ライフサイエンスコーパス: primary cilium

1 s SMO activation and its localization to the primary cilium.

2 y mediator of cargo protein targeting to the primary cilium.

3 hies are clinically diverse disorders of the primary cilium.

4 or WASF3, and efficiently recruits it to the primary cilium.

5 on of the Hh signaling pathway relies on the primary cilium.

6 bral cortical progenitors and neurons have a primary cilium.

7 elerated by the combined loss of Vhl and the primary cilium.

8 A hallmark of ccRCC is loss of the primary cilium.

9 ) activities, which drive disassembly of the primary cilium.

10 ne, in histone deacetylase 6 delivery to the primary cilium.

11 tion, and blocks accumulation of Rab8 at the primary cilium.

12 1 cells) neural stem cells (NSCs) contains a primary cilium.

13 either precursor results in the loss of the primary cilium.

14 rosomes and spindle poles, as well as to the primary cilium.

15 is involved in vesicular trafficking to the primary cilium.

16 onsistent with the developmental role of the primary cilium.

17 e receptors, Patched and Smoothened, and the primary cilium.

18 he receptors patched-1 and Smoothened in the primary cilium.

19 e, destabilizes axonemal microtubules in the primary cilium.

20 in genes encoding proteins localising to the primary cilium.

21 ration by promoting protein removal from the primary cilium.

22 showed defective Arl13b localization to the primary cilium.

23 specific trafficking events to and from the primary cilium.

24 Rilpl2 regulate protein localization in the primary cilium.

25 sis by delivering Rab8 to the basal body and primary cilium.

26 networks/modules that build and maintain the primary cilium.

27 ivity, a signaling pathway that requires the primary cilium.

28 elocalizes from centriolar satellites to the primary cilium.

29 edgehog signaling by Evc proteins within the primary cilium.

30 that Sec15 co-localized with Rab8 along the primary cilium.

31 (Smo), a seven-transmembrane protein, to the primary cilium.

32 and that Cdc42 colocalizes with Sec10 at the primary cilium.

33 tivation result in a rapid elongation of the primary cilium.

34 gehog (Shh) signal transduction requires the primary cilium.

35 been shown to be partially controlled by the primary cilium.

36 i-organ diseases caused by disruption of the primary cilium.

37 ndidate for regulation of the exocyst at the primary cilium.

38 hosphate transients apparent at the neuronal primary cilium.

39 retaining receptor-signaling pathways in the primary cilium.

40 l geometry can regulate the elaboration of a primary cilium.

41 ing of how signal transduction occurs at the primary cilium.

42 ntriole, which becomes the basal body of the primary cilium.

43 tion by the microtubule-based organelle, the primary cilium.

44 indicator to visualize Ca(2+) fluxes in the primary cilium.

45 , with SHH targeting these cells through the primary cilium.

46 were impaired in fibroblasts depleted of the primary cilium.

47 sts in the neonatal and adult heart harbor a primary cilium.

48 sess a cellular sensory organelle called the primary cilium.

49 Hh signaling is triggered at the primary cilium.

50 anscriptional regulation and function of the primary cilium.

51 adation of AURKA is required to maintain the primary cilium.

52 ers (TFs) regulate cilia gating and make the primary cilium a distinct functional entity.

53 thermore, we found that the formation of the primary cilium, a cellular organelle that is essential f

54 The primary cilium, a hair-like extension from a cell's surf

55 eover, we show that NRP1 localization to the primary cilium, a key platform for HH signal transductio

56 The membrane protein composition of the primary cilium, a key sensory organelle, is dynamically

57 basal cell carcinoma, are transduced by the primary cilium, a microtubular projection found on many

58 the inability of the cell to disassemble the primary cilium, a microtubule-based cellular organelle,

59 The primary cilium, a microtubule-based signaling center, is

60 prompted us to analyze the formation of the primary cilium, a non-motile organelle that is specializ

61 The primary cilium, a sensory appendage that is present in m

62 PKD arises from abnormalities of the primary cilium, a sensory organelle located on the cell

63 The primary cilium, a sensory organelle, regulates cell prol

64 We found that the primary cilium, a signaling structure that arises from t

65 and quantify the nanoscale morphology of the primary cilium, a tiny tubular cellular structure (~2-6

66 ebrate Hh signaling is its dependence on the primary cilium, a vestigial organelle that is largely ab

67 The primary cilium acts as a cellular antenna, transducing d

68 study, we report for the first time that the primary cilium acts as a crucial sensor for electrical f

69 The primary cilium acts as a transducer of extracellular sti

70 Although the primary cilium also participates in each of these pathwa

71 ith BBS, which encode proteins active at the primary cilium, an antenna-like organelle that acts as t

72 Polycystins localize to the primary cilium, an organelle essential for cell signalin

73 rpiosin exhibit compromised formation of the primary cilium, an organelle that functions as an assemb

74 found in organelle membranes, including the primary cilium-an antennae-like structure on the luminal

75 activity as a mechanism contributing to the primary cilium and BB formation defects seen after KIF14

76 The neuronal primary cilium and centriolar satellites have functions

77 Rilpl1 and Rilpl2 both localize to the primary cilium and centrosome, Rilpl1 specifically to th

78 is a necessary antecedent for removal of the primary cilium and cessation of Hh signaling during myog

79 dromes, we examined the role of USP9X in the primary cilium and found that endogenous USP9X localizes

80 nd that this phenotype is independent of the primary cilium and instead can be attributed to alterati

81 ne protein 107 (TMEM107) is localized in the primary cilium and is enriched at the transition zone wh

82 dromes, is essential for the function of the primary cilium and maintenance of phosphoinositide balan

83 racellular transport, cell architecture, and primary cilium and mitotic spindle organization.

84 membrane protein Smoothened (Smo) within the primary cilium and of the zinc finger transcription fact

85 naling, which is negatively regulated by the primary cilium and several NPH proteins, although the me

86 e site, which is notably not targeted to the primary cilium and strongly potentiated by forskolin and

87 or gp135 protein delivery at the base of the primary cilium and suggest the existence of a novel micr

88 anoctamin-1 (ANO1/TMEM16A) is located in the primary cilium and that blocking its channel function ph

89 es showed that MAPKBP1 is not present at the primary cilium and that fibroblasts from affected indivi

90 PKC (aPKC), both of which distribute to the primary cilium and the apicolateral cell membrane in NP

91 of the mitotic spindle, the function of the primary cilium and the DNA damage response.

92 Being homologous organelles, the primary cilium and the OS share common building blocks a

93 we compare the structural properties of the primary cilium and the OS, and propose a hypothesis that

94 to identify cells in adult heart harboring a primary cilium and to determine whether primary cilia pl

95 er biopsies, disorders of the cholangiocytes primary cilium and various degrees of bile duct paucity

96 Polycystins are expressed in the primary cilium, and disrupting cilia structure significa

97 bulbous appearance, increased length of the primary cilium, and dysregulated SHH signaling.

98 ertebrates, SHH signaling is mediated by the primary cilium, and genetic defects affecting either SHH

99 uces the accumulation of Gli proteins in the primary cilium, and its ability to induce Gli-dependent

100 RF2 in controlling a cellular organelle, the primary cilium, and its associated Hh signaling pathway

101 human diseases resulting from defects of the primary cilium, and these patients often have cleft lip

102 h as dendritic spines, the yeast bud and the primary cilium, and to serve as membrane diffusion barri

103 anges in membrane protein composition of the primary cilium are central to development and homeostasi

104 Here, we identify the primary cilium as a critical determinant controlling tum

105 insights into BCC treatment and identify the primary cilium as an important lineage gatekeeper, preve

106 nctional hedgehog pathway machinery from the primary cilium, as well as GLI-dependent transcription i

107 Autophagy and primary cilium assembly have long been known to be induc

108 anization of satellite proteins and perturbs primary cilium assembly.

109 microtubules and for the normal kinetics of primary cilium assembly.

110 g regulator EHD1 as a novel regulator of the primary cilium-associated trafficking of Smoothened and

111 PCP protein Dishevelled and to position the primary cilium at the abneural edge of the apical surfac

112 Thus, we have identified a primary cilium-autophagy-Nrf2 (PAN) control axis coupled

113 Meckelin localizes to the primary cilium, basal body and elsewhere within the cell

114 embrane protein generally known to be on the primary cilium, basal body and plasma membrane.

115 ing endosome compartment in proximity to the primary cilium base.

116 The life cycle of a primary cilium begins in quiescence and ends prior to mi

117 taining 3 (C2cd3), an essential regulator of primary cilium biogenesis.

118 ndrome 1), at centriolar satellites promotes primary cilium biogenesis.

119 gulating cell migration independently of the primary cilium, but how IFT proteins integrate with the

120 gehog signaling, localizes to the tip of the primary cilium, but the importance of its ciliary locali

121 Hedgehog signaling is transduced at the primary cilium, but the precise mechanisms underlying th

122 Bromi and CCRK control the structure of the primary cilium by coordinating assembly of the axoneme a

123 esterol accessibility in the membrane of the primary cilium by inactivating the transporter-like prot

124 rk we measure the mechanical properties of a primary cilium by using an optical trap to induce resona

125 As genetic variants affecting the primary cilium can cause ciliopathies in which RD may be

126 As nucleators of the mitotic spindle and primary cilium, centrosomes play crucial roles in equal

127 s and the transition zone at the base of the primary cilium, CEP290 also localizes to the nucleus; ho

128 The clinical consequences of defective primary cilium (ciliopathies) are characterized by marke

129 use mutants deficient in Polaris, a critical primary cilium component, in cartilage.

130 The primary cilium constitutes a subcellular compartment tha

131 photoreceptors consist of a highly modified primary cilium containing phototransduction machinery ne

132 ogenic lineage commitmentin vivoand that the primary cilium contributes to this process.

133 As the primary cilium coordinates several signaling pathways es

134 Although the primary cilium critically influences signaling in develo

135 Finally, primary cilium-dependent lipophagy and mitochondrial bio

136 d transiently decreased cAMP production in a primary cilium-dependent manner.

137 4 osteocyte-like cells, may play a role in a primary cilium-dependent mechanism of osteocyte mechanot

138 ora kinase A (AURKA) is necessary for proper primary cilium disassembly before mitosis.

139 from the mother centriole to the tip of the primary cilium during ciliogenesis.

140 matrix (ECM) turnover and biogenesis of the primary cilium during mouse embryogenesis.

141 o explore the fate and potential role of the primary cilium during myofibroblast formation.

142 regulate signaling pathways localized to the primary cilium during the differentiation process.

143 sorder with a spectrum of symptoms caused by primary cilium dysfunction.

144 primary cilium formation and the dynamics of primary cilium elongation, and disrupts the localization

145 These changes in turn cause defects in primary cilium elongation, Smo ciliary translocation, an

146 Similarly, VxPx inhibited primary cilium enrichment of a chimera of rhodopsin and

147 ytosolic or transmembrane molecules form the primary cilium, few secreted molecules are known to cont

148 ertebrate photoreceptor is a highly modified primary cilium filled with disc-shaped membranes that pr

149 g the older mother centriole usually grows a primary cilium first.

150 mutations permit transposition of SMO to the primary cilium followed by enhanced expression of transc

151 ivered to a ring surrounding the base of the primary cilium, followed by microtubule-dependent radial

152 Hh signal transduction requires the primary cilium for several steps in the pathway [1-5].

153 were associated with significantly decreased primary cilium formation and attenuated hedgehog signali

154 The transcriptional control of primary cilium formation and ciliary motility are beginn

155 is, as its absence hampers the efficiency of primary cilium formation and the dynamics of primary cil

156 Depletion of FOP strongly inhibits primary cilium formation in human RPE-1 cells.

157 e transcription factor Atoh1/MATH1 regulates primary cilium formation, enabling SHH signaling.

158 rization and also reduces the probability of primary cilium formation, whereas USP21 knockdown in PC1

159 acquire subdistal appendages (sDAPs) during primary cilium formation.

160 Golgi morphology and trafficking and normal primary cilium formation.

161 the regulation of vesicular trafficking for primary cilium formation.

162 The primary cilium, formed in nonhematopoietic cells, is ess

163 l orientation patterns that the chondrocytic primary cilium forms in articular cartilage in the prese

164 d candidates, including a subset involved in primary cilium function.

165 The primary cilium has an important role in signaling; defec

166 The primary cilium has been found to be associated with a nu

167 The primary cilium has critical roles in human development a

168 Many cells possess a single, nonmotile, primary cilium highly enriched in receptors and sensory

169 ruption of the mechanosensing organelle, the primary cilium in a progenitor population, significantly

170 ue, and its encoded protein localizes to the primary cilium in an in vitro model of human neurogenesi

171 mponent, mainly localizes at the base of the primary cilium in developing podocytes from human fetal

172 The role of the primary cilium in key signaling pathways depends on dyna

173 nce of the mechano-sensorial function of the primary cilium in kidney tubule epithelial cells and (ii

174 Thus, we have uncovered a function of the primary cilium in maintaining homeostasis of the CE by b

175 his study was to investigate the role of the primary cilium in mechanosensing by osteoblasts.

176 We investigated the role of the chondrocyte primary cilium in mechanotransduction events related to

177 Mammalian Smo translocates to the primary cilium in response to Sonic hedgehog (Shh) ligan

178 sposes renal epithelial cells to loss of the primary cilium in response to specific signals.

179 cilia and Kif7-eGFP localizes to base of the primary cilium in the absence of Shh.

180 ture to determine what we now know about the primary cilium in the developing and adult CNS and what

181 igates the role of the immotile chondrocytic primary cilium in the growth plate.

182 We examined the assembly and function of the primary cilium in the synaptic integration of adult-born

183 ith Shh signaling, and the importance of the primary cilium in this neoplastic process.

184 Here we report a role for the beta-cell primary cilium in type 2 diabetes susceptibility.

185 protein localises to the proximal end of the primary cilium, in the transition zone, where it control

186 cilium after Gli proteins have transited the primary cilium; in this model the sequential movement of

187 Failure to reabsorb the primary cilium induces cellular senescence.

188 In quiescent cells, the primary cilium insulates itself from contiguous dynamic

189 Thus, the primary cilium integrates Hedgehog and Wnt signaling bet

190 receptor sensory cilium, which is a modified primary cilium involved with polarized trafficking of pr

191 The primary cilium is a cellular organelle that is almost ub

192 The primary cilium is a cellular sensor that detects light,

193 The primary cilium is a central signaling hub in cell prolif

194 The primary cilium is a conserved organelle increasingly vie

195 ssifying this disease as a "ciliopathy." The primary cilium is a critical regulator of several cell s

196 The non-motile primary cilium is a critical sensory organelle on the ce

197 The primary cilium is a highly conserved environmental senso

198 The primary cilium is a highly conserved organelle housing s

199 The membrane of the primary cilium is a highly specialized compartment that

200 The primary cilium is a membrane protrusion that is crucial

201 The primary cilium is a microtubule-based organelle that fun

202 The primary cilium is a microtubule-based organelle that sen

203 The primary cilium is a microtubule-based structure found in

204 The primary cilium is a nexus of cell signaling, and ciliary

205 The primary cilium is a paradigmatic organelle for studying

206 The primary cilium is a singular cellular structure that ext

207 Primary cilium is a solitary organelle that emanates fro

208 The primary cilium is a solitary organelle that responds to

209 A primary cilium is a solitary, slender, non-motile protub

210 or the first time, that the formation of the primary cilium is altered in NPC1 disease.

211 Non-motile primary cilium is an antenna-like structure whose defect

212 The primary cilium is an apically projecting solitary organe

213 The primary cilium is an evolutionarily conserved dynamic or

214 The primary cilium is an organelle essential for cell signal

215 The primary cilium is an outward projecting antenna-like org

216 The membrane of the primary cilium is continuous with the plasma membrane bu

217 The primary cilium is critical for transducing Sonic hedgeho

218 With the revelation that the primary cilium is crucial for mammalian Hh signaling, th

219 The primary cilium is emerging as a crucial regulator of sig

220 The primary cilium is essential for skin morphogenesis throu

221 Our data indicate 1) the primary cilium is not a simple cantilevered beam; 2) the

222 The primary cilium is nucleated by the mother centriole-deri

223 A primary cilium is present on most eukaryotic cells and r

224 The primary cilium is required for Hedgehog signaling.

225 The primary cilium is required for Sonic hedgehog (Shh) sign

226 The primary cilium is the sensory organelle that is responsi

227 The primary cilium is the site where a subset of the cell's

228 The primary cilium is thought to be disassembled prior to mi

229 ndicate that the exocyst, acting through the primary cilium, is necessary for renal ciliogenesis, cys

230 apical markers and displays microvilli and a primary cilium; its lumenal space is rich in Ca(2+) Time

231 Each bundle is comprised of a single primary cilium (kinocilium) flanked by multiple rows of

232 Apical abscission also dismantles the primary cilium, known to transduce sonic-hedgehog signal

233 evins perturb protein trafficking within the primary cilium, leading to their malformation and Hedgeh

234 ystic cholangiocytes UDCA-HDAC6i #1 restored primary cilium length and exhibited potent antiprolifera

235 aling is associated with a shortening of the primary cilium length and with a reduction of the fracti

236 quent protein kinase A activation, increases primary cilium length in mammalian epithelial and mesenc

237 cking PI3K-C2alpha rescues Rab11 activation, primary cilium length, and Shh pathway induction.

238 Live-cell microscopy reveals that Rilpl2 primary cilium localization is dynamic and that it is as

239 Wnt tone, and disrupts Notch1 signaling and primary cilium maintenance necessary for radial progenit

240 the gene products localize in and around the primary cilium, making JS a canonical ciliopathy.

241 st time that pharmaceutical targeting of the primary cilium may have therapeutic benefits in the trea

242 rgmann glia cells Gpr37l1 is associated with primary cilium membranes and it specifically interacts a

243 , including regulation of centrosome number, primary cilium morphology, nuclear membrane morphology,

244 The primary cilium must be disassembled to free its centriol

245 ost NPH gene products (NPHP) function at the primary cilium, NPH is classified as a ciliopathy.

246 ein Smoothened (SMO), which localizes to the primary cilium of a cell on activation and is both posit

247 show that opsin can enter and move along the primary cilium of a nonphotoreceptor cell (an hTERT-RPE1

248 Here, we show that SPATA7 localizes at the primary cilium of cells and at the connecting cilium (CC

249 Galphas is highly enriched at the primary cilium of granule neuron precursors and suppress

250 lex involved in membrane trafficking, to the primary cilium of Madin-Darby canine kidney cells and sh

251 Here, we show that the primary cilium of renal epithelial cells contains a prot

252 Our results show that OCRL localizes to the primary cilium of retinal pigment epithelial cells, fibr

253 Our results suggest that the primary cilium or an associated structure influences the

254 The primary cilium originates from the mother centriole and

255 ance of the signaling pathways hosted by the primary cilium, our results suggest hitherto unrecognize

256 way is that signal transduction requires the primary cilium (PC) where major pathway components are d

257 Hh components partially reside in the primary cilium (PC), and the small fraction of cells in

258 The primary cilium permits compartmentalization of specific

259 The primary cilium plays critical roles in vertebrate develo

260 The primary cilium regulates cellular signalling including i

261 Signaling from the primary cilium regulates kidney tubule development and c

262 The orientation of the primary cilium, relative to the major axis of the chondr

263 C1 and other ciliary proteins traffic to the primary cilium remain poorly understood.

264 ectively transported to and organized in the primary cilium remains unclear.

265 The motility and signaling functions of the primary cilium require a unique protein and lipid compos

266 The primary cilium's functions range from the movement of ce

267 x that transports membrane proteins into the primary cilium signaling organelle in eukaryotes and is

268 Primary cilium size, architecture, and assembly-disassem

269 segment (OS) is a unique modification of the primary cilium, specialized for light perception.

270 We examined primary cilium structure and composition in fibroblast c

271 diseases that are associated with defects in primary cilium structure and function.

272 We highlight the importance of the primary cilium structure in mechanosensing and lineage s

273 Hedgehog signaling requires the primary cilium such that maintenance of this compartment

274 Because the primary cilium suppresses renal cyst formation, loss of

275 owever, its relationship to disorders of the primary cilium, termed ciliopathies, has not been explor

276 ammalian brain possess an appendage called a primary cilium that projects from the soma into the extr

277 une synapse, even though immune cells lack a primary cilium that would be the typical setting for thi

278 aracterized center-to-edge displacement of a primary cilium, the kinocilium, at their apical surface.

279 d adjacent cellular structures of a modified primary cilium, the rod outer segment, from wild-type an

280 INPP5E is targeted to the primary cilium through a motif near the C terminus and p

281 intracellular source and may traffic to the primary cilium through an intraflagellar transport (IFT)

282 hat in renal epithelia, RP2 localizes to the primary cilium through dual acylation of the amino-termi

283 that vertebrate CK1gamma is localized at the primary cilium to promote Smo phosphorylation and Sonic

284 the outer segment structure evolved from the primary cilium to provide photoreceptor cells with vast

285 In animal cells, the primary cilium transduces extracellular signals through

286 Further, primary cilium transience may have implications for othe

287 ly characterize morphological changes of the primary cilium under different treatments and uses stimu

288 ork, the equilibrium shape and dynamics of a primary cilium under flow are investigated by using both

289 Many cells only build a primary cilium upon cell cycle exit, in G0.

290 eletion of Vhl together with ablation of the primary cilium via deletion of the kinesin family member

291 s CEP170's localization to the basal body of primary cilium, where CEP170 recruits microtubule-depoly

292 docytic compartment (PRE) at the base of the primary cilium, where it regulates production of a speci

293 localizes to the proximal compartment of the primary cilium, where it regulates signaling.

294 in which Cdc42 localizes the exocyst to the primary cilium, whereupon the exocyst then targets and d

295 ereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, lead

296 senescence by preventing reabsorption of the primary cilium, which inhibits centrosome and mitotic sp

297 ignaling and showed that the GCP possessed a primary cilium with CEP290 at its base.

298 reports the three-dimensional structure of a primary cilium with unprecedented clarity.

299 Ciliopathies are clinical disorders of the primary cilium with widely recognized phenotypic and gen

300 ly little is known about ion channels in the primary cilium (with the exception of TRPP2).