ライフサイエンスコーパス: premorbid

1 was significantly predicted by high verbal (premorbid) abilities (beta = 0.40; hazard ratio [HR], 1.

2 The results suggest that higher levels of premorbid ability are associated with greater pathophysi

3 se to test the effect of differing levels of premorbid ability on neurophysiological dysfunction.

4 It has been hypothesized that premorbid ability, as measured by educational experience

5 lications were assessed without knowledge of premorbid abnormalities and were compared in the patient

6 otic drug use showed that patients with poor premorbid adaptation to school and premorbid social with

7 is (t=-0.86, p=0.031, CI -1.65 to -0.08) and premorbid adjustment (t=-2.26, p=0.017, CI -4.11 to -0.4

8 dinal cohort assessed premorbid delinquency (premorbid adjustment adaptation subscale across childhoo

9 ems, physical disorders in infancy, and poor premorbid adjustment in childhood and adolescence appear

10 he authors examined the relationship between premorbid adjustment in schizophrenia and event-related

11 Worse premorbid adjustment in the schizophrenic patients was s

12 Premorbid adjustment may predict the severity of specifi

13 Psychosocial function was assessed using the Premorbid Adjustment Scale and the Global Assessment of

14 Worse Premorbid Adjustment Scale scores were significantly ass

15 nterview for DSM-III-R--Patient Version, the Premorbid Adjustment Scale, and a semistructured intervi

16 ed from inpatients with schizophrenia on the Premorbid Adjustment Scale.

17 and objective data to score the Cannon-Spoor Premorbid Adjustment Scale.

18 Specifically, gender, premorbid adjustment, and clinical symptoms were examine

19 a high rate of birth complications and poor premorbid adjustment, appear to be associated with funct

20 between DUP and outcome was not explained by premorbid adjustment.

21 iods of untreated psychosis and prodrome and premorbid adjustment.

22 normal or high premorbid admissions) over the duration of vasopressor u

23 Of 653 consecutive eligible patients, premorbid and acute-phase blood pressure readings were a

24 of premorbid and current IQ showed different premorbid and clinical characteristics, which converged

25 E is complicated by the presence of multiple premorbid and comorbid factors affecting cognitive reser

26 lthy control subjects to examine patterns of premorbid and current intellect (measured by means of re

27 ne metric, defined as the difference between premorbid and current IQ estimates, in a logistic regres

28 Subgroups derived from patterns of premorbid and current IQ showed different premorbid and

29 of schizophrenia have been defined based on premorbid and current IQ, but little is known about the

30 through cluster analysis using estimates of premorbid and current IQ.

31 rential relationships of these measures with premorbid and present function and with clinical course

32 both prepsychotic developmental abnormality (Premorbid Assessment Scale, P = .06) and Brief Psychiatr

33 At multiple times throughout the study, premorbid attention-deficit/hyperactivity disorder, anxi

34 demonstrated a significant association with premorbid autoimmune diseases (adjusted OR 1.34 [1.14-1.

35 RS had a higher significant association with premorbid autoimmune diseases (adjusted OR 1.39 [1.28-1.

36 demonstrated a significant association with premorbid autoimmune diseases (adjusted OR 2.02 [1.72-2.

37 nvestigating the association between CRS and premorbid autoimmune diseases by using the National Heal

38 n, a significant association between CRS and premorbid autoimmune diseases has been identified.

39 In adjusted models, premorbid B-blocker exposure was associated with decreas

40 These included the known (premorbid) B(m) (WD(2)), a proposed correction for unkno

41 ed admission glycated hemoglobin to estimate premorbid baseline blood glucose concentration.

42 tal neurodegenerative disorder, there may be premorbid benefits of carrying the mutation.

43 asurement of plasma Abeta may be useful as a premorbid biomarker for AD.

44 Premorbid blood pressure (total readings 13,244) had bee

45 ves: To investigate the relationship between premorbid blood pressure and vasopressor duration for pa

46 ral haemorrhage, we compared acute-phase and premorbid blood pressure levels in these two disorders.

47 Premorbid blood pressure was higher in patients with typ

48 han premorbid normal admissions.Conclusions: Premorbid blood pressure was inversely associated with v

49 We examined associations of premorbid blood pressure with vasopressor duration and l

50 The primary exposure was premorbid blood pressure: low (systolic <100); normal (s

51 However, the role of premorbid BMI in the development of ALS and survival aft

52 Prior to the onset of AN, premorbid body mass index (BMI) spans the entire range f

53 f independent positive associations of a low premorbid body mass index and a high fat intake together

54 s transgenic for SOD1 and earlier reports on premorbid body mass index support a role for increased r

55 In this study we investigated the impact of premorbid brain microstructural integrity, as measured b

56 nistering in vivo neutralizing Ab to PD-1 to premorbid BWF(1) and healthy control mice.

57 Premorbid, clinical, prenatal, perinatal, and magnetic r

58 the time of the event, after adjustment for premorbid cognition but MI hospitalization was not.

59 neural substrate for the association between premorbid cognition, as measured by general cognitive pe

60 educational attainment as a proxy measure of premorbid cognition.

61 How do joint measures of premorbid cognitive ability and familial cognitive aptit

62 l-Hill Vocabulary Scale was used to estimate premorbid cognitive ability.

63 Do all premorbid cognitive deficits follow the same course?

64 Premorbid cognitive deficits in schizophrenia are well d

65 Are premorbid cognitive deficits specific to schizophrenia o

66 s associated with prenatal brain insults and premorbid cognitive deficits, we tested the a priori hyp

67 e following three unresolved questions about premorbid cognitive deficits: What is their developmenta

68 oke Scale score <8) and assessed current and premorbid cognitive functioning (Addenbrooke's Cognitive

69 ormalities in psychosis are related to lower premorbid cognitive functioning implicating early antece

70 as to investigate the longitudinal course of premorbid cognitive functioning in individuals with schi

71 In contrast, low premorbid cognitive functioning was associated with smal

72 nding variables, such as estimated levels of premorbid cognitive functioning, and for use of alcohol

73 Studies suggest the presence of premorbid cognitive impairment in patients with schizoph

74 ps did not differ regarding baseline data or premorbid cognitive impairments.

75 ucational status, socioeconomic disparities, premorbid cognitive or functional decline, life-course e

76 These two premorbid cognitive patterns were not observed in childr

77 stigating the contribution of sex, genetics, premorbid cognitive strengths and weaknesses, and brain

78 mechanical ventilation and supportive care, premorbid condition is the most important determinant of

79 the esophagoscope confirmed that GERD was a premorbid condition.

80 ome 32 days later with a status close to his premorbid condition.

81 Patients with premorbid conditions (eg, previous head injury, learning

82 istic regression was performed to adjust for premorbid conditions and presentation physiology.

83 To evaluate premorbid conditions and sociodemographic characteristic

84 his cohort of youth tackle football players, premorbid conditions, including attention-deficit/hypera

85 nd critical illnesses is strongly related to premorbid conditions: the strength of the mucosal barrie

86 itories and multiple treatable risk factors, premorbid control is poor.

87 bjects with schizophrenia showed significant premorbid deficits on all intellectual and behavioral me

88 e concerning issues of intellectual decline, premorbid deficits, a modal deficit pattern, and preserv

89 Midlands) Study longitudinal cohort assessed premorbid delinquency (premorbid adjustment adaptation s

90 Stable high premorbid delinquency from childhood onwards appears to

91 d high (odds ratio, 3.53; 95% CI, 1.85-6.73) premorbid delinquency trajectories increased the risk fo

92 Group trajectories of premorbid delinquency were estimated using latent class

93 Four groups of premorbid delinquency were identified: stable low, adole

94 e view of schizophrenic men as having poorer premorbid development, earlier age at onset, and worse o

95 Premorbid developmental impairments are common in childh

96 Lower performance IQ and more pronounced premorbid developmental impairments were seen in this su

97 nset independent of family history of BD and premorbid diagnoses of ADHD or anxiety.

98 for demographic and medical risk factors, a premorbid diagnosis of a schizophrenia spectrum disorder

99 n areas 9 and 46) from 19 individuals with a premorbid diagnosis of SZ and 33 control individuals.

100 and unique potential drug targets, determine premorbid diagnosis, predict drug responsiveness for ind

101 ral sclerosis (ALS), the association between premorbid dietary intake and the risk of sporadic ALS wi

102 zations by demographics, comorbidity burden, premorbid disability, hospitalization length, and intens

103 were developed controlling for education and premorbid disability.

104 Premorbid diseases were forward traced to 1996.

105 related significantly and independently with premorbid educational achievement, cognitive symptoms, g

106 dherence) and time-invariant (eg, genetic or premorbid environment) unobserved confounders revealed t

107 d with frequency-matched control subjects on premorbid factors in the immediate (0-6 months), interme

108 Our findings indicate that treatment of premorbid female NZB/NZW mice with DMPA reduces mortalit

109 sociated with increased risk of no return to premorbid function (RRfor each additional day = 1.01; 95

110 he MMN deficits are independently related to premorbid function and illness duration, suggesting inde

111 the year after critical illness, recovery of premorbid function was observed for 169 of the ICU admis

112 aluate the incidence and time to recovery of premorbid function within 6 months of a critical illness

113 aluate the incidence and time to recovery of premorbid function within 6 months of major surgery and

114 ive longitudinal study evaluated recovery of premorbid function within 6 months of major surgery, and

115 re frequent and associated with no return to premorbid function, death, and prolonged ICU- and hospit

116 Premorbid function, symptom, and global outcome measures

117 Low socioeconomic status, poor premorbid function, treatment noncompliance, and substan

118 ferentially reduced in individuals with poor premorbid function.

119 ciated with functional recovery, as was good premorbid function.

120 grades, provides evidence for deteriorating premorbid functional adjustment in schizophrenia.

121 status epilepticus termination and return to premorbid functional baseline.

122 Marital status, premorbid functional status, clinical service (neurology

123 n individual domains and clinical variables (premorbid functioning and negative domain; absence of re

124 ms, but GM volume was associated with better premorbid functioning in women (r, 0.36-0.51).

125 The premorbid functioning of these subjects was compared to

126 roke (n=432) and MI (n=450), controlling for premorbid functioning using fixed-effects regression.

127 Remission may reflect a return to premorbid functioning, consistent with neurodevelopmenta

128 izophrenia versus schizoaffective disorder), premorbid functioning, duration of psychotic symptoms pr

129 l volume in women was associated with poorer premorbid functioning, more severe negative symptoms, an

130 rked improvement in symptoms and a return to premorbid functioning, now more than 2.5 and 4.5 years a

131 erences are small relative to differences in premorbid functioning, particularly those associated wit

132 ted problems, physical disorders in infancy, premorbid functioning, presence of mixed episodes and ra

133 n samples with first-episode psychosis, poor premorbid functioning, stable negative symptoms and impa

134 correlating with illness duration, and worse premorbid functioning.

135 een untreated initial psychosis duration and premorbid functioning.

136 Transcriptome analysis of premorbid genetic risk identified the enrichment terms m

137 uated whether ESLD death was associated with premorbid HCV RNA level or specific HCV protein antibodi

138 se cognitive or behavioral scores, whereas a premorbid headache disorder or history of concussion was

139 come are factors such advanced age; impaired premorbid health status, especially diabetes and high bo

140 ICU and hospital mortality were higher age, premorbid heart disease, lower Pao2/FiO2 at ICU admissio

141 vs. normal, 0.78 [0.73-0.85]; P < 0.001) and premorbid high admissions had shorter use (median, 0.84

142 Older age at injury, a premorbid history of brain illness or physical disabilit

143 eimer's disease (the majority of whom had no premorbid history of major depression), common emergence

144 Activation of macrophages from premorbid HLA-B27 transgenic rats with IFN-gamma increas

145 In multivariate analysis, patients with premorbid HTN had a higher risk of in-hospital aneurysm

146 Premorbid HTN is associated with increased severity of t

147 We aimed to assess the impact of premorbid HTN on the severity of initial bleeding and th

148 Patients with premorbid HTN presented more frequently as Hunt-Hess Gra

149 consecutive patients with SAH; 643 (49%) had premorbid HTN.

150 of intracerebral haemorrhage associated with premorbid hypertension (blood pressure >or=160/100 mm Hg

151 amount of intracranial blood (p = 0.001) and premorbid hypertension (p < 0.001).

152 case fatality, but also the association with premorbid hypertension.

153 Premorbid illness, neurological features, treatment with

154 This systematic review summarizes all premorbid, illness-related, and ICU-related factors asso

155 hrenia, including (1) genetic, prenatal, and premorbid immune risk factors and (2) immune markers acr

156 rate of gray matter reduction was related to premorbid impairment and baseline severity of clinical s

157 The rate of reduction was related to premorbid impairment and baseline symptom severity, but

158 In relapse-onset MS, higher premorbid income and education correlated with lower dis

159 cohort study of working-age adults with MS, premorbid income, education, and marital status correlat

160 caine addicts may, in part, be determined by premorbid influences.

161 We studied the premorbid intake of nutrients in association with the ri

162 lues reported as odds ratio (95% CI), higher premorbid intake of total fat (1.14; 1.07-1.23; P < .001

163 tients (23%) with consistently low estimated premorbid intellect and current intellectual levels who

164 Premorbid intellectual ability was assessed by a demogra

165 ics and dementia severity, both estimates of premorbid intellectual ability were inversely correlated

166 ession of dementia in Alzheimer's disease is premorbid intellectual ability.

167 vestigated the relation between estimates of premorbid intellectual function and cerebral glucose met

168 tients (25%) who displayed average estimated premorbid intellectual levels did not show IQ decline an

169 The premorbid intellectual, language, and behavioral functio

170 rticipants with higher scores on measures of premorbid intelligence (-14.0 vs -11.2 points) and with

171 There was no association between premorbid intelligence and treatment preferences.

172 es of both cognitive and brain reserve (i.e. premorbid intelligence and whole brain grey matter volum

173 , it is not clear whether this below-average premorbid intelligence is stable or progressive.

174 a group of controls (matched on age, sex and premorbid intelligence quotient), the patients showed de

175 se), and baseline demographics and estimated premorbid intelligence quotient, non-HIV-related comorbi

176 er for people with psychiatric symptoms, low premorbid intelligence quotient, or minimal information

177 line age, fatigue, cognitive complaints, and premorbid intelligence quotient.

178 mines the influence of cognitive impairment, premorbid intelligence, and decision-making capacity to

179 mery-Asberg Depression Rating Scale [MADRS], premorbid intelligence, cognitive function, history of a

180 ality of life profiles, as well as estimated premorbid intelligence, were evaluated to explore the po

181 differences in a measure thought to reflect premorbid intelligence, Wide Range Achievement Test 3 re

182 parental socioeconomic status, and estimated premorbid intelligence.

183 education, occupational level, and estimated premorbid intelligence.

184 endently positively associated with OCI, and premorbid IQ (one IQ point increase: OR, 0.91; 95%CI, 0.

185 However, tests of the association between premorbid IQ and adult mental disorders other than schiz

186 compared with nonalcoholics, despite similar premorbid IQ and education.

187 cluster analysis on the basis of current and premorbid IQ differences.

188 w was to provide an updated meta-analysis of premorbid IQ in individuals who later develop schizophre

189 risk were not associated with TRS; however, premorbid IQ in males and schizophrenia family history w

190 ast quantitative review of the literature on premorbid IQ in schizophrenia was published more than tw

191 In males, a decrease of premorbid IQ of one standard deviation was significantly

192 There was no association between premorbid IQ score and risk of bipolar disorder.

193 or population-based, longitudinal studies of premorbid IQ score and risk of developing severe depress

194 Despite within-normal-range premorbid IQ scores, apparently healthy adolescents who

195 After controlling for estimated premorbid IQ, current cognitive performance was associat

196 After adjustment for age, age at onset, and premorbid IQ, male chronic patients performed worse than

197 rated a reliable, medium-sized impairment in premorbid IQ.

198 nt of psychotic symptoms and (iii) decreased premorbid IQ.

199 ctive studies are needed to evaluate whether premorbid iron levels are increased in individuals who d

200 Premorbid language, motor, and social impairments were a

201 6-2.6) or in the number of ADLs recovered to premorbid level (difference, 0.09 ADL; 95% CI, -0.27-0.4

202 gher premorbid level of openness and a lower premorbid level of agreeableness.

203 n relative to men and in those with a higher premorbid level of openness and a lower premorbid level

204 0 mm Hg higher, on average, than the maximum premorbid level whereas that after ischaemic stroke was

205 vels (increase of 10.6 mm Hg vs 10-year mean premorbid level), and decreased only slightly during the

206 e is much closer to the accustomed long-term premorbid level, providing a potential explanation for w

207 Hg [37.4], p<0.0001), was little higher than premorbid levels (increase of 10.6 mm Hg vs 10-year mean

208 al haemorrhage was substantially higher than premorbid levels (mean increase of 40.7 mm Hg, p<0.0001)

209 is substantially raised compared with usual premorbid levels after intracerebral haemorrhage, wherea

210 cline of 10 points or greater from estimated premorbid levels also exhibited deficits of executive fu

211 e versus no impairment after controlling for premorbid levels of cognitive ability.

212 ive variation and to validate solutions with premorbid, longitudinal, and genetic risk measures.

213 Premorbid low admissions had longer adjusted length of s

214 After adjustment, premorbid low admissions had longer vasopressor use (med

215 Premorbid low admissions had lower MAPs (vs.

216 3,542 admissions with shock, 177 (5.0%) had premorbid low, 2,887 (81.5%) normal, and 478 (13.5%) hig

217 The implications for patients with premorbid low/high blood pressure are unknown.Objectives

218 Premorbid lower limb dysfunction was associated with inc

219 Particularly in infants with premorbid lung function and inflammation, air pollution

220 10 mug/m(3) PM10 levels) and in infants with premorbid lung function.

221 Using premorbid magnetic resonance images, brain regions from

222 use (P = 0.003) and were maintained nearest premorbid MAPs while receiving vasopressors (P < 0.001).

223 sis suggest that childhood enuresis may be a premorbid marker for neurodevelopmental abnormalities re

224 re is comparatively little information about premorbid maturational brain abnormalities in schizophre

225 m cognitive impairment but have not included premorbid measures of cognitive functioning and have not

226 ce and evaluate associations with a range of premorbid medical conditions for chronic rhinosinusitis

227 s, together with associated risk factors and premorbid medications.

228 Patient premorbid mood disorders were associated with increased

229 All athletes reported no premorbid mood disorders, anxiety disorders, substance a

230 The boys had more premorbid motor abnormalities, but early language and so

231 Within this context, premorbid movement abnormalities are of particular inter

232 Scale score, history of atrial fibrillation, premorbid mRS score, and stroke parent artery status, th

233 teral activations basically overlapping with premorbid naming networks observed in healthy subjects.

234 As both premorbid neurodevelopmental impairments and familial ri

235 tus epilepticus termination for no return to premorbid neurologic function were estimated by Poisson

236 Few studies have addressed the premorbid neuropsychological alterations in subjects at

237 the observation of minor physical anomalies, premorbid neuropsychological and social deficits, obstet

238 ies of childhood sexual abuse (36.4%, n=12), premorbid non-dissociative mental illness (81.1%, n=27)

239 h of stay and higher adjusted mortality than premorbid normal admissions.Conclusions: Premorbid blood

240 ematous weight loss of more than 7.5% of the premorbid normal weight occurs over a time period of mor

241 le score </=8), and functional (regaining of premorbid occupational and residential status).

242 were initial mood-congruent psychosis, lower premorbid occupational status, and initial manic present

243 The 6-OPRI group had lower premorbid optimal levels of functioning (assessed on the

244 ations were observed between visual ERPs and premorbid or global outcome measures or illness duration

245 D2 receptor densities in drug users, whether premorbid or the consequence of substance misuse, imply

246 High rates of premorbid overweight and higher BMIs at various stages o

247 sence of a relative decline in IQ during the premorbid period in individuals with schizophrenia.

248 ors compared the patterns and specificity of premorbid personality dimensions in first-episode schizo

249 Premorbid personality may reflect subtle changes in cere

250 d 2) determine the feasibility of extracting premorbid physical activity (step and global position sy

251 Obtaining premorbid physical activity data from the current-genera

252 ators, including 1) familial aggregation, 2) premorbid presence, 3) syndromal specificity, 4) trait s

253 o are given a diagnosis of CRS have a higher premorbid prevalence of anxiety, headaches, gastroesopha

254 Patients with CRSsNP had a higher premorbid prevalence of infections of the upper and lowe

255 contrast, mood disorders were predicted by a premorbid psychiatric history (2.3 [1.4-3.9]), an emotio

256 Inclusion criteria were 1) premorbid psychometric measures of IQ in subjects who we

257 r to what extent this relationship is due to premorbid psychosis among people who use the drug.

258 In contrast, macrophages derived from premorbid rats do not exhibit a strong UPR or evidence o

259 ding below eighth grade level despite intact premorbid reading ability.

260 hase post-event blood pressure readings with premorbid readings from 10-year primary care records in

261 Outcomes were adjusted for premorbid residence and function, caregiver availability

262 Finding predisposition genes may improve premorbid risk assessment, genetic counseling, and manag

263 owever, whether exaggerated impulsivity is a premorbid risk factor or a consequence of alcohol intake

264 study aims to investigate the prevalence of premorbid risk factors and comorbid diseases and its ass

265 The prevalence of premorbid risk factors and comorbid diseases was signifi

266 Premorbid risk factors and comorbid diseases were more p

267 Comparison of premorbid risk factors revealed substantial reductions i

268 reventive treatments and major reductions in premorbid risk factors.

269 of the empirically derived trajectories with premorbid social adjustment, diagnosis, and 20-year outc

270 e no other significant relationships between premorbid social or motor abnormalities and the risk fac

271 There was anecdotal evidence of low premorbid social performance in the 6-OPRI but not P102L

272 with poor premorbid adaptation to school and premorbid social withdrawal relapsed earlier.

273 tion; they were excluded if they had another premorbid speech and language disorder caused by a neuro

274 The patients with premorbid speech and language impairments had higher fam

275 ations) were increased for the probands with premorbid speech and language impairments, suggesting th

276 cardinal feature of the progression from the premorbid stage to the chronic form of schizophrenia, fe

277 anges can be investigated from the earliest, premorbid stages of HD.

278 Restoration of the gut microbiota to a premorbid state is a key novel therapeutic approach of i

279 s use early (i.e., before age 17 years) show premorbid structural abnormalities in the amygdala, hipp

280 ricular dysfunction, and clinical history of premorbid symptoms.

281 of word repetition that comprised a default premorbid system and a less used alternative system.

282 IQ measure, sample ascertainment, and age at premorbid testing, contributed minimally to the effect s

283 here was no evidence of negative change from premorbid to postmorbid assessment in any of the persona

284 chological decline in schizophrenia from the premorbid to the postonset period, but the extent and de

285 This vulnerability could be either a premorbid trait marker of the disorder or an acquired co

286 ence of malnutrition and unlikely to reflect premorbid trait markers or permanent scars, but longitud

287 As a premorbid trait, vulnerability to unpredictability could

288 istic, and anxious personality styles may be premorbid traits that contribute to this pathogenesis.

289 AN and BN tend to have premorbid traits, such as perfectionism and anxiety that

290 rst mood disorder diagnosis suggest distinct premorbid trajectories that could be useful for next ste

291 via messenger RNA sequencing to identify the premorbid transcriptome and the binge-induced transcript

292 tolic blood pressures and major increases in premorbid treatment with antiplatelet, lipid-lowering, a

293 chaemic attack and stroke, risk factors, and premorbid use of preventive treatments from 1981-84 (Oxf

294 ggests that MBL deficiency in humans maybe a premorbid variable in the predisposition to infection in

295 Calendar time, premorbid vascular risk factors, and occupation.

296 accounting for half or more of the presumed premorbid volume, was unlikely to have contained domain-

297 whether heightened amygdala reactivity is a premorbid vulnerability or a consequence of the disorder

298 These may either represent premorbid vulnerability or a plasticity phenomenon relat

299 e role of the superior temporal gyrus in the premorbid vulnerability to schizophrenia.

300 ment between patients and surrogates for all premorbid walking metrics (mean bias 108% [99% lower to