ライフサイエンスコーパス: prickle

1 red and reversed by the products of the gene prickle.

2 polarity proteins including Dishevelled and Prickle.

3 wo other tissue polarity genes, flamingo and prickle.

4 and the cytoplasmic proteins Dishevelled and Prickle.

5 interactions with mutations in frizzled and prickle.

6 For example, a missense mutation in Prickle 1 (Pk1) is associated with progressive myoclonus

7 of NTD prevalence in humans and ascribes to Prickle-1 a critical role in lower spinal cord formation

8 Moreover, the planar-cell-polarity member, Prickle-1, is recruited specifically during junctional n

9 de-mediated knockdown of PCP genes including prickle-1a (pk1a) led to developmental biliary abnormali

10 ing function of Prickle on Frizzled requires Prickle activity in neighboring cells.

11 ed by mutations in disheveled, inturned, and prickle all make hair patterns globally irregular yet lo

12 rast the cytoplasmic components Dishevelled, Prickle and Diego are not needed for intercellular commu

13 Asymmetrical localization of Prickle and Dishevelled to the opposite cell edges in ze

14 Strabismus binds directly to Dishevelled and Prickle and is able to recruit them to membranes.

15 angl2 mutant shows reduced interactions with Prickle and PTK7, and disrupted planar polarity in the n

16 y the core proteins Strabismus, Dishevelled, Prickle, and Diego.

17 nts, including Frizzled, Van Gogh, Flamingo, Prickle, and Dishevelled, to establish their characteris

18 genes) and upstream genes such as frizzled, prickle, and starry night (frizzled-like genes).

19 ge from pleasantly cool to painfully aching, prickling, and burning.

20 that isoforms of the Fz PCP pathway protein Prickle are differentially required for the two PCP Phas

21 the planar polarity proteins Dishevelled and Prickle are mislocalised in the cell.

22 In the second phase, Dishevelled and Prickle are required for these proteins to become asymme

23 Among these, prickles are particularly interesting due to their morph

24 m leaves, thorns from stems or branches, and prickles as epidermal outgrowths-but converge in functio

25 evel is similar to frizzled, dishevelled and prickle, as many cells form a single hair of abnormal po

26 tubules are not required for accumulation of Prickle at the anterior cell edge.

27 However, Prickle axonal localization depends on Frizzled and Stra

28 la melanogaster, the cytoplasmic PCP protein Prickle binds Van Gogh and regulates its function.

29 Y1Rs are present in the parabasal prickle cell layer and the granular layer, while differe

30 that basal cells predominantly expressed m3, prickle cells had equally high levels of m4 and m5, and

31 We show that a VANG-1/Van Gogh and PRKL-1/Prickle containing PCP pathway and a Slit-independent SA

32 type is similar to frizzled, dishevelled and prickle, dachsous mutant wings display a unique and dist

33 e of the spatial patterns and reproduced the prickle density distribution on rose stems.

34 We describe a Prickle-dependent intercellular feedback loop that gener

35 However, prickle development is still unclear and this is the fir

36 genetic, and molecular mechanisms underlying prickle development, emphasizing the LOG gene family.

37 plant species may lead to novel insights for prickle development.

38 ytokinin biosynthesis, as a key regulator of prickle development.

39 ne (Vangl, Frizzled, Celsr) and cytoplasmic (Prickle, Dishevelled) molecules.

40 In "Spiny Solanums," prickles evolved approximately six million years ago, wi

41 last DNA phylogeny indicates that thorn-like prickles evolved at least four times and leaf dimorphism

42 , physical defenses like spines, thorns, and prickles exemplifies this phenomenon.

43 Homologs underlie prickle formation across angiosperms that collectively d

44 d agriculture applications, such as breeding prickle-free crops, offering broader insights into plant

45 In the absence of Prickle, Frizzled and Dishevelled remain symmetrically d

46 r data suggest that Strabismus, Flamingo and Prickle function together to regulate the establishment

47 , dishevelled (dsh), Van Gogh/strabismus and prickle, function to regulate wing hair, bristle and omm

48 he genus Solanum serve as model for studying prickle genetics.

49 In bdpox mutants, prickle hair cells were smaller and stomata were longer.

50 subdomains within r4, with one gene, a novel prickle homolog (pk1b), expressed specifically within th

51 Conversely, Prickle in the same cell has a destabilizing effect on F

52 ms, we leveraged this discovery to eliminate prickles in a wild species and an indigenously foraged b

53 ene caused at least 16 independent losses of prickles in eggplants and wild relatives in the genus So

54 (Pk3), a vertebrate homologue of Drosophila Prickle, in Xenopus gastrocoel roof plate (GRP).

55 marily active in the Early PCP Phase and the Prickle isoform in the Late PCP Phase.

56 merely altering the balance of the two adult prickle isoforms in neurons can predispose flies to seiz

57 We report that the putative PCP protein Prickle-like 2 (Pk2) is distributed in crescents on the

58 ns is required for the other's localization, Prickle localization is influenced by Strabismus functio

59 otein Strabismus and the cytoplasmic protein Prickle localize proximally, and the seven-pass transmem

60 mesoderm C&E, the noncanonical Wnt component Prickle localizes at the anterior cell edge, whereas Dis

61 Prickle localizes to the proximal side of pupal wing cel

62 ed approximately six million years ago, with prickle loss occurring multiple times as seen in domesti

63 more generalized cellular mechanism whereby Prickle mediates polarity by influencing microtubule-med

64 Additionally, we show that seizure-prone prickle mutant flies have electrophysiological defects s

65 stering at intercellular junctions, and that Prickle negatively regulates Strabismus phosphorylation.

66 ar, we show that the stabilizing function of Prickle on Frizzled requires Prickle activity in neighbo

67 buted, but we deciphered spatial patterns of prickles on Rosa hybrida cv. 'Red Queen' stem.

68 Prickles on rose stems appear to be randomly distributed

69 sults indicated that the spatial patterns of prickles on stems of different plant species are organiz

70 s or signs were experienced by 27 patients; 'prickling' or 'asleep numbness' in 20, mild pain in 13 a

71 ed for a gradient of frizzled, starry night, prickle, or spiny-legs expression to repolarize wing cel

72 Here, we show that Prickle organizes microtubule polarity and affects their

73 brafish, and humans showed that mutations in prickle orthologs result in epileptic phenotypes, althou

74 nfirmed the model can reproduce the observed prickle patterning on stems of other plant species using

75 ebrafish homologs of the Drosophila PCP gene prickle (pk) [8], both of which show discrete and dynami

76 the planar cell polarity (PCP) gene products prickle (pk) and dishevelled (dsh) show M/L polarization

77 Its cytoplasmic core components Prickle (Pk) and Dishevelled (Dvl) often localize as den

78 (Fzd), as well as the cytoplasmic effectors Prickle (Pk) and Dishevelled (Dvl).

79 The PCP genes prickle (pk) and strabismus (stbm) are thought to antago

80 This function of Dgo is redundant with Prickle (Pk) and Strabismus (Stbm), and only appreciable

81 olarity (PCP), with anterior localization of Prickle (Pk) and Strabismus (Stbm).

82 Here we show that the tissue polarity gene prickle (pk) encodes a protein with a triple LIM domain

83 acterise a zebrafish homologue of Drosophila prickle (pk), a gene that is implicated in the regulatio

84 One of the key members of this pathway is Prickle (Pk), a protein that regulates cell movement thr

85 ed (Fz)/PCP core components, Diego (Dgo) and Prickle (Pk), and screened these against the DrosDel gen

86 We study four polarity genes, frizzled (fz), prickle (pk), Van gogh/strabismus (Vang/stbm) and starry

87 ity (PCP) proteins, we find that alternative Prickle (Pk-Sple) protein isoforms control the polarity

88 ce mGluR1 in cancer cells through the Wnt-5a/prickle planar cell polarity protein 1 (PRICKLE1)/RE1 si

89 different developmental pathways (PRICKLE2, Prickle Planar Cell Polarity Protein 2 and ABI1, Abl-Int

90 The prickles primarily emerged at 90 to 135 degrees from the

91 y signaling components Van Gogh (VANG-1) and Prickle (PRKL-1).

92 ynamic interplay between two isoforms of the Prickle protein determines right- or left-handed bristle

93 PET-LIM proteins such as Prickle regulate cell behavior during gastrulation in Xe

94 in ascidians, the planar cell polarity gene prickle regulates sequential establishment of cell polar

95 t simultaneous depletion of Xtes and Xenopus Prickle results in axial defects that are more severe th

96 tongue or lips, elicits painful burning and prickling sensations through unknown mechanisms.

97 lly dissected repeated origins and losses of prickles-sharp epidermal projections-that convergently e

98 till unclear and this is the first report of prickle spatial pattern with a mathematical model.

99 ugh characterization of the contributions of Prickle, Spiny-legs, Dachsous, Fat, and Dachs to PCP in

100 Prickle-Spiny-Legs (Pk) is an essential component of the

101 nected through the Spiny-legs isoform of the Prickle-Spiny-legs locus.

102 and alfalfa, suggesting a conserved role in prickle suppression.

103 including interactions with Dishevelled and Prickle that function in a context-dependent manner.

104 Prickle therefore functions in a feedback loop that ampl

105 d/Dishevelled/Diego (Fz/Dsh/Dgo) or Van Gogh/Prickle (Vang/Pk) complexes within the same cell, stabil

106 im), a mutation in the PCP pathway component Prickle, which has a severe defect in early mediolateral

107 ssays and key Wnt/PCP factors (RhoA, Vangl2, Prickle, Wnt11) rescued Gsc-mediated NTDs.