ライフサイエンスコーパス: prenylation

1 enylated peptides distinguished the types of prenylation.

2 aracterized by a severe reduction in protein prenylation.

3 of the interaryl linker, and (iii) (dihydro)prenylation.

4 c effects determine the position and type of prenylation.

5 EBP-2) cleavage, causing decrease of protein prenylation.

6 afficking secondary to inhibition of protein prenylation.

7 se (FPPS) in osteoclasts, preventing protein prenylation.

8 -terminal mutation used to eliminate protein prenylation.

9 logy because many oncogenic proteins undergo prenylation.

10 s of post-translational modifications termed prenylation.

11 direct interference of small GTPases protein prenylation.

12 he community of researchers studying protein prenylation.

13 xpressed without C-terminal processing after prenylation.

14 ffect of alendronate or zoledronate on Rap1A prenylation.

15 hosphate synthase (FPPS) and inhibit protein prenylation.

16 se] pathway synthesizes lipids for G-protein prenylation.

17 ous vacuoles through its GTPase activity and prenylation.

18 strate binding that define reverse or normal prenylation.

19 banions in enantioselective carbonyl reverse prenylation.

20 disease by additionally inhibiting progerin prenylation.

21 ndicated the location of the PDE6 C-terminal prenylations.

22 regioselectivity in Orf2-catalyzed aromatic prenylations.

23 ylation 1c-6c, and carbonyl reverse 2-methyl prenylation 1d-6d.

24 iridium-catalyzed alcohol C-H tert-(hydroxy)prenylation - a byproduct-free process that forms an all

25 t combine to form products of tert-(hydroxy)-prenylation, a motif found in >2000 terpenoid natural pr

26 Protein prenylation, a well-defined protein consensus motifs dir

27 ic acid monohydrate, an inhibitor of protein prenylation, act synergistically to reverse outcomes of

28 We conclude that protein prenylation, acting downstream of Hmgcr1b and possibly t

29 Y42X/y) fibroblasts, there was a recovery of prenylation activity following treatment with either PTC

30 vage activity for phylloquinone but a strong prenylation activity for menadione (vitamin K3), which h

31 link between a mutation in p53 and cellular prenylation activity.

32 e bisphosphonate-induced inhibition of Rap1A prenylation, an effect that was reversed by addition of

33 nflammation and target enzymes essential for prenylation, an important process in the activation and

34 eptide synthetase (NRPS) followed by reverse prenylation and a cascade of post-NRPS reactions culmina

35 statin was associated with disruption of Ras prenylation and activation.

36 es, and linear peptides as substrates for C4-prenylation and also acts as regiospecific O-dimethylall

37 s of a C-terminal CAAX sequence that include prenylation and are thought to be required for biologica

38 ddition, aplexone treatment inhibits protein prenylation and blocking the activity of geranylgeranyl

39 stigated the effect of lovastatin on protein prenylation and cell signaling.

40 ity shown by this system makes it useful for prenylation and crotylation processes in the synthesis o

41 an important characterization of prokaryotic prenylation and demonstrate that this process is central

42 optosis pathway via inhibition of Rho family prenylation and depletion of GGPP, in a variety of diffe

43 4-position, resulting in direct carbinol C-H prenylation and geranylation, respectively.

44 yristoylation, S-acylation (palmitoylation), prenylation and GPI anchors but until recently little wa

45 ficant inhibitory effect of Abeta on protein prenylation and identify SREBP-2 as a target of oAbeta(4

46 sis inhibitor, selectively inhibited protein prenylation and induced apoptosis in MESN cells, while h

47 B binding to SmgGDS-607 and diminishes Rap1B prenylation and membrane localization.

48 Unlike prenylation and myristoylation, palmitoylation is a reve

49 that should be useful in studies of protein prenylation and other structurally related biological pr

50 acid that serves as substrate for subsequent prenylation and oxidative cyclization to the five ring C

51 n: classical CaaX processing or novel tandem prenylation and palmitoylation at the CCaX cysteines.

52 , using recombinant and purified enzymes for prenylation and protein-binding assays, we demonstrate t

53 eagents in enantioselective carbonyl reverse prenylation and represents the first use of allenes in e

54 ncated mutant RABL3 protein accelerates KRAS prenylation and requires RAS proteins to promote cell pr

55 reported that SmgGDS splice variants promote prenylation and trafficking of GTPases containing a C-te

56 tablish context-dependent effects of protein prenylation and unique roles of geranylgeranylation in t

57 tin induced a significant inhibition of RhoB prenylation, and a combination of these drugs at 1 micro

58 sylation, is not a substrate for alternative prenylation, and plays a role in SCH66336 enhancement of

59 ed GTP loading of RAS, abrogated alternative prenylation, and sensitized RAS-mutant cells to growth i

60 bbranch of the pathway important for protein prenylation, and showed improved mitochondrial function

61 ional modifications such as phosphorylation, prenylation, and ubiquitination can additionally alter t

62 8 ratio is required for optimal small GTPase prenylation, and validate this innovative approach of ta

63 Significant to AD, reduced levels of protein prenylation are present in the cerebral cortex of the Tg

64 s potential utility for the study of protein prenylation, are discussed.

65 ellular phenotypes, as well as to the use of prenylation as a biomarker.

66 e in axons, counter to the canonical view of prenylation as constitutive, and strikingly, in a manner

67 ause of the ability of statins to block Rac1 prenylation as geranylgeranyl transferase inhibitors wer

68 ap1, which is dictated by post-translational prenylation as well as by a stretch of basic residues wi

69 mical function as confirmed through in vitro prenylation assays (98 +/- 2% [PTC124] and 68 +/- 5% [PT

70 h was confirmed by western blot and in vitro prenylation assays.

71 equivocally the highly regiospecific regular prenylation at C-5 of the indole nucleus of the simple i

72 n synthase catalyzed both normal and reverse prenylation at C3 of the indole ring and normal prenylat

73 o- and chemoselective Pd(0)-catalyzed linear prenylation at C4 of l-tryptophan boronic pinacol ester

74 an, another alternate substrate, gave normal prenylation at C5 and C7.

75 an was an alternate substrate, giving normal prenylation at C5 as the major product.

76 fications at a carboxyl-terminal CaaX motif: prenylation at cysteine, proteolysis of the aaX tripepti

77 pimer of hapalindole U, and catalyzes normal prenylation at its C-2 position.

78 the indole nucleus, with normal and reverse prenylation at one of the sites, is consistent with a di

79 of FPP could not be accounted for by protein prenylation, because inhibition of farnesylation did not

80 The ability to measure protein prenylation before and after FTI and GGTI treatment is i

81 muM) of lovastatin inhibit Ras, Rho, and Rap prenylation but that therapeutic levels of lovastatin (5

82 rovide evidence that isoprenoids and protein prenylation, but not cholesterol, are required in OPCs t

83 Activation of GPCRs suppresses Rap1A prenylation, but unlike this effect on Rap1B, the GPCR-m

84 e protocols to measure the degree of protein prenylation by farnesyl transferase or geranylgeranyl tr

85 AX box of several small GTPases and inhibits prenylation by impeding their entry into the geranylgera

86 a effectors encode a prototypical eukaryotic prenylation CAAX motif (where C represents a cysteine re

87 n pathways are prenylated, and inhibition of prenylation can be useful as a therapeutic intervention.

88 ap1B, the GPCR-mediated suppression of Rap1A prenylation can occur independently of Rap1A phosphoryla

89 g that increased cellular demand for protein prenylation cannot explain increased statin sensitivity.

90 structural basis for the normal and reverse prenylations catalyzed by a single enzyme, and it offers

91 sphate (GGPP), which is required for protein prenylation, caused cell stress in monocytes, followed b

92 on, our findings call for a revision of the 'prenylation code'.

93 by which geranylgeranyltransferase-mediated prenylation controls T-cell localization to the intestin

94 A prenylation-deficient mutant of C17orf37 is functionally

95 ents and characterizing proteins involved in prenylation-dependent cellular pathways.

96 utes an important step towards understanding prenylation-dependent cellular processes.

97 eracts with a newly identified EhRhoGDI in a prenylation-dependent manner.

98 creased expression of KLF2 through a HMG-CoA/prenylation-dependent pathway.

99 ides, proteome-wide quantitative analysis of prenylation dynamics and alternative prenylation in resp

100 Posttranslational prenylation (e.g., farnesylation) of small G-proteins is

101 ation due to reduced expression of the Rho-A prenylation enzyme geranylgeranyltransferase-I (GGTase-I

102 en proposed as the recognition motif for two prenylation enzymes, protein farnesyltransferase (FTase)

103 anylgeranyl lipids, a process called protein prenylation, facilitates interactions of proteins with m

104 To determine whether protein prenylation (farnesyl/geranylgeranylation) regulates mat

105 t Chp depends on palmitoylation, rather than prenylation, for association with cellular membranes.

106 he position of the exocyclic acyl group, the prenylation grade of the core, and the relative configur

107 inhibitors of small G-protein methylation or prenylation had no effect on the early aldosterone-induc

108 ibitors, and quantification of defective Rab prenylation in a model of the retinal degenerative disea

109 lated proteins and reveal a role for protein prenylation in host defense against viral infections.

110 ED 3 microM) than (-)-3-E2 in inhibiting Rab prenylation in J774 cells and >26x more active in the ce

111 1, 3 selectively inhibited Rab11 vs. Rap 1A prenylation in J774 cells, and decreased cell viability,

112 eptides open the door for studies of protein prenylation in living cells, including enzymatic process

113 duction and elucidate the effects of protein prenylation in monocytes.

114 The role of prenylation in patients with mevalonate kinase deficienc

115 otes, little is known about the influence of prenylation in prokaryotic species.

116 fication and differentiation of the types of prenylation in proteins in large-scale studies and will

117 ysis of prenylation dynamics and alternative prenylation in response to four different prenyltransfer

118 that Ral GTPases do not undergo alternative prenylation in response to GGTI treatment.

119 and in vitro transcription, translation and prenylation in reticulocyte lysates.

120 specificity and functional roles for protein prenylation in Rho GTPase function.

121 We identify a localized requirement for prenylation in sympathetic axons to promote axonal growt

122 improved mitochondrial function and protein prenylation in the presence of statins.

123 gress has been made in understanding protein prenylation in vitro, we have been interested in studyin

124 eriovenous-dependent requirement for protein prenylation in zebrafish and human endothelial cells.

125 identifying and differentiating large-scale prenylations in vivo or in vitro.

126 phosphate (GGPP), which are used for protein prenylation, including the oncoproteins of the RAS super

127 Although it is clear that prenylation increases membrane affinity of CAAX proteins

128 alytic activity and is induced by Cdc42 in a prenylation-independent manner, arguing that Cdc42 bindi

129 r smaller potency difference in the RGGT and prenylation inhibition assays.

130 active as 7 in J774 cell viability and Rab11 prenylation inhibition assays.

131 ults also demonstrate that the efficiency of prenylation inhibition by statins is Ggamma subtype-depe

132 oviding further evidence for the efficacy of prenylation inhibition in chronic HDV.

133 es RAB activity because treatment with a RAB prenylation inhibitor and transfection of dominant negat

134 RNA levels, safety, and tolerability of the prenylation inhibitor lonafarnib in patients with chroni

135 Prenylation is a common biological reaction in all domai

136 Protein prenylation is a common post-translational modification

137 Protein prenylation is a post-translational modification that ha

138 Protein prenylation is a post-translational modification whereby

139 Prenylation is a posttranslational modification essentia

140 Prenylation is a posttranslational modification whereby

141 -propanol, enantioselective carbonyl reverse prenylation is achieved directly from the alcohol oxidat

142 Inhibiting protein prenylation is an attractive means to modulate cellular

143 S-prenylation is an important lipid modification that targ

144 Protein prenylation is believed to be catalyzed by three heterod

145 Protein prenylation is carried out by a pair of cytosolic enzyme

146 Prenylation is essential for HDV and inhibition abrogate

147 dividuals, is one pathogen for which protein prenylation is essential for survival.

148 nditional mutant mice, we found that protein prenylation is essential for sympathetic axon innervatio

149 s indicate that Cx32 is prenylated, but that prenylation is not required for proper trafficking of Cx

150 Here we demonstrate that C-terminal prenylation is not required for Rab13 to associate with

151 Protein prenylation is required for a variety of growth and deve

152 We show that KRAS4b prenylation is required for binding to CaM and that the

153 transferase inhibitors indicate that protein prenylation is required for malaria parasite development

154 the shift in molecular mass, and that rab17 prenylation is required for sumoylation.

155 These findings demonstrate that prenylation is required for the function of the C17orf37

156 Prenylation is the addition of prenyl groups to peptide

157 Prenylation is the posttranslational modification of a c

158 Since prenylation is thought to enhance the bioactivity of man

159 Although protein prenylation is widely studied, there are few good method

160 ent attachment of a single isoprenoid lipid (prenylation), is carried out by the CaaX prenyltransfera

161 Our results show that statin lowering of prenylation isoprenoids activates caspase-1/IL-1beta inf

162 AT reduced prenylation levels of GTPases, abolished T-bet expressio

163 Perturbation of the host prenylation machinery during infection adversely affecte

164 radigm of microbial exploitation of the host prenylation machinery for anchoring of injected effector

165 ta indicate that Legionella utilize the host prenylation machinery to facilitate targeting of effecto

166 n, underlining the unique ability of the Rab prenylation machinery to process the Rab family with div

167 or-2147 (GGTI-2147), an inhibitor of protein prenylation, markedly increased cytosolic accumulation o

168 o studies suggest that inhibition of protein prenylation may underlie the myotoxic effects of statins

169 pecific targeting of enzymes responsible for prenylation mimicked the inhibitory effects of statins o

170 Both the polybasic residues and the adjacent prenylation motif are required for proper PRL1 subcellul

171 features include a long hydrophobic tail and prenylation motif in Hex-1, and a long hydrophilic inser

172 ly relevant C(x)3X proteins begins, this new prenylation motif nearly doubles the number of proteins

173 C terminus of human Cx32 contains a putative prenylation motif that is conserved in Cx32 orthologs.

174 spite having a typical carboxy-terminal CaaX prenylation motif that is predicted to be recognized by

175 olybasic region that precedes the C-terminal prenylation motif.

176 Our results thus suggest that prenylation normally restrains innate immune responses b

177 The selective reverse prenylation of 3-substituted-1H-indoles at C3 is describ

178 Studies indicate GGTI-DU40 blocks prenylation of a number of geranylgeranylated CaaX prote

179 yl protein transferase inhibitor that blocks prenylation of a number of proteins important in cell pr

180 Arabidopsis Rab-GGTs may have preference for prenylation of C-terminal cysteines in particular positi

181 ansferases, providing a unique model for the prenylation of diverse metabolites.

182 he terpene cyclase structural fold for the N-prenylation of glutamic acid during the biosynthesis of

183 ocopherol forms of vitamin E is initiated by prenylation of homogentisate.

184 ation of Rac1, and does not detectably alter prenylation of K-Ras.

185 At a fundamental level, the mechanism of C4-prenylation of l-tryptophan recently has surfaced to eng

186 , this is the first report on an enzymatic C-prenylation of l-tyrosine as free amino acid and alterin

187 esyltransferase (FTase), which catalyzes the prenylation of many cellular signaling proteins includin

188 results indicate that SSO Ex5 suppresses the prenylation of multiple small GTPases in the Ras, Rho, a

189 nylation at C3 of the indole ring and normal prenylation of N1.

190 Prenylation of natural compounds adds structural diversi

191 Pd-catalyzed asymmetric prenylation of oxindoles to afford selectively either th

192 The prenylation of peptides and proteins is an important pos

193 Prenylation of protein (farnesylation and geranylgeranyl

194 NGF triggers prenylation of proteins including the Rac1 GTPase in axo

195 s of cholesterol(8), and the acetylation and prenylation of proteins(9,10).

196 and farnesylpyrophosphate (FPP) used in the prenylation of proteins.

197 l transferase (RGGT), selectively preventing prenylation of Rab GTPases.

198 l transferase (RabGGTase) is responsible for prenylation of Rab proteins.

199 shes prenylation of Rap1A and RhoA, enhances prenylation of Rac1, and does not detectably alter preny

200 These events depend on the prenylation of Rap1, which promotes its membrane localiz

201 ation to inhibit GDP/GTP exchange diminishes prenylation of Rap1A and RhoA, enhances prenylation of R

202 unsuspected differences in the regulation of prenylation of Rap1A versus Rap1B, due in part to their

203 nces in the ability of GPCRs to regulate the prenylation of Rap1B compared to Rap1A.

204 cancer effect of statins is independent from prenylation of RAS family proteins and is associated wit

205 th RAP1GDS1 (SmgGDS), a chaperone regulating prenylation of RAS GTPases(3).

206 argely based upon their ability to block the prenylation of Rho GTPases, including RhoA.

207 These findings uncover deficient prenylation of Rho-A as a key player in the pathogenesis

208 ects of statins are attributed to inhibiting prenylation of RhoA and effects on other intracellular s

209 rnesyl monophosphate) have been evaluated on prenylation of RhoB and on the cell cycle in a human mal

210 esterol biosynthesis pathway and changed the prenylation of RhoB.

211 This results in prenylation of RHOC, which is concomitantly induced by i

212 These results implicate prenylation of RPGR as a critical modification for its l

213 rily influences cholesterol biosynthesis and prenylation of signaling proteins.

214 biosynthetic pathway, the post-translational prenylation of small GTP-binding proteins such as Rho an

215 hase (hFPPS) controls the post-translational prenylation of small GTPase proteins that are essential

216 ellular levels of FPP and post-translational prenylation of small GTPase proteins, which are essentia

217 s suggest that SmgGDS proteins also regulate prenylation of small GTPases in vivo in a substrate-sele

218 It is not clear how protein prenylation of small GTPases relates to GTP hydrolysis a

219 ays a crucial role in the post-translational prenylation of small GTPases that perform a plethora of

220 e in the mevalonate pathway, crucial for the prenylation of small GTPases.

221 e, they support our original hypothesis that prenylation of specific G-proteins may be necessary for

222 Post-translational lipidation by prenylation of the CaaX-box C-terminal motif in eukaryot

223 yzes the final step of CAAX processing after prenylation of the cysteine residue and endoproteolysis

224 These reactions involve prenylation of the cysteine residue, cleavage at the AAX

225 spergillus fumigatus catalyze C(4)- and C(7)-prenylation of the indole ring, respectively.

226 PPi release is equal to the rate constant of prenylation of the peptide, as measured by other assays,

227 h triggered by statins can be uncoupled from prenylation of the RAS superfamily of oncoproteins.

228 renyltransferase AmbP3 catalyzes the reverse prenylation of the tetracyclic indole alkaloid hapalindo

229 Surprisingly, we find that C-terminal prenylation of these GTPases both promotes the interacti

230 e in Claviceps purpurea catalyzes the normal prenylation of tryptophan at C4 of the indole nucleus in

231 These results suggest a common mechanism for prenylation of tryptophan by all of the members of the s

232 In addition, a diastereoselective reverse prenylation of tryptophan methyl ester is disclosed, and

233 were treated with some inhibitors of protein prenylation or by further monoterpenes.

234 ation, exposing the C-terminal extension for prenylation or enabling OsCaM61 to be transferred to the

235 PBR of Rap1A does not detectably inhibit its prenylation or its binding to SmgGDS-607.

236 (3,4,5)-trisphosphate-binding domain; (iv) a prenylation/palmitoylation tag, and (v) a type-1 plasma

237 We identified five enzymes in the prenylation pathway and SAFB, a nuclear protein with bot

238 Our work establishes the prenylation pathway as paramount in KRAS membrane associ

239 The prenylation pathway consists of three enzymatic steps; t

240 l avenue for probing both the selectivity of prenylation pathway enzymes and the effects of prenylati

241 ches of mevalonate metabolism-fueled protein prenylation pathway in thymocyte egress and immune homeo

242 d passage of these small GTPases through the prenylation pathway is regulated by two splice variants

243 enylation pathway enzymes and the effects of prenylation pathway modifications on the cellular functi

244 rain nonprenylated GTPases from entering the prenylation pathway, leading to the general belief that

245 ing are post-translationally modified by the prenylation pathway.

246 of PBR-possessing small GTPases through the prenylation pathway.

247 the entry of Rap1A, RhoA, and Rac1 into the prenylation pathway.

248 ltransferase (Icmt) is the final step in the prenylation pathway.

249 h membrane trafficking via regulation of the prenylation pathway.

250 bling the creation of bioengineered parallel prenylation pathways with altered substrate selectivity

251 a(2)X sequence and would likely generate the prenylation pattern described here.

252 ositol metabolism, AMPylation, deAMPylation, prenylation, polyubiquitination, proteasomal degradation

253 of indole prenyltransferases regarding their prenylation positions.

254 of the three-step posttranslational protein prenylation process for the so-called CaaX proteins, whi

255 both sterol metabolite synthesis and protein prenylation processes.

256 enzyme of the last step of posttranslational prenylation processing pathway that modifies several onc

257 use non-native connections, the Pd-catalyzed prenylation produces the natural n-prenylthioether bond.

258 nzoic acid, and (S)-SEGPHOS delivers reverse-prenylation products 4a-i in good to excellent isolated

259 posttranslational modifications that include prenylation, proteolysis, and carboxyl methylation.

260 post-translational modifications, including prenylation, proteolysis, and methylation.

261 The synthesis features an optimized aromatic prenylation reaction in which an arylcopper intermediate

262 One particular prenylation reaction, farnesylation of an mCherry-CAAX f

263 ccording to the current understanding of the prenylation reaction.

264 This work indicates that post-prenylation reactions can generate multiple products det

265 (42)-treated neurons recovers normal protein prenylation, reduces cholesterol sequestration, and prev

266 by covalent attachment of isoprenoid lipids (prenylation) regulates the functions and biological acti

267 Inhibition of protein prenylation represents a mechanism of oAbeta(42)-induced

268 us farnesol, which enhances membrane protein prenylation, reversed viperin-mediated inhibition of HIV

269 This work expands our understanding of prenylation's impact within the proteome, establishes th

270 Defects in prenylation, seen in HIDS, led to RhoA inactivation and

271 ompounds are micromolar inhibitors of Rab11A prenylation, simultaneously being inactive against Rap1A

272 two PDE6D binding sites with the C-terminal prenylation site being the predominant PDE6D binding sit

273 le Hex-1 protein, supporting that the unique prenylation site in Hex-1 facilitates covalent JH bindin

274 Whereas the C-terminal prenylation site is critical for ZAP70 interaction, subc

275 e C terminus of RPGR(1-19) that contains the prenylation site regulates its interaction with PDE6D, I

276 palmitoylation sites) and cysteine 193 (the prenylation site) point mutations abolish RhoB functions

277 1 bears a unique C-terminal extension with a prenylation site.

278 r both the PRL-2 catalytic functionality and prenylation site.

279 lated by C-terminal motifs, including a CKIF prenylation site.

280 We also introduced epoxy groups in the prenylation sites of the proteins to make them more hydr

281 osynthesis pathway and, consequently, of the prenylation status and activity of RhoB, resulting in in

282 phytyltransferase (HPT), which catalyzes the prenylation step in tocopherol synthesis.

283 We conclude that blocking prenylation stimulates Rac1 effector interactions and un

284 onsequences of loss of function of all known prenylation subunits in the moss Physcomitrella patens.

285 Ras family small GTPases undergo prenylation (such as farnesylation) for proper localizat

286 esyltransferase to K-Ras and increased K-Ras prenylation, suggesting that KRAS mutation might synergi

287 study, a variety of proteins with C-terminal prenylation target ("CAAX box") sequences were enzymatic

288 re caused primarily through impaired protein prenylation that results in mitochondria dysfunction.

289 Following prenylation, the last three amino acids are cleaved off

290 Protein prenylation, the specific prenyl modification (farnesyl

291 nate the potential for in vivo regulation of prenylation through modulation of STO versus MTO peptide

292 Thus, coupling of prenylation to local protein synthesis presents a mechan

293 re, we investigated the contribution of RhoA prenylation to the biochemical pathways that underlie MK

294 lowering of isoprenoids required for protein prenylation triggered NLRP3/caspase-1 inflammasome activ

295 The PEGylated Rab proteins undergo normal prenylation, underlining the unique ability of the Rab p

296 ty of the intermediates required for protein prenylation was responsible for decreased gammaherpesvir

297 Bent conformation and chain prenylation, were molecular features of main prenylated

298 bility to bind guanine nucleotides and their prenylation with a geranylgeranyl or farnesyl isoprenoid

299 cent human fibroblasts by inhibiting protein prenylation, without affecting the senescent growth arre

300 bout whether any treatment targeting protein prenylation would be particularly effective.