ライフサイエンスコーパス: preneoplastic

1 is related to histopathological features of preneoplastic aberrant crypt foci (ACF), gene expression

2 ce of mPGES-1 reduced the size and number of preneoplastic aberrant crypt foci (ACF).

3 al hepatectomy but no signs of neoplastic or preneoplastic abnormalities for up to 18 months.

4 The preneoplastic "acidic" MUC2 mucin was detected only in t

5 ic analysis of cuSCC development through the preneoplastic AK stage using matched human samples and a

6 sion increased the rate of apoptosis of both preneoplastic and carcinomatous mammary epithelial cells

7 crease in the proliferation rate and size of preneoplastic and early neoplastic lesions, although hav

8 n and progesterone receptors was observed in preneoplastic and early neoplastic lesions, suggesting a

9 ent of the adult pancreas as well as in both preneoplastic and malignant lesions.

10 d mice to permit the growth of primary human preneoplastic and malignant plasma cells together with n

11 solated from a tumor stimulate the growth of preneoplastic and neoplastic cells in xenograft models.

12 h for preferential induction of apoptosis in preneoplastic and neoplastic cells.

13 emble human ESCC, we visualized the probe in preneoplastic and neoplastic esophageal lesions using ne

14 alization of IGFBP-3 in the preponderance of preneoplastic and neoplastic esophageal lesions.

15 t was modified and improved to yield ovarian preneoplastic and neoplastic lesions that pathogenetical

16 CCSA-4 in the detection of individuals with preneoplastic and neoplastic lesions using ELISAs.

17 spring were examined at four time points for preneoplastic and neoplastic lesions.

18 ty acid oxidation and gluconeogenesis in rat preneoplastic and neoplastic liver lesions, when compare

19 hepatectomy and is strongly overexpressed in preneoplastic and neoplastic mouse liver.

20 We used preneoplastic and neoplastic mouse models of prostate ca

21 reduced the production of NO in NMBA-induced preneoplastic and papillomatous esophageal lesions when

22 ures associated with the early inflammatory, preneoplastic and tumour stages.

23 clinical trials for a variety of neoplastic, preneoplastic, and inflammatory conditions.

24 cumulation of MKlp2 in normal proliferating, preneoplastic, and transformed hepatocytes suggests that

25 of Akt activity is necessary for survival of preneoplastic as well as transformed lung epithelial cel

26 These preneoplastic B lymphocytes did not progress to detectab

27 o implicated acidic pH in the development of preneoplastic Barrett's esophagus in human.

28 contributes to DCA induced carcinogenesis in preneoplastic BE.

29 Akt and Mcl-1 are strongly expressed in the preneoplastic bile duct inflammatory disease primary scl

30 ated in luminal progenitor cells resident in preneoplastic BRCA1(mut/+) breast tissue.

31 ate whole-body quantitative SPECT imaging of preneoplastic breast cancer tissue using (111)In-labeled

32 3 region had the highest frequency of LOH in preneoplastic breast epithelium (36%), followed by 3p21.

33 A damage, which may limit the progression of preneoplastic breast lesions, and uncovers complex macro

34 HER2/neu, which has also been identified in preneoplastic breast lesions, has been shown to regulate

35 elta3 are overexpressed in breast cancer and preneoplastic breast tissue.

36 their presence is hypothesized to facilitate preneoplastic cell growth and tumor formation in older i

37 Similarly, senescent fibroblasts promote preneoplastic cell growth in vitro and in vivo.

38 factors directly responsible for stimulating preneoplastic cell growth, we carried out whole-genome t

39 PN is necessary for paracrine stimulation of preneoplastic cell growth.

40 recombinant OPN was sufficient to stimulate preneoplastic cell growth.

41 These results indicate that the preneoplastic cell populations found in this genetically

42 DB[a,l]P-induced early preneoplastic cell proliferation correlated with H-ras a

43 Preneoplastic cells (PNCs) are found in most ptc mutants

44 Early preneoplastic cells (sup+) exhibit increased susceptibil

45 ty to apoptosis, which is lost in late stage preneoplastic cells (sup-).

46 ory phenotype, prevents the proliferation of preneoplastic cells and has beneficial roles in tissue r

47 n but facilitating progression and growth of preneoplastic cells and subclinical cancers, which are c

48 Alterations in cyclin D1 activity in preneoplastic cells could represent an early biomarker o

49 ce a permissive genetic environment in which preneoplastic cells evolve to reach their full tumorigen

50 ivo models to study the interaction of human preneoplastic cells in the bone marrow microenvironment

51 characteristic structural reorganization of preneoplastic cells may involve changes in the microtubu

52 Most ptc1+/- mice form clusters of preneoplastic cells on the surface of the mature cerebel

53 d by proliferation so that the population of preneoplastic cells remains constant.

54 stitutive expression of Dss1 in JB6 Cl 41-5a preneoplastic cells strongly increased focus formation a

55 h prevents paraspeckle formation, sensitized preneoplastic cells to DNA-damage-induced cell death and

56 ads to Igf2 overexpression, which transforms preneoplastic cells to malignant tumors.

57 In approximately 15% of mice, these preneoplastic cells will become fast-growing, lethal tum

58 s in mtDNA among normal stem cells, immortal/preneoplastic cells, and tumorigenic cells.

59 that blocks Akt signaling in neoplastic and preneoplastic cells.

60 ell proliferation and result in promotion of preneoplastic cells.

61 in both apoptosis and cell proliferation in preneoplastic cells.

62 , and drive the expansion of intraurothelial preneoplastic cells.

63 TVrtTA-TetOPELP1 Tg mice had hyperplasia and preneoplastic changes as early as 12 weeks, and ER-posit

64 high-fat diet to induce obesity, we examined preneoplastic changes associated with epithelial cell-sp

65 Although the sequential preneoplastic changes have been defined for centrally ar

66 Preneoplastic changes in gene expression result from alt

67 Prominent preneoplastic changes in glandular tissue adjacent to th

68 Identification of preneoplastic changes in histologically normal epitheliu

69 ted whether 4D-ELF would be able to identify preneoplastic changes in the colonocytes of the azoxymet

70 he bone marrow to peripheral organs predicts preneoplastic changes in the gastric microenvironment.

71 incomplete understanding of how CS initiates preneoplastic changes in the normal airway hinders early

72 Silencing TRIM29 in MCF10A cells resulted in preneoplastic changes that included loss of polarity in

73 Bacterial colonization, gastric atrophy and preneoplastic changes were assessed histologically and c

74 rding the molecular characterization of lung preneoplastic changes, especially for squamous cell carc

75 postinoculation (p.i.) time on inflammation, preneoplastic changes, invasive lesions, and helicobacte

76 branching, hyperplasia, dysplasia, and other preneoplastic changes, which are indicative of increased

77 We conclude that preneoplastic clones do not derive from long-lived, self

78 est power to predict interval development of preneoplastic colonic adenoma.

79 alcoholic steatohepatitis (NASH) is a common preneoplastic condition of hepatocellular carcinoma (HCC

80 model of human chronic atrophic gastritis, a preneoplastic condition.

81 se findings are relevant to human tumors and preneoplastic conditions accompanied by altered IGF2 exp

82 age-PCGT methylation signature is present in preneoplastic conditions and may drive gene expression c

83 serve as a potential therapeutic target for preneoplastic conditions of the GI tract.

84 nt and progression of neoplasia from in situ preneoplastic conditions to invasive disease was analyse

85 Even preneoplastic cystic structures may harbor entire loss o

86 educing prevalence of noninvasive cancer and preneoplastic disease.

87 ion of exocrine acinar cells into pancreatic preneoplastic ductal lesions by oncogenic Kras and/or pa

88 nhibited the formation of estrogen-dependent preneoplastic ductal lesions induced by 7,12-dimethylben

89 Preneoplastic ductal metaplasia developed in mice lackin

90 s of bone marrow and lymph nodes from young (preneoplastic) E micro -c-myc transgenic mice revealed i

91 er) was determined by a factorial design and preneoplastic endpoints in chemically induced rats and v

92 es were used to analyze the clonal growth of preneoplastic, enzyme-altered foci during liver carcinog

93 JB6 Cl 41-5a and TPA-resistant JB6 Cl 30-7b preneoplastic epidermal cell lines showed a remarkable g

94 Although EBV infection of preneoplastic epithelial cells is not immortalizing, EBV

95 s from 45 primary breast cancers, 47 mammary preneoplastic epithelial foci, and 18 breast cancer cell

96 L at the earliest stage of development, or a preneoplastic event, requiring a second hit for neoplast

97 clonality in these populations, suggesting a preneoplastic expansion of CD5(+) B cell clones, with th

98 e results suggest that dysplasia arises in a preneoplastic field of chronic inflammation, which leads

99 We hypothesized that a preneoplastic field of inflammation, telomere shortening

100 mocysteine concentrations and development of preneoplastic foci in the liver (increased placental glu

101 high likelihood of clonal relatedness of the preneoplastic foci to the tumors.

102 F2rl2 and is associated with development of preneoplastic foci.

103 ant, protective effect on the development of preneoplastic fundic lesions and invasive carcinoma attr

104 of Th17-1 cells compared with the marrow in preneoplastic gammopathy (monoclonal gammopathy of undet

105 Here we show that patients with preneoplastic gammopathy mount a vigorous T cell respons

106 Moreover, xenografts from patients with preneoplastic gammopathy showed progressive growth, sugg

107 or decreasing pattern of expression from the preneoplastic ganglia to end stage tumors.

108 t mouse model to detect molecular changes in preneoplastic gastric dysplasia.

109 and the development of hypergastrinemia and preneoplastic gastric lesions.

110 in 17 (G17) offers the possibility to detect preneoplastic gastric mucosal conditions.

111 omas and hyperplastic EGL lesions, formed by preneoplastic GCPs.

112 ather than sequential, knockout of canonical preneoplastic genetic drivers that are likely to set-off

113 ns that originally drove the plasticity of a preneoplastic genome.

114 /80 antibodies to deplete macrophages during preneoplastic growth.

115 sine kinase inhibitors inhibit the growth of preneoplastic HBEC cells, suggesting their potential for

116 creases size and number of aflatoxin-induced preneoplastic hepatic lesions in rats by >90%.

117 ese factors may enhance the survival of both preneoplastic hepatocytes and activated hepatic stellate

118 likely essential for the clonal expansion of preneoplastic hepatocytes to HCC, while Ctnnb1 mutations

119 3 impaired Akt and p44/42 phosphorylation in preneoplastic HER2-overexpressing mammary glands and in

120 We exposed preneoplastic, hTERT-immortalized Barrett's cell, CP-C a

121 field carcinogenesis, will further delineate preneoplastic initiation and progression, and will help

122 we found reduced BCMO1 expression in normal preneoplastic intestine of folate-deficient tumor-prone

123 s effective in preventing the progression of preneoplastic intraepithelial lesions to invasive pancre

124 s cell metaplasia is considered the critical preneoplastic lesion for gastric cancer.

125 and multiplicity, proliferation indices and preneoplastic lesion formation.

126 biquitous isoform, p110beta, did not prevent preneoplastic lesion initiation.

127 creatic ductal adenocarcinoma (PDAC) and its preneoplastic lesion intraductal papillary mucinous neop

128 liferative state is thought to represent the preneoplastic lesion of small-cell lung carcinoma.

129 No preneoplastic lesion or LOH was found in normal gallblad

130 id in the diagnosis and surveillance of this preneoplastic lesion.

131 in those with dysplasia compared with other preneoplastic lesions (0.31 vs 0.22; P = 0.042).

132 ase in PKC betaII expression was observed in preneoplastic lesions (aberrant crypt foci, 3.7-fold) co

133 nting the stepwise carcinogenic process from preneoplastic lesions (cirrhosis and dysplasia) to HCC,

134 D1(-/-) females developed significantly more preneoplastic lesions (eg, epithelial hyperplasias and m

135 easuring inhibition of formation of putative preneoplastic lesions (glutathione S-transferase P posit

136 e, the effect of resveratrol on formation of preneoplastic lesions (induced by 7,12-dimethylbenz(a)an

137 ents with gallstones had a high frequency of preneoplastic lesions and accumulation of LOH at various

138 , and senescence are frequently activated in preneoplastic lesions and are barriers to progression to

139 llomaviruses (HPVs) are linked to anogenital preneoplastic lesions and cancer.

140 1 occurred at a much lower frequency in both preneoplastic lesions and HCCs and were mutually exclusi

141 rinsulinism that leads to the development of preneoplastic lesions and hepatocellular carcinoma (HCC)

142 and TRalpha1 and their target genes in early preneoplastic lesions and hepatocellular carcinoma (HCCs

143 a pivotal role for RelA in regulating OIS in preneoplastic lesions and implicate the RelA/CXCL1/CXCR2

144 Keap1 mutations were present in 71% of early preneoplastic lesions and in 78.6% and 59.3% of early an

145 tors Ena/VASP, is overexpressed in high-risk preneoplastic lesions and in primary breast tumors and h

146 e incidence and reduced the latency of other preneoplastic lesions and increased cellular turnover in

147 that cured meat promotes carcinogen-induced preneoplastic lesions and increases specific biomarkers

148 s strongly ectopically expressed in advanced preneoplastic lesions and invasive human PDAC.

149 In rodent models, carcinogen-induced preneoplastic lesions and mammary tumors are inhibited.

150 ressor PTEN by accelerating the formation of preneoplastic lesions and mammary tumors.

151 he development of pancreatic intraepithelial preneoplastic lesions and progression to adenocarcinoma

152 wever, DDR signaling was strongly induced in preneoplastic lesions arising from individual mammary ce

153 s required to drive the development of human preneoplastic lesions as well as invasive adenocarcinoma

154 85% reduction in the hepatic focal burden of preneoplastic lesions at 1 micromol/kg body weight and a

155 t and amino acid defined (CDAA) diet develop preneoplastic lesions at 65 weeks and hepatocellular car

156 LOH was present in 2.1% to 47.8% of all the preneoplastic lesions at different loci.

157 We found that igf2 is not expressed in preneoplastic lesions but is induced as these lesions pr

158 Igf2 is not required for formation of preneoplastic lesions but is necessary for progression t

159 ic ductal cancers to arise from Kras-induced preneoplastic lesions by increasing epithelial cell prol

160 is highly up-regulated in the epithelium of preneoplastic lesions compared with benign epithelium, b

161 Obesity also promoted the growth of preneoplastic lesions containing elevated numbers of lum

162 Twenty-one of 47 (45%) preneoplastic lesions demonstrated 3p LOH, including 12

163 Preneoplastic lesions developed in BPA-exposed female of

164 s the progression of KRAS-induced pancreatic preneoplastic lesions in mice with pancreas-specific Cre

165 c epithelia, we evaluated the development of preneoplastic lesions in ovariectomized wild-type (WT) a

166 cific agents can suppress cured meat-induced preneoplastic lesions in rats and associated biomarkers

167 EITC had a protective effect on NMBA-induced preneoplastic lesions in the rat esophagus.

168 ms underlying the fate of the enzyme-altered preneoplastic lesions in the resistant hepatocyte (RH) m

169 CXCR2 upregulation is also observed in preneoplastic lesions in vivo.

170 Liver biopsy also helps identify preneoplastic lesions including large cell and small cel

171 pancreatic and lung adenocarcinomas converts preneoplastic lesions into invasive and metastatic carci

172 umor initiation promoting the progression of preneoplastic lesions into tumors is well established.

173 ts also suggest that a hypothyroid status of preneoplastic lesions may contribute to their progressio

174 ed to development of multiple neoplastic and preneoplastic lesions of different organs.

175 hic gastritis (NAG), and is ineffective once preneoplastic lesions of multifocal atrophic gastritis (

176 ify EZH2 as a potential marker for detecting preneoplastic lesions of the breast in vivo and as a pos

177 s well as the level of prostaglandin E(2) in preneoplastic lesions of the esophagus at week 25.

178 Studies of preneoplastic lesions or early-stage cancer showed absen

179 Ralpha1 down-regulation was observed only in preneoplastic lesions positive for the progenitor cell m

180 genes in HCC were similarly altered in early preneoplastic lesions positive for the stem/progenitor c

181 There are three main morphologic forms of preneoplastic lesions recognized in the lung: squamous d

182 static epithelial cells and the formation of preneoplastic lesions resembling prostatic intraepitheli

183 OPN is expressed in senescent stroma within preneoplastic lesions that arise following 7,12-dimethyl

184 n of PKCepsilon in the mouse prostate causes preneoplastic lesions that display significant NF-kappaB

185 f murine prostate cancer, beginning from the preneoplastic lesions to distant metastases that suggest

186 d status favors the onset and progression of preneoplastic lesions to HCC.

187 contributes to the onset and progression of preneoplastic lesions towards malignancy.

188 quent stages of tumor development when early preneoplastic lesions transition into adenomas.

189 ated with GBC was tested from microdissected preneoplastic lesions using microsatellite markers.

190 tion between inflammation and hyperplasia or preneoplastic lesions was not identified.

191 was accompanied by increased apoptosis, and preneoplastic lesions were cleared by focal degenerative

192 Furthermore, preneoplastic lesions with eosinophilic phenotype freque

193 sible benefit of improved early detection of preneoplastic lesions with methylene blue chromoendoscop

194 ghly resistant to azoxymethane (AOM)-induced preneoplastic lesions, aberrant crypt foci.

195 morphologic features, increased incidence of preneoplastic lesions, and accelerated mammary tumor dev

196 Heme iron increased the number of preneoplastic lesions, but dietary heterocyclic amines a

197 In the initial development of preneoplastic lesions, cellular proliferation is control

198 been useful for the detection of cancer and preneoplastic lesions, for staging of inflammatory and a

199 d alveoli are polyclonal, and putative early preneoplastic lesions, hyperplastic alveolar nodules (HA

200 Tetraploid cells are frequently found in preneoplastic lesions, including intestinal cancers aris

201 genetic lesions with the formation of these preneoplastic lesions, recent data suggest that the tumo

202 ion, as well as TP33 copy number, in gastric preneoplastic lesions.

203 noncancerous colonocytes, resulting in fewer preneoplastic lesions.

204 umor subtypes, and its occurrence in "early" preneoplastic lesions.

205 diseases, such as prostatic hyperplasia and preneoplastic lesions.

206 tatic epithelium leads to the development of preneoplastic lesions.

207 terations were also present in head and neck preneoplastic lesions.

208 A insertions, and it can be found mutated in preneoplastic lesions.

209 on of the gallbladder specimens was done for preneoplastic lesions.

210 microenvironment that can be used to detect preneoplastic lesions.

211 ase in the activation of STAT3 in pancreatic preneoplastic lesions; STAT3 is a transcription factor r

212 lin D1, the incidence and overall volume of ;preneoplastic' lesions were significantly decreased.

213 associated with the malignant conversion of preneoplastic liver lesions.

214 nisms that generate metastatic stem cells in preneoplastic liver tissue are not well understood.

215 CD133(+) LSCs derived from preneoplastic livers of beta2SP(+/-) mice treated with i

216 reover, transcriptomic analysis reveals that preneoplastic livers of Ncoa5(+/-) mice are similar to t

217 formation and the likely clonal outgrowth of preneoplastic lung epithelial cells that occurs in the c

218 association with IGF-1R activation in human preneoplastic lung lesions in smokers.

219 of these genes (82) was also changed in the preneoplastic mammary glands compared to wild-type contr

220 llular signal-regulated kinase activation in preneoplastic mammary glands from compound mutant mice.

221 sion of the luminal progenitor population in preneoplastic mammary glands of Her2/neu transgenic mice

222 progenitor cell population significantly in preneoplastic mammary glands of MMTV-Her2 mice which sho

223 Analyses of preneoplastic mammary tissue collected 1 month after DFM

224 ed expression profiles of mammary tumors and preneoplastic mammary tissue from MMTV-Neu transgenic mi

225 ne that spans the progression from normal to preneoplastic mammary tissue.

226 gamma target genes Adfp, Fabp4, and Pdhk4 in preneoplastic mammary tissue.

227 The preneoplastic mammary tissues of the PyMT/Fet-/- mice sh

228 Hence, these antibodies may serve as preneoplastic markers for HCC in HBV carriers with chron

229 of specific genes and their potential use as preneoplastic markers was further validated using an ind

230 ia, and increased staining for stem cell and preneoplastic markers.

231 orphogenesis and growth of normal MCF10A and preneoplastic MCF10AT1-EIII8 (referred as EIII8) human b

232 Interestingly, although in preneoplastic Mdr2(-/-) livers RAGE ablation did not aff

233 of neutrophils that trigger proliferation of preneoplastic melanocytes.

234 signaling by inhibition of MEK might reverse preneoplastic metaplasia in the stomach.

235 sought to uncover new biomarkers for stomach preneoplastic metaplasias and neoplastic lesions by gene

236 mplex regulation of tumor development by the preneoplastic microenvironment, but also that this regul

237 duced neoplastic transformation in JB6-Cl.41 preneoplastic model.

238 mice develop uterine hyperplasia and ovarian preneoplastic morphological changes at a high frequency.

239 d cyclooxygenase activity contributes to the preneoplastic morphological changes of the ovarian surfa

240 gical and genetic properties of the p53 null preneoplastic mouse mammary epithelium in a p53 wild-typ

241 ction among many preexisting, low-penetrance preneoplastic mutations or stable epigenetic variants, f

242 We isolated preneoplastic neuroendocrine cells from a mouse model of

243 ons include differential susceptibilities of preneoplastic neuroglial cell types in different brain r

244 is as an endogenous anti-tumor signal in the preneoplastic niche.

245 t, FMD diet) fed to rats is known to produce preneoplastic nodules (PNNs) after 36 weeks and hepatoce

246 For many years the finding of preneoplastic nodules in the liver during experimental i

247 developed HCC whereas WT mice developed only preneoplastic nodules suggesting that loss of MT acceler

248 evelops nonalcoholic steatohepatitis (NASH), preneoplastic nodules, and hepatocellular carcinoma (HCC

249 ung cancer, either through direct actions on preneoplastic or neoplastic cells or through indirect ac

250 may provide a selective clonal advantage for preneoplastic or neoplastic hepatocytes and contribute t

251 is sufficient to lead to the development of preneoplastic or neoplastic lesions.

252 on of transforming growth factor beta, and a preneoplastic or tumor state of the hepatocytes influenc

253 The preneoplastic outgrowth lines were immortal and exhibite

254 the ovarian surface epithelium gives rise to preneoplastic ovarian lesions with an endometrioid gland

255 quently detected in the superficial cells of preneoplastic over non-neoplastic epithelia (P<0.0001),

256 th downstream MAPK/ERK pathway activation in preneoplastic pancreatic epithelium, whereas nontumorige

257 Only a small percentage of preneoplastic pancreatic intraductal neoplasia lesions l

258 ithelium led to the development of increased preneoplastic pathology, however the role of specific NF

259 ssue architecture, which plays a role in the preneoplastic phenotype and contributes to epithelial tu

260 clusion, increased mTOR activity conferred a preneoplastic phenotype to the HepaRG cells by altering

261 are an essential hematopoietic component for preneoplastic polyp development and are a novel target f

262 ability of Kras to reprogram acini into PDA preneoplastic precursors.

263 ne the transcriptome of very early stages of preneoplastic progression in an in vivo model that mimic

264 The function of EZH2 during preneoplastic progression in the mammary gland is unknow

265 Using an inducible transgenic mouse model of preneoplastic progression in the mammary gland, we disco

266 ts in an inducible transgenic mouse model of preneoplastic progression.

267 Evaluation of preneoplastic proliferative lesions in the pancreata fro

268 Neither pancreatitis nor preneoplastic proliferative lesions was found in monkeys

269 TRbeta1 and of its target genes in Krt-19(+) preneoplastic rat lesions and was associated with nodule

270 aR, VDR, CYP27B1, and CYP24A1 as modifiable, preneoplastic risk biomarkers for colorectal neoplasms.

271 In addition, when 21 preneoplastic samples showing LOH were compared to their

272 ce uniformly contain intraganglionic, likely preneoplastic, Schwann cell proliferations.

273 fic CTLs capable of eliminating Mut H-ras(+) preneoplastic skin cells, demonstrating that immunosurve

274 genically mutated cells proliferate in early preneoplastic skin.

275 We identified a preneoplastic stage in the patched (ptc) mutant mouse, a

276 During the long preneoplastic stage, in which the liver is often the sit

277 mice as early as 32 weeks that persisted at preneoplastic stage.

278 st responses during persistent infection and preneoplastic stages can shape the outcome of cancer pro

279 ession was elevated at the proliferative and preneoplastic stages in X/c-myc bitransgenic livers, whe

280 or types, the influence of the stroma during preneoplastic stages is unknown.

281 hough folate supplementation administered in preneoplastic stages may lower the risk of colorectal ca

282 ver, whether the immune system can recognize preneoplastic stages of human cancer is not known.

283 permissive microenvironment at the earliest, preneoplastic stages of MB.

284 catalytic activity is critical in the early preneoplastic stages of the liver because DeltaEGFR mice

285 d in the p53 null mammary outgrowth lines at preneoplastic stages, and in all its derived tumors.

286 taining heterozygosity; and is seen in early preneoplastic stages, which demonstrate clonal relatedne

287 expression of Runx2 in the thymus leads to a preneoplastic state defined by an accumulation of cells

288 used the human P493-6 B cells, which have a preneoplastic state dependent on the Epstein-Barr viral

289 with adjacent VLS lesions, in 5 of which VIN preneoplastic tissue was also present (patient age, 64.3

290 ets claudin-4 expression in frank tumors and preneoplastic tissue, and cCPE imaging may be used as an

291 ction by conferring TNFalpha resistance to a preneoplastic TNFalpha sensitive cell, while simultaneou

292 these results show that RhoA can induce the preneoplastic transformation of hMECs by altering multip

293 o overcome senescence checkpoints and induce preneoplastic transformation of human mammary epithelial

294 MEC strains led to their immortalization and preneoplastic transformation.

295 y epithelium using a unique in vivo model of preneoplastic transformation.

296 = 0.003) with a 40% reduction in a marker of preneoplastic transformation.

297 ly bursal development and progresses through preneoplastic transformed follicles to metastatic lympho

298 with myc, may be important for generation of preneoplastic transformed follicles.

299 es multi-staged tumorigenesis beginning with preneoplastic-transformed follicles (TF) and progressing

300 creatic acinar-to-ductal metaplasia (ADM), a preneoplastic transition in oncogenic Kras-driven pancre