 87 patients had been included.

126 Study inclusion was prematurely closed after an unplanned interim analysis w

127 EE1 protein levels fell and CDKB levels rose prematurely, coinciding with early mitosis.

128 to 0.5 mg semaglutide discontinued treatment prematurely, compared with 55 (15%) assigned to 1.0 mg s

129 function is lacking, resulting in cells that prematurely condense their chromosomes during mid G2-pha

130 rtunately, this approach can cause models to prematurely converge to sub-optimal solutions, through a

131 the primary response, FDC-less GC dissipated prematurely, correlating with impaired affinity maturati

132 significantly higher density in live versus prematurely deceased females indicating a potentially mu

133 ially susceptible to Parkinson's disease and prematurely degenerate in the course of disease progress

134 enome and IN from ALLINI-treated virions are prematurely degraded in target cells, whereas reverse tr

135 RNA genome and IN in eccentric particles are prematurely degraded, whereas reverse transcriptase rema

136 ized by the ER quality-control machinery and prematurely degraded, whereas the secretable LGI1(S473L)

137 , which has residual channel activity but is prematurely degraded.

138 F508del-CFTR is misfolded and prematurely degraded.

139 not receive adequate medical attention, were prematurely detached from the health system, or held unr

140 a number of nonurinary etiologies for fever, prematurely diagnosing urinary tract infection, and pres

141 ing compartment, cortical interstitial cells prematurely differentiate.

142 1 null in which misexpressed DCN produced by prematurely differentiated interstitial cells accumulate

143 tcomes included QT prolongation, the need to prematurely discontinue any of the medications due to QT

144 rt one had reached post-treatment week 12 or prematurely discontinued from the study.

145 Treatment was prematurely discontinued in four patients.

146 Sixteen patients (12.3%) prematurely discontinued therapy or were lost to follow-

147 in alanine aminotransferase and no patients prematurely discontinued treatment because of adverse ev

148 from the first 104 patients who completed or prematurely discontinued treatment by January 1, 2014 ar

149 However, more patients prematurely discontinued treatment with ticagrelor than

150 of active Nek2A, but not kinase-dead Nek2A, prematurely displaced DAs from the interphase centrosome

151 germ cell divisions within the niche, but by prematurely displacing proliferating cells from their no

152 The mice fail to grow and die prematurely, displaying systemic inflammation, nutrient

153 ich value-related signals are prevented from prematurely driving choice.

154 domization to TAC Elimination was terminated prematurely due to a higher rate of treated biopsy-prove

155 lence of cardiovascular diseases was stopped prematurely due to adverse cardiovascular events raising

156 ents (2%) discontinued ledipasvir-sofosbuvir prematurely due to adverse events.

157 Nevertheless, p53(KQ/-) mice died prematurely due to anemia and hematopoiesis failure.

158 es may not be averted when DAA therapy fails prematurely due to emergence of resistant HCV variants.

159 Everolimus 3.0 mg was terminated prematurely due to higher mortality.

160 Recruitment was closed prematurely due to poor accrual after 89 of 200 planned

161 ice with T cell-specific Stim1 deletion died prematurely during the chronic phase of infection and ha

162 Over 15 million babies are born prematurely each year with approximately 1 million of th

163 re responsible for almost 500,000 lives lost prematurely each year.

164 cell-programming transcription factors from prematurely enacting lineage commitment.

165 The trial prematurely ended after inclusion of 266 patients (38% o

166 olar masses) indicates that the outburst was prematurely ended when a sizeable fraction of the outer

167 tion, preventing the incomplete subunit from prematurely engaging in translation.

168 knowledge on how UV exposure causes cells to prematurely enter cellular senescence.

169 in FSHD myoblasts, which nonetheless did not prematurely enter myogenic differentiation.

170 to rapidly depart from migratory streams and prematurely enter the cortical plate.

171 ockout (KO) and in thalamus-specific KO mice prematurely entered the cortical plate, eventually inner

172 thaliana plants in which starch reserves are prematurely exhausted.

173 eumophila replication and causes bacteria to prematurely exit the host cell.

174 In seven cases, two meshes were prematurely exposed (within 4 to 6 weeks), and five were

175 re affected and 47 pollen-related genes were prematurely expressed at a higher level.

176 ct KEAP1, the major suppressor of Nrf2, from prematurely extracting the transcription factor off of a

177 cling at 0.1-2 mA cm(-2) , while baseline Cu prematurely fails when the current reaches 0.5 mA cm(-2)

178 Moreover, we caution against prematurely focusing on redistricting as the only method

179 ch that cells lacking both inhibitors divide prematurely following DNA damage, with lethal consequenc

180 an sPLA2 inhibitor (varespladib) was stopped prematurely for lack of efficacy.

181 The study was stopped prematurely for safety reasons after 16 patients (61+/-8

182 of the placebo before the trial was stopped prematurely for safety reasons.

183 Moreover, the prematurely formed cyclodehydrogenation products during

184 The enteral feeding tube was withdrawn prematurely from 48.5% of patients, and serious adverse

185 5.6 million adolescents alive today will die prematurely from a smoking-related illness.

186 ft ventricular systolic dysfunction and died prematurely from heart failure.

187 t study, patients with bipolar disorder died prematurely from multiple causes, including cardiovascul

188 iption from all coding exons, to remove REST prematurely from neural progenitors.

189 nt trends continue, the probability of dying prematurely from the four main NCDs is projected to incr

190 rgos driven by a few motors tended to unbind prematurely from the microtubule, whereas cargos driven

191 Adults with repaired tetralogy of Fallot die prematurely from ventricular tachycardia (VT) and sudden

192 nt (of a planned 1600 events), the trial was prematurely halted based on an interim analysis that ind

193 Analysis of a recent prematurely halted vaccine trial revealed increased mort

194 ntial that this process is well-informed, as prematurely halting treatment and surveillance programs

195 Among the 188 852 subjects born prematurely (i.e., at <37 weeks of gestation), there wer

196 Eco1 degradation also occurs prematurely if Mcm complex loading at origins is prevent

197 involuting thymus and acquire a shrunken and prematurely immunoinhibitory peripheral T cell repertoir

198 This process is arrested prematurely in albinism.

199 Furthermore, the CMG complex assembles prematurely in G1 in mutant cells, but not wild-type cel

200 importance of not terminating resuscitation prematurely in gasping patients and the need to routinel

201 ited closer together and the PLLp terminates prematurely in lef1-deficient zebrafish embryos.

202 We find that expressing Ttk69 prematurely in R7s collapses their growth cones and disr

203 uring that telomere cohesion is not resolved prematurely in S phase.

204 -null mice, keratinocyte migration initiates prematurely in the excisional wounds, resulting in wound

205 s completed treatment, treatment was stopped prematurely in the simvastatin 40 mg/day plus rifaximin

206 o a sleep-promoting region, and loss of PDM3 prematurely increases DA inhibition of the sleep center,

207 l methods is of much greater importance than prematurely increasing their perceptions of the risk of

208 r, misexpression of miR-14 was sufficient to prematurely induce autophagy in salivary glands, but not

209 of vascular Dll4, haematopoietic stem cells prematurely induced a myeloid transcriptional program.

210 In contrast, early triggering prematurely induced by energy poisons resulted in many f

211 H3K4me3-positive euchromatic promoters were prematurely induced in hepatocytes with loss of Ezh1 and

212 hila after infection of macrophages that was prematurely induced in the absence of MavN, consistent w

213 s accumulated dysfunctional mitochondria and prematurely induced p53 and proliferative arrest, which

214 Cortical depletion of PTBP2 prematurely induces axonogenesis-associated splicing, ca

215 olve in motor-related cortical areas without prematurely inducing movement.

216 Some CD4mc have been shown to trigger Env prematurely, initially activating Env function, followed

217 , hE3) deficiency (OMIM# 246900) is an often prematurely lethal genetic disease usually caused by ina

218 Exogenous DslA, added ex vivo, is able to prematurely liberate B. bacteriovorus from prey, part-wa

219 progenitors in lsd1 or CoRest heterozygotes prematurely lose epigenetic plasticity, undergo the Notc

220 Thus, mitochondria are prematurely lost in bdh2-inactivated erythrocytes.

221 e could amplify ribosomal protein imbalance, prematurely lower GATA1, and impede mitosis, these data

222 lems in one-third of children born extremely prematurely (<27 weeks' gestation).

223 eterm babies, including those born extremely prematurely (<28 weeks), are capable of rapidly acquirin

224 icipants were excluded if they had been born prematurely (<37 weeks gestation); had a congenital hear

225 Forty-eight patients discontinued the study prematurely, mainly because of relaparotomy (control, n=

226 Persons born prematurely may need early preventive evaluation and lon

227 ence, and 3.3% of men and 2.0% of women died prematurely of any cause).

228 Isolation and identification of extended but prematurely offloaded shunt products suggested that the

229 colonoscopy interval, but eventually stopped prematurely on 1 October 2004.

230 Trial recruitment was halted prematurely on the advice of the Trial Steering Committe

231 The study was unblinded prematurely, on Nov 17, 2017, after more fractures and d

232 were at increased risk of dying and of dying prematurely, particularly from conditions associated wit

233 oid of >4 consecutive AAA codons, sensing of prematurely placed polyA tails by a specialized RNA-bind

234 ed neurites, accumulated synuclein, and died prematurely, recapitulating key features of PD.

235 hat did not initially activate or which have prematurely recovered from refractoriness might release

236 e awareness if the inspired concentration is prematurely reduced.

237 ADAM within premigratory neural crest cells prematurely reduces or maintains Cad6B, respectively.

238 Thus, the ability of TE2 to prematurely release fatty acids from FASN parallels the

239 s finding as PD could lead to patients being prematurely removed from a treatment from which they act

240 never starting IFN-alpha-2b and for stopping prematurely, respectively.

241 tion from the fovea was delayed and arrested prematurely, resulting in a significantly thicker centra

242 taining progenitor cells exit the cell cycle prematurely, resulting in reduced clonal output.

243 phosphatase PP2A-B55, which would otherwise prematurely reverse many CDK-driven phosphorylations.

244 Prematurely slowing MCM loading in pluripotent cells not

245 By contrast, k-MTs are prematurely stabilized in cyclin-A-deficient cells.

246 urora phosphorylation of the tail results in prematurely stable attachments that restrain spindle elo

247 One patient receiving oral RBV had to prematurely stop drug due to significant nausea and vomi

248 malformation formed when neocortical neurons prematurely stop their migration in the white matter, fo

249 eveloped a systemic drug eruption, or had to prematurely stop triple therapy secondary to a cutaneous

250 The trial was prematurely stopped after the inclusion of 77% of the pl

251 he enrollment of 205 patients, the trial was prematurely stopped by the data and safety monitoring bo

252 frequently started in older patients and was prematurely stopped in a higher proportion of that popul

253 We show that Rho can prematurely terminate transcription of bacterial CRISPR

254 In this prematurely terminated and thus underpowered randomized

255 During lysogeny, the late transcript is prematurely terminated at t(R') immediately downstream o

256 Due to lack of efficacy, the study was prematurely terminated at the end of the treatment phase

257 The trial was prematurely terminated due to recruitment problems, leav

258 The study was prematurely terminated for futility.

259 teral photostimulation targeting the preBotC prematurely terminated inspiration, whereas expiratory-p

260 d to close, and short arcs are suggestive of prematurely terminated LH1 complex assembly.

261 Although prematurely terminated MHC-TCR/CD4 interaction in transg

262 aged children by demonstrating findings of a prematurely terminated multi-center clinical trial, disc

263 In this post hoc analysis of a prematurely terminated randomized clinical trial of umbi

264 A SF2 DNA helicase, which governs restart of prematurely terminated replication processes in bacteria

265 ted in accumulation of two types of lncRNAs: prematurely terminated RNAs (ptRNAs) and upstream antise

266 chanism whereby Paf1 loss leads to aberrant, prematurely terminated transcripts and diminution of ful

267 Stable prematurely terminated transcripts contribute to the tra

268 ripts, whereas the second primarily produces prematurely terminated transcripts.

269 ry efficacy analysis at 12 weeks, but it was prematurely terminated when another study found that epr

270 Mc1r(e/e)J mice, in which endogenous MC1R is prematurely terminated, expressing Mc1r RHC variants, we

271 To ensure that lytic activation is not prematurely terminated, expression of the virally encode

272 ne expression, and most such transcripts are prematurely terminated.

273 diminished and extension of the body axis is prematurely terminated.

274 In Drosophila, loss of Notch prematurely terminates the self-renewal of larval type I

275 CKD are five to ten times more likely to die prematurely than they are to progress to end stage kidne

276 volving children who had been born extremely prematurely, those who had undergone HFOV, as compared w

277 Compared with infants born prematurely to untreated women with and without preeclam

278 xpression of viral late transcripts that are prematurely transcribed, presumably due to cryptic trans

279 The um18 mutation prematurely truncated Vegfc, blocking its secretion and

280 rdiac SCN5A mRNA splice variants that encode prematurely truncated, nonfunctional Na(+) channels.

281 rs Ca(2+) too early in the cardiac cycle and prematurely truncates sarcomere shortening in the facili

282 e might reduce crop yield when it is induced prematurely under adverse environmental conditions.

283 Females who enter menopause prematurely via bilateral ovariectomy (surgical menopaus

284 y of each craniofacial articulation to close prematurely, we used a network model of the skull to qua

285 is study included 132 children who were born prematurely, were initially screened between October 2,

286 adulthood when E93 is reduced and terminates prematurely when E93 is overexpressed.

287 Without Ndj1, meiotic SPBs lost cohesion prematurely, whereas overproduction of Ndj1 delayed SPB

288 re more likely than white infants to be born prematurely, which has been associated with disparities

289 re associated with high toxicity and degrade prematurely, which limits their effectiveness.

290 g the mismatched base or switching templates prematurely, while AZT(R) RT primarily misaligned the pr

291 AZ levels are reduced, shedding takes place prematurely, while if they are enhanced, organ loss is d

292 mino-terminal EF-hands activates proteolysis prematurely, while residues in cytoplasmic loops connect

293 Children born prematurely who develop retinopathy of prematurity (ROP)

294 luded 38,055 otherwise healthy children born prematurely who were enrolled for more than 6 months in

295 The patient was born prematurely with a gestation age of 27 weeks and a body

296 hat in UGT1-deficient cells, CD1d associates prematurely with beta2-microglobulin (beta2m) and is abl

297 cophenolate mofetil than on cyclophosphamide prematurely withdrew from study drug (20 vs 32) or met p

298 the activation signal; mutant sperm activate prematurely without an activation signal in males, and m

299 Impulsivity describes the tendency to act prematurely without appropriate foresight and is symptom

300 cer have been underpowered and/or terminated prematurely, yielding inconsistent results and creating